adisease

Showing entry for Drug Dependence

General Disease Information
BXGD Id	BXGD013170
Disease Name	Drug Dependence
Disease CUI Id	C1510472
MeSH Codes	C25 F03
Disease Class Name	Chemically-Induced Disorders; Mental Disorders
Semantic Type	Mental or Behavioral Dysfunction
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id
Disease Ontology Class Name
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
A1Z1Q3	BXGT001069	ADP-ribose glycohydrolase MACROD2	140733	reviewed
O00141	BXGT003882	Serine/threonine-protein kinase Sgk1	6446	reviewed	Kinase
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O00519	BXGT003934	Fatty-acid amide hydrolase 1	2166	reviewed
O14733	BXGT004087	Dual specificity mitogen-activated protein kinase kinase 7	5609	reviewed	Kinase
O15439	BXGT004169	Multidrug resistance-associated protein 4	10257	reviewed	Transporter
O43612	BXGT004605	Orexin	3060	reviewed
O60760	BXGT004899	Hematopoietic prostaglandin D synthase	27306	reviewed
O75030	BXGT005096	Microphthalmia-associated transcription factor	4286	reviewed
O75469	BXGT005128	Nuclear receptor subfamily 1 group I member 2	8856	reviewed	Nuclear receptor
O75751	BXGT005150	Solute carrier family 22 member 3	6581	reviewed	Transporter
O95264	BXGT005367	5-hydroxytryptamine receptor 3B	9177	reviewed	Ion channel
P00325	BXGT005498	Alcohol dehydrogenase 1B	125	reviewed	Enzyme
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P01138	BXGT005738	Beta-nerve growth factor	4803	reviewed	Signaling
P01189	BXGT005742	Pro-opiomelanocortin	5443	reviewed
P01275	BXGT005747	Glucagon	2641	reviewed
P01303	BXGT005748	Pro-neuropeptide Y	4852	reviewed	Signaling
P04839	BXGT006273	Cytochrome b-245 heavy chain	1536	reviewed	Ion channel
P05026	BXGT006296	Sodium/potassium-transporting ATPase subunit beta-1	481	reviewed	Transporter
P05089	BXGT006310	Arginase-1	383	reviewed	Enzyme
P05091	BXGT006312	Aldehyde dehydrogenase, mitochondrial	217	reviewed	Enzyme
P05177	BXGT006336	Cytochrome P450 1A2	1544	reviewed	Enzyme
P05181	BXGT006337	Cytochrome P450 2E1	1571	reviewed
P06213	BXGT006425	Insulin receptor	3643	reviewed	Kinase
P06748	BXGT006497	Nucleophosmin	4869	reviewed	Chaperone
P06850	BXGT006511	Corticoliberin	1392	reviewed	Signaling
P07203	BXGT006566	Glutathione peroxidase 1	2876	reviewed	Enzyme
P07949	BXGT006703	Proto-oncogene tyrosine-protein kinase receptor Ret	5979	reviewed	Kinase
P08172	BXGT006737	Muscarinic acetylcholine receptor M2	1129	reviewed	G-protein coupled receptor
P08183	BXGT006741	ATP-dependent translocase ABCB1	5243	reviewed	Transporter
P08319	BXGT006764	Alcohol dehydrogenase 4	127	reviewed	Enzyme
P08581	BXGT006794	Hepatocyte growth factor receptor	4233	reviewed	Kinase
P08684	BXGT006812	Cytochrome P450 3A4	1576	reviewed	Enzyme
P08908	BXGT006837	5-hydroxytryptamine receptor 1A	3350	reviewed	G-protein coupled receptor
P09038	BXGT006851	Fibroblast growth factor 2	2247	reviewed	Signaling
P09211	BXGT006869	Glutathione S-transferase P	2950	reviewed
P09429	BXGT006889	High mobility group protein B1	3146	reviewed	Nucleic acid binding
P10275	BXGT007552	Androgen receptor	367	reviewed	Nuclear receptor
P10635	BXGT007595	Cytochrome P450 2D6	1565	reviewed
P13569	BXGT007923	Cystic fibrosis transmembrane conductance regulator	1080	reviewed	Ion channel
P14416	BXGT008011	D(2) dopamine receptor	1813	reviewed	G-protein coupled receptor
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P15056	BXGT008075	Serine/threonine-protein kinase B-raf	673	reviewed	Kinase
P16220	BXGT008206	Cyclic AMP-responsive element-binding protein 1	1385	reviewed
P21397	BXGT008644	Amine oxidase [flavin-containing] A	4128	reviewed
P21554	BXGT008662	Cannabinoid receptor 1	1268	reviewed	G-protein coupled receptor
P21728	BXGT008686	D(1A) dopamine receptor	1812	reviewed	G-protein coupled receptor
P21917	BXGT008707	D(4) dopamine receptor	1815	reviewed	G-protein coupled receptor
P21918	BXGT008708	D(1B) dopamine receptor	1816	reviewed	G-protein coupled receptor
P22303	BXGT008751	Acetylcholinesterase	43	reviewed	Enzyme
P23467	BXGT008869	Receptor-type tyrosine-protein phosphatase beta	5787	reviewed
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P24723	BXGT008989	Protein kinase C eta type	5583	reviewed	Kinase
P28072	BXGT009231	Proteasome subunit beta type-6	5694	reviewed
P28222	BXGT009238	5-hydroxytryptamine receptor 1B	3351	reviewed	G-protein coupled receptor
P28335	BXGT009255	5-hydroxytryptamine receptor 2C	3358	reviewed	G-protein coupled receptor
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P29323	BXGT009334	Ephrin type-B receptor 2	2048	reviewed	Kinase
P30532	BXGT009433	Neuronal acetylcholine receptor subunit alpha-5	1138	reviewed	Ion channel
P31645	BXGT009558	Sodium-dependent serotonin transporter	6532	reviewed	Transporter
P34998	BXGT009781	Corticotropin-releasing factor receptor 1	1394	reviewed
P35372	BXGT009823	Mu-type opioid receptor	4988	reviewed	G-protein coupled receptor
P35462	BXGT009835	D(3) dopamine receptor	1814	reviewed	G-protein coupled receptor
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P37840	BXGT010015	Alpha-synuclein	6622	reviewed	Transporter
P40261	BXGT010170	Nicotinamide N-methyltransferase	4837	reviewed	Enzyme
P40926	BXGT010207	Malate dehydrogenase, mitochondrial	4191	reviewed	Enzyme
P41143	BXGT010223	Delta-type opioid receptor	4985	reviewed	G-protein coupled receptor
P41145	BXGT010225	Kappa-type opioid receptor	4986	reviewed	G-protein coupled receptor
P41146	BXGT010226	Nociceptin receptor	4987	reviewed	G-protein coupled receptor
P41212	BXGT010235	Transcription factor ETV6	2120	reviewed	Transcription factor
P41594	BXGT010266	Metabotropic glutamate receptor 5	2915	reviewed	G-protein coupled receptor
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P43003	BXGT010347	Excitatory amino acid transporter 1	6507	reviewed	Transporter
P43004	BXGT010348	Excitatory amino acid transporter 2	6506	reviewed	Transporter
P43681	BXGT010407	Neuronal acetylcholine receptor subunit alpha-4	1137	reviewed	Ion channel
P47869	BXGT010590	Gamma-aminobutyric acid receptor subunit alpha-2	2555	reviewed	Ion channel
P48058	BXGT010614	Glutamate receptor 4	2893	reviewed	Ion channel
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P49773	BXGT010741	Histidine triad nucleotide-binding protein 1	3094	reviewed	Enzyme
P49789	BXGT010742	Bis(5'-adenosyl)-triphosphatase	2272	reviewed
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
Q00535	BXGT012534	Cyclin-dependent-like kinase 5	1020	reviewed	Kinase
Q01959	BXGT012624	Sodium-dependent dopamine transporter	6531	reviewed	Transporter
Q02156	BXGT012639	Protein kinase C epsilon type	5581	reviewed	Kinase
Q05586	BXGT012826	Glutamate receptor ionotropic, NMDA 1	2902	reviewed	Ion channel
Q05940	BXGT012846	Synaptic vesicular amine transporter	6571	reviewed	Transporter
Q12879	BXGT013275	Glutamate receptor ionotropic, NMDA 2A	2903	reviewed	Ion channel
Q12908	BXGT013278	Ileal sodium/bile acid cotransporter	6555	reviewed	Transporter
Q13002	BXGT013303	Glutamate receptor ionotropic, kainate 2	2898	reviewed	Ion channel
Q13224	BXGT013328	Glutamate receptor ionotropic, NMDA 2B	2904	reviewed	Ion channel
Q13427	BXGT013354	Peptidyl-prolyl cis-trans isomerase G	9360	reviewed
Q14123	BXGT013445	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	5137	reviewed
Q14416	BXGT013468	Metabotropic glutamate receptor 2	2912	reviewed	G-protein coupled receptor
Q14831	BXGT013506	Metabotropic glutamate receptor 7	2917	reviewed	G-protein coupled receptor
Q14832	BXGT013507	Metabotropic glutamate receptor 3	2913	reviewed	G-protein coupled receptor
Q15822	BXGT013602	Neuronal acetylcholine receptor subunit alpha-2	1135	reviewed	Ion channel
Q16568	BXGT013640	Cocaine- and amphetamine-regulated transcript protein	9607	reviewed
Q16698	BXGT013659	2,4-dienoyl-CoA reductase, mitochondrial	1666	reviewed	Enzyme
Q5KU26	BXGT015462	Collectin-12	81035	reviewed	Extracellular structure
Q8IVA8	BXGT018342	Glutamate decarboxylase 1 (Brain, 67kDa)	2571	unreviewed
Q8NER1	BXGT018556	Transient receptor potential cation channel subfamily V member 1	7442	reviewed	Ion channel
Q8NFD2	BXGT018559	Ankyrin repeat and protein kinase domain-containing protein 1	255239	reviewed	Kinase
Q8TCU5	BXGT018802	Glutamate receptor ionotropic, NMDA 3A	116443	reviewed	Ion channel
Q92499	BXGT019350	ATP-dependent RNA helicase DDX1	1653	reviewed
Q96C19	BXGT019630	EF-hand domain-containing protein D2	79180	reviewed	Calcium-binding protein
Q96QU1	BXGT019721	Protocadherin-15	65217	reviewed
Q96RJ0	BXGT019728	Trace amine-associated receptor 1	134864	reviewed	G-protein coupled receptor
Q99259	BXGT019915	Glutamate decarboxylase 1	2571	reviewed	Enzyme
Q99685	BXGT019948	Monoglyceride lipase	11343	reviewed	Enzyme
Q9BUB5	BXGT020133	MAP kinase-interacting serine/threonine-protein kinase 1	8569	reviewed	Kinase
Q9H227	BXGT020447	Cytosolic beta-glucosidase	57733	reviewed	Enzyme
Q9H2G2	BXGT020452	STE20-like serine/threonine-protein kinase	9748	reviewed	Kinase
Q9NQX4	BXGT021173	Unconventional myosin-Vc	55930	reviewed	Cellular structure
Q9NT68	BXGT021210	Teneurin-2	57451	reviewed
Q9NVD7	BXGT021223	Alpha-parvin	55742	reviewed	Cellular structure
Q9NZQ7	BXGT021281	Programmed cell death 1 ligand 1	29126	reviewed	Receptor
Q9UM73	BXGT021773	ALK tyrosine kinase receptor	238	reviewed	Kinase
Q9UNQ0	BXGT021792	ATP-binding cassette sub-family G member 2	9429	reviewed	Transporter
Q92847	BXGT022673	Growth hormone secretagogue receptor type 1	2693	reviewed	G-protein coupled receptor
Q15397	BXGT022873	Pumilio homolog 3	9933	reviewed
Q8NEU8	BXGT022976	DCC-interacting protein 13-beta	55198	reviewed
Q5BJF2	BXGT026107	Sigma intracellular receptor 2	27346	reviewed	Enzyme
Q8N573	BXGT026157	Oxidation resistance protein 1	55074	reviewed
O43172	BXGT026158	U4/U6 small nuclear ribonucleoprotein Prp4	9128	reviewed	Nucleic acid binding

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}