Showing entry for Solute carrier family 22 member 4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT020432
Protein NameSolute carrier family 22 member 4
Uniport IdQ9H015
GeneSLC22A4
Gene Id6583
DomainSugar_tr
Pfam PF00083  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.1 Cancers: Overview hsa05231 Choline metabolism in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0089718 amino acid import across plasma membrane
Biological Process GO:0007589 body fluid secretion
Biological Process GO:0009437 carnitine metabolic process
Biological Process GO:0015879 carnitine transport
Biological Process GO:0015695 organic cation transport
Biological Process GO:0015697 quaternary ammonium group transport
Biological Process GO:0006814 sodium ion transport
Biological Process GO:0006641 triglyceride metabolic process
Biological Process GO:0042908 xenobiotic transport
molecular function GO:0015171 amino acid transmembrane transporter activity
molecular function GO:0005524 ATP binding
molecular function GO:0015226 carnitine transmembrane transporter activity
molecular function GO:0015491 cation:cation antiporter activity
molecular function GO:0000166 nucleotide binding
molecular function GO:0030165 PDZ domain binding
molecular function GO:0015651 quaternary ammonium group transmembrane transporter activity
molecular function GO:0008513 secondary active organic cation transmembrane transporter activity
molecular function GO:0015293 symporter activity
cellular component GO:0016324 apical plasma membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005739 mitochondrion
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-382551 Transport of small molecules
R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds
R-HSA-425407 SLC-mediated transmembrane transport
R-HSA-549127 Organic cation transport
R-HSA-549132 Organic cation/anion/zwitterion transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003507 BXGD000203 Aortic Valve Stenosis Cardiovascular Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004943 BXGD000297 Behcet Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases; Stomatognathic Diseases; Cardiovascular Diseases
C0007570 BXGD000467 Celiac Disease Digestive System Diseases; Nutritional and Metabolic Diseases
C0008497 BXGD000549 Choriocarcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010246 BXGD000656 Coxsackievirus Infections Infections
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011195 BXGD000702 Dejerine-Sottas Disease (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0014356 BXGD000910 Enterocolitis Digestive System Diseases
C0014378 BXGD000912 Enterovirus Infections Infections
C0016169 BXGD001048 pathologic fistula Pathological Conditions, Signs and Symptoms
C0017654 BXGD001136 Glomerular Filtration Rate
C0018213 BXGD001187 Graves Disease Eye Diseases; Immune System Diseases; Endocrine System Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023508 BXGD001675 White Blood Cell Count procedure
C0024115 BXGD001732 Lung diseases Respiratory Tract Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0027059 BXGD001965 Myocarditis Cardiovascular Diseases
C0027430 BXGD001988 Nasal Polyps Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0027497 BXGD001993 Nausea Pathological Conditions, Signs and Symptoms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030524 BXGD002236 Paratuberculosis Infections; Animal Diseases
C0031117 BXGD002285 Peripheral Neuropathy Nervous System Diseases
C0032584 BXGD002363 polyps Pathological Conditions, Signs and Symptoms
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0035220 BXGD002512 Respiratory Distress Syndrome, Newborn Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C0035222 BXGD002513 Respiratory Distress Syndrome, Adult Respiratory Tract Diseases
C0037369 BXGD002691 Smoking Behavior and Behavior Mechanisms
C0041296 BXGD002903 Tuberculosis Infections
C0042384 BXGD002979 Vasculitis Cardiovascular Diseases
C0152459 BXGD003600 Linear atrophy Pathological Conditions, Signs and Symptoms
C0175697 BXGD004004 Van der Woude syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Musculoskeletal Diseases; Stomatognathic Diseases
C0178468 BXGD004029 Autoimmune thyroid disease Immune System Diseases; Endocrine System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0200633 BXGD004040 Neutrophil count (procedure)
C0200637 BXGD004042 Monocyte count procedure
C0200638 BXGD004043 Eosinophil count procedure
C0200641 BXGD004044 Blood basophil count (lab test)
C0200665 BXGD004045 Platelet mean volume determination (procedure)
C0206161 BXGD004167 Reticulocyte count (procedure)
C0206666 BXGD004227 Trophoblastic Tumor, Placental Site Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0238198 BXGD004893 Gastrointestinal Stromal Tumors Digestive System Diseases; Neoplasms
C0333307 BXGD006946 Superficial ulcer Pathological Conditions, Signs and Symptoms
C0337428 BXGD007155 Fibrinogen assay
C0337438 BXGD007159 Glucose measurement
C0341332 BXGD007403 Indeterminate colitis Digestive System Diseases
C0342788 BXGD007552 Renal carnitine transport defect Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases; Cardiovascular Diseases
C0427460 BXGD008616 Red cell distribution width determination
C0495706 BXGD009038 elevated blood glucose level
C0497552 BXGD009067 Congenital neurologic anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0523446 BXGD009207 Acylcarnitines measurement
C0677607 BXGD009721 Hashimoto Disease Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0750880 BXGD010239 Monocyte count result
C0850715 BXGD010907 Abnormality of blood and blood-forming tissues
C0852283 BXGD010939 Respiratory Distress Syndrome
C0857490 BXGD011150 Granulocyte count
C0869523 BXGD011307 Carditis Cardiovascular Diseases
C1266159 BXGD011981 Trophoblastic tumor, epithelioid Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C1304746 BXGD012343 RDW - Red blood cell distribution width result
C1325327 BXGD012455 fibrinogen activity
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1519383 BXGD013237 Smoking Behaviors Behavior and Behavior Mechanisms
C1561955 BXGD013367 Fibrinogen, CTCAE
C1611743 BXGD013456 Familial (FPAH)
C1846647 BXGD014833 DEAFNESS, AUTOSOMAL RECESSIVE (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1848296 BXGD014918 DOSAGE-SENSITIVE SEX REVERSAL Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C1853438 BXGD015335 INFLAMMATORY BOWEL DISEASE 5 Digestive System Diseases
C1859308 BXGD015871 PREMATURE CENTROMERE DIVISION
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2931133 BXGD017964 Pediatric Crohn's disease Digestive System Diseases
C3887524 BXGD019892 Skin Erosion Skin and Connective Tissue Diseases
C4018871 BXGD020463 Abnormality of the respiratory system
C4021753 BXGD020758 Abnormality of the immune system
C4551720 BXGD023400 Primary Ciliary Dyskinesia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000218 L-Lysine 146.19
BXGC0000289 Carnitine 161.2
BXGC0000409 Choline 104.17
BXGC0000985 Putrescine 88.15
BXGC0001630 Arginine 174.2
BXGC0002390 Spermine 202.34
BXGC0002796 Nicotine 162.23
BXGC0003342 Guanidine 59.07
BXGC0004139 Sperminidine 145.25
BXGC0035201 Quinidine 324.18
BXGC0036512 D-Carnitine 161.11
BXGC0039601 Levocarnitine 161.11
BXGC0044017 Verapamil 454.28
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein