Showing entry for Cytokine receptor common subunit gamma


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009577
Protein NameCytokine receptor common subunit gamma
Uniport IdP31785
GeneIL2RG
Gene Id3561
DomainIL6Ra-bind
Pfam PF09240  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04060 Cytokine-cytokine receptor interaction
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04061 Viral protein interaction with cytokine and cytokine receptor
4. Cellular Processes 4.1 Transport and catabolism hsa04144 Endocytosis
3. Environmental Information Processing 3.2 Signal transduction hsa04151 PI3K-Akt signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04630 Jak-STAT signaling pathway
5. Organismal Systems 5.1 Immune system hsa04658 Th1 and Th2 cell differentiation
5. Organismal Systems 5.1 Immune system hsa04659 Th17 cell differentiation
6. Human Diseases 6.9 Infectious diseases: Viral hsa05162 Measles
6. Human Diseases 6.9 Infectious diseases: Viral hsa05166 Human T-cell leukemia virus 1 infection
6. Human Diseases 6.1 Cancers: Overview hsa05200 Pathways in cancer
6. Human Diseases 6.3 Immune diseases hsa05321 Inflammatory bowel disease (IBD)
6. Human Diseases 6.3 Immune diseases hsa05340 Primary immunodeficiency
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0019221 cytokine-mediated signaling pathway
Biological Process GO:0006955 immune response
Biological Process GO:0035723 interleukin-15-mediated signaling pathway
Biological Process GO:0038114 interleukin-21-mediated signaling pathway
Biological Process GO:0038110 interleukin-2-mediated signaling pathway
Biological Process GO:0035771 interleukin-4-mediated signaling pathway
Biological Process GO:0038111 interleukin-7-mediated signaling pathway
Biological Process GO:0038113 interleukin-9-mediated signaling pathway
Biological Process GO:0000165 MAPK cascade
Biological Process GO:0050766 positive regulation of phagocytosis
Biological Process GO:0007165 signal transduction
Biological Process GO:0016032 viral process
molecular function GO:0019955 cytokine binding
molecular function GO:0004896 cytokine receptor activity
molecular function GO:0042010 interleukin-15 receptor activity
molecular function GO:0019976 interleukin-2 binding
cellular component GO:0009986 cell surface
cellular component GO:0005829 cytosol
cellular component GO:0005768 endosome
cellular component GO:0009897 external side of plasma membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0016020 membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0043235 receptor complex
Reactome
Pathway Id Pathway Name
R-HSA-1266695 Interleukin-7 signaling
R-HSA-1266695 Interleukin-7 signaling
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-162582 Signal Transduction
R-HSA-168256 Immune System
R-HSA-168256 Immune System
R-HSA-449147 Signaling by Interleukins
R-HSA-449147 Signaling by Interleukins
R-HSA-451927 Interleukin-2 family signaling
R-HSA-451927 Interleukin-2 family signaling
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-8983432 Interleukin-15 signaling
R-HSA-8983432 Interleukin-15 signaling
R-HSA-8985947 Interleukin-9 signaling
R-HSA-9020558 Interleukin-2 signaling
R-HSA-9020958 Interleukin-21 signaling
R-HSA-912526 Interleukin receptor SHC signaling
R-HSA-9607240 FLT3 Signaling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001768 BXGD000075 Agammaglobulinemia Immune System Diseases; Hemic and Lymphatic Diseases
C0002170 BXGD000105 Alopecia Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004135 BXGD000257 Ataxia Telangiectasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004368 BXGD000271 Autoimmune state
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007766 BXGD000478 Intracranial Aneurysm Nervous System Diseases; Cardiovascular Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009691 BXGD000622 Congenital cataract Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Eye Diseases; Nervous System Diseases
C0010200 BXGD000653 Coughing Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0011606 BXGD000735 Exfoliative dermatitis Skin and Connective Tissue Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013604 BXGD000859 Edema Pathological Conditions, Signs and Symptoms
C0014457 BXGD000915 Eosinophilia Hemic and Lymphatic Diseases
C0015230 BXGD000969 Exanthema Skin and Connective Tissue Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0018133 BXGD001176 Graft-vs-Host Disease Immune System Diseases
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0022346 BXGD001537 Icterus Pathological Conditions, Signs and Symptoms
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023465 BXGD001656 Acute monocytic leukemia Neoplasms
C0023492 BXGD001671 Leukemia, T-Cell Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023493 BXGD001672 Adult T-Cell Lymphoma/Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024305 BXGD001763 Lymphoma, Non-Hodgkin Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024312 BXGD001766 Lymphopenia Immune System Diseases; Hemic and Lymphatic Diseases
C0024314 BXGD001767 Lymphoproliferative Disorders Immune System Diseases; Hemic and Lymphatic Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0025289 BXGD001851 Meningitis Nervous System Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027726 BXGD002030 Nephrotic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0029118 BXGD002111 Opportunistic Infections Infections
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029882 BXGD002177 Otitis Media Otorhinolaryngologic Diseases
C0031029 BXGD002271 Periapical Granuloma Stomatognathic Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0033774 BXGD002419 Pruritus Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0035021 BXGD002501 Relapsing Fever Infections
C0035243 BXGD002522 Respiratory Tract Infections Infections; Respiratory Tract Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0035436 BXGD002550 Rheumatic Fever Infections; Musculoskeletal Diseases
C0036224 BXGD002589 Sarcoma, Yoshida Neoplasms
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036920 BXGD002645 Sezary Syndrome Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0037199 BXGD002671 Sinusitis Infections; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0037769 BXGD002701 West Syndrome Nervous System Diseases
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0038013 BXGD002725 Ankylosing spondylitis Musculoskeletal Diseases
C0040147 BXGD002847 Thyroiditis Endocrine System Diseases
C0043194 BXGD003036 Wiskott-Aldrich Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C0079772 BXGD003099 T-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079773 BXGD003100 Lymphoma, T-Cell, Cutaneous Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079774 BXGD003101 Peripheral T-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085110 BXGD003126 Severe Combined Immunodeficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0151908 BXGD003502 Dry skin Skin and Connective Tissue Diseases
C0205699 BXGD004110 Carcinomatosis Neoplasms
C0220621 BXGD004300 Childhood Acute Myeloid Leukemia Neoplasms
C0221026 BXGD004371 X-linked agammaglobulinemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C0221277 BXGD004434 Atypical lymphocyte
C0221765 BXGD004477 Chronic schizophrenia Mental Disorders
C0241165 BXGD005083 Thick skin
C0242172 BXGD005138 Pelvic Inflammatory Disease Female Urogenital Diseases and Pregnancy Complications; Infections
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0264490 BXGD005394 Acute respiratory failure Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Respiratory Tract Diseases
C0266537 BXGD005688 Congenital lamellar cataract Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0268124 BXGD005825 Adenosine deaminase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0278488 BXGD006515 Carcinoma breast stage IV
C0279629 BXGD006660 Adult Acute Monoblastic Leukemia Neoplasms
C0279645 BXGD006669 Childhood Acute Monoblastic Leukemia
C0339508 BXGD007256 Hereditary macular dystrophy
C0342288 BXGD007456 Insulin-dependent diabetes mellitus secretory diarrhea syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0346990 BXGD007842 Carcinomatosis of peritoneal cavity Digestive System Diseases; Neoplasms
C0349639 BXGD007943 Juvenile Myelomonocytic Leukemia Neoplasms; Hemic and Lymphatic Diseases
C0392607 BXGD008057 Severe combined immunodeficiency due to adenosine deaminase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases; Hemic and Lymphatic Diseases
C0398686 BXGD008215 Primary immune deficiency disorder Immune System Diseases
C0401151 BXGD008274 Chronic diarrhea Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0457334 BXGD008888 Acute monoblastic leukemia Neoplasms
C0494261 BXGD009023 Combined immunodeficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0497156 BXGD009053 Lymphadenopathy Hemic and Lymphatic Diseases
C0543687 BXGD009290 Thymic alymphoplasia Immune System Diseases
C0549463 BXGD009382 X-Linked Lymphoproliferative Disorder Immune System Diseases; Hemic and Lymphatic Diseases
C0553681 BXGD009406 Hypofibrinogenemia
C0576093 BXGD009525 Knee joint valgus deformity Musculoskeletal Diseases
C0576999 BXGD009530 Tonsil absent
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0685891 BXGD009824 Congenital hypoplasia of thymus Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0700216 BXGD009881 Structural Clinical Interview for DSM-III
C0730290 BXGD009946 Cone Dystrophy Eye Diseases
C0730292 BXGD009947 Macular dystrophy Eye Diseases
C0740451 BXGD009999 Granulomatous disorder
C0741796 BXGD010041 Recurrent bronchitis Infections; Respiratory Tract Diseases
C0878787 BXGD011392 Growth failure
C1261473 BXGD011855 Sarcoma Neoplasms
C1279481 BXGD012123 X-Linked Combined Immunodeficiency Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases
C1292769 BXGD012230 Precursor B-cell lymphoblastic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1301034 BXGD012282 Pancreatic intraepithelial neoplasia Neoplasms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1333431 BXGD012627 EBV-Related Lymphoma
C1336745 BXGD012857 Thymic Lymphoma Neoplasms; Hemic and Lymphatic Diseases
C1744558 BXGD013748 T-lymphocyte deficiency
C1832324 BXGD013828 Recurrent opportunistic infections Infections
C1833487 BXGD013928 Varicella, Severe Recurrent Infections
C1835686 BXGD014043 Recurrent bacterial skin infections
C1836195 BXGD014094 Short toe
C1839304 BXGD014365 Decreased proportion of CD4-positive T cells Immune System Diseases; Hemic and Lymphatic Diseases
C1839305 BXGD014366 Decreased proportion of CD8-positive T cells Immune System Diseases; Hemic and Lymphatic Diseases
C1842714 BXGD014535 Desquamation of skin soon after birth
C1844384 BXGD014629 Recurrent fungal infections
C1845604 BXGD014754 Recurrent bacterial meningitis
C1845977 BXGD014769 X- linked recessive
C1849236 BXGD015026 Severe combined immunodeficiency, atypical Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C1852429 BXGD015280 Cataract, Variable Zonular Pulverulent Eye Diseases
C1852438 BXGD015281 CATARACT, COPPOCK-LIKE Eye Diseases
C1853193 BXGD015312 Recurrent skin infections Infections; Skin and Connective Tissue Diseases
C1855767 BXGD015541 Reduced natural killer cell count
C1855771 BXGD015542 Immune Deficiency Disease Immune System Diseases
C1861828 BXGD016079 Cataract, Zonular Pulverulent 1 Eye Diseases
C1960398 BXGD016658 HER2-positive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C1961099 BXGD016672 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1963094 BXGD016681 Dry Skin, CTCAE
C2004493 BXGD016875 Leukemia, B-Cell Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2363142 BXGD017096 T-Cell Prolymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2363741 BXGD017100 HIV-1 infection
C2700553 BXGD017472 Omenn Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C2712971 BXGD017492 Enteritis due to Norovirus Infections
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3534585 BXGD019063 Infection caused by Norovirus Infections
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3714772 BXGD019433 Recurrent fevers
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4021956 BXGD020839 Aplasia/Hypoplasia of the eyebrow
C4023393 BXGD021173 Recurrent viral skin infections
C4024599 BXGD021333 Chronic oral candidiasis Infections; Skin and Connective Tissue Diseases
C4025204 BXGD021590 Recurrent Haemophilus influenzae infections
C4025683 BXGD021732 Lymph node hypoplasia
C4025814 BXGD021806 Abnormality of the metaphysis
C4048329 BXGD021904 Immunosuppression
C4477053 BXGD022911 Decreased proportion of CD3-positive T cells Immune System Diseases; Hemic and Lymphatic Diseases
C4531052 BXGD023182 Abnormally low T cell receptor excision circle level
C4531152 BXGD023196 Reduced proportion of naive T cells
C4531166 BXGD023200 Decreased lymphocyte proliferation in response to mitogen
C4551686 BXGD023391 Malignant neoplasm of soft tissue Neoplasms
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C4733095 BXGD023910 HER2-negative breast cancer
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein