Showing entry for Leukotriene A-4 hydrolase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006952
Protein NameLeukotriene A-4 hydrolase
Uniport IdP09960
GeneLTA4H
Gene Id4048
DomainLeuk-A4-hydro_C; Peptidase_M1; Peptidase_M1_N
Pfam PF09127   PF01433  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00590 Arachidonic acid metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0044255 cellular lipid metabolic process
Biological Process GO:0044267 cellular protein metabolic process
Biological Process GO:0019370 leukotriene biosynthetic process
Biological Process GO:0006691 leukotriene metabolic process
Biological Process GO:0042759 long-chain fatty acid biosynthetic process
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0043171 peptide catabolic process
molecular function GO:0004177 aminopeptidase activity
molecular function GO:0004301 epoxide hydrolase activity
molecular function GO:0004463 leukotriene-A4 hydrolase activity
molecular function GO:0070006 metalloaminopeptidase activity
molecular function GO:0008233 peptidase activity
molecular function GO:0003723 RNA binding
molecular function GO:0008270 zinc ion binding
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:1904813 ficolin-1-rich granule lumen
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:1904724 tertiary granule lumen
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-HSA-2142753 Arachidonic acid metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-6798695 Neutrophil degranulation
R-HSA-8978868 Fatty acid metabolism
R-HSA-9018676 Biosynthesis of D-series resolvins
R-HSA-9018677 Biosynthesis of DHA-derived SPMs
R-HSA-9018678 Biosynthesis of specialized proresolving mediators (SPMs)
R-HSA-9018679 Biosynthesis of EPA-derived SPMs
R-HSA-9018681 Biosynthesis of protectins
R-HSA-9018896 Biosynthesis of E-series 18(S)-resolvins
R-HSA-9020265 Biosynthesis of aspirin-triggered D-series resolvins
R-HSA-9023661 Biosynthesis of E-series 18(R)-resolvins
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007114 BXGD000431 Malignant neoplasm of skin Neoplasms; Skin and Connective Tissue Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023485 BXGD001667 Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0026918 BXGD001948 Mycobacterium Infections Infections
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027726 BXGD002030 Nephrotic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0041318 BXGD002909 Tuberculosis, Meningeal Infections; Nervous System Diseases
C0041327 BXGD002916 Tuberculosis, Pulmonary Infections; Respiratory Tract Diseases
C0085437 BXGD003178 Meningitis, Bacterial Infections; Nervous System Diseases
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0201874 BXGD004054 Amino acids measurement
C0202202 BXGD004082 Protein measurement
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0239211 BXGD004972 Oedema auricular Pathological Conditions, Signs and Symptoms
C0264408 BXGD005387 Childhood asthma Respiratory Tract Diseases; Immune System Diseases
C0275708 BXGD006387 Mycobacterium marinum Infection Infections
C0275911 BXGD006391 Tuberculosis of intestines Digestive System Diseases; Infections
C0280324 BXGD006740 Laryngeal Squamous Cell Carcinoma Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0523465 BXGD009209 Serum albumin measurement
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0679362 BXGD009767 Tuberculosis, extrapulmonary Infections
C0746556 BXGD010144 metabolic disturbance
C0751688 BXGD010551 Malignant Squamous Cell Neoplasm Neoplasms
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1292753 BXGD012226 Primary Effusion Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1292769 BXGD012230 Precursor B-cell lymphoblastic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1519346 BXGD013235 Skin Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1562585 BXGD013375 Leprosy, Multibacillary Infections
C1563937 BXGD013397 Atherogenesis Cardiovascular Diseases
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C1851585 BXGD015222 MYELOPROLIFERATIVE DISORDER, CHRONIC, WITH EOSINOPHILIA Hemic and Lymphatic Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2959467 BXGD018193 Tuberculous pleural effusion Infections; Respiratory Tract Diseases
C3665444 BXGD019288 Neutrophilia (disorder) Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4520841 BXGD023042 Pure Erythroid Leukemia Neoplasms; Hemic and Lymphatic Diseases
C4521042 BXGD023055 Complete Trisomy 21 Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000671 Methylgingerol 308.41
BXGC0000694 (S)-[6]-Gingerol 294.39
BXGC0001767 (E)-Resveratrol 228.25
BXGC0003705 Chloride 35.45
BXGC0004058 [8]-Shogaol 276.37
BXGC0004277 Acetic acid 60.05
BXGC0004767 Batatasin IV 244.29
BXGC0005536 (S)-[8]-Gingerol 322.44
BXGC0005537 (S)-[10]-Gingerol 350.49
BXGC0005995 Imidazole 68.08
BXGC0006400 Diphenyl ether 170.21
BXGC0021248 Shogaol 276.17
BXGC0024132 1H-Indol-5-Ol 133.05
BXGC0040952 Dihydroresveratrol 230.09
BXGC0042971 4-Gingerol 266.15
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein