Showing entry for Adrenocorticotropic hormone receptor


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012609
Protein NameAdrenocorticotropic hormone receptor
Uniport IdQ01718
GeneMC2R
Gene Id4158
Domain7tm_1
Pfam PF00001  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04024 cAMP signaling pathway
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
5. Organismal Systems 5.2 Endocrine system hsa04925 Aldosterone synthesis and secretion
5. Organismal Systems 5.2 Endocrine system hsa04927 Cortisol synthesis and secretion
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04934 Cushing syndrome
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
Biological Process GO:0001890 placenta development
Biological Process GO:0019222 regulation of metabolic process
molecular function GO:0004978 corticotropin receptor activity
molecular function GO:0004930 G protein-coupled receptor activity
molecular function GO:0004977 melanocortin receptor activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-372790 Signaling by GPCR
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-418555 G alpha (s) signalling events
R-HSA-500792 GPCR ligand binding
R-HSA-5579029 Metabolic disorders of biological oxidation enzymes
R-HSA-5579031 Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
R-HSA-5663205 Infectious disease
R-HSA-5668914 Diseases of metabolism
R-HSA-9658195 Leishmania infection
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection
R-HSA-9664433 Leishmania parasite growth and survival
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001349 BXGD000044 Acute-Phase Reaction Pathological Conditions, Signs and Symptoms
C0001403 BXGD000048 Addison Disease Immune System Diseases; Endocrine System Diseases
C0001430 BXGD000054 Adenoma Neoplasms
C0001618 BXGD000063 Tumors of Adrenal Cortex Neoplasms; Endocrine System Diseases
C0001621 BXGD000064 Adrenal Gland Diseases Endocrine System Diseases
C0001623 BXGD000066 Adrenal gland hypofunction Endocrine System Diseases
C0001624 BXGD000067 Adrenal Gland Neoplasms Neoplasms; Endocrine System Diseases
C0001627 BXGD000068 Congenital adrenal hyperplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0001630 BXGD000069 Adrenal Rest Tumor Neoplasms
C0002170 BXGD000105 Alopecia Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0002171 BXGD000106 Alopecia Areata Skin and Connective Tissue Diseases
C0002793 BXGD000130 Anaplasia Pathological Conditions, Signs and Symptoms; Neoplasms
C0003123 BXGD000178 Anorexia Pathological Conditions, Signs and Symptoms
C0004509 BXGD000275 Azoospermia Male Urogenital Diseases
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0009421 BXGD000608 Comatose Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0009777 BXGD000630 Conn Adenoma Neoplasms; Endocrine System Diseases
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0010308 BXGD000661 Congenital Hypothyroidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0010481 BXGD000673 Cushing Syndrome Endocrine System Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0019337 BXGD001319 Heroin Dependence Chemically-Induced Disorders; Mental Disorders
C0020461 BXGD001395 Hyperkalemia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020595 BXGD001438 Hypoaldosteronism Endocrine System Diseases
C0020617 BXGD001446 Hypoglycemic coma Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Nervous System Diseases; Endocrine System Diseases
C0020625 BXGD001451 Hyponatremia Nutritional and Metabolic Diseases
C0020649 BXGD001459 Hypotension Cardiovascular Diseases
C0021670 BXGD001509 insulinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0032002 BXGD002320 Pituitary Diseases Nervous System Diseases; Endocrine System Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0034013 BXGD002450 Precocious Puberty Endocrine System Diseases
C0034372 BXGD002480 Quadriplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037769 BXGD002701 West Syndrome Nervous System Diseases
C0042963 BXGD003018 Vomiting Pathological Conditions, Signs and Symptoms
C0162834 BXGD003988 Hyperpigmentation Skin and Connective Tissue Diseases
C0175701 BXGD004007 Aarskog syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0175754 BXGD004015 Agenesis of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0206635 BXGD004200 Myelolipoma Neoplasms
C0206667 BXGD004228 Adrenal Cortical Adenoma Neoplasms; Endocrine System Diseases
C0206686 BXGD004241 Adrenocortical carcinoma Neoplasms; Endocrine System Diseases
C0220766 BXGD004341 Congenital hypoplasia of adrenal gland Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Endocrine System Diseases
C0221406 BXGD004459 Pituitary-dependent Cushing's disease Nervous System Diseases; Endocrine System Diseases
C0239998 BXGD005012 Recurrent infections Pathological Conditions, Signs and Symptoms; Infections; Musculoskeletal Diseases
C0241240 BXGD005089 Tall stature
C0262655 BXGD005264 Recurrent urinary tract infection Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0271713 BXGD006247 Ketotic hypoglycemia Nutritional and Metabolic Diseases
C0271742 BXGD006254 Glucocorticoid deficiency with achalasia Digestive System Diseases; Endocrine System Diseases
C0282160 BXGD006797 Aplasia Cutis Congenita Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0342443 BXGD007481 Adrenal Cushing's syndrome Endocrine System Diseases
C0342482 BXGD007486 X-linked Adrenal Hypoplasia Endocrine System Diseases
C0342495 BXGD007490 Macronodular adrenal hyperplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0342541 BXGD007499 Precocious pubarche Endocrine System Diseases
C0342546 BXGD007502 Premature adrenarche
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0405580 BXGD008325 Adrenal cortical hypofunction Endocrine System Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0518656 BXGD009071 Chronic fatigue Pathological Conditions, Signs and Symptoms
C0520463 BXGD009085 Chronic active hepatitis Digestive System Diseases
C0543698 BXGD009292 Hypersensitive syndrome Immune System Diseases
C0545053 BXGD009323 Advanced bone age
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600327 BXGD009704 Toxic Shock Syndrome Pathological Conditions, Signs and Symptoms; Infections
C0740457 BXGD010000 Malignant neoplasm of kidney Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0857899 BXGD011166 Decreased circulating aldosterone level Immune System Diseases; Endocrine System Diseases
C0877056 BXGD011334 Hypoglycemic seizures Nutritional and Metabolic Diseases
C1262477 BXGD011882 Weight decreased Pathological Conditions, Signs and Symptoms
C1306214 BXGD012356 ACTH-Secreting Pituitary Adenoma Neoplasms; Nervous System Diseases; Endocrine System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1378703 BXGD012933 Renal carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1384514 BXGD012940 Conn Syndrome Endocrine System Diseases
C1836623 BXGD014139 Decreased circulating cortisol level Immune System Diseases; Endocrine System Diseases
C1846288 BXGD014796 Recurrent hypoglycemia Nutritional and Metabolic Diseases
C1846347 BXGD014802 Renal salt wasting
C1848296 BXGD014918 DOSAGE-SENSITIVE SEX REVERSAL Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C1852529 BXGD015288 Corticosteroid-Binding Globulin Deficiency Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1857276 BXGD015688 Trichohepatoenteric Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C1857451 BXGD015702 Acth-Independent Macronodular Adrenal Hyperplasia Endocrine System Diseases
C1862382 BXGD016125 SVEINSSON CHORIORETINAL ATROPHY Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1955741 BXGD016606 Glucocorticoid deficiency
C1955743 BXGD016607 Mineralocorticoid deficiency Endocrine System Diseases
C2609247 BXGD017170 Adrenal incidentaloma Neoplasms; Endocrine System Diseases
C3178789 BXGD018537 Widespread Chronic Pain Pathological Conditions, Signs and Symptoms
C3671887 BXGD019330 Hypernatriuria
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3808022 BXGD019536 Episodic abdominal pain Pathological Conditions, Signs and Symptoms
C3887898 BXGD019926 Infantile Spasm Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4021740 BXGD020748 Increased circulating ACTH level
C4022011 BXGD020867 Leydig cell neoplasia Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C4023574 BXGD021219 Abnormality of circulating adrenocorticotropin level
C4024878 BXGD021453 Generalized hyperpigmentation Skin and Connective Tissue Diseases
C4049650 BXGD021946 Familial Glucocorticoid Deficiency Type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Endocrine System Diseases
C4054695 BXGD021986 Familial glucocorticoid deficiency
C4285817 BXGD022456 Cortisol deficiency
C4476786 BXGD022868 Testicular adrenal rest tumor Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C4476955 BXGD022895 Impaired cortisol response to insulin stimulation test
C4531272 BXGD023211 Decreased circulating dehydroepiandrosterone level
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0030248 2-(4-Hydroxyphenyl)Chromen-4-One 238.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein