Showing entry for Aldo-keto reductase family 1 member C3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010301
Protein NameAldo-keto reductase family 1 member C3
Uniport IdP42330
GeneAKR1C3
Gene Id8644
DomainAldo_ket_red
Pfam PF00248  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00140 Steroid hormone biosynthesis
1. Metabolism 1.3 Lipid metabolism hsa00590 Arachidonic acid metabolism
1. Metabolism 1.8 Metabolism of cofactors and vitamins hsa00790 Folate biosynthesis
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
5. Organismal Systems 5.2 Endocrine system hsa04913 Ovarian steroidogenesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0008207 C21-steroid hormone metabolic process
Biological Process GO:0071276 cellular response to cadmium ion
Biological Process GO:0071277 cellular response to calcium ion
Biological Process GO:0071384 cellular response to corticosteroid stimulus
Biological Process GO:0071395 cellular response to jasmonic acid stimulus
Biological Process GO:0071799 cellular response to prostaglandin D stimulus
Biological Process GO:0071379 cellular response to prostaglandin stimulus
Biological Process GO:0034614 cellular response to reactive oxygen species
Biological Process GO:0009267 cellular response to starvation
Biological Process GO:0019371 cyclooxygenase pathway
Biological Process GO:0044597 daunorubicin metabolic process
Biological Process GO:0044598 doxorubicin metabolic process
Biological Process GO:0016488 farnesol catabolic process
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0030216 keratinocyte differentiation
Biological Process GO:0043170 macromolecule metabolic process
Biological Process GO:0008584 male gonad development
Biological Process GO:1900053 negative regulation of retinoic acid biosynthetic process
Biological Process GO:0055114 oxidation-reduction process
Biological Process GO:0010942 positive regulation of cell death
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:2000353 positive regulation of endothelial cell apoptotic process
Biological Process GO:0051897 positive regulation of protein kinase B signaling
Biological Process GO:2000379 positive regulation of reactive oxygen species metabolic process
Biological Process GO:0042448 progesterone metabolic process
Biological Process GO:0006693 prostaglandin metabolic process
Biological Process GO:0048385 regulation of retinoic acid receptor signaling pathway
Biological Process GO:2000224 regulation of testosterone biosynthetic process
Biological Process GO:0070293 renal absorption
Biological Process GO:0007584 response to nutrient
Biological Process GO:0042574 retinal metabolic process
Biological Process GO:0001523 retinoid metabolic process
Biological Process GO:0008202 steroid metabolic process
Biological Process GO:0061370 testosterone biosynthetic process
molecular function GO:0047020 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity
molecular function GO:0008106 alcohol dehydrogenase (NADP+) activity
molecular function GO:0004032 alditol:NADP+ 1-oxidoreductase activity
molecular function GO:0004033 aldo-keto reductase (NADP) activity
molecular function GO:0047023 androsterone dehydrogenase activity
molecular function GO:0032052 bile acid binding
molecular function GO:0047787 delta4-3-oxosteroid 5beta-reductase activity
molecular function GO:0035410 dihydrotestosterone 17-beta-dehydrogenase activity
molecular function GO:0045550 geranylgeranyl reductase activity
molecular function GO:0047718 indanol dehydrogenase activity
molecular function GO:0045703 ketoreductase activity
molecular function GO:0047086 ketosteroid monooxygenase activity
molecular function GO:0052650 NADP-retinol dehydrogenase activity
molecular function GO:0016491 oxidoreductase activity
molecular function GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
molecular function GO:0018636 phenanthrene 9,10-monooxygenase activity
molecular function GO:0036131 prostaglandin D2 11-ketoreductase activity
molecular function GO:0047017 prostaglandin-F synthase activity
molecular function GO:0036130 prostaglandin H2 endoperoxidase reductase activity
molecular function GO:0001758 retinal dehydrogenase activity
molecular function GO:0004745 retinol dehydrogenase activity
molecular function GO:0005496 steroid binding
molecular function GO:0016229 steroid dehydrogenase activity
molecular function GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity
molecular function GO:0047035 testosterone dehydrogenase (NAD+) activity
molecular function GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005622 intracellular
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-162582 Signal Transduction
R-HSA-192105 Synthesis of bile acids and bile salts
R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol
R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-HSA-194068 Bile acid and bile salt metabolism
R-HSA-196854 Metabolism of vitamins and cofactors
R-HSA-2142753 Arachidonic acid metabolism
R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
R-HSA-2187338 Visual phototransduction
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-418594 G alpha (i) signalling events
R-HSA-5362517 Signaling by Retinoic Acid
R-HSA-5365859 RA biosynthesis pathway
R-HSA-556833 Metabolism of lipids
R-HSA-6806667 Metabolism of fat-soluble vitamins
R-HSA-8957322 Metabolism of steroids
R-HSA-8978868 Fatty acid metabolism
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-975634 Retinoid metabolism and transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0003504 BXGD000202 Aortic Valve Insufficiency Cardiovascular Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005699 BXGD000325 Blast Phase Pathological Conditions, Signs and Symptoms; Neoplasms; Hemic and Lymphatic Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007112 BXGD000429 Adenocarcinoma of prostate Neoplasms; Male Urogenital Diseases
C0007124 BXGD000437 Noninfiltrating Intraductal Carcinoma Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007621 BXGD000468 Neoplastic Cell Transformation Pathological Conditions, Signs and Symptoms; Neoplasms
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0008497 BXGD000549 Choriocarcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0009777 BXGD000630 Conn Adenoma Neoplasms; Endocrine System Diseases
C0011603 BXGD000734 Dermatitis Skin and Connective Tissue Diseases
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0011649 BXGD000746 Dermoid Cyst Neoplasms
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0014170 BXGD000902 Endometrial Neoplasms Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0014173 BXGD000903 Endometrial Hyperplasia Female Urogenital Diseases and Pregnancy Complications
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0017601 BXGD001125 Glaucoma Eye Diseases
C0019269 BXGD001310 Hermaphroditism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0022665 BXGD001573 Kidney Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023980 BXGD001725 Longevity
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024305 BXGD001763 Lymphoma, Non-Hodgkin Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025500 BXGD001874 Mesothelioma Neoplasms
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027661 BXGD002014 Neoplasms, Hormone-Dependent Neoplasms
C0027708 BXGD002025 Nephroblastoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030319 BXGD002208 Panic Disorder Mental Disorders
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0032914 BXGD002379 Pre-Eclampsia Female Urogenital Diseases and Pregnancy Complications
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0033804 BXGD002426 Pseudohermaphroditism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0036875 BXGD002640 Disorders of Sex Development Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0037284 BXGD002679 Skin lesion Skin and Connective Tissue Diseases
C0038356 BXGD002747 Stomach Neoplasms Digestive System Diseases; Neoplasms
C0039585 BXGD002821 Androgen-Insensitivity Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0153690 BXGD003684 Secondary malignant neoplasm of bone Pathological Conditions, Signs and Symptoms; Neoplasms; Musculoskeletal Diseases
C0205851 BXGD004132 Germ cell tumor Neoplasms
C0206081 BXGD004152 Hyperandrogenism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0206667 BXGD004228 Adrenal Cortical Adenoma Neoplasms; Endocrine System Diseases
C0206686 BXGD004241 Adrenocortical carcinoma Neoplasms; Endocrine System Diseases
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0262587 BXGD005259 Parathyroid Adenoma Neoplasms; Endocrine System Diseases
C0263361 BXGD005292 Psoriasis vulgaris Skin and Connective Tissue Diseases
C0266362 BXGD005657 Ambiguous Genitalia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0269102 BXGD006053 Endometrioma Female Urogenital Diseases and Pregnancy Complications
C0278838 BXGD006599 Prostate cancer recurrent Neoplasms; Male Urogenital Diseases
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279014 BXGD006623 Childhood Germ Cell Tumor Neoplasms
C0279565 BXGD006638 Invasive Lobular Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280280 BXGD006731 stage, prostate cancer Neoplasms; Male Urogenital Diseases
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0337438 BXGD007159 Glucose measurement
C0342541 BXGD007499 Precocious pubarche Endocrine System Diseases
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0396072 BXGD008182 Laryngeal papillomatosis Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0495706 BXGD009038 elevated blood glucose level
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0553723 BXGD009416 Squamous cell carcinoma of skin Neoplasms; Skin and Connective Tissue Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0677936 BXGD009737 Refractory cancer Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0687150 BXGD009842 Parathyroid Gland Adenocarcinoma Neoplasms; Endocrine System Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0742132 BXGD010057 cervical cancer metastasis
C0751606 BXGD010523 Adult Acute Lymphocytic Leukemia
C0852654 BXGD010947 21-hydroxylase deficiency
C0936223 BXGD011477 Metastatic Prostate Carcinoma Neoplasms; Male Urogenital Diseases
C1136382 BXGD011717 Sclerocystic Ovaries Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1153706 BXGD011769 Endometrial adenocarcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C1176475 BXGD011798 Ductal Carcinoma Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1282359 BXGD012144 Ocular Cicatricial Pemphigoid Eye Diseases; Skin and Connective Tissue Diseases
C1282496 BXGD012147 Metastasis from malignant tumor of prostate
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1333015 BXGD012581 Childhood Kidney Wilms Tumor Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1368911 BXGD012906 Papillary urothelial carcinoma
C1402294 BXGD013016 Primary Lesion
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1519670 BXGD013241 Tumor Angiogenesis Pathological Conditions, Signs and Symptoms
C1608408 BXGD013434 Malignant transformation
C1691215 BXGD013491 Penile hypospadias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1708349 BXGD013597 Hereditary Diffuse Gastric Cancer Digestive System Diseases; Neoplasms
C1961099 BXGD016672 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2930618 BXGD017889 Intersex Conditions Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C2930619 BXGD017890 Sex Differentiation Disorders Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3658266 BXGD019254 Prostatic Cancer, Castration-Resistant Neoplasms; Male Urogenital Diseases
C3658267 BXGD019255 Prostatic Neoplasms, Castration-Resistant Neoplasms; Male Urogenital Diseases
C3875321 BXGD019874 Inflammatory dermatosis Skin and Connective Tissue Diseases
C3900101 BXGD020109 Adult Germ Cell Tumor Neoplasms
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4086152 BXGD022123 Childhood Astrocytoma Neoplasms
C4721208 BXGD023733 Metastatic castration-resistant prostate cancer
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C4744714 BXGD023951 Advanced Prostate Adenocarcinoma
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0000537 Acetylsalicylic acid 180.16
BXGC0000663 Papain 206.28
BXGC0001550 Ficus Latex peptide 2 244.26
BXGC0001837 Quercetin 3-rutinoside 610.52
BXGC0001857 Caffeic acid 180.16
BXGC0001889 p-Coumaric acid 164.16
BXGC0002867 Lappaurin 284.74
BXGC0002906 Caffeic acid ester 284.31
BXGC0003131 N,N-Dimethylformamide 73.09
BXGC0003611 Latex 416.57
BXGC0003705 Chloride 35.45
BXGC0008138 Jasmonic acid 210.27
BXGC0012243 Ukonan D 151.16
BXGC0017757 Androstenedione 286.19
BXGC0025368 2'-hydroxyflavone 238.06
BXGC0027374 Glyburide 493.14
BXGC0030612 tetraethylene glycol 194.12
BXGC0032375 Artepillin 300.17
BXGC0037687 (4S)-2-methylpentane-2,4-diol 118.1
BXGC0040667 Drupanin 232.11
BXGC0049447 acetate 59.01
BXGC0049738 Dexibuprofen 206.13
BXGC0052021 (R)-Ibuprophen 206.13
BXGC0052454 Baccharin 364.17
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein