Showing entry for Serine/threonine-protein kinase D2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT020199
Protein NameSerine/threonine-protein kinase D2
Uniport IdQ9BZL6
GenePRKD2
Gene Id25865
DomainC1_1; Pkinase
Pfam PF00130   PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04015 Rap1 signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04925 Aldosterone synthesis and secretion
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002250 adaptive immune response
Biological Process GO:0001525 angiogenesis
Biological Process GO:0007155 cell adhesion
Biological Process GO:0008219 cell death
Biological Process GO:0035924 cellular response to vascular endothelial growth factor stimulus
Biological Process GO:0061154 endothelial tube morphogenesis
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0018107 peptidyl-threonine phosphorylation
Biological Process GO:0045766 positive regulation of angiogenesis
Biological Process GO:0043536 positive regulation of blood vessel endothelial cell migration
Biological Process GO:0045785 positive regulation of cell adhesion
Biological Process GO:0032793 positive regulation of CREB transcription factor activity
Biological Process GO:0051091 positive regulation of DNA-binding transcription factor activity
Biological Process GO:2000573 positive regulation of DNA biosynthetic process
Biological Process GO:2001028 positive regulation of endothelial cell chemotaxis
Biological Process GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
Biological Process GO:0010595 positive regulation of endothelial cell migration
Biological Process GO:0001938 positive regulation of endothelial cell proliferation
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway
Biological Process GO:1901727 positive regulation of histone deacetylase activity
Biological Process GO:0032743 positive regulation of interleukin-2 production
Biological Process GO:0032757 positive regulation of interleukin-8 production
Biological Process GO:1902533 positive regulation of intracellular signal transduction
Biological Process GO:0051092 positive regulation of NF-kappaB transcription factor activity
Biological Process GO:0033138 positive regulation of peptidyl-serine phosphorylation
Biological Process GO:0050862 positive regulation of T cell receptor signaling pathway
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0089700 protein kinase D signaling
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0030148 sphingolipid biosynthetic process
Biological Process GO:0050852 T cell receptor signaling pathway
Biological Process GO:0048010 vascular endothelial growth factor receptor signaling pathway
molecular function GO:0005524 ATP binding
molecular function GO:0004698 calcium-dependent protein kinase C activity
molecular function GO:0046872 metal ion binding
molecular function GO:0004672 protein kinase activity
molecular function GO:0005080 protein kinase C binding
molecular function GO:0004674 protein serine/threonine kinase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005794 Golgi apparatus
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1660661 Sphingolipid de novo biosynthesis
R-HSA-428157 Sphingolipid metabolism
R-HSA-556833 Metabolism of lipids
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007095 BXGD000423 Carcinoid Tumor Neoplasms
C0008313 BXGD000528 Cholangitis, Sclerosing Digestive System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0016529 BXGD001068 Forced expiratory volume function
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0019269 BXGD001310 Hermaphroditism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0022680 BXGD001576 Polycystic Kidney Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023465 BXGD001656 Acute monocytic leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023470 BXGD001659 Myeloid Leukemia Neoplasms
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0038356 BXGD002747 Stomach Neoplasms Digestive System Diseases; Neoplasms
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206632 BXGD004197 Angiolipoma Neoplasms
C0278701 BXGD006566 Gastric Adenocarcinoma Digestive System Diseases; Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0566602 BXGD009489 Primary sclerosing cholangitis Digestive System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0855095 BXGD011071 Small Lymphocytic Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1136382 BXGD011717 Sclerocystic Ovaries Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1266086 BXGD011952 Polymorphous low grade adenocarcinoma
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0012352 Chelerythrine 348.12
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
BXGC0050099 (2E,5S,6S,8Z,11S)-5,6,15-Trihydroxy-17-Methoxy-11-Methyl-12-Oxabicyclo[12.4.0]Octadeca-1(14),2,8,15,17-Pentaene-7,13-Dione 362.14
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein