Showing entry for Atrial natriuretic peptide receptor 3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008302
Protein NameAtrial natriuretic peptide receptor 3
Uniport IdP17342
GeneNPR3
Gene Id4883
DomainANF_receptor
Pfam PF01094  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Biological Process GO:0007194 negative regulation of adenylate cyclase activity
Biological Process GO:0120163 negative regulation of cold-induced thermogenesis
Biological Process GO:0048662 negative regulation of smooth muscle cell proliferation
Biological Process GO:0002158 osteoclast proliferation
Biological Process GO:0030157 pancreatic juice secretion
Biological Process GO:0048015 phosphatidylinositol-mediated signaling
Biological Process GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
Biological Process GO:0051000 positive regulation of nitric-oxide synthase activity
Biological Process GO:0035810 positive regulation of urine volume
Biological Process GO:0008217 regulation of blood pressure
Biological Process GO:0033688 regulation of osteoblast proliferation
Biological Process GO:0001501 skeletal system development
molecular function GO:0031404 chloride ion binding
molecular function GO:0008528 G protein-coupled peptide receptor activity
molecular function GO:0042562 hormone binding
molecular function GO:0016941 natriuretic peptide receptor activity
molecular function GO:0042277 peptide binding
molecular function GO:0017046 peptide hormone binding
molecular function GO:0042803 protein homodimerization activity
cellular component GO:0070062 extracellular exosome
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0032991 protein-containing complex
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001948 BXGD000091 Alcohol consumption Behavior and Behavior Mechanisms
C0003706 BXGD000215 Arachnodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0005823 BXGD000339 Blood Pressure
C0005890 BXGD000345 Body Height
C0005940 BXGD000352 Bone Diseases Musculoskeletal Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007820 BXGD000491 Cerebrovascular Disorders Nervous System Diseases; Cardiovascular Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0017178 BXGD001102 Gastrointestinal Diseases Digestive System Diseases
C0017185 BXGD001104 Gastrointestinal Neoplasms Digestive System Diseases; Neoplasms
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020545 BXGD001427 Hypertension, Renovascular Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Cardiovascular Diseases
C0020651 BXGD001460 Hypotension, Orthostatic Nervous System Diseases; Cardiovascular Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0022104 BXGD001529 Irritable Bowel Syndrome Digestive System Diseases
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027055 BXGD001964 Myocardial Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0035078 BXGD002505 Kidney Failure Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0043094 BXGD003026 Weight Gain Pathological Conditions, Signs and Symptoms
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205682 BXGD004105 Waist-Hip Ratio
C0232491 BXGD004548 Chronic abdominal pain Pathological Conditions, Signs and Symptoms
C0241240 BXGD005089 Tall stature
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0243050 BXGD005212 Cardiovascular Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0265004 BXGD005446 Dilatation of aorta Cardiovascular Diseases
C0267509 BXGD005755 Chronic idiopathic constipation Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0267663 BXGD005765 Congenital secretory diarrhea, sodium type (disorder) Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0278510 BXGD006526 Childhood Medulloblastoma Neoplasms
C0278876 BXGD006607 Adult Medulloblastoma Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0424678 BXGD008537 Lean body mass
C0428883 BXGD008639 Diastolic blood pressure
C0489786 BXGD009018 Height
C0494165 BXGD009022 Secondary malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0520679 BXGD009101 Sleep Apnea, Obstructive Respiratory Tract Diseases; Nervous System Diseases
C0559031 BXGD009464 Functional Gastrointestinal Disorders Digestive System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0679395 BXGD009769 vascular ischemia Pathological Conditions, Signs and Symptoms
C0742343 BXGD010061 Acute Chest Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C0871470 BXGD011316 Systolic Pressure
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C0948089 BXGD011504 Acute Coronary Syndrome Cardiovascular Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1301700 BXGD012296 Cardiovascular morbidity
C1305849 BXGD012347 Diastolic blood pressure measurement
C1306620 BXGD012371 Systolic blood pressure measurement
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1704436 BXGD013564 Peripheral Arterial Diseases Cardiovascular Diseases
C1849718 BXGD015080 POPLITEAL PTERYGIUM SYNDROME, LETHAL TYPE Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Musculoskeletal Diseases; Stomatognathic Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2931480 BXGD018027 Neurofibromatosis, Type 3, mixed central and peripheral Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C3845502 BXGD019809 Myocardial infarction, stroke
C3850153 BXGD019812 Ovarian Reserve
C4025272 BXGD021615 Peripheral arterial stenosis
C4049938 BXGD021956 Physical Activity Measurement
C4268639 BXGD022323 Irritable bowel syndrome with constipation Digestive System Diseases
C4721579 BXGD023759 Secondary malignant neoplasm of colon and/or rectum Digestive System Diseases; Neoplasms
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
BXGC0018397 beta-1,4-mannan 180.06
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein