Showing entry for Bone morphogenetic protein receptor type-1B


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT003900
Protein NameBone morphogenetic protein receptor type-1B
Uniport IdO00238
GeneBMPR1B
Gene Id658
DomainActivin_recp; Pkinase_Tyr; TGF_beta_GS
Pfam PF01064   PF07714   PF08515  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04060 Cytokine-cytokine receptor interaction
3. Environmental Information Processing 3.2 Signal transduction hsa04350 TGF-beta signaling pathway
5. Organismal Systems 5.8 Development hsa04360 Axon guidance
3. Environmental Information Processing 3.2 Signal transduction hsa04390 Hippo signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04550 Signaling pathways regulating pluripotency of stem cells
6. Human Diseases 6.6 Cardiovascular diseases hsa05418 Fluid shear stress and atherosclerosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030509 BMP signaling pathway
Biological Process GO:0001502 cartilage condensation
Biological Process GO:0071773 cellular response to BMP stimulus
Biological Process GO:0071363 cellular response to growth factor stimulus
Biological Process GO:0002063 chondrocyte development
Biological Process GO:0009953 dorsal/ventral pattern formation
Biological Process GO:0060350 endochondral bone morphogenesis
Biological Process GO:0001654 eye development
Biological Process GO:0006954 inflammatory response
Biological Process GO:0035108 limb morphogenesis
Biological Process GO:1902731 negative regulation of chondrocyte proliferation
Biological Process GO:0001550 ovarian cumulus expansion
Biological Process GO:0042698 ovulation cycle
Biological Process GO:0030501 positive regulation of bone mineralization
Biological Process GO:0061036 positive regulation of cartilage development
Biological Process GO:0045597 positive regulation of cell differentiation
Biological Process GO:0032332 positive regulation of chondrocyte differentiation
Biological Process GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
Biological Process GO:0045669 positive regulation of osteoblast differentiation
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0030166 proteoglycan biosynthetic process
Biological Process GO:0060041 retina development in camera-type eye
Biological Process GO:0031290 retinal ganglion cell axon guidance
Biological Process GO:0001501 skeletal system development
molecular function GO:0005524 ATP binding
molecular function GO:0046872 metal ion binding
molecular function GO:0004674 protein serine/threonine kinase activity
molecular function GO:0046332 SMAD binding
molecular function GO:0005025 transforming growth factor beta receptor activity, type I
molecular function GO:0004675 transmembrane receptor protein serine/threonine kinase activity
cellular component GO:0030425 dendrite
cellular component GO:1990712 HFE-transferrin receptor complex
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0043025 neuronal cell body
cellular component GO:0005886 plasma membrane
cellular component GO:0043235 receptor complex
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-201451 Signaling by BMP
R-HSA-9006936 Signaling by TGFB family members
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0005941 BXGD000353 Bone Diseases, Developmental Musculoskeletal Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007113 BXGD000430 Rectal Carcinoma Digestive System Diseases; Neoplasms
C0009081 BXGD000581 Congenital clubfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0015393 BXGD000981 Eye Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0018536 BXGD001201 Hallux Valgus Musculoskeletal Diseases
C0020542 BXGD001425 Pulmonary Hypertension Respiratory Tract Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0021364 BXGD001500 Male infertility Male Urogenital Diseases
C0025322 BXGD001863 Premature Menopause Female Urogenital Diseases and Pregnancy Complications
C0025995 BXGD001885 Micromelia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0029422 BXGD002142 Osteochondrodysplasias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0031900 BXGD002313 Pierre Robin Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0039075 BXGD002788 Syndactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0085215 BXGD003141 Ovarian Failure, Premature Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0152171 BXGD003552 Idiopathic pulmonary hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C0162298 BXGD003933 Joint stiffness Musculoskeletal Diseases
C0206762 BXGD004290 Limb Deformities, Congenital Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0220620 BXGD004299 Gastrointestinal Carcinoid Tumor Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0221357 BXGD004449 Brachydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0231679 BXGD004507 Ulnar deviation of the fingers
C0232939 BXGD004568 Primary physiologic amenorrhea Pathological Conditions, Signs and Symptoms
C0239594 BXGD004987 Short finger
C0265260 BXGD005488 Chondrodysplasia, Grebe type Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0265654 BXGD005559 Tarsal Coalition Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0266399 BXGD005663 Infantile uterus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0278701 BXGD006566 Gastric Adenocarcinoma Digestive System Diseases; Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0278883 BXGD006614 Metastatic melanoma Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0302142 BXGD006831 Deformity Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0343284 BXGD007613 Chondrodysplasia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0349588 BXGD007933 Short stature
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376634 BXGD008006 Craniofacial Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0410528 BXGD008430 Skeletal dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0431863 BXGD008709 Carpal synostosis
C0431890 BXGD008712 Hypoplasia of thumb Musculoskeletal Diseases
C0431904 BXGD008713 Ulnar polydactyly of fingers Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0576226 BXGD009527 Short foot
C0577631 BXGD009535 Carotid Atherosclerosis Nervous System Diseases; Cardiovascular Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0747845 BXGD010184 early pregnancy
C0871470 BXGD011316 Systolic Pressure
C0877165 BXGD011338 Short phalanx of finger
C0878659 BXGD011380 Disproportionate short stature Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0948896 BXGD011563 Primary hypogonadism Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1261473 BXGD011855 Sarcoma Neoplasms
C1300268 BXGD012276 Brachydactyly syndrome type C Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C1305855 BXGD012348 Body mass index
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1519689 BXGD013245 Tumor Promotion Pathological Conditions, Signs and Symptoms; Neoplasms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1832119 BXGD013799 Fibular hypoplasia
C1832702 BXGD013871 BRACHYDACTYLY, TYPE A2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1834034 BXGD013951 Aplasia/Hypoplasia of the middle phalanx of the 5th finger
C1834060 BXGD013954 Short middle phalanx of the 5th finger
C1836182 BXGD014087 Chondrodysplasia, acromesomelic, with genital anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases; Endocrine System Diseases
C1836184 BXGD014088 Short femoral neck
C1836186 BXGD014089 Fibular aplasia
C1836187 BXGD014090 Widened proximal tibial metaphyses
C1836189 BXGD014091 Radial deviation of finger
C1836192 BXGD014092 Aplasia/Hypoplasia involving the metacarpal bones
C1836193 BXGD014093 Synostosis of carpal bones
C1836195 BXGD014094 Short toe
C1839730 BXGD014396 Prieto X-linked mental retardation syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1842229 BXGD014505 Broad metacarpals
C1844548 BXGD014642 Hypoplastic finger
C1844709 BXGD014667 Radial deviation of the 2nd finger
C1844891 BXGD014691 Ulnar deviation of the 2nd finger
C1846950 BXGD014848 Short middle phalanx of finger
C1848453 BXGD014926 Poor motor coordination
C1848673 BXGD014963 Hypoplastic feet
C1849020 BXGD014996 Short metatarsal
C1849937 BXGD015091 Disproportionate short-limb short stature
C1850049 BXGD015101 Clinodactyly of the 5th finger
C1850259 BXGD015125 Short tibia
C1855091 BXGD015456 Short proximal phalanx of thumb
C1855340 BXGD015490 Bowing of the long bones
C1856732 BXGD015639 Aplasia/Hypoplasia of the fibula
C1856738 BXGD015640 Fibular hypoplasia and complex brachydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1857108 BXGD015677 Limitation of joint mobility
C1858430 BXGD015792 Death in infancy
C1860606 BXGD015989 Short proximal phalanx of finger
C1860614 BXGD015992 ULNAR HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1862095 BXGD016100 Bilateral single transverse palmar creases
C1862103 BXGD016103 Brachydactyly type C Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1862142 BXGD016107 Short 2nd finger
C1862144 BXGD016108 Aplasia/Hypoplasia of the middle phalanx of the 2nd finger
C1862147 BXGD016109 Medially deviated second toe
C1862151 BXGD016110 BRACHYDACTYLY, TYPE A1 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1862158 BXGD016112 Terminal symphalangism of hands Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1862313 BXGD016121 Short distal phalanx of the thumb
C1865037 BXGD016289 Cone-shaped epiphysis
C1865992 BXGD016359 Short hallux
C1866241 BXGD016389 Broad foot Musculoskeletal Diseases
C1867131 BXGD016440 Broad hallux
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1969397 BXGD016776 Short 2nd metacarpal
C2919142 BXGD017867 Short Stature, CTCAE
C2930970 BXGD017921 Acromesomelic dysplasia Hunter-Thompson type Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C3179508 BXGD018554 Aplasia/Hypoplasia of the thumb Musculoskeletal Diseases
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C3714899 BXGD019437 SYMPHALANGISM, PROXIMAL, 1A Musculoskeletal Diseases
C4021302 BXGD020607 Aplasia of the proximal phalanges of the hand
C4021390 BXGD020622 Symphalangism affecting the phalanges of the hand
C4021427 BXGD020630 Complete duplication of distal phalanx of the thumb
C4021438 BXGD020635 Short distal phalanx of the 2nd finger
C4021465 BXGD020638 Pseudoepiphyses of the 2nd finger
C4021611 BXGD020697 Abnormality of epiphysis morphology
C4021735 BXGD020743 Abnormality of the hip bone
C4022107 BXGD020880 Aplasia of the middle phalanges of the toes
C4024098 BXGD021288 Aplasia/Hypoplasia of the 1st metacarpal
C4024235 BXGD021314 Stippling of the epiphysis of the distal phalanx of the thumb
C4024283 BXGD021316 Triangular shaped middle phalanx of the 2nd finger
C4024552 BXGD021327 Triangular shaped middle phalanx of the 5th finger
C4025662 BXGD021716 Abnormality of the ulna
C4025663 BXGD021717 Abnormality of tibia morphology
C4025675 BXGD021726 Abnormality of the radius
C4082144 BXGD022081 Metatarsal Valgus Musculoskeletal Diseases
C4225183 BXGD022171 BRACHYDACTYLY, TYPE A1, D
C4225404 BXGD022265 ACROMESOMELIC DYSPLASIA, DEMIRHAN TYPE
C4317009 BXGD022717 Diverticular Diseases Digestive System Diseases
C4505353 BXGD022958 Diverticular Bleeding Digestive System Diseases
C4551564 BXGD023352 Narrow nasal bridge
C4551570 BXGD023357 2-3 toe syndactyly
C4551838 BXGD023417 Talipes transversoplanus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein