Showing entry for Lysyl oxidase homolog 3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT026106
Protein NameLysyl oxidase homolog 3
Uniport IdP58215
GeneLOXL3
Gene Id84695
DomainLysyl_oxidase; SRCR
Pfam PF01186   PF00530  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030199 collagen fibril organization
Biological Process GO:0001837 epithelial to mesenchymal transition
Biological Process GO:1905590 fibronectin fibril organization
Biological Process GO:0006954 inflammatory response
Biological Process GO:0030324 lung development
Biological Process GO:2000329 negative regulation of T-helper 17 cell lineage commitment
Biological Process GO:0045892 negative regulation of transcription, DNA-templated
Biological Process GO:0018057 peptidyl-lysine oxidation
Biological Process GO:2001046 positive regulation of integrin-mediated signaling pathway
Biological Process GO:0060021 roof of mouth development
Biological Process GO:0061053 somite development
Biological Process GO:0021510 spinal cord development
molecular function GO:0005507 copper ion binding
molecular function GO:0001968 fibronectin binding
molecular function GO:0004720 protein-lysine 6-oxidase activity
molecular function GO:0005044 scavenger receptor activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0016020 membrane
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1474244 Extracellular matrix organization
R-HSA-1474290 Collagen formation
R-HSA-1566948 Elastic fibre formation
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-2243919 Crosslinking of collagen fibrils
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0002418 BXGD000112 Amblyopia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0004106 BXGD000254 Astigmatism Eye Diseases
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007766 BXGD000478 Intracranial Aneurysm Nervous System Diseases; Cardiovascular Diseases
C0008925 BXGD000575 Cleft Palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0025990 BXGD001884 Micrognathism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0027092 BXGD001971 Myopia Eye Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028259 BXGD002073 Nodule
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0035305 BXGD002529 Retinal Detachment Eye Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0265253 BXGD005484 Stickler syndrome (disorder) Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Musculoskeletal Diseases
C0271183 BXGD006169 Severe myopia Eye Diseases
C0344290 BXGD007662 Vitreoretinal degeneration
C0349588 BXGD007933 Short stature
C0392476 BXGD008046 Epiphyseal dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0410702 BXGD008447 Adolescent idiopathic scoliosis Musculoskeletal Diseases
C0576093 BXGD009525 Knee joint valgus deformity Musculoskeletal Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1402315 BXGD013017 Vascular lesions
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C1837218 BXGD014207 Cleft palate, isolated Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C1842153 BXGD014499 Irregular vertebral endplates
C1844704 BXGD014665 Platyspondyly
C1853241 BXGD015321 Flat face
C1858085 BXGD015770 Malar flattening
C2020284 BXGD016881 Stickler syndrome, type 1 Pathological Conditions, Signs and Symptoms; Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C2919142 BXGD017867 Short Stature, CTCAE
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C2981150 BXGD018211 Uranostaphyloschisis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Respiratory Tract Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C3553764 BXGD019187 Joint hyperflexibility
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0006184 3-Aminopropanenitrile 70.09
BXGC0041560 Thiram 239.99
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein