Showing entry for L-(-)-Phenylalanine


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0003214
Compound NameL-(-)-Phenylalanine
Structure
FormulaC9H11NO2
InchiKeyCOLNVLDHVKWLRT-QMMMGPOBSA-N
SMILESN[C@@H](CC1=CC=CC=C1)C(O)=O
InchiInChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1
IUPAC(2S)-2-amino-3-phenylpropanoic acid
Molecular Weight165.19
Pubchem Id6140
Chembl IdCHEMBL301523
Targets of Information Source
DrugBank DB00120
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P17735 BXGT008335 Tyrosine aminotransferase reviewed - TAT approved; investigational; nutraceutical -
Q9UHI5 BXGT021700 Large neutral amino acids transporter small subunit 2 reviewed Transporter SLC7A8 approved; investigational; nutraceutical -
Q9Y285 BXGT022224 Phenylalanine--tRNA ligase alpha subunit reviewed - FARSA approved; investigational; nutraceutical -
P00439 BXGT005539 Phenylalanine-4-hydroxylase reviewed - PAH approved; investigational; nutraceutical -
O95363 BXGT005375 Phenylalanine--tRNA ligase, mitochondrial reviewed Enzyme FARS2 approved; investigational; nutraceutical -
Q9NSD9 BXGT021206 Phenylalanine--tRNA ligase beta subunit reviewed Enzyme FARSB approved; investigational; nutraceutical -
P07101 BXGT006547 Tyrosine 3-monooxygenase reviewed - TH approved; investigational; nutraceutical binder
PDB PHE
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P0C061 BXGT007382 Gramicidin S synthase 1 reviewed grsA - - - - -
P27001 BXGT009149 Phenylalanine--tRNA ligase alpha subunit reviewed pheS - - - - -
Q59771 BXGT015265 Phenylalanine dehydrogenase reviewed pdh - - - - -
P80561 BXGT011917 Aminopeptidase S reviewed SGR_5809 - 12700000 - - -
Q9QWW1 BXGT021381 Homer protein homolog 2 reviewed Homer2 - - - - -
P70552 BXGT011674 GTP cyclohydrolase 1 feedback regulatory protein reviewed Gchfr - - - - -
P0AB91 BXGT007223 Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive reviewed aroG - - - - -
P32449 BXGT009639 Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited reviewed ARO4 - - - - -
Q6STF1 BXGT016527 L-amino-acid oxidase reviewed - - - - -
P08254 BXGT006758 Stromelysin-1 reviewed MMP3 Enzyme - - - -
P04816 BXGT006268 Leucine-specific-binding protein reviewed livK - - - 180 -
Q16773 BXGT013667 Kynurenine--oxoglutarate transaminase 1 reviewed KYAT1 Enzyme - - - -
P96084 BXGT012167 Proline iminopeptidase reviewed pip - - - - -
P05187 BXGT006339 Alkaline phosphatase, placental type reviewed ALPP Enzyme - - - -
P00772 BXGT005648 Chymotrypsin-like elastase family member 1 reviewed CELA1 - - - - -
P01180 BXGT005741 Vasopressin-neurophysin 2-copeptin reviewed AVP - - - - -
Q9LCC8 BXGT021067 D-Amino acid amidase unreviewed daaA - - - - -
P00918 BXGT005690 Carbonic anhydrase 2 reviewed CA2 - - - - -
P01175 BXGT005740 Oxytocin-neurophysin 1 reviewed OXT - - - - -
Q9YBQ2 BXGT022365 Acylamino-acid-releasing enzyme reviewed APE_1547.1 - - - - -
P81382 BXGT011946 L-amino-acid oxidase reviewed - - - - -
Q8VPD4 BXGT018940 L-amino acid oxidase reviewed - - - - -
Q8KBW6 BXGT018410 Prephenate dehydratase unreviewed pheA - - - - -
P96896 BXGT012192 Leucine-responsive regulatory protein unreviewed lrp - - - - -
O53512 BXGT004702 Phospho-2-dehydro-3-deoxyheptonate aldolase AroG reviewed aroG - - - 21000 -
P0A8P1 BXGT007151 Leucyl/phenylalanyl-tRNA--protein transferase reviewed aat - - - - -
Q5W9R9 BXGT015899 Phenylalanine 2-monooxygenase precursor reviewed - - - - -
P04825 BXGT006271 Aminopeptidase N reviewed pepN - - - - -
Q9S7N2 BXGT021570 L-tryptophan--pyruvate aminotransferase 1 reviewed TAA1 - - - - -
Q9WXM1 BXGT021955 L-Ala-D/L-Glu epimerase reviewed TM_0006 - - - - -
Q16651 BXGT013649 Prostasin reviewed PRSS8 Enzyme - - - -
O53512 BXGT004702 Phospho-2-dehydro-3-deoxyheptonate aldolase AroG reviewed aroG - - - - -
Q9Y285 BXGT022224 Phenylalanine--tRNA ligase alpha subunit reviewed FARSA - - - - -
Q9KT04 BXGT020994 Uncharacterized protein unreviewed VC_1101 - - - - -
A1R118 BXGT001027 Prephenate dehydratase unreviewed pheA - - - - -
P08312 BXGT006763 Phenylalanine--tRNA ligase alpha subunit reviewed pheS - - - - -
P30967 BXGT009487 Phenylalanine-4-hydroxylase reviewed phhA - - - - -
Q9X0L9 BXGT022068 Branched chain amino acid ABC transporter, periplasmic amino acid-binding protein unreviewed TM_1135 - - - - -
Q84FL5 BXGT017553 AdmH unreviewed - - - - -
Q5M4H8 BXGT015569 Di-or tripeptide:H+ symporter unreviewed dtpT - - - - -
P14618 BXGT008027 Pyruvate kinase PKM reviewed PKM Kinase - - - -
E9P5T5 BXGT003186 Glutamate receptor 1 unreviewed - - - - -
P0A988 BXGT007175 Beta sliding clamp reviewed dnaN - - - - -
P42738 BXGT010336 Chorismate mutase 1, chloroplastic reviewed CM1 - - - - -
A7Y7W1 BXGT001643 Periplasmic dipeptide-binding protein unreviewed dppA - - - - -
P9WML5 BXGT012392 Putative phenylalanine aminotransferase reviewed pat - - - - -
Q9K169 BXGT020867 Phospho-2-dehydro-3-deoxyheptonate aldolase unreviewed aroG - - - - -
P03418 BXGT006066 Nucleoprotein reviewed N - - - - -
P00439 BXGT005539 Phenylalanine-4-hydroxylase reviewed PAH - - - - -
O95363 BXGT005375 Phenylalanine--tRNA ligase, mitochondrial reviewed FARS2 Enzyme - - - -
Q4QDU3 BXGT014873 UTP--glucose-1-phosphate uridylyltransferase unreviewed UGP - - - - -
P14779 BXGT008052 Bifunctional cytochrome P450/NADPH--P450 reductase reviewed cyp102A1 - - - - -
P25084 BXGT009013 Transcriptional activator protein LasR reviewed lasR - - - - -
Q8RY79 BXGT018751 Tyrosine decarboxylase 1 reviewed ELI5 - - - - -
P40969 BXGT010213 Centromere DNA-binding protein complex CBF3 subunit B reviewed CEP3 - - - - -
C4YJ02 BXGT024201 Aromatic amino acid aminotransferase I unreviewed CAWG_03814 - - - - -
A0A1D8PMC5 BXGT024202 Aromatic-amino-acid:2-oxoglutarate transaminase unreviewed ARO9 - - - - -
F8W4B7 BXGT003330 Histone deacetylase 6 unreviewed hdac6 - - - - -
Q2YPM5 BXGT025823 Prephenate dehydratase unreviewed pheA - - - - -
Q0P864 BXGT013112 Putative methyl-accepting chemotaxis signal transduction protein unreviewed Cj1564 - - - - -
O67854 BXGT005012 Na(+):neurotransmitter symporter (Snf family) unreviewed snf - - - - -
Q16769 BXGT013665 Glutaminyl-peptide cyclotransferase reviewed QPCT Enzyme - - - -
A0A4Y7X244 BXGT026014 Sodium-dependent transporter unreviewed E2L07_01100 - - - - -
A0A0J9X1X3 BXGT026057 L-lysine oxidase unreviewed - - - - -
Binding DB 18073
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT006898 Alkaline phosphatase, tissue-nonspecific isozyme reviewed ALPL - 80210 - -
reviewed BXGT008457 Intestinal-type alkaline phosphatase reviewed ALPI - 80200 - -
reviewed BXGT008457 Intestinal-type alkaline phosphatase reviewed ALPI - 80210 - -
reviewed BXGT004027 Voltage-dependent calcium channel subunit alpha-2/delta-1 reviewed Cacna2d1 980 - - -
reviewed BXGT022220 Phospholipase A-2-activating protein reviewed Enzyme modulator PLAA - >5000 - -
reviewed BXGT006338 Alkaline phosphatase, tissue-nonspecific isozyme reviewed Enzyme ALPL - >5000 - -
reviewed BXGT006942 Intestinal-type alkaline phosphatase reviewed Enzyme ALPI - >5000 - -
reviewed BXGT016057 Large neutral amino acids transporter small subunit 1 reviewed Slc7a5 55000 - - -
CHEMBL CHEMBL301523
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Potency - 15848 nM
P53615 BXGT011003 Carbonic anhydrase reviewed - NCE103 Ka '=' 86 uM
P10828 BXGT007624 Thyroid hormone receptor beta reviewed Nuclear receptor THRB Potency - 15 nM
Q05BR4 BXGT012851 SLC16A10 protein unreviewed - SLC16A10 Activity '=' 60 %
Q91Y77 BXGT019323 Monocarboxylate transporter 10 reviewed - Slc16a10 Activity '=' 40 %
P07451 BXGT006627 Carbonic anhydrase 3 reviewed - CA3 KA '=' 34 uM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 AC50 - - -
P40881 BXGT010205 Carbonic anhydrase reviewed - KA '=' 68 uM
P00915 BXGT005689 Carbonic anhydrase 1 reviewed - CA1 Ka '=' 0 uM
Q9Y263 BXGT022220 Phospholipase A-2-activating protein reviewed Enzyme modulator PLAA IC50 '>' 5000 nM
P25094 BXGT009014 Peripheral myelin protein 22 reviewed - Pmp22 Potency - 4547 nM
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Kcat '=' 5 10^6/s
Q16790 BXGT013670 Carbonic anhydrase 9 reviewed - CA9 Kcat '=' 4 10^5/s
Q8K1P8 BXGT018393 Monocarboxylate transporter 8 reviewed - SLC16A2 Activity - - -
O43570 BXGT004601 Carbonic anhydrase 12 reviewed - CA12 Kcat '=' 12 10^5/s
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 KA '=' 0 uM
Q16790 BXGT013670 Carbonic anhydrase 9 reviewed - CA9 KA '=' 16 uM
Q9Y2D0 BXGT022229 Carbonic anhydrase 5B, mitochondrial reviewed - CA5B KA '=' 10 uM
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Activity '=' 210 %
P35218 BXGT009796 Carbonic anhydrase 5A, mitochondrial reviewed - CA5A KA '=' 9 uM
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 AC50 - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Potency - 11220 nM
Q99N23 BXGT019994 Carbonic anhydrase 15 reviewed - Ca15 KA '=' 33 uM
P43166 BXGT010364 Carbonic anhydrase 7 reviewed - CA7 KA '=' 10 uM
P22748 BXGT008802 Carbonic anhydrase 4 reviewed - CA4 KA '=' 36 uM
P22748 BXGT008802 Carbonic anhydrase 4 reviewed - CA4 KA '=' 4 uM
P23280 BXGT008844 Carbonic anhydrase 6 reviewed - CA6 Kcat '=' 10 10^5/s
P05186 BXGT006338 Alkaline phosphatase, tissue-nonspecific isozyme reviewed Enzyme ALPL IC50 '>' 5000 nM
O08532 BXGT004027 Voltage-dependent calcium channel subunit alpha-2/delta-1 reviewed - Cacna2d1 Ki '=' 980 nM
P14679 BXGT008039 Tyrosinase reviewed Enzyme TYR IC50 - - -
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 21689 nM
P19145 BXGT008463 General amino-acid permease GAP1 reviewed - GAP1 Activity - - -
P00915 BXGT005689 Carbonic anhydrase 1 reviewed - CA1 Kcat '=' 19 10^5/s
Q63016 BXGT016057 Large neutral amino acids transporter small subunit 1 reviewed - Slc7a5 Inhibition - - -
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Kcat '=' 5 10'6/s
Q3I4V7 BXGT014421 Carbonic anhydrase unreviewed - CAN2 KA '=' 44 uM
Q63016 BXGT016057 Large neutral amino acids transporter small subunit 1 reviewed - Slc7a5 Ki '=' 55000 nM
P09923 BXGT006942 Intestinal-type alkaline phosphatase reviewed Enzyme ALPI IC50 '>' 5000 nM
Q9ULX7 BXGT021769 Carbonic anhydrase 14 reviewed - CA14 KA '=' 0 uM
P43166 BXGT010364 Carbonic anhydrase 7 reviewed - CA7 Kcat '=' 14 10^5/s
Q5AJ71 BXGT015288 Carbonic anhydrase reviewed - NCE103 KA '=' 15 uM
Q9D6N1 BXGT020260 Carbonic anhydrase 13 reviewed - Ca13 KA '=' 1 uM
Q9ULX7 BXGT021769 Carbonic anhydrase 14 reviewed - CA14 Kcat '=' 12 10^5/s
Q05BR4 BXGT012851 SLC16A10 protein unreviewed - SLC16A10 Km '=' 740500 nM
Q50565 BXGT014936 Carbonic anhydrase unreviewed - MTH_1582 Ka '=' 70 uM
Q91Y77 BXGT019323 Monocarboxylate transporter 10 reviewed - Slc16a10 Km '=' 7020000 nM
P00915 BXGT005689 Carbonic anhydrase 1 reviewed - CA1 Activity '=' 160 %
Q6FTL6 BXGT016286 Carbonic anhydrase unreviewed - NCE103 Ka '=' 24 uM
O43570 BXGT004601 Carbonic anhydrase 12 reviewed - CA12 KA '=' 1 uM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 AC50 - - -
O08532 BXGT004027 Voltage-dependent calcium channel subunit alpha-2/delta-1 reviewed - Cacna2d1 Ki '=' 977 nM
Q91Y77 BXGT019323 Monocarboxylate transporter 10 reviewed - Slc16a10 Activity - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 AC50 - - -
P00915 BXGT005689 Carbonic anhydrase 1 reviewed - CA1 Kcat '=' 19 10'5/s
P23280 BXGT008844 Carbonic anhydrase 6 reviewed - CA6 Ka '=' 1 uM
Q91Y77 BXGT019323 Monocarboxylate transporter 10 reviewed - Slc16a10 Activity '=' 50 %
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - Potency - 28695 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 AC50 - - -
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 54482 nM
P19111 BXGT008457 Intestinal-type alkaline phosphatase reviewed - ALPI IC50 '=' 80210 nM
P05186 BXGT006338 Alkaline phosphatase, tissue-nonspecific isozyme reviewed Enzyme ALPL IC50 '=' 100100 nM
Q01650 BXGT012603 Large neutral amino acids transporter small subunit 1 reviewed Transporter SLC7A5 Inhibition '=' 85 %
Q01650 BXGT012603 Large neutral amino acids transporter small subunit 1 reviewed Transporter SLC7A5 Activity '=' 3 fmol/min
Q4CVY4 BXGT026093 Carbonic anhydrase-like protein, putative unreviewed - Tc00.1047053509597.20 KA '=' 12 uM
P09923 BXGT006942 Intestinal-type alkaline phosphatase reviewed Enzyme ALPI IC50 '=' 80200 nM
P05186 BXGT006338 Alkaline phosphatase, tissue-nonspecific isozyme reviewed Enzyme ALPL IC50 '>' 200000 nM
P09923 BXGT006942 Intestinal-type alkaline phosphatase reviewed Enzyme ALPI IC50 '=' 100000 nM
Q01650 BXGT012603 Large neutral amino acids transporter small subunit 1 reviewed Transporter SLC7A5 Activity '=' 100 %
Q01650 BXGT012603 Large neutral amino acids transporter small subunit 1 reviewed Transporter SLC7A5 IC50 '=' 69000 nM
Q01650 BXGT012603 Large neutral amino acids transporter small subunit 1 reviewed Transporter SLC7A5 Km '=' 11000 nM
P98170 BXGT012231 E3 ubiquitin-protein ligase XIAP reviewed Enzyme modulator XIAP IC50 '=' 80200 nM
Q01650 BXGT012603 Large neutral amino acids transporter small subunit 1 reviewed Transporter SLC7A5 Km '=' 14200 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00008 Garlic Allium sativum Herbs and Spices
BXGF00027 Chinese mustard Brassica juncea Vegetables
BXGF00052 Watermelon Citrullus lanatus Gourds
BXGF00079 Common buckwheat Fagopyrum esculentum Cereals and cereal products
BXGF00181 Dandelion Taraxacum officinale Herbs and Spices
BXGF00337 Ginkgo nuts Ginkgo biloba Herbs and Spices
BXGF00380 White mustard Sinapis alba Herbs and Spices
BXGF00979 Cistanche deserticola Cistanche deserticola Medicinal Plant
BXGF01154 Elephantopus angustifolius Elephantopus angustifolius Others
BXGF01426 Cornus officinalis Cornus officinalis Medicinal Plant
BXGF01521 Sarcocephalus latifolius Sarcocephalus latifolius Human Edible Plant
BXGF01668 Taraxacum platycarpum Taraxacum platycarpum Medicinal Plant
BXGF01716 Mentha canadensis Mentha canadensis Medicinal Plant
BXGF01972 Ficus simplicissima Ficus simplicissima Medicinal Plant
BXGF02152 Taraxacum borealisinense Taraxacum borealisinense Others
BXGF02275 Trichosanthes kirilowii maxim Trichosanthes kirilowii maxim Others
BXGF02330 Codonopsis pilosula Codonopsis pilosula Medicinal Plant
BXGF02526 Santalum album Santalum album Medicinal Plant
BXGF02815 Pinellia ternata Pinellia ternata Medicinal Plant
BXGF03099 Berberis integerrima Berberis integerrima Medicinal Plant
BXGF03103 Cheilanthes fragrans Cheilanthes fragrans Medicinal Plant
BXGF03239 Fadogia agrestis Fadogia agrestis Medicinal Plant
BXGF03289 Ostrya carpinifolia Ostrya carpinifolia Medicinal Plant
BXGF03305 Aconitum variegatum Aconitum variegatum Medicinal Plant
BXGF03477 Stephania dielsiana Stephania dielsiana Medicinal Plant
BXGF03490 Atractylodes macrocephala koidz Atractylodes macrocephala koidz Others
BXGF03630 Taraxacum coreanum Taraxacum coreanum Others
BXGF03645 Lycium barbarum Lycium barbarum Medicinal Plant
BXGF04310 Taraxacum mongolicum Taraxacum mongolicum Medicinal Plant
BXGF05014 Loranthus parasiticus Loranthus parasiticus Medicinal Plant
BXGF05203 Chlamydomonas reinhardtii Chlamydomonas reinhardtii Others
BXGF05233 Libocedrus decurrens Libocedrus decurrens Others
BXGF05571 Ziziphus jujuba Ziziphus jujuba Medicinal Plant
BXGF05962 Rehmannia glutinosa Rehmannia glutinosa Medicinal Plant
BXGF05971 Aniba megaphylla Aniba megaphylla Others
BXGF06097 Herbertus sakuraii Herbertus sakuraii Others
BXGF06108 Centipeda minima Centipeda minima Medicinal Plant
BXGF06317 Isoplexis sceptrum Isoplexis sceptrum Others
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease