Showing entry for Aconitate hydratase, mitochondrial


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019962
Protein NameAconitate hydratase, mitochondrial
Uniport IdQ99798
GeneACO2
Gene Id50
DomainAconitase; Aconitase_C
Pfam PF00330   PF00694  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.1 Carbohydrate metabolism hsa00020 Citrate cycle (TCA cycle)
1. Metabolism 1.1 Carbohydrate metabolism hsa00630 Glyoxylate and dicarboxylate metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
1. Metabolism 1.0 Global and overview maps hsa01200 Carbon metabolism
1. Metabolism 1.0 Global and overview maps hsa01210 2-Oxocarboxylic acid metabolism
1. Metabolism 1.0 Global and overview maps hsa01230 Biosynthesis of amino acids
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006101 citrate metabolic process
Biological Process GO:0006091 generation of precursor metabolites and energy
Biological Process GO:0006102 isocitrate metabolic process
Biological Process GO:0001889 liver development
Biological Process GO:0035900 response to isolation stress
Biological Process GO:0006099 tricarboxylic acid cycle
molecular function GO:0051538 3 iron, 4 sulfur cluster binding
molecular function GO:0051539 4 iron, 4 sulfur cluster binding
molecular function GO:0003994 aconitate hydratase activity
molecular function GO:0047780 citrate dehydratase activity
molecular function GO:0005506 iron ion binding
cellular component GO:0005829 cytosol
cellular component GO:0005759 mitochondrial matrix
cellular component GO:0005739 mitochondrion
Reactome
Pathway Id Pathway Name
R-HSA-1268020 Mitochondrial protein import
R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport
R-HSA-1430728 Metabolism
R-HSA-71403 Citric acid cycle (TCA cycle)
R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle
R-HSA-9609507 Protein localization
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004158 BXGD000261 Athetosis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0021670 BXGD001509 insulinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0026650 BXGD001913 Movement Disorders Nervous System Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0029132 BXGD002117 Disorder of the optic nerve Eye Diseases; Nervous System Diseases
C0030232 BXGD002197 Pallor Pathological Conditions, Signs and Symptoms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0035222 BXGD002513 Respiratory Distress Syndrome, Adult Respiratory Tract Diseases
C0035242 BXGD002521 Respiratory Tract Diseases Respiratory Tract Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036857 BXGD002638 Severe intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0078981 BXGD003059 Arachnoid Cysts Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0151888 BXGD003497 Hyporeflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0155016 BXGD003765 Color Blindness, Red-Green Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0221354 BXGD004446 Frontal bossing Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0234146 BXGD004626 Absent reflex Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234632 BXGD004691 Reduced visual acuity Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0270922 BXGD006134 Peripheral demyelinating neuropathy Immune System Diseases; Nervous System Diseases
C0271197 BXGD006172 Scotoma, Paracentral Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0338508 BXGD007196 Optic Atrophy 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Nervous System Diseases
C0342770 BXGD007545 Fumarase deficiency Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Behavior and Behavior Mechanisms
C0342782 BXGD007549 Depletion of mitochondrial DNA
C0344482 BXGD007678 Hypoplasia of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0423110 BXGD008471 Downward slant of palpebral fissure
C0427190 BXGD008611 Ataxia, Truncal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0452138 BXGD008831 Sensorineural hearing loss, bilateral Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0740279 BXGD009973 Cerebellar atrophy
C0740457 BXGD010000 Malignant neoplasm of kidney Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0854723 BXGD011026 Retinal Dystrophies Eye Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1378703 BXGD012933 Renal carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1837397 BXGD014227 Severe global developmental delay
C1850456 BXGD015146 Progressive microcephaly
C1856689 BXGD015630 FRIEDREICH ATAXIA 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3276549 BXGD018691 OPTIC ATROPHY WITH OR WITHOUT DEAFNESS, OPHTHALMOPLEGIA, MYOPATHY, ATAXIA, AND NEUROPATHY
C3281192 BXGD018887 INFANTILE CEREBELLAR-RETINAL DEGENERATION
C3714948 BXGD019440 PACHYONYCHIA CONGENITA 3
C3806442 BXGD019510 Myoclonic spasms Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3887709 BXGD019918 Optic Neuropathy Eye Diseases; Nervous System Diseases
C4022919 BXGD021038 Appendicular hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4225384 BXGD022256 OPTIC ATROPHY 9
C4551583 BXGD023361 Cerebral cortical atrophy
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002382 1,2,3-Propanetricarboxylic acid 176.12
BXGC0046768 isocitric acid 192.03
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein