Showing entry for Platelet glycoprotein VI


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT020535
Protein NamePlatelet glycoprotein VI
Uniport IdQ9HCN6
GeneGP6
Gene Id51206
DomainIg_2
Pfam PF13895  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04512 ECM-receptor interaction
5. Organismal Systems 5.1 Immune system hsa04611 Platelet activation
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007596 blood coagulation
Biological Process GO:0007167 enzyme linked receptor protein signaling pathway
Biological Process GO:0050900 leukocyte migration
Biological Process GO:0030168 platelet activation
molecular function GO:0005518 collagen binding
molecular function GO:0038023 signaling receptor activity
molecular function GO:0004888 transmembrane signaling receptor activity
cellular component GO:0009986 cell surface
cellular component GO:0070062 extracellular exosome
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0097197 tetraspanin-enriched microdomain
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-114604 GPVI-mediated activation cascade
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-75892 Platelet Adhesion to exposed collagen
R-HSA-76002 Platelet activation, signaling and aggregation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0005779 BXGD000336 Blood Coagulation Disorders Hemic and Lymphatic Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0008031 BXGD000511 Chest Pain Pathological Conditions, Signs and Symptoms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010072 BXGD000649 Coronary Thrombosis Cardiovascular Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0013491 BXGD000847 Ecchymosis Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0014591 BXGD000938 Epistaxis Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0016057 BXGD001042 Fibrosarcoma Neoplasms
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0021053 BXGD001476 Immune System Diseases Immune System Diseases
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0025323 BXGD001864 Menorrhagia Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0027022 BXGD001962 Myeloproliferative disease Hemic and Lymphatic Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0032176 BXGD002331 Platelet aggregation
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0040015 BXGD002833 Thrombasthenia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0040053 BXGD002839 Thrombosis Cardiovascular Diseases
C0042974 BXGD003019 von Willebrand Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0085292 BXGD003153 Stiff-Person Syndrome Immune System Diseases; Nervous System Diseases
C0149871 BXGD003375 Deep Vein Thrombosis Cardiovascular Diseases
C0151529 BXGD003433 Prolonged bleeding time
C0155626 BXGD003806 Acute myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0155773 BXGD003820 Portal Vein Thrombosis Cardiovascular Diseases
C0162429 BXGD003942 Malnutrition Nutritional and Metabolic Diseases
C0200665 BXGD004045 Platelet mean volume determination (procedure)
C0206161 BXGD004167 Reticulocyte count (procedure)
C0221292 BXGD004440 Basophilic leukemia Neoplasms
C0242584 BXGD005179 Autoimmune thrombocytopenia Immune System Diseases; Hemic and Lymphatic Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0272285 BXGD006336 Heparin-induced thrombocytopenia Hemic and Lymphatic Diseases
C0272286 BXGD006337 Thrombocytopenia due to platelet alloimmunization Hemic and Lymphatic Diseases
C0272302 BXGD006340 Gray Platelet Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0278595 BXGD006545 Adult Fibrosarcoma Neoplasms
C0333209 BXGD006934 Platelet thrombus Cardiovascular Diseases
C0340288 BXGD007316 Stable angina Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0398636 BXGD008207 Acquired platelet disorder Hemic and Lymphatic Diseases
C0398639 BXGD008208 Amegakaryocytic thrombocytopenia Hemic and Lymphatic Diseases
C0398650 BXGD008212 Immune thrombocytopenic purpura Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases
C0409651 BXGD008389 Seropositive rheumatoid arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0423798 BXGD008510 Increased tendency to bruise Wounds and Injuries
C0751956 BXGD010653 Acute Cerebrovascular Accidents Nervous System Diseases; Cardiovascular Diseases
C0947751 BXGD011494 Vascular inflammations Cardiovascular Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C0948089 BXGD011504 Acute Coronary Syndrome Cardiovascular Diseases
C1261473 BXGD011855 Sarcoma Neoplasms
C1261502 BXGD011856 Finding of Mean Corpuscular Hemoglobin
C1264039 BXGD011909 von Willebrand Disease, Type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1264041 BXGD011911 von Willebrand Disease, Type 3 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1290884 BXGD012198 Inflammatory disorder Pathological Conditions, Signs and Symptoms
C1292778 BXGD012237 Chronic myeloproliferative disorder Neoplasms; Hemic and Lymphatic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1402315 BXGD013017 Vascular lesions
C1608426 BXGD013436 Compensated cirrhosis
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1840061 BXGD014431 SMALL PATELLA SYNDROME Musculoskeletal Diseases
C1861172 BXGD016016 Venous Thromboembolism Cardiovascular Diseases
C1861403 BXGD016045 Variable expressivity
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1963943 BXGD016706 Atherothrombosis
C2609046 BXGD017161 Sticky platelet syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C2717961 BXGD017519 Thrombotic Microangiopathies Hemic and Lymphatic Diseases
C2985280 BXGD018223 Blood Protein Measurement
C3280120 BXGD018805 Glycoprotein VI deficiency
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3828530 BXGD019744 Platelet Component Distribution Width Measurement
C4551686 BXGD023391 Malignant neoplasm of soft tissue Neoplasms
C4552766 BXGD023523 Miscarriage Female Urogenital Diseases and Pregnancy Complications
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000537 Acetylsalicylic acid 180.16
BXGC0003705 Chloride 35.45
BXGC0030612 tetraethylene glycol 194.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein