Showing entry for Sodium/potassium-transporting ATPase subunit beta-1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006296
Protein NameSodium/potassium-transporting ATPase subunit beta-1
Uniport IdP05026
GeneATP1B1
Gene Id481
DomainNa_K-ATPase
Pfam PF00287  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04022 cGMP-PKG signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04024 cAMP signaling pathway
5. Organismal Systems 5.3 Circulatory system hsa04260 Cardiac muscle contraction
5. Organismal Systems 5.3 Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes
5. Organismal Systems 5.2 Endocrine system hsa04911 Insulin secretion
5. Organismal Systems 5.2 Endocrine system hsa04918 Thyroid hormone synthesis
5. Organismal Systems 5.2 Endocrine system hsa04919 Thyroid hormone signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04925 Aldosterone synthesis and secretion
5. Organismal Systems 5.5 Excretory system hsa04960 Aldosterone-regulated sodium reabsorption
5. Organismal Systems 5.5 Excretory system hsa04961 Endocrine and other factor-regulated calcium reabsorption
5. Organismal Systems 5.5 Excretory system hsa04964 Proximal tubule bicarbonate reclamation
5. Organismal Systems 5.4 Digestive system hsa04970 Salivary secretion
5. Organismal Systems 5.4 Digestive system hsa04971 Gastric acid secretion
5. Organismal Systems 5.4 Digestive system hsa04972 Pancreatic secretion
5. Organismal Systems 5.4 Digestive system hsa04973 Carbohydrate digestion and absorption
5. Organismal Systems 5.4 Digestive system hsa04974 Protein digestion and absorption
5. Organismal Systems 5.4 Digestive system hsa04976 Bile secretion
5. Organismal Systems 5.4 Digestive system hsa04978 Mineral absorption
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0046034 ATP metabolic process
Biological Process GO:0060048 cardiac muscle contraction
Biological Process GO:0098655 cation transmembrane transport
Biological Process GO:0007155 cell adhesion
Biological Process GO:0086064 cell communication by electrical coupling involved in cardiac conduction
Biological Process GO:0006874 cellular calcium ion homeostasis
Biological Process GO:0030007 cellular potassium ion homeostasis
Biological Process GO:0006883 cellular sodium ion homeostasis
Biological Process GO:0034220 ion transmembrane transport
Biological Process GO:0050900 leukocyte migration
Biological Process GO:0086009 membrane repolarization
Biological Process GO:0086013 membrane repolarization during cardiac muscle cell action potential
Biological Process GO:0032781 positive regulation of ATPase activity
Biological Process GO:1903281 positive regulation of calcium:sodium antiporter activity
Biological Process GO:1903288 positive regulation of potassium ion import across plasma membrane
Biological Process GO:1901018 positive regulation of potassium ion transmembrane transporter activity
Biological Process GO:1903278 positive regulation of sodium ion export across plasma membrane
Biological Process GO:1990573 potassium ion import across plasma membrane
Biological Process GO:0071805 potassium ion transmembrane transport
Biological Process GO:0072659 protein localization to plasma membrane
Biological Process GO:0050821 protein stabilization
Biological Process GO:0044861 protein transport into plasma membrane raft
Biological Process GO:1903779 regulation of cardiac conduction
Biological Process GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling
Biological Process GO:0010468 regulation of gene expression
Biological Process GO:0055119 relaxation of cardiac muscle
Biological Process GO:0001666 response to hypoxia
Biological Process GO:0036376 sodium ion export across plasma membrane
Biological Process GO:0035725 sodium ion transmembrane transport
molecular function GO:0001671 ATPase activator activity
molecular function GO:0051117 ATPase binding
molecular function GO:0023026 MHC class II protein complex binding
molecular function GO:0008022 protein C-terminus binding
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0019901 protein kinase binding
molecular function GO:0005391 sodium:potassium-exchanging ATPase activity
cellular component GO:0016324 apical plasma membrane
cellular component GO:0016323 basolateral plasma membrane
cellular component GO:0005901 caveola
cellular component GO:0070062 extracellular exosome
cellular component GO:1903561 extracellular vesicle
cellular component GO:0014704 intercalated disc
cellular component GO:0016328 lateral plasma membrane
cellular component GO:0016020 membrane
cellular component GO:0031090 organelle membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0042383 sarcolemma
cellular component GO:0005890 sodium:potassium-exchanging ATPase complex
cellular component GO:0036126 sperm flagellum
cellular component GO:0030315 T-tubule
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-1643685 Disease
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-210991 Basigin interactions
R-HSA-382551 Transport of small molecules
R-HSA-397014 Muscle contraction
R-HSA-5576891 Cardiac conduction
R-HSA-5578775 Ion homeostasis
R-HSA-5663205 Infectious disease
R-HSA-936837 Ion transport by P-type ATPases
R-HSA-9679191 Potential therapeutics for SARS
R-HSA-9679506 SARS-CoV Infections
R-HSA-983712 Ion channel transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0013146 BXGD000801 Drug abuse Chemically-Induced Disorders; Mental Disorders
C0013170 BXGD000802 Drug habituation Chemically-Induced Disorders; Mental Disorders
C0013222 BXGD000805 Drug Use Disorders Chemically-Induced Disorders; Mental Disorders
C0016781 BXGD001079 Fuchs Endothelial Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0018776 BXGD001216 Hearing Loss, Central Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018780 BXGD001218 Hearing Loss, High-Frequency Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0019562 BXGD001336 Von Hippel-Lindau Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Cardiovascular Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0026998 BXGD001959 Acute Myeloid Leukemia, M1 Neoplasms
C0029231 BXGD002125 Organic Mental Disorders, Substance-Induced Chemically-Induced Disorders; Mental Disorders
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0038580 BXGD002771 Substance Dependence Chemically-Induced Disorders; Mental Disorders
C0038586 BXGD002772 Substance Use Disorders Chemically-Induced Disorders; Mental Disorders
C0042487 BXGD002986 Venous Thrombosis Cardiovascular Diseases
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0236969 BXGD004842 Substance-Related Disorders Chemically-Induced Disorders; Mental Disorders
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0429028 BXGD008646 QT interval feature (observable entity)
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0740457 BXGD010000 Malignant neoplasm of kidney Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0740858 BXGD010012 Substance abuse problem Chemically-Induced Disorders; Mental Disorders
C0871470 BXGD011316 Systolic Pressure
C1269955 BXGD012005 Tumor Cell Invasion
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1510472 BXGD013170 Drug Dependence Chemically-Induced Disorders; Mental Disorders
C1861172 BXGD016016 Venous Thromboembolism Cardiovascular Diseases
C1879321 BXGD016572 Acute Myeloid Leukemia (AML-M2) Neoplasms
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C3839868 BXGD019788 Cytogenetically normal acute myeloid leukemia Neoplasms
C4316881 BXGD022709 Prescription Drug Abuse Chemically-Induced Disorders; Mental Disorders
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003690 Glucokinin 764.94
BXGC0015208 Getiacaulein 288.06
BXGC0020220 panaxatriol 476.39
BXGC0022544 Digoxin 780.43
BXGC0023461 methylswertianin 288.06
BXGC0025733 1,3,5,6-Tetrahydroxyxanthen-9-One 260.03
BXGC0036400 1,3,5-Trihydroxyxanthen-9-One 244.04
BXGC0039507 Digitoxigenin 374.25
BXGC0044158 3,4,5-Trihydroxyxanthen-9-One 244.04
BXGC0048644 1,2,3,7-Tetramethoxyxanthone 316.09
BXGC0050699 \N 260.03
BXGC0051524 Ouabain 584.28
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein