Showing entry for Histone-arginine methyltransferase CARM1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT017627
Protein NameHistone-arginine methyltransferase CARM1
Uniport IdQ86X55
GeneCARM1
Gene Id10498
DomainCARM1; PrmA
Pfam PF11531  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.12 Drug resistance: Antineoplastic hsa01522 Endocrine resistance
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007568 aging
Biological Process GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
Biological Process GO:0060350 endochondral bone morphogenesis
Biological Process GO:0034971 histone H3-R17 methylation
Biological Process GO:0034970 histone H3-R2 methylation
Biological Process GO:0016571 histone methylation
Biological Process GO:0030520 intracellular estrogen receptor signaling pathway
Biological Process GO:2000171 negative regulation of dendrite development
Biological Process GO:0032091 negative regulation of protein binding
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0045600 positive regulation of fat cell differentiation
Biological Process GO:0051092 positive regulation of NF-kappaB transcription factor activity
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0071168 protein localization to chromatin
Biological Process GO:0003420 regulation of growth plate cartilage chondrocyte proliferation
Biological Process GO:0033146 regulation of intracellular estrogen receptor signaling pathway
Biological Process GO:0019216 regulation of lipid metabolic process
Biological Process GO:1902415 regulation of mRNA binding
Biological Process GO:0006355 regulation of transcription, DNA-templated
Biological Process GO:0051591 response to cAMP
Biological Process GO:0016032 viral process
molecular function GO:0008013 beta-catenin binding
molecular function GO:0008469 histone-arginine N-methyltransferase activity
molecular function GO:0042054 histone methyltransferase activity
molecular function GO:0035642 histone methyltransferase activity (H3-R17 specific)
molecular function GO:0070577 lysine-acetylated histone binding
molecular function GO:0030374 nuclear receptor transcription coactivator activity
molecular function GO:0016274 protein-arginine N-methyltransferase activity
molecular function GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0008276 protein methyltransferase activity
molecular function GO:0003713 transcription coactivator activity
molecular function GO:0000976 transcription regulatory region sequence-specific DNA binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0090575 RNA polymerase II transcription regulator complex
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-1368082 RORA activates gene expression
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression
R-HSA-1430728 Metabolism
R-HSA-1430728 Metabolism
R-HSA-1592230 Mitochondrial biogenesis
R-HSA-162582 Signal Transduction
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF)
R-HSA-1852241 Organelle biogenesis and maintenance
R-HSA-1989781 PPARA activates gene expression
R-HSA-1989781 PPARA activates gene expression
R-HSA-212436 Generic Transcription Pathway
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
R-HSA-3214858 RMTs methylate histone arginines
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-400206 Regulation of lipid metabolism by PPARalpha
R-HSA-400206 Regulation of lipid metabolism by PPARalpha
R-HSA-400253 Circadian Clock
R-HSA-4839726 Chromatin organization
R-HSA-556833 Metabolism of lipids
R-HSA-556833 Metabolism of lipids
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes
R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-8939211 ESR-mediated signaling
R-HSA-8957322 Metabolism of steroids
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-9018519 Estrogen-dependent gene expression
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0013264 BXGD000808 Muscular Dystrophy, Duchenne Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0020445 BXGD001386 Hypercholesterolemia, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0023440 BXGD001646 Acute Erythroblastic Leukemia Neoplasms; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023508 BXGD001675 White Blood Cell Count procedure
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024115 BXGD001732 Lung diseases Respiratory Tract Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026847 BXGD001940 Spinal Muscular Atrophy Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027794 BXGD002036 Neural Tube Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0028960 BXGD002101 Oligospermia Male Urogenital Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030246 BXGD002198 Pustulosis of Palms and Soles Skin and Connective Tissue Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0035412 BXGD002548 Rhabdomyosarcoma Neoplasms
C0037369 BXGD002691 Smoking Behavior and Behavior Mechanisms
C0085281 BXGD003152 Addictive Behavior Behavior and Behavior Mechanisms
C0153381 BXGD003626 Malignant neoplasm of mouth Neoplasms; Stomatognathic Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0201657 BXGD004051 C-reactive protein measurement
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0206624 BXGD004190 Hepatoblastoma Neoplasms
C0206669 BXGD004229 Hepatocellular Adenoma Digestive System Diseases; Neoplasms
C0220611 BXGD004295 Childhood Rhabdomyosarcoma Neoplasms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0220641 BXGD004305 Lip and Oral Cavity Carcinoma Neoplasms; Stomatognathic Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279550 BXGD006635 Adult Rhabdomyosarcoma Neoplasms
C0338451 BXGD007176 Frontotemporal dementia Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0346156 BXGD007783 Benign neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0742343 BXGD010061 Acute Chest Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C0751214 BXGD010353 Hyperalgesia, Thermal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0948089 BXGD011504 Acute Coronary Syndrome Cardiovascular Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1445957 BXGD013081 Serum total cholesterol measurement
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1519383 BXGD013237 Smoking Behaviors Behavior and Behavior Mechanisms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2347748 BXGD017041 Adult Erythroleukemia
C2676033 BXGD017322 Hepatoblastoma Caused By Somatic Mutation Digestive System Diseases; Neoplasms
C2936719 BXGD018130 Mechanical Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4520840 BXGD023041 Erythroleukemia (Erythroid/Myeloid) Neoplasms; Hemic and Lymphatic Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0003705 Chloride 35.45
BXGC0006193 Ellagic acid 302.19
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein