protein

Showing entry for Cadherin-23

General Target Information
BXGT Id	BXGT020449
Protein Name	Cadherin-23
Uniport Id	Q9H251
Gene	CDH23
Gene Id	64072
Domain	Cadherin
Pfam	PF00028
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
Biological Process	GO:0006816	calcium ion transport
Biological Process	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules
Biological Process	GO:0050957	equilibrioception
Biological Process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
Biological Process	GO:0060122	inner ear receptor cell stereocilium organization
Biological Process	GO:0007626	locomotory behavior
Biological Process	GO:0045494	photoreceptor cell maintenance
Biological Process	GO:0051480	regulation of cytosolic calcium ion concentration
Biological Process	GO:0050896	response to stimulus
Biological Process	GO:0050953	sensory perception of light stimulus
Biological Process	GO:0007605	sensory perception of sound
Biological Process	GO:0007601	visual perception
molecular function	GO:0045296	cadherin binding
molecular function	GO:0005509	calcium ion binding
cellular component	GO:0016342	catenin complex
cellular component	GO:0016021	integral component of membrane
cellular component	GO:0016020	membrane
cellular component	GO:0032420	stereocilium

Reactome

Pathway Id	Pathway Name

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0000737	BXGD000005	Abdominal Pain	Pathological Conditions, Signs and Symptoms
C0000768	BXGD000007	Congenital Abnormality	Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0000772	BXGD000009	Multiple congenital anomalies	Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0001627	BXGD000068	Congenital adrenal hyperplasia	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0002453	BXGD000117	Amenorrhea	Pathological Conditions, Signs and Symptoms
C0002895	BXGD000152	Anemia, Sickle Cell	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0003467	BXGD000194	Anxiety	Behavior and Behavior Mechanisms
C0004134	BXGD000256	Ataxia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004681	BXGD000286	Bagassosis	Respiratory Tract Diseases; Occupational Diseases
C0005586	BXGD000315	Bipolar Disorder	Mental Disorders
C0005745	BXGD000331	Blepharoptosis	Eye Diseases
C0006142	BXGD000374	Malignant neoplasm of breast	Neoplasms; Skin and Connective Tissue Diseases
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0007758	BXGD000475	Cerebellar Ataxia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0010068	BXGD000648	Coronary heart disease	Cardiovascular Diseases
C0010481	BXGD000673	Cushing Syndrome	Endocrine System Diseases
C0011053	BXGD000694	Deafness	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0011581	BXGD000733	Depressive disorder	Mental Disorders
C0011849	BXGD000751	Diabetes Mellitus	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0012569	BXGD000777	Diplopia	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0015397	BXGD000983	Disorder of eye	Eye Diseases
C0015544	BXGD001003	Failure to Thrive	Pathological Conditions, Signs and Symptoms
C0015672	BXGD001011	Fatigue	Pathological Conditions, Signs and Symptoms
C0018021	BXGD001162	Goiter	Endocrine System Diseases
C0018418	BXGD001192	Gynecomastia	Skin and Connective Tissue Diseases
C0018524	BXGD001200	Hallucinations	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0018681	BXGD001214	Headache	Pathological Conditions, Signs and Symptoms
C0018784	BXGD001220	Sensorineural Hearing Loss (disorder)	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018802	BXGD001227	Congestive heart failure	Cardiovascular Diseases
C0018979	BXGD001260	Hemianopsia	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0020458	BXGD001393	Hyperhidrosis disorder	Skin and Connective Tissue Diseases
C0020538	BXGD001422	Hypertensive disease	Cardiovascular Diseases
C0020621	BXGD001449	Hypokalemia	Nutritional and Metabolic Diseases
C0020649	BXGD001459	Hypotension	Cardiovascular Diseases
C0021051	BXGD001475	Immunologic Deficiency Syndromes	Immune System Diseases
C0021359	BXGD001498	Infertility	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023380	BXGD001640	Lethargy	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0023508	BXGD001675	White Blood Cell Count procedure
C0023787	BXGD001698	Lipodystrophy	Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0025322	BXGD001863	Premature Menopause	Female Urogenital Diseases and Pregnancy Complications
C0025323	BXGD001864	Menorrhagia	Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0025874	BXGD001880	Metrorrhagia	Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0026837	BXGD001937	Muscle Rigidity	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0026848	BXGD001941	Myopathy	Musculoskeletal Diseases; Nervous System Diseases
C0027543	BXGD001997	Avascular necrosis of bone	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0027627	BXGD002006	Neoplasm Metastasis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651	BXGD002009	Neoplasms	Neoplasms
C0027794	BXGD002036	Neural Tube Defects	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0028077	BXGD002069	Nyctalopia	Eye Diseases
C0028866	BXGD002094	Oculomotor Nerve Paralysis	Eye Diseases; Nervous System Diseases
C0029453	BXGD002154	Osteopenia	Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029456	BXGD002157	Osteoporosis	Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030232	BXGD002197	Pallor	Pathological Conditions, Signs and Symptoms
C0030252	BXGD002199	Palpitations	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0031039	BXGD002274	Pericardial effusion	Cardiovascular Diseases
C0032000	BXGD002318	Pituitary Adenoma	Neoplasms; Nervous System Diseases; Endocrine System Diseases
C0032273	BXGD002343	Pneumoconiosis	Respiratory Tract Diseases; Occupational Diseases
C0033074	BXGD002393	Presbycusis	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0033375	BXGD002405	Prolactinoma	Neoplasms; Nervous System Diseases; Endocrine System Diseases
C0033377	BXGD002406	Ptosis	Pathological Conditions, Signs and Symptoms
C0033975	BXGD002447	Psychotic Disorders	Mental Disorders
C0034012	BXGD002449	Delayed Puberty	Endocrine System Diseases
C0035334	BXGD002539	Retinitis Pigmentosa	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0036341	BXGD002600	Schizophrenia	Mental Disorders
C0036454	BXGD002616	Scotoma	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0036572	BXGD002625	Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037317	BXGD002689	Sleep disturbances	Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0040127	BXGD002843	Thyroid Crisis	Endocrine System Diseases
C0040261	BXGD002855	Onychomycosis	Infections; Skin and Connective Tissue Diseases
C0040822	BXGD002885	Tremor	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0042487	BXGD002986	Venous Thrombosis	Cardiovascular Diseases
C0042571	BXGD002991	Vertigo	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0042798	BXGD003003	Low Vision	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0042963	BXGD003018	Vomiting	Pathological Conditions, Signs and Symptoms
C0085612	BXGD003204	Ventricular arrhythmia	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085660	BXGD003228	Aseptic necrosis	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0086543	BXGD003294	Cataract	Eye Diseases
C0151639	BXGD003452	Decreased fertility in females	Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0151640	BXGD003453	Decreased fertility in males	Male Urogenital Diseases
C0151721	BXGD003465	Testicular hypogonadism	Endocrine System Diseases
C0152013	BXGD003516	Adenocarcinoma of lung (disorder)	Neoplasms
C0154823	BXGD003744	Retinal defect	Eye Diseases
C0154860	BXGD003752	Hereditary retinal dystrophy	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0154920	BXGD003755	Pigmentary iris degeneration	Eye Diseases; Skin and Connective Tissue Diseases
C0200635	BXGD004041	Lymphocyte Count measurement
C0200637	BXGD004042	Monocyte count procedure
C0221184	BXGD004402	Bitemporal Hemianopia	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0221406	BXGD004459	Pituitary-dependent Cushing's disease	Nervous System Diseases; Endocrine System Diseases
C0235986	BXGD004799	Growth hormone excess	Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases
C0239479	BXGD004982	Round face
C0242350	BXGD005154	Erectile dysfunction	Male Urogenital Diseases; Mental Disorders
C0268425	BXGD005943	Alstrom Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C0271097	BXGD006163	Usher Syndrome	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C0271375	BXGD006188	Fourth cranial nerve paresis	Nervous System Diseases
C0271578	BXGD006216	Female hypogonadism syndrome	Female Urogenital Diseases and Pregnancy Complications; Nervous System Diseases; Endocrine System Diseases
C0271623	BXGD006222	Hypogonadotropic hypogonadism	Endocrine System Diseases
C0279626	BXGD006657	Squamous cell carcinoma of esophagus	Digestive System Diseases; Neoplasms
C0302142	BXGD006831	Deformity	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0339693	BXGD007279	Internal Ophthalmoplegia	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0339789	BXGD007282	Congenital deafness	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Nervous System Diseases; Otorhinolaryngologic Diseases
C0342388	BXGD007473	Adrenocorticotropic hormone (ACTH) deficiency (disorder)	Endocrine System Diseases
C0342422	BXGD007479	Pituitary gland enlarged	Nervous System Diseases; Endocrine System Diseases
C0342788	BXGD007552	Renal carnitine transport defect	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases; Cardiovascular Diseases
C0344424	BXGD007669	Ventricular Arrhythmia by ECG Finding
C0346303	BXGD007808	Thyrotroph adenoma	Neoplasms; Nervous System Diseases; Endocrine System Diseases
C0392525	BXGD008052	Nephrolithiasis	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0423757	BXGD008504	Thin skin
C0423798	BXGD008510	Increased tendency to bruise	Wounds and Injuries
C0427460	BXGD008616	Red cell distribution width determination
C0428974	BXGD008642	Supraventricular arrhythmia	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0428975	BXGD008643	Supraventricular Arrhythmia by ECG Finding
C0452138	BXGD008831	Sensorineural hearing loss, bilateral	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0456909	BXGD008883	Blindness	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0476397	BXGD008991	Electroretinogram abnormal
C0494463	BXGD009029	Alzheimer Disease, Late Onset	Nervous System Diseases; Mental Disorders
C0557874	BXGD009444	Global developmental delay
C0586553	BXGD009609	Raised TSH level	Endocrine System Diseases
C0678222	BXGD009749	Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C0700201	BXGD009880	Dyssomnias	Nervous System Diseases; Mental Disorders
C0702166	BXGD009912	Acne	Skin and Connective Tissue Diseases
C0750880	BXGD010239	Monocyte count result
C0851578	BXGD010925	Sleep Disorders	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0854021	BXGD010990	Abnormal visual field test
C0854723	BXGD011026	Retinal Dystrophies	Eye Diseases
C0859886	BXGD011203	Inherited hearing loss
C0878544	BXGD011368	Cardiomyopathies	Cardiovascular Diseases
C1262477	BXGD011882	Weight decreased	Pathological Conditions, Signs and Symptoms
C1304746	BXGD012343	RDW - Red blood cell distribution width result
C1306459	BXGD012361	Primary malignant neoplasm	Neoplasms
C1384606	BXGD012946	Dyspareunia	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Mental Disorders
C1384666	BXGD012948	hearing impairment	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1568247	BXGD013418	Usher Syndrome, Type I	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C1621895	BXGD013466	Adrenal hyperplasia	Pathological Conditions, Signs and Symptoms; Neoplasms; Endocrine System Diseases
C1832394	BXGD013838	Deafness, Autosomal Recessive 12	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1832845	BXGD013878	USHER SYNDROME, TYPE ID	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C1837098	BXGD014198	Easy fatigability
C1839364	BXGD014371	Progressive visual loss
C1839839	BXGD014416	MAJOR AFFECTIVE DISORDER 2	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Mental Disorders
C1842981	BXGD014547	NEUROTICISM	Behavior and Behavior Mechanisms
C1843865	BXGD014615	Vestibular dysfunction
C1846647	BXGD014833	DEAFNESS, AUTOSOMAL RECESSIVE (disorder)	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1848606	BXGD014950	Vestibular hypofunction
C1848634	BXGD014951	USHER SYNDROME, TYPE IIA	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C1848638	BXGD014952	USHER SYNDROME, TYPE IB (disorder)	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C1848639	BXGD014953	USHER SYNDROME, TYPE IA, FORMERLY
C1848640	BXGD014954	USHER SYNDROME, TYPE I, FRENCH VARIETY, FORMERLY
C1848641	BXGD014955	Profound sensorineural hearing loss	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1849211	BXGD015023	Generalized hirsutism	Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C1852197	BXGD015264	MAJOR AFFECTIVE DISORDER 1	Mental Disorders
C1853193	BXGD015312	Recurrent skin infections	Infections; Skin and Connective Tissue Diseases
C1855925	BXGD015561	Hyperopia, High	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1862265	BXGD016119	Increased circulating gonadotropin level	Nervous System Diseases; Endocrine System Diseases
C1863340	BXGD016166	PITUITARY ADENOMA PREDISPOSITION (disorder)
C1883529	BXGD016597	Ventricular Arrhythmia, CTCAE 3.0
C1970943	BXGD016852	MAJOR AFFECTIVE DISORDER 4	Mental Disorders
C1970945	BXGD016853	MAJOR AFFECTIVE DISORDER 6	Mental Disorders
C2700438	BXGD017469	MAJOR AFFECTIVE DISORDER 7	Mental Disorders
C2700439	BXGD017470	MAJOR AFFECTIVE DISORDER 8	Mental Disorders
C2700440	BXGD017471	MAJOR AFFECTIVE DISORDER 9	Mental Disorders
C2931205	BXGD017977	Usher syndrome, type 1A	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C2931208	BXGD017980	Usher syndrome, type 1D	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C2985280	BXGD018223	Blood Protein Measurement
C3150654	BXGD018317	DEAFNESS, AUTOSOMAL RECESSIVE 84A
C3152102	BXGD018458	USH1D/F, CDH23/PCDH15, DIGENIC
C3160712	BXGD018467	Palpitations, CTCAE
C3275872	BXGD018677	USHER SYNDROME, TYPE ID/F, CDH23/PCDH15, DIGENIC
C3275929	BXGD018680	Superior semicircular canal dehiscence syndrome	Otorhinolaryngologic Diseases
C3276419	BXGD018690	USHER SYNDROME, TYPE ID/F, DIGENIC
C3279222	BXGD018751	Aplasia/Hypoplasia of the cerebellum
C3665346	BXGD019278	Unspecified visual loss	Pathological Conditions, Signs and Symptoms; Eye Diseases
C3665347	BXGD019279	Visual Impairment	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3665349	BXGD019280	Secondary hypothyroidism	Endocrine System Diseases
C3665358	BXGD019281	Galactorrhea	Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C3665386	BXGD019284	Abnormal vision	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3711374	BXGD019382	Nonsyndromic Deafness	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C3714756	BXGD019429	Intellectual Disability	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3805574	BXGD019481	Increased fracture rate
C3887513	BXGD019887	Avascular necrosis	Pathological Conditions, Signs and Symptoms
C4021549	BXGD020665	Euthyroid hyperthyroxinemia
C4021553	BXGD020669	Periodic hypokalemic paresis
C4021800	BXGD020790	Abnormality of dental enamel
C4021806	BXGD020795	Prelingual sensorineural hearing impairment
C4022018	BXGD020872	Telangiectasia of the skin	Cardiovascular Diseases
C4022676	BXGD020953	Decreased female libido
C4023018	BXGD021068	Subcortical cerebral atrophy
C4023211	BXGD021145	Adrenocorticotropin deficient adrenal insufficiency
C4023401	BXGD021177	Abnormality of hair density
C4024716	BXGD021383	Secondary growth hormone deficiency
C4024878	BXGD021453	Generalized hyperpigmentation	Skin and Connective Tissue Diseases
C4025669	BXGD021720	Decreased circulating ACTH level
C4025858	BXGD021832	Abnormal cochlea morphology
C4025888	BXGD021848	Abnormality of the menstrual cycle	Pathological Conditions, Signs and Symptoms
C4072828	BXGD022005	Sudden loss of visual acuity
C4255193	BXGD022313	Bilateral Vestibulopathy	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C4277690	BXGD022377	Ciliopathies	Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C4316870	BXGD022707	Abnormality of the eye
C4539685	BXGD023226	PITUITARY ADENOMA 5, MULTIPLE TYPES
C4551519	BXGD023335	Abducens Nerve Palsy	Nervous System Diseases
C4551560	BXGD023349	Truncal obesity	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C4551583	BXGD023361	Cerebral cortical atrophy
C4551714	BXGD023398	Rod-Cone Dystrophy	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4553018	BXGD023532	Avascular Necrosis, CTCAE
C4553764	BXGD023550	Ventricular Arrhythmia, CTCAE 5.0

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0002586	Calcium		40.08
BXGC0002591	Potassium		39.1
BXGC0003705	Chloride		35.45

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}