Showing entry for Juvenile Myelomonocytic Leukemia


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD007943
Disease NameJuvenile Myelomonocytic Leukemia
Disease CUI IdC0349639
MeSH Codes C04   C15  
Disease Class NameNeoplasms; Hemic and Lymphatic Diseases
Semantic TypeNeoplastic Process
Human Phenotype Ontology Id HP:0002715   HP:0002664   HP:0001871  
Human Phenotype Ontology TermAbnormality of the immune system; Neoplasm; Abnormality of blood and blood-forming tissues
Disease Ontology Id DOID:7   DOID:14566  
Disease Ontology Class Namedisease of anatomical entity; disease of cellular proliferation
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
A0A024RAV5 BXGT000013 V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b 3845 unreviewed
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O00459 BXGT003924 Phosphatidylinositol 3-kinase regulatory subunit beta 5296 reviewed Enzyme modulator
O14733 BXGT004087 Dual specificity mitogen-activated protein kinase kinase 7 5609 reviewed Kinase
O15550 BXGT004179 Lysine-specific demethylase 6A 7403 reviewed Epigenetic regulator
O15553 BXGT004181 Pyrin 4210 reviewed
O60260 BXGT004864 E3 ubiquitin-protein ligase parkin 5071 reviewed Enzyme
O60341 BXGT004873 Lysine-specific histone demethylase 1A 23028 reviewed Epigenetic regulator
O60462 BXGT004876 Neuropilin-2 8828 reviewed
O60674 BXGT004892 Tyrosine-protein kinase JAK2 3717 reviewed Kinase
P00519 BXGT005570 Tyrosine-protein kinase ABL1 25 reviewed Kinase
P00740 BXGT005634 Coagulation factor IX 2158 reviewed Enzyme
P01106 BXGT005730 Myc proto-oncogene protein 4609 reviewed Transcription factor
P01111 BXGT005731 GTPase NRas 4893 reviewed Enzyme modulator
P01112 BXGT005732 GTPase HRas 3265 reviewed Enzyme modulator
P01116 BXGT005733 GTPase KRas 3845 reviewed Enzyme modulator
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P04049 BXGT006133 RAF proto-oncogene serine/threonine-protein kinase 5894 reviewed Kinase
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P04839 BXGT006273 Cytochrome b-245 heavy chain 1536 reviewed Ion channel
P05089 BXGT006310 Arginase-1 383 reviewed Enzyme
P06730 BXGT006487 Eukaryotic translation initiation factor 4E 1977 reviewed Nucleic acid binding
P06748 BXGT006497 Nucleophosmin 4869 reviewed Chaperone
P07204 BXGT006567 Thrombomodulin 7056 reviewed
P07355 BXGT006609 Annexin A2 302 reviewed
P07949 BXGT006703 Proto-oncogene tyrosine-protein kinase receptor Ret 5979 reviewed Kinase
P08700 BXGT006816 Interleukin-3 3562 reviewed
P08922 BXGT006843 Proto-oncogene tyrosine-protein kinase ROS 6098 reviewed Kinase
P09619 BXGT006911 Platelet-derived growth factor receptor beta 5159 reviewed Kinase
P09874 BXGT006934 Poly [ADP-ribose] polymerase 1 142 reviewed
P10275 BXGT007552 Androgen receptor 367 reviewed Nuclear receptor
P10301 BXGT007556 Ras-related protein R-Ras 6237 reviewed Enzyme modulator
P10721 BXGT007605 Mast/stem cell growth factor receptor Kit 3815 reviewed Kinase
P11274 BXGT007681 Breakpoint cluster region protein 613 reviewed Enzyme modulator
P11362 BXGT007693 Fibroblast growth factor receptor 1 2260 reviewed Kinase
P12724 BXGT007837 Eosinophil cationic protein 6037 reviewed
P12931 BXGT007859 Proto-oncogene tyrosine-protein kinase Src 6714 reviewed Kinase
P15056 BXGT008075 Serine/threonine-protein kinase B-raf 673 reviewed Kinase
P15153 BXGT008090 Ras-related C3 botulinum toxin substrate 2 5880 reviewed Enzyme modulator
P16220 BXGT008206 Cyclic AMP-responsive element-binding protein 1 1385 reviewed
P16234 BXGT008209 Platelet-derived growth factor receptor alpha 5156 reviewed Kinase
P21359 BXGT008640 Neurofibromin 4763 reviewed Enzyme modulator
P21583 BXGT008667 Kit ligand 4254 reviewed
P22083 BXGT008727 Alpha-(1,3)-fucosyltransferase 4 2526 reviewed Enzyme
P22681 BXGT008795 E3 ubiquitin-protein ligase CBL 867 reviewed Enzyme
P26358 BXGT009104 DNA (cytosine-5)-methyltransferase 1 1786 reviewed Epigenetic regulator
P26951 BXGT009147 Interleukin-3 receptor subunit alpha 3563 reviewed Signaling
P27797 BXGT009206 Calreticulin 811 reviewed Calcium-binding protein
P27815 BXGT009208 cAMP-specific 3',5'-cyclic phosphodiesterase 4A 5141 reviewed
P27986 BXGT009216 Phosphatidylinositol 3-kinase regulatory subunit alpha 5295 reviewed Kinase
P28482 BXGT009263 Mitogen-activated protein kinase 1 5594 reviewed Kinase
P28907 BXGT009301 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 952 reviewed Enzyme
P29323 BXGT009334 Ephrin type-B receptor 2 2048 reviewed Kinase
P29350 BXGT009335 Tyrosine-protein phosphatase non-receptor type 6 5777 reviewed
P30086 BXGT009400 Phosphatidylethanolamine-binding protein 1 5037 reviewed Enzyme modulator
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase 207 reviewed Kinase
P31785 BXGT009577 Cytokine receptor common subunit gamma 3561 reviewed Signaling
P35579 BXGT009852 Myosin-9 4627 reviewed
P35580 BXGT009853 Myosin-10 4628 reviewed
P35610 BXGT009855 Sterol O-acyltransferase 1 6646 reviewed Enzyme
P36888 BXGT009938 Receptor-type tyrosine-protein kinase FLT3 2322 reviewed Kinase
P40225 BXGT010168 Thrombopoietin 7066 reviewed
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P41212 BXGT010235 Transcription factor ETV6 2120 reviewed Transcription factor
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5291 reviewed Kinase
P47736 BXGT010579 Rap1 GTPase-activating protein 1 5909 reviewed Enzyme modulator
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 reviewed Kinase
P51692 BXGT010885 Signal transducer and activator of transcription 5B 6777 reviewed Nucleic acid binding
P52333 BXGT010928 Tyrosine-protein kinase JAK3 3718 reviewed Kinase
P54136 BXGT011033 Arginine--tRNA ligase, cytoplasmic 5917 reviewed
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
P61073 BXGT011352 C-X-C chemokine receptor type 4 7852 reviewed G-protein coupled receptor
P62070 BXGT011404 Ras-related protein R-Ras2 22800 reviewed Enzyme modulator
P69891 BXGT011646 Hemoglobin subunit gamma-1 3047 reviewed
P69892 BXGT011647 Hemoglobin subunit gamma-2 3048 reviewed
Q01081 BXGT012566 Splicing factor U2AF 35 kDa subunit 7307 reviewed
Q01196 BXGT012575 Runt-related transcription factor 1 861 reviewed Transcription factor
Q02763 BXGT012667 Angiopoietin-1 receptor 7010 reviewed Kinase
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A 4297 reviewed
Q06124 BXGT012856 Tyrosine-protein phosphatase non-receptor type 11 5781 reviewed
Q07889 BXGT012946 Son of sevenless homolog 1 6654 reviewed Enzyme modulator
Q07912 BXGT012947 Activated CDC42 kinase 1 10188 reviewed Kinase
Q13478 BXGT013362 Interleukin-18 receptor 1 8809 reviewed Receptor
Q14683 BXGT013500 Structural maintenance of chromosomes protein 1A 8243 reviewed
Q15910 BXGT013612 Histone-lysine N-methyltransferase EZH2 2146 reviewed Epigenetic regulator
Q6N021 BXGT016378 Methylcytosine dioxygenase TET2 54790 reviewed
Q6ZN17 BXGT016631 Protein lin-28 homolog B 389421 reviewed
Q92793 BXGT019374 CREB-binding protein 1387 reviewed
Q92835 BXGT019382 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 3635 reviewed
Q92963 BXGT019401 GTP-binding protein Rit1 6016 reviewed Enzyme modulator
Q969R2 BXGT019611 Oxysterol-binding protein 2 23762 reviewed
Q9UBC3 BXGT021650 DNA (cytosine-5)-methyltransferase 3B 1789 reviewed
Q9UM73 BXGT021773 ALK tyrosine kinase receptor 238 reviewed Kinase
Q9UPN9 BXGT021799 E3 ubiquitin-protein ligase TRIM33 51592 reviewed
Q9Y6K1 BXGT022331 DNA (cytosine-5)-methyltransferase 3A 1788 reviewed
P15509 BXGT022826 Granulocyte-macrophage colony-stimulating factor receptor subunit alpha 1438 reviewed Signaling
O95251 BXGT024818 Histone acetyltransferase KAT7 11143 reviewed Enzyme
Q99435 BXGT025240 Protein kinase C-binding protein NELL2 4753 reviewed Calcium-binding protein
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease