Showing entry for Serine/threonine-protein kinase LATS1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005400
Protein NameSerine/threonine-protein kinase LATS1
Uniport IdO95835
GeneLATS1
Gene Id9113
DomainPkinase; UBA
Pfam PF00069   PF00627  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04390 Hippo signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04392 Hippo signaling pathway - multiple species
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0051301 cell division
Biological Process GO:0034613 cellular protein localization
Biological Process GO:0051220 cytoplasmic sequestering of protein
Biological Process GO:0000082 G1/S transition of mitotic cell cycle
Biological Process GO:0000086 G2/M transition of mitotic cell cycle
Biological Process GO:0035329 hippo signaling
Biological Process GO:0009755 hormone-mediated signaling pathway
Biological Process GO:0001827 inner cell mass cell fate commitment
Biological Process GO:0001828 inner cell mass cellular morphogenesis
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0030216 keratinocyte differentiation
Biological Process GO:0060644 mammary gland epithelial cell differentiation
Biological Process GO:0090090 negative regulation of canonical Wnt signaling pathway
Biological Process GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0033138 positive regulation of peptidyl-serine phosphorylation
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0030833 regulation of actin filament polymerization
Biological Process GO:0033146 regulation of intracellular estrogen receptor signaling pathway
Biological Process GO:0046620 regulation of organ growth
Biological Process GO:0043254 regulation of protein-containing complex assembly
Biological Process GO:2000058 regulation of ubiquitin-dependent protein catabolic process
Biological Process GO:0000819 sister chromatid segregation
molecular function GO:0005524 ATP binding
molecular function GO:0030331 estrogen receptor binding
molecular function GO:0000287 magnesium ion binding
molecular function GO:0019901 protein kinase binding
molecular function GO:0004674 protein serine/threonine kinase activity
cellular component GO:0005829 cytosol
cellular component GO:0005815 microtubule organizing center
cellular component GO:0000922 spindle pole
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-2028269 Signaling by Hippo
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004114 BXGD000255 Astrocytoma Neoplasms
C0004779 BXGD000291 Basal Cell Nevus Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Musculoskeletal Diseases; Stomatognathic Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0008479 BXGD000544 Chondrosarcoma Neoplasms
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0017638 BXGD001132 Glioma Neoplasms
C0017920 BXGD001151 Glycogen Storage Disease Type I Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0023269 BXGD001627 leiomyosarcoma Neoplasms
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027660 BXGD002013 Neoplasms, Glandular and Epithelial Neoplasms
C0027766 BXGD002034 Nervous System Neoplasms Neoplasms; Nervous System Diseases
C0027809 BXGD002040 Neurilemmoma Neoplasms
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0032580 BXGD002362 Adenomatous Polyposis Coli Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0035222 BXGD002513 Respiratory Distress Syndrome, Adult Respiratory Tract Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205768 BXGD004119 Subependymal Giant Cell Astrocytoma Neoplasms
C0205854 BXGD004134 Glandular Neoplasms Neoplasms
C0206669 BXGD004229 Hepatocellular Adenoma Digestive System Diseases; Neoplasms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0220633 BXGD004303 Uveal melanoma Neoplasms; Eye Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0278607 BXGD006548 Adult Leiomyosarcoma Neoplasms
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0279986 BXGD006705 Childhood Leiomyosarcoma Neoplasms
C0280783 BXGD006759 Juvenile Pilocytic Astrocytoma Neoplasms
C0280785 BXGD006760 Diffuse Astrocytoma Neoplasms
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0334579 BXGD007120 Anaplastic astrocytoma Neoplasms
C0334580 BXGD007121 Protoplasmic astrocytoma Neoplasms
C0334581 BXGD007122 Gemistocytic astrocytoma Neoplasms
C0334582 BXGD007123 Fibrillary Astrocytoma Neoplasms
C0334583 BXGD007124 Pilocytic Astrocytoma Neoplasms
C0338070 BXGD007165 Childhood Cerebral Astrocytoma Neoplasms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0340643 BXGD007357 Dissection of aorta Cardiovascular Diseases
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0345958 BXGD007751 Large cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0345967 BXGD007756 Malignant mesothelioma Neoplasms; Respiratory Tract Diseases
C0346109 BXGD007779 Malignant Mesothelioma of Peritoneum Neoplasms; Respiratory Tract Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0547065 BXGD009355 Mixed oligoastrocytoma Neoplasms
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600113 BXGD009691 Stromal tumor of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0740457 BXGD010000 Malignant neoplasm of kidney Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0750935 BXGD010257 Cerebral Astrocytoma Neoplasms
C0750936 BXGD010258 Intracranial Astrocytoma Neoplasms
C0751690 BXGD010553 Malignant Peripheral Nerve Sheath Tumor Neoplasms; Nervous System Diseases
C0856742 BXGD011111 Post MI Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0878500 BXGD011365 Intraepithelial Neoplasia Neoplasms
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1261473 BXGD011855 Sarcoma Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1368275 BXGD012897 Pigmented Basal Cell Carcinoma Neoplasms
C1368683 BXGD012900 Epithelioma Neoplasms
C1378703 BXGD012933 Renal carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1704230 BXGD013533 Grade I Astrocytoma Neoplasms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3665596 BXGD019295 Warts Infections; Skin and Connective Tissue Diseases
C3811653 BXGD019662 Experimental Organism Basal Cell Carcinoma Neoplasms
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4086152 BXGD022123 Childhood Astrocytoma Neoplasms
C4551686 BXGD023391 Malignant neoplasm of soft tissue Neoplasms
C4551687 BXGD023392 Sarcoma of soft tissue Neoplasms
C4721806 BXGD023772 Carcinoma, Basal Cell Neoplasms
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
BXGC0050099 (2E,5S,6S,8Z,11S)-5,6,15-Trihydroxy-17-Methoxy-11-Methyl-12-Oxabicyclo[12.4.0]Octadeca-1(14),2,8,15,17-Pentaene-7,13-Dione 362.14
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein