Showing entry for ATP-dependent RNA helicase DDX1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019350
Protein NameATP-dependent RNA helicase DDX1
Uniport IdQ92499
GeneDDX1
Gene Id1653
DomainDEAD; Helicase_C; SPRY
Pfam PF00270   PF00271   PF00622  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0051607 defense response to virus
Biological Process GO:0032508 DNA duplex unwinding
Biological Process GO:0006302 double-strand break repair
Biological Process GO:0045087 innate immune response
Biological Process GO:0007275 multicellular organism development
Biological Process GO:0090305 nucleic acid phosphodiester bond hydrolysis
Biological Process GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process GO:0002735 positive regulation of myeloid dendritic cell cytokine production
Biological Process GO:1903608 protein localization to cytoplasmic stress granule
Biological Process GO:0006446 regulation of translational initiation
Biological Process GO:0043330 response to exogenous dsRNA
Biological Process GO:0000245 spliceosomal complex assembly
Biological Process GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation
Biological Process GO:0016032 viral process
molecular function GO:0005524 ATP binding
molecular function GO:0003682 chromatin binding
molecular function GO:0033677 DNA/RNA helicase activity
molecular function GO:0003677 DNA binding
molecular function GO:0003725 double-stranded RNA binding
molecular function GO:0004527 exonuclease activity
molecular function GO:0004386 helicase activity
molecular function GO:0004518 nuclease activity
molecular function GO:0008143 poly(A) binding
molecular function GO:0003723 RNA binding
molecular function GO:0003724 RNA helicase activity
molecular function GO:0003712 transcription coregulator activity
cellular component GO:0071920 cleavage body
cellular component GO:0005737 cytoplasm
cellular component GO:0010494 cytoplasmic stress granule
cellular component GO:0005829 cytosol
cellular component GO:0016020 membrane
cellular component GO:0005739 mitochondrion
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:1990904 ribonucleoprotein complex
cellular component GO:0072669 tRNA-splicing ligase complex
Reactome
Pathway Id Pathway Name
R-HSA-6784531 tRNA processing in the nucleus
R-HSA-72306 tRNA processing
R-HSA-8953854 Metabolism of RNA
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0005859 BXGD000342 Bloom Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0013146 BXGD000801 Drug abuse Chemically-Induced Disorders; Mental Disorders
C0013170 BXGD000802 Drug habituation Chemically-Induced Disorders; Mental Disorders
C0013222 BXGD000805 Drug Use Disorders Chemically-Induced Disorders; Mental Disorders
C0014173 BXGD000903 Endometrial Hyperplasia Female Urogenital Diseases and Pregnancy Complications
C0016514 BXGD001066 Foot-and-Mouth Disease Infections; Animal Diseases
C0017160 BXGD001099 Gastroenteritis Digestive System Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027708 BXGD002025 Nephroblastoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029231 BXGD002125 Organic Mental Disorders, Substance-Induced Chemically-Induced Disorders; Mental Disorders
C0035335 BXGD002540 Retinoblastoma Neoplasms; Eye Diseases
C0036631 BXGD002626 Seminoma Neoplasms
C0038580 BXGD002771 Substance Dependence Chemically-Induced Disorders; Mental Disorders
C0038586 BXGD002772 Substance Use Disorders Chemically-Induced Disorders; Mental Disorders
C0039590 BXGD002822 Testicular Neoplasms Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C0236969 BXGD004842 Substance-Related Disorders Chemically-Induced Disorders; Mental Disorders
C0280100 BXGD006713 Solid Neoplasm Neoplasms
C0349578 BXGD007930 Complex Endometrial Hyperplasia Female Urogenital Diseases and Pregnancy Complications
C0349579 BXGD007931 Atypical Endometrial Hyperplasia Female Urogenital Diseases and Pregnancy Complications
C0456483 BXGD008872 Simple Endometrial Hyperplasia Female Urogenital Diseases and Pregnancy Complications
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0677483 BXGD009717 Carcinoma testes Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0740858 BXGD010012 Substance abuse problem Chemically-Induced Disorders; Mental Disorders
C0857836 BXGD011159 JC virus infection Infections
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1335059 BXGD012755 testicular nonseminoma
C1510472 BXGD013170 Drug Dependence Chemically-Induced Disorders; Mental Disorders
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3160889 BXGD018491 Node-negative breast cancer
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4316881 BXGD022709 Prescription Drug Abuse Chemically-Induced Disorders; Mental Disorders
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein