Showing entry for Substance Dependence


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD002771
Disease NameSubstance Dependence
Disease CUI IdC0038580
MeSH Codes C25   F03  
Disease Class NameChemically-Induced Disorders; Mental Disorders
Semantic TypeMental or Behavioral Dysfunction
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id   
Disease Ontology Class Name
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
A1Z1Q3 BXGT001069 ADP-ribose glycohydrolase MACROD2 140733 reviewed
O00519 BXGT003934 Fatty-acid amide hydrolase 1 2166 reviewed
O15439 BXGT004169 Multidrug resistance-associated protein 4 10257 reviewed Transporter
O75751 BXGT005150 Solute carrier family 22 member 3 6581 reviewed Transporter
P01009 BXGT005714 Alpha-1-antitrypsin 5265 reviewed Enzyme modulator
P01189 BXGT005742 Pro-opiomelanocortin 5443 reviewed
P01303 BXGT005748 Pro-neuropeptide Y 4852 reviewed Signaling
P05026 BXGT006296 Sodium/potassium-transporting ATPase subunit beta-1 481 reviewed Transporter
P05091 BXGT006312 Aldehyde dehydrogenase, mitochondrial 217 reviewed Enzyme
P06213 BXGT006425 Insulin receptor 3643 reviewed Kinase
P07327 BXGT006598 Alcohol dehydrogenase 1A 124 reviewed Enzyme
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 1129 reviewed G-protein coupled receptor
P08319 BXGT006764 Alcohol dehydrogenase 4 127 reviewed Enzyme
P10635 BXGT007595 Cytochrome P450 2D6 1565 reviewed
P13569 BXGT007923 Cystic fibrosis transmembrane conductance regulator 1080 reviewed Ion channel
P14416 BXGT008011 D(2) dopamine receptor 1813 reviewed G-protein coupled receptor
P14550 BXGT008019 Aldo-keto reductase family 1 member A1 10327 reviewed Enzyme
P18507 BXGT008411 Gamma-aminobutyric acid receptor subunit gamma-2 2566 reviewed Ion channel
P20813 BXGT008603 Cytochrome P450 2B6 1555 reviewed
P21397 BXGT008644 Amine oxidase [flavin-containing] A 4128 reviewed
P21554 BXGT008662 Cannabinoid receptor 1 1268 reviewed G-protein coupled receptor
P21728 BXGT008686 D(1A) dopamine receptor 1812 reviewed G-protein coupled receptor
P21917 BXGT008707 D(4) dopamine receptor 1815 reviewed G-protein coupled receptor
P21918 BXGT008708 D(1B) dopamine receptor 1816 reviewed G-protein coupled receptor
P21964 BXGT008714 Catechol O-methyltransferase 1312 reviewed Enzyme
P22303 BXGT008751 Acetylcholinesterase 43 reviewed Enzyme
P23560 BXGT008883 Brain-derived neurotrophic factor 627 reviewed Signaling
P24723 BXGT008989 Protein kinase C eta type 5583 reviewed Kinase
P25116 BXGT009025 Proteinase-activated receptor 1 2149 reviewed G-protein coupled receptor
P28222 BXGT009238 5-hydroxytryptamine receptor 1B 3351 reviewed G-protein coupled receptor
P30532 BXGT009433 Neuronal acetylcholine receptor subunit alpha-5 1138 reviewed Ion channel
P31645 BXGT009558 Sodium-dependent serotonin transporter 6532 reviewed Transporter
P35372 BXGT009823 Mu-type opioid receptor 4988 reviewed G-protein coupled receptor
P40394 BXGT010178 Alcohol dehydrogenase class 4 mu/sigma chain 131 reviewed Enzyme
P41143 BXGT010223 Delta-type opioid receptor 4985 reviewed G-protein coupled receptor
P41145 BXGT010225 Kappa-type opioid receptor 4986 reviewed G-protein coupled receptor
P41212 BXGT010235 Transcription factor ETV6 2120 reviewed Transcription factor
P41594 BXGT010266 Metabotropic glutamate receptor 5 2915 reviewed G-protein coupled receptor
P47869 BXGT010590 Gamma-aminobutyric acid receptor subunit alpha-2 2555 reviewed Ion channel
P48058 BXGT010614 Glutamate receptor 4 2893 reviewed Ion channel
P49789 BXGT010742 Bis(5'-adenosyl)-triphosphatase 2272 reviewed
Q02156 BXGT012639 Protein kinase C epsilon type 5581 reviewed Kinase
Q05940 BXGT012846 Synaptic vesicular amine transporter 6571 reviewed Transporter
Q12908 BXGT013278 Ileal sodium/bile acid cotransporter 6555 reviewed Transporter
Q13002 BXGT013303 Glutamate receptor ionotropic, kainate 2 2898 reviewed Ion channel
Q13451 BXGT013356 Peptidyl-prolyl cis-trans isomerase FKBP5 2289 reviewed Enzyme
Q14123 BXGT013445 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C 5137 reviewed
Q14831 BXGT013506 Metabotropic glutamate receptor 7 2917 reviewed G-protein coupled receptor
Q5KU26 BXGT015462 Collectin-12 81035 reviewed Extracellular structure
Q8NFD2 BXGT018559 Ankyrin repeat and protein kinase domain-containing protein 1 255239 reviewed Kinase
Q92499 BXGT019350 ATP-dependent RNA helicase DDX1 1653 reviewed
Q96QU1 BXGT019721 Protocadherin-15 65217 reviewed
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 10280 reviewed
Q9BUB5 BXGT020133 MAP kinase-interacting serine/threonine-protein kinase 1 8569 reviewed Kinase
Q9H227 BXGT020447 Cytosolic beta-glucosidase 57733 reviewed Enzyme
Q9H2G2 BXGT020452 STE20-like serine/threonine-protein kinase 9748 reviewed Kinase
Q9NQX4 BXGT021173 Unconventional myosin-Vc 55930 reviewed Cellular structure
Q9NR12 BXGT021174 PDZ and LIM domain protein 7 9260 reviewed Cellular structure
Q9NT68 BXGT021210 Teneurin-2 57451 reviewed
Q9NVD7 BXGT021223 Alpha-parvin 55742 reviewed Cellular structure
Q9NZQ7 BXGT021281 Programmed cell death 1 ligand 1 29126 reviewed Receptor
Q8NEU8 BXGT022976 DCC-interacting protein 13-beta 55198 reviewed
Q9UGC6 BXGT023734 Regulator of G-protein signaling 17 26575 reviewed Enzyme modulator
O43172 BXGT026158 U4/U6 small nuclear ribonucleoprotein Prp4 9128 reviewed Nucleic acid binding
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease