adisease

Showing entry for Prolactinoma

General Disease Information
BXGD Id	BXGD002405
Disease Name	Prolactinoma
Disease CUI Id	C0033375
MeSH Codes	C04 C10 C19
Disease Class Name	Neoplasms; Nervous System Diseases; Endocrine System Diseases
Semantic Type	Neoplastic Process
Human Phenotype Ontology Id	HP:0000818 HP:0000707 HP:0002664
Human Phenotype Ontology Term	Abnormality of the endocrine system; Abnormality of the nervous system; Neoplasm
Disease Ontology Id	DOID:7 DOID:14566
Disease Ontology Class Name	disease of anatomical entity; disease of cellular proliferation
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00255	BXGT003903	Menin	4221	reviewed
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O14788	BXGT004100	Tumor necrosis factor ligand superfamily member 11	8600	reviewed	Signaling
O43451	BXGT004594	Maltase-glucoamylase, intestinal	8972	reviewed	Enzyme
O75030	BXGT005096	Microphthalmia-associated transcription factor	4286	reviewed
P00352	BXGT005510	Retinal dehydrogenase 1	216	reviewed	Enzyme
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P00915	BXGT005689	Carbonic anhydrase 1	759	reviewed
P01100	BXGT005727	Proto-oncogene c-Fos	2353	reviewed	Transcription factor
P01106	BXGT005730	Myc proto-oncogene protein	4609	reviewed	Transcription factor
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01138	BXGT005738	Beta-nerve growth factor	4803	reviewed	Signaling
P01189	BXGT005742	Pro-opiomelanocortin	5443	reviewed
P01236	BXGT005744	Prolactin	5617	reviewed	Signaling
P01303	BXGT005748	Pro-neuropeptide Y	4852	reviewed	Signaling
P02743	BXGT005937	Serum amyloid P-component	325	reviewed
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P04406	BXGT006207	Glyceraldehyde-3-phosphate dehydrogenase	2597	reviewed	Enzyme
P04626	BXGT006238	Receptor tyrosine-protein kinase erbB-2	2064	reviewed	Kinase
P04629	BXGT006239	High affinity nerve growth factor receptor	4914	reviewed	Kinase
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P05231	BXGT006345	Interleukin-6	3569	reviewed
P06870	BXGT006518	Kallikrein-1	3816	reviewed	Enzyme
P07101	BXGT006547	Tyrosine 3-monooxygenase	7054	reviewed
P08138	BXGT006729	Tumor necrosis factor receptor superfamily member 16	4804	reviewed	Receptor
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P08620	BXGT006800	Fibroblast growth factor 4	2249	reviewed	Signaling
P09038	BXGT006851	Fibroblast growth factor 2	2247	reviewed	Signaling
P09488	BXGT006899	Glutathione S-transferase Mu 1	2944	reviewed
P10586	BXGT007581	Receptor-type tyrosine-protein phosphatase F	5792	reviewed	Enzyme
P10600	BXGT007584	Transforming growth factor beta-3 proprotein	7043	reviewed	Signaling
P10644	BXGT007597	cAMP-dependent protein kinase type I-alpha regulatory subunit	5573	reviewed
P11362	BXGT007693	Fibroblast growth factor receptor 1	2260	reviewed	Kinase
P11511	BXGT007717	Aromatase	1588	reviewed	Enzyme
P12004	BXGT007766	Proliferating cell nuclear antigen	5111	reviewed	Nucleic acid binding
P12830	BXGT007852	Cadherin-1	999	reviewed
P14410	BXGT008009	Sucrase-isomaltase, intestinal	6476	reviewed	Enzyme
P14416	BXGT008011	D(2) dopamine receptor	1813	reviewed	G-protein coupled receptor
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P15428	BXGT008121	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	3248	reviewed
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P16455	BXGT008229	Methylated-DNA--protein-cysteine methyltransferase	4255	reviewed
P16471	BXGT008233	Prolactin receptor	5618	reviewed	Signaling
P17643	BXGT008323	5,6-dihydroxyindole-2-carboxylic acid oxidase	7306	reviewed	Enzyme
P17861	BXGT008348	X-box-binding protein 1	7494	reviewed
P17931	BXGT008356	Galectin-3	3958	reviewed	Signaling
P18146	BXGT008384	Early growth response protein 1	1958	reviewed	Nucleic acid binding
P21333	BXGT008638	Filamin-A	2316	reviewed
P21860	BXGT008698	Receptor tyrosine-protein kinase erbB-3	2065	reviewed	Kinase
P21980	BXGT008715	Protein-glutamine gamma-glutamyltransferase 2	7052	reviewed	Enzyme
P24385	BXGT008965	G1/S-specific cyclin-D1	595	reviewed	Enzyme modulator
P25440	BXGT009044	Bromodomain-containing protein 2	6046	reviewed	Epigenetic regulator
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P29323	BXGT009334	Ephrin type-B receptor 2	2048	reviewed	Kinase
P30872	BXGT009474	Somatostatin receptor type 1	6751	reviewed	G-protein coupled receptor
P30874	BXGT009475	Somatostatin receptor type 2	6752	reviewed	G-protein coupled receptor
P31040	BXGT009503	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	6389	reviewed	Enzyme
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P35346	BXGT009813	Somatostatin receptor type 5	6755	reviewed	G-protein coupled receptor
P35354	BXGT009816	Prostaglandin G/H synthase 2	5743	reviewed	Enzyme
P37173	BXGT009970	TGF-beta receptor type-2	7048	reviewed	Kinase
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P38936	BXGT010074	Cyclin-dependent kinase inhibitor 1	1026	reviewed
P40189	BXGT010164	Interleukin-6 receptor subunit beta	3572	reviewed	Signaling
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P42702	BXGT010335	Leukemia inhibitory factor receptor	3977	reviewed	Signaling
P46527	BXGT010525	Cyclin-dependent kinase inhibitor 1B	1027	reviewed
P46531	BXGT010526	Neurogenic locus notch homolog protein 1	4851	reviewed
P48443	BXGT010631	Retinoic acid receptor RXR-gamma	6258	reviewed	Nuclear receptor
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P51692	BXGT010885	Signal transducer and activator of transcription 5B	6777	reviewed	Nucleic acid binding
P52701	BXGT010943	DNA mismatch repair protein Msh6	2956	reviewed	Nucleic acid binding
P54578	BXGT011056	Ubiquitin carboxyl-terminal hydrolase 14	9097	reviewed	Enzyme
P56537	BXGT011177	Eukaryotic translation initiation factor 6	3692	reviewed	Nucleic acid binding
P56937	BXGT011205	3-keto-steroid reductase	51478	reviewed
P60880	BXGT011335	Synaptosomal-associated protein 25	6616	reviewed	Transporter
P63092	BXGT011495	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	2778	reviewed
P84022	BXGT012027	Mothers against decapentaplegic homolog 3	4088	reviewed	Transcription factor
P98164	BXGT012230	Low-density lipoprotein receptor-related protein 2	4036	reviewed
Q00987	BXGT012559	E3 ubiquitin-protein ligase Mdm2	4193	reviewed	Nucleic acid binding
Q01094	BXGT012568	Transcription factor E2F1	1869	reviewed	Nucleic acid binding
Q02643	BXGT012660	Growth hormone-releasing hormone receptor	2692	reviewed	G-protein coupled receptor
Q06520	BXGT012880	Bile salt sulfotransferase	6822	reviewed
Q07869	BXGT012945	Peroxisome proliferator-activated receptor alpha	5465	reviewed	Nuclear receptor
Q12778	BXGT013263	Forkhead box protein O1	2308	reviewed
Q13309	BXGT013338	S-phase kinase-associated protein 2	6502	reviewed
Q13541	BXGT013371	Eukaryotic translation initiation factor 4E-binding protein 1	1978	reviewed	Nucleic acid binding
Q14623	BXGT013490	Indian hedgehog protein	3549	reviewed
Q15303	BXGT013557	Receptor tyrosine-protein kinase erbB-4	2066	reviewed	Kinase
Q15761	BXGT013596	Neuropeptide Y receptor type 5	4889	reviewed	G-protein coupled receptor
Q8NB16	BXGT018535	Mixed lineage kinase domain-like protein	197259	reviewed	Kinase
Q95460	BXGT019580	Major histocompatibility complex class I-related gene protein	3140	reviewed
Q96A58	BXGT019614	Ras-related and estrogen-regulated growth inhibitor	85004	reviewed	Enzyme modulator
Q96EN8	BXGT019649	Molybdenum cofactor sulfurase	55034	reviewed
Q96HS1	BXGT019672	Serine/threonine-protein phosphatase PGAM5, mitochondrial	192111	reviewed
Q99828	BXGT019967	Calcium and integrin-binding protein 1	10519	reviewed
Q9BXR0	BXGT020173	Queuine tRNA-ribosyltransferase catalytic subunit 1	81890	reviewed
Q9H251	BXGT020449	Cadherin-23	64072	reviewed
Q9UM07	BXGT021771	Protein-arginine deiminase type-4	23569	reviewed
Q9UN36	BXGT021780	Protein NDRG2	57447	reviewed	Enzyme
Q9Y572	BXGT022289	Receptor-interacting serine/threonine-protein kinase 3	11035	reviewed	Kinase
Q13029	BXGT022688	PR domain zinc finger protein 2	7799	reviewed
O60232	BXGT024169	Protein ZNRD2	10534	reviewed
Q9BQ69	BXGT026098	ADP-ribose glycohydrolase MACROD1	28992	reviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}