Showing entry for Formylglycine-generating enzyme


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT018538
Protein NameFormylglycine-generating enzyme
Uniport IdQ8NBK3
GeneSUMF1
Gene Id285362
DomainFGE-sulfatase
Pfam PF03781  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04142 Lysosome
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006687 glycosphingolipid metabolic process
Biological Process GO:0043687 post-translational protein modification
Biological Process GO:0018158 protein oxidation
molecular function GO:1903135 cupric ion binding
molecular function GO:0120147 Formylglycine-generating oxidase activity
molecular function GO:0042802 identical protein binding
molecular function GO:0016491 oxidoreductase activity
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005788 endoplasmic reticulum lumen
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-163841 Gamma carboxylation, hypusine formation and arylsulfatase activation
R-HSA-1660662 Glycosphingolipid metabolism
R-HSA-1663150 The activation of arylsulfatases
R-HSA-392499 Metabolism of proteins
R-HSA-428157 Sphingolipid metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-597592 Post-translational protein modification
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0008445 BXGD000541 Chondrodysplasia Punctata Musculoskeletal Diseases
C0010038 BXGD000643 Corneal Opacity Eye Diseases
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0020255 BXGD001369 Hydrocephalus Nervous System Diseases
C0020757 BXGD001466 Ichthyoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0023522 BXGD001680 Leukodystrophy, Metachromatic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0025521 BXGD001876 Inborn Errors of Metabolism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026703 BXGD001919 Mucopolysaccharidoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027404 BXGD001984 Narcolepsy Nervous System Diseases; Mental Disorders
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0035304 BXGD002528 Retinal Degeneration Eye Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0079588 BXGD003084 Ichthyosis, X-Linked Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0085078 BXGD003118 Lysosomal Storage Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0086647 BXGD003298 Mucopolysaccharidosis Type IIIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0086651 BXGD003302 Mucopolysaccharidosis, MPS-IV-A Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0086795 BXGD003311 Pfaundler-Hurler Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0087012 BXGD003318 Ataxia, Spinocerebellar Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0151205 BXGD003406 Periorbital edema Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Eye Diseases; Skin and Connective Tissue Diseases; Immune System Diseases; Cardiovascular Diseases
C0162298 BXGD003933 Joint stiffness Musculoskeletal Diseases
C0221355 BXGD004447 Macrocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0235946 BXGD004789 Cerebral atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0268263 BXGD005873 Multiple Sulfatase Deficiency Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0277959 BXGD006487 Coarse hair
C0338474 BXGD007183 Central nervous system demyelination
C0349588 BXGD007933 Short stature
C0426891 BXGD008595 Broad thumbs
C0557874 BXGD009444 Global developmental delay
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0596887 BXGD009648 mathematical ability
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0740279 BXGD009973 Cerebellar atrophy
C0742468 BXGD010063 Central nervous system lesion
C0878575 BXGD011372 Peripheral demyelination Nervous System Diseases
C1142533 BXGD011758 Smooth philtrum
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1531647 BXGD013301 Cerebral ventriculomegaly Nervous System Diseases
C1720864 BXGD013693 Sulfatidosis, Juvenile, Austin Type Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C1806780 BXGD013759 Increased CSF protein
C1836542 BXGD014129 Depressed nasal bridge
C1836696 BXGD014151 Lower limb hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1836830 BXGD014165 Developmental regression Mental Disorders
C1837260 BXGD014214 Prominent forehead
C1839783 BXGD014407 Large forehead
C1840077 BXGD014434 Anteverted nostril
C1845847 BXGD014760 Coarse facial features Pathological Conditions, Signs and Symptoms
C1853241 BXGD015321 Flat face
C1853487 BXGD015340 Thick eyebrow
C1862475 BXGD016132 Abnormality of retinal pigmentation
C1863353 BXGD016168 Hypoplastic vertebral bodies
C1867131 BXGD016440 Broad hallux
C2267233 BXGD017017 Neonatal Hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2673431 BXGD017202 Abnormality of the periventricular white matter Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2720163 BXGD017530 Placental Steroid Sulfatase Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C2919142 BXGD017867 Short Stature, CTCAE
C2985280 BXGD018223 Blood Protein Measurement
C3278923 BXGD018748 Dilated ventricles (finding)
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4014261 BXGD020138 SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 16 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4020690 BXGD020468 Abnormality of peripheral nerve conduction
C4021343 BXGD020613 Broad hallux phalanx
C4024726 BXGD021387 Mucopolysacchariduria
C4024908 BXGD021467 Rapid neurologic deterioration
C4553313 BXGD023540 Periorbital Edema, CTCAE
C4553743 BXGD023548 Spasticity, CTCAE
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0002708 Strontium 87.62
BXGC0003705 Chloride 35.45
BXGC0004276 Acetamide 59.07
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein