Showing entry for Ankyrin-1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008203
Protein NameAnkyrin-1
Uniport IdP16157
GeneANK1
Gene Id286
DomainAnk; Death; UPA_2; ZU5
Pfam PF00023   PF12796   PF00531   PF17809   PF00791  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.1 Cancers: Overview hsa05205 Proteoglycans in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007010 cytoskeleton organization
Biological Process GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
Biological Process GO:0006887 exocytosis
Biological Process GO:0045199 maintenance of epithelial cell apical/basal polarity
Biological Process GO:0010638 positive regulation of organelle organization
Biological Process GO:0072659 protein localization to plasma membrane
Biological Process GO:0007165 signal transduction
molecular function GO:0051117 ATPase binding
molecular function GO:0008093 cytoskeletal anchor activity
molecular function GO:0019899 enzyme binding
molecular function GO:0044325 ion channel binding
molecular function GO:0019903 protein phosphatase binding
molecular function GO:0030507 spectrin binding
molecular function GO:0005200 structural constituent of cytoskeleton
molecular function GO:0005198 structural molecule activity
cellular component GO:0030673 axolemma
cellular component GO:0016323 basolateral plasma membrane
cellular component GO:0009898 cytoplasmic side of plasma membrane
cellular component GO:0005856 cytoskeleton
cellular component GO:0005829 cytosol
cellular component GO:0031430 M band
cellular component GO:0043005 neuron projection
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
cellular component GO:0045211 postsynaptic membrane
cellular component GO:0042383 sarcolemma
cellular component GO:0016529 sarcoplasmic reticulum
cellular component GO:0014731 spectrin-associated cytoskeleton
cellular component GO:0030018 Z disc
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-1266738 Developmental Biology
R-HSA-199977 ER to Golgi Anterograde Transport
R-HSA-199991 Membrane Trafficking
R-HSA-373760 L1CAM interactions
R-HSA-373760 L1CAM interactions
R-HSA-392499 Metabolism of proteins
R-HSA-422475 Axon guidance
R-HSA-422475 Axon guidance
R-HSA-445095 Interaction between L1 and Ankyrins
R-HSA-445095 Interaction between L1 and Ankyrins
R-HSA-446203 Asparagine N-linked glycosylation
R-HSA-447038 NrCAM interactions
R-HSA-447041 CHL1 interactions
R-HSA-447043 Neurofascin interactions
R-HSA-447043 Neurofascin interactions
R-HSA-5653656 Vesicle-mediated transport
R-HSA-597592 Post-translational protein modification
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-948021 Transport to the Golgi and subsequent modification
R-HSA-9675108 Nervous system development
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000731 BXGD000002 Abdomen distended Digestive System Diseases
C0000737 BXGD000005 Abdominal Pain Pathological Conditions, Signs and Symptoms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0002878 BXGD000137 Anemia, Hemolytic Hemic and Lymphatic Diseases
C0003126 BXGD000180 Anosmia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0004509 BXGD000275 Azoospermia Male Urogenital Diseases
C0005612 BXGD000317 Birth Weight Pathological Conditions, Signs and Symptoms
C0005744 BXGD000330 Blepharophimosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0005940 BXGD000352 Bone Diseases Musculoskeletal Diseases
C0005941 BXGD000353 Bone Diseases, Developmental Musculoskeletal Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007196 BXGD000453 Restrictive cardiomyopathy Cardiovascular Diseases
C0007758 BXGD000475 Cerebellar Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0007787 BXGD000487 Transient Ischemic Attack Nervous System Diseases; Cardiovascular Diseases
C0008350 BXGD000531 Cholelithiasis Digestive System Diseases
C0009081 BXGD000581 Congenital clubfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0010278 BXGD000660 Craniosynostosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011269 BXGD000710 Dementia, Vascular Nervous System Diseases; Mental Disorders; Cardiovascular Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0012546 BXGD000776 Diphtheria Infections
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0013274 BXGD000809 Patent ductus arteriosus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013902 BXGD000865 Elliptocytosis, Hereditary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0014772 BXGD000948 Red Blood Cell Count measurement
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0018099 BXGD001172 Gout Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0018777 BXGD001217 Conductive hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018817 BXGD001235 Atrial Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018952 BXGD001257 Extramedullary Hematopoiesis Function
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020433 BXGD001379 Hyperbilirubinemia Pathological Conditions, Signs and Symptoms
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0020534 BXGD001421 Orbital separation excessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0022104 BXGD001529 Irritable Bowel Syndrome Digestive System Diseases
C0022346 BXGD001537 Icterus Pathological Conditions, Signs and Symptoms
C0022408 BXGD001544 Arthropathy Musculoskeletal Diseases
C0023364 BXGD001638 Leptospirosis Infections
C0023418 BXGD001642 leukemia Neoplasms
C0023462 BXGD001654 Acute Megakaryocytic Leukemias Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023493 BXGD001672 Adult T-Cell Lymphoma/Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024530 BXGD001783 Malaria Infections
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0025990 BXGD001884 Micrognathism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0026267 BXGD001896 Mitral Valve Prolapse Syndrome Cardiovascular Diseases
C0027055 BXGD001964 Myocardial Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030232 BXGD002197 Pallor Pathological Conditions, Signs and Symptoms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0031117 BXGD002285 Peripheral Neuropathy Nervous System Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0033802 BXGD002425 Pseudogout Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037299 BXGD002685 Skin Ulcer Skin and Connective Tissue Diseases
C0037889 BXGD002709 Hereditary spherocytosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0038013 BXGD002725 Ankylosing spondylitis Musculoskeletal Diseases
C0043119 BXGD003029 Werner Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0085593 BXGD003196 Chills Pathological Conditions, Signs and Symptoms
C0085625 BXGD003212 Hypoalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0162809 BXGD003981 Kallmann Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0200635 BXGD004041 Lymphocyte Count measurement
C0206160 BXGD004166 Reticulocytosis Pathological Conditions, Signs and Symptoms
C0206161 BXGD004167 Reticulocyte count (procedure)
C0221409 BXGD004460 Anemia, hereditary spherocytic hemolytic Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0231528 BXGD004496 Myalgia Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0232466 BXGD004543 Feeding difficulties
C0234251 BXGD004645 Inflammatory pain Pathological Conditions, Signs and Symptoms
C0240063 BXGD005015 Coloboma of iris Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0240635 BXGD005047 Byzanthine arch palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Stomatognathic Diseases
C0242183 BXGD005139 Jaundice, Hemolytic Pathological Conditions, Signs and Symptoms
C0242217 BXGD005142 Calcium Pyrophosphate Dihydrate Deposition Musculoskeletal Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0265292 BXGD005504 Schwartz-Lelek syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0266435 BXGD005668 Congenital hypoplasia of penis Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0266544 BXGD005691 Microcornea Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0266551 BXGD005693 Congenital coloboma of iris Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0266589 BXGD005698 Congenital ear anomaly NOS (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Otorhinolaryngologic Diseases
C0266610 BXGD005699 Preauricular dimple Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0271623 BXGD006222 Hypogonadotropic hypogonadism Endocrine System Diseases
C0272051 BXGD006298 Xerocytosis Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Immune System Diseases; Hemic and Lymphatic Diseases
C0280100 BXGD006713 Solid Neoplasm Neoplasms
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0345397 BXGD007734 Accessory rib Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0349588 BXGD007933 Short stature
C0398623 BXGD008202 Thrombophilia Hemic and Lymphatic Diseases
C0423109 BXGD008470 Upward slant of palpebral fissure
C0423791 BXGD008509 Maculopapular Lesion Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Immune System Diseases
C0426848 BXGD008590 Sacral dimple Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0427460 BXGD008616 Red cell distribution width determination
C0456070 BXGD008863 Growth delay
C0483368 BXGD009016 Human anaplasmosis due to Anaplasma phagocytophilum Infections; Animal Diseases
C0494463 BXGD009029 Alzheimer Disease, Late Onset Nervous System Diseases; Mental Disorders
C0524587 BXGD009232 Mean Corpuscular Volume (result)
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0553681 BXGD009406 Hypofibrinogenemia
C0553720 BXGD009414 Spherocytosis
C0553730 BXGD009417 Calcium pyrophosphate deposition disease Musculoskeletal Diseases
C0557874 BXGD009444 Global developmental delay
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678230 BXGD009750 Congenital Epicanthus
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0751956 BXGD010653 Acute Cerebrovascular Accidents Nervous System Diseases; Cardiovascular Diseases
C0752123 BXGD010671 Spinocerebellar Ataxia Type 5 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0752347 BXGD010721 Lewy Body Disease Nervous System Diseases; Mental Disorders
C0854723 BXGD011026 Retinal Dystrophies Eye Diseases
C0856830 BXGD011119 Calcium pyrophosphate arthropathy Musculoskeletal Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1304746 BXGD012343 RDW - Red blood cell distribution width result
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1328319 BXGD012461 Ankle brachial pressure index (observable entity)
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1611743 BXGD013456 Familial (FPAH)
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C1836542 BXGD014129 Depressed nasal bridge
C1844680 BXGD014661 DEAFNESS-HYPOGONADISM SYNDROME Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Endocrine System Diseases; Otorhinolaryngologic Diseases
C1846460 BXGD014820 Abnormality of the outer ear
C1849478 BXGD015056 Increased red cell osmotic fragility
C1852502 BXGD015286 CRANIOMETAPHYSEAL DYSPLASIA, AUTOSOMAL DOMINANT Musculoskeletal Diseases; Stomatognathic Diseases
C1858556 BXGD015805 OVERLAP CONNECTIVE TISSUE DISEASE Eye Diseases; Skin and Connective Tissue Diseases; Cardiovascular Diseases
C1861922 BXGD016094 CAMPOMELIC DYSPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1959635 BXGD016646 Parvovirus B19 (disease)
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2674218 BXGD017240 SPHEROCYTOSIS, TYPE 1 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C2827469 BXGD017798 Coronary Microvascular Disease
C2919142 BXGD017867 Short Stature, CTCAE
C2936719 BXGD018130 Mechanical Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3541994 BXGD019100 Drug Hypersensitivity Syndrome Skin and Connective Tissue Diseases; Immune System Diseases; Chemically-Induced Disorders
C3544347 BXGD019116 Intestinal fibrosis
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3873567 BXGD019863 Peripheral neuropathy due to and following chemotherapy Nervous System Diseases
C4017275 BXGD020428 SPHEROCYTOSIS, TYPE 1, AUTOSOMAL RECESSIVE
C4025184 BXGD021580 Spontaneous hemolytic crises Hemic and Lymphatic Diseases
C4025819 BXGD021808 Abnormality of the hypothalamus-pituitary axis
C4304505 BXGD022576 8p11.2 deletion syndrome
C4316812 BXGD022704 Fibrinogen Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C4521042 BXGD023055 Complete Trisomy 21 Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4528257 BXGD023159 Corpuscular Hemoglobin Concentration Mean
C4531297 BXGD023215 Increased mean corpuscular hemoglobin concentration
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000434 Ethanol 46.07
BXGC0000436 Glycerol 92.09
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein