Showing entry for Perilipin-1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004860
Protein NamePerilipin-1
Uniport IdO60240
GenePLIN1
Gene Id5346
DomainPerilipin
Pfam PF03036  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.2 Endocrine system hsa03320 PPAR signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04371 Apelin signaling pathway
5. Organismal Systems 5.10 Environmental adaptation hsa04714 Thermogenesis
5. Organismal Systems 5.2 Endocrine system hsa04923 Regulation of lipolysis in adipocytes
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0016042 lipid catabolic process
Biological Process GO:0006629 lipid metabolic process
molecular function GO:0008289 lipid binding
cellular component GO:0005829 cytosol
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005811 lipid droplet
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-1430728 Metabolism
R-HSA-162582 Signal Transduction
R-HSA-163560 Triglyceride catabolism
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-556833 Metabolism of lipids
R-HSA-8979227 Triglyceride metabolism
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling
R-HSA-9031528 NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000889 BXGD000018 Acanthosis Nigricans Skin and Connective Tissue Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0006625 BXGD000401 Cachexia Pathological Conditions, Signs and Symptoms
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020557 BXGD001432 Hypertriglyceridemia Nutritional and Metabolic Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0020757 BXGD001466 Ichthyoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0020758 BXGD001467 Congenital ichthyosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0021359 BXGD001498 Infertility Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0021831 BXGD001516 Intestinal Diseases Digestive System Diseases
C0023348 BXGD001636 Leprosy, Lepromatous Infections
C0023787 BXGD001698 Lipodystrophy Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0023827 BXGD001707 liposarcoma Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0028756 BXGD002083 Obesity, Morbid Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0028949 BXGD002100 Oligomenorrhea Pathological Conditions, Signs and Symptoms
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0043119 BXGD003029 Werner Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0079102 BXGD003062 Cerebral Thrombosis Nervous System Diseases; Cardiovascular Diseases
C0085207 BXGD003140 Gestational Diabetes Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0151945 BXGD003508 Thrombosis of cerebral veins Nervous System Diseases; Cardiovascular Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0153690 BXGD003684 Secondary malignant neoplasm of bone Pathological Conditions, Signs and Symptoms; Neoplasms; Musculoskeletal Diseases
C0205824 BXGD004128 Liposarcoma, Dedifferentiated Neoplasms
C0205825 BXGD004129 Liposarcoma, Pleomorphic Neoplasms
C0220613 BXGD004297 Adult Soft Tissue Sarcoma
C0220645 BXGD004307 Childhood Soft Tissue Sarcoma
C0221032 BXGD004374 Familial generalized lipodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0268238 BXGD005862 Triglyceride storage disease with ichthyosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0271693 BXGD006238 Acquired generalized lipodystrophy Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases; Endocrine System Diseases
C0271694 BXGD006239 Familial partial lipodystrophy Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0278488 BXGD006515 Carcinoma breast stage IV
C0278608 BXGD006549 Adult Liposarcoma Neoplasms
C0279565 BXGD006638 Invasive Lobular Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0279984 BXGD006703 Childhood Liposarcoma Neoplasms
C0333559 BXGD006960 Infarction, Lacunar Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0338508 BXGD007196 Optic Atrophy 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Nervous System Diseases
C0392885 BXGD008071 High density lipoprotein measurement
C0409959 BXGD008400 Osteoarthritis, Knee Musculoskeletal Diseases
C0494463 BXGD009029 Alzheimer Disease, Late Onset Nervous System Diseases; Mental Disorders
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0795687 BXGD010726 Cerebral arterial thrombosis Nervous System Diseases; Cardiovascular Diseases
C0812437 BXGD010850 Oculo-dento-digital syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Musculoskeletal Diseases; Stomatognathic Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1261473 BXGD011855 Sarcoma Neoplasms
C1266129 BXGD011970 Atypical Lipoma Neoplasms
C1280433 BXGD012125 Lipoatrophy Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1370889 BXGD012920 Liposarcoma, well differentiated Neoplasms
C1391732 BXGD012971 Cancer cachexia
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1720859 BXGD013688 Familial Partial Lipodystrophy, Type 1 Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C1720860 BXGD013689 Familial Partial Lipodystrophy, Type 2 Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C1720861 BXGD013690 Familial Partial Lipodystrophy, Type 3 Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C1837764 BXGD014268 Loss of subcutaneous adipose tissue in limbs
C1837792 BXGD014272 Insulin-resistant diabetes mellitus at puberty
C1843057 BXGD014552 Calf muscle hypertrophy
C1857657 BXGD015732 Reduced subcutaneous adipose tissue
C2265792 BXGD017012 Skeletal muscle hypertrophy
C2362324 BXGD017091 Pediatric Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C3151268 BXGD018413 LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 4
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3898127 BXGD020061 Non-Metastatic Childhood Soft Tissue Sarcoma
C4024606 BXGD021337 Loss of gluteal subcutaneous adipose tissue
C4316789 BXGD022698 Partial lipodystrophy Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C4317112 BXGD022726 Generalized Lipodystrophy Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C4551686 BXGD023391 Malignant neoplasm of soft tissue Neoplasms
C4551687 BXGD023392 Sarcoma of soft tissue Neoplasms
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0005982 Curcumin 368.38
BXGC0006198 Citric acid 192.12
BXGC0015879 Chlorhexidine 504.2
BXGC0024810 curcumin 368.13
BXGC0024988 Nifedipine 346.12
BXGC0025020 Methyl (2R)-2-Amino-3-Sulfanylpropanoate 135.04
BXGC0033999 Zuclomiphene 405.19
BXGC0037718 Ethacrynic Acid 302.01
BXGC0044200 Menadione 172.05
BXGC0046510 Tpck 351.07
BXGC0049858 Chalcone 208.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein