Showing entry for cAMP-dependent protein kinase catalytic subunit beta


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008797
Protein NamecAMP-dependent protein kinase catalytic subunit beta
Uniport IdP22694
GenePRKACB
Gene Id5567
DomainPkinase
Pfam PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.12 Drug resistance: Antineoplastic hsa01522 Endocrine resistance
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04014 Ras signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04020 Calcium signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04024 cAMP signaling pathway
5. Organismal Systems 5.1 Immune system hsa04062 Chemokine signaling pathway
4. Cellular Processes 4.2 Cell growth and death hsa04114 Oocyte meiosis
4. Cellular Processes 4.1 Transport and catabolism hsa04140 Autophagy - animal
5. Organismal Systems 5.9 Aging hsa04211 Longevity regulating pathway
5. Organismal Systems 5.9 Aging hsa04213 Longevity regulating pathway - multiple species
5. Organismal Systems 5.3 Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes
5. Organismal Systems 5.3 Circulatory system hsa04270 Vascular smooth muscle contraction
3. Environmental Information Processing 3.2 Signal transduction hsa04310 Wnt signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04340 Hedgehog signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04371 Apelin signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04530 Tight junction
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04540 Gap junction
5. Organismal Systems 5.1 Immune system hsa04611 Platelet activation
5. Organismal Systems 5.10 Environmental adaptation hsa04713 Circadian entrainment
5. Organismal Systems 5.10 Environmental adaptation hsa04714 Thermogenesis
5. Organismal Systems 5.6 Nervous system hsa04720 Long-term potentiation
5. Organismal Systems 5.6 Nervous system hsa04723 Retrograde endocannabinoid signaling
5. Organismal Systems 5.6 Nervous system hsa04724 Glutamatergic synapse
5. Organismal Systems 5.6 Nervous system hsa04725 Cholinergic synapse
5. Organismal Systems 5.6 Nervous system hsa04726 Serotonergic synapse
5. Organismal Systems 5.6 Nervous system hsa04727 GABAergic synapse
5. Organismal Systems 5.6 Nervous system hsa04728 Dopaminergic synapse
5. Organismal Systems 5.7 Sensory system hsa04740 Olfactory transduction
5. Organismal Systems 5.7 Sensory system hsa04742 Taste transduction
5. Organismal Systems 5.7 Sensory system hsa04750 Inflammatory mediator regulation of TRP channels
5. Organismal Systems 5.2 Endocrine system hsa04910 Insulin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04911 Insulin secretion
5. Organismal Systems 5.2 Endocrine system hsa04912 GnRH signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04913 Ovarian steroidogenesis
5. Organismal Systems 5.2 Endocrine system hsa04914 Progesterone-mediated oocyte maturation
5. Organismal Systems 5.2 Endocrine system hsa04915 Estrogen signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04916 Melanogenesis
5. Organismal Systems 5.2 Endocrine system hsa04918 Thyroid hormone synthesis
5. Organismal Systems 5.2 Endocrine system hsa04919 Thyroid hormone signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04921 Oxytocin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04922 Glucagon signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04923 Regulation of lipolysis in adipocytes
5. Organismal Systems 5.2 Endocrine system hsa04924 Renin secretion
5. Organismal Systems 5.2 Endocrine system hsa04925 Aldosterone synthesis and secretion
5. Organismal Systems 5.2 Endocrine system hsa04926 Relaxin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04927 Cortisol synthesis and secretion
5. Organismal Systems 5.2 Endocrine system hsa04928 Parathyroid hormone synthesis, secretion and action
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04934 Cushing syndrome
5. Organismal Systems 5.5 Excretory system hsa04961 Endocrine and other factor-regulated calcium reabsorption
5. Organismal Systems 5.5 Excretory system hsa04962 Vasopressin-regulated water reabsorption
5. Organismal Systems 5.4 Digestive system hsa04970 Salivary secretion
5. Organismal Systems 5.4 Digestive system hsa04971 Gastric acid secretion
5. Organismal Systems 5.4 Digestive system hsa04976 Bile secretion
6. Human Diseases 6.4 Neurodegenerative diseases hsa05012 Parkinson disease
6. Human Diseases 6.4 Neurodegenerative diseases hsa05020 Prion diseases
6. Human Diseases 6.5 Substance dependence hsa05030 Cocaine addiction
6. Human Diseases 6.5 Substance dependence hsa05031 Amphetamine addiction
6. Human Diseases 6.5 Substance dependence hsa05032 Morphine addiction
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05110 Vibrio cholerae infection
6. Human Diseases 6.10 Infectious diseases: Parasitic hsa05146 Amoebiasis
6. Human Diseases 6.9 Infectious diseases: Viral hsa05163 Human cytomegalovirus infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05165 Human papillomavirus infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05166 Human T-cell leukemia virus 1 infection
6. Human Diseases 6.1 Cancers: Overview hsa05200 Pathways in cancer
6. Human Diseases 6.1 Cancers: Overview hsa05203 Viral carcinogenesis
6. Human Diseases 6.1 Cancers: Overview hsa05205 Proteoglycans in cancer
6. Human Diseases 6.6 Cardiovascular diseases hsa05414 Dilated cardiomyopathy (DCM)
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0034199 activation of protein kinase A activity
Biological Process GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
Biological Process GO:0007596 blood coagulation
Biological Process GO:0071377 cellular response to glucagon stimulus
Biological Process GO:0034380 high-density lipoprotein particle assembly
Biological Process GO:0051447 negative regulation of meiotic cell cycle
Biological Process GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
Biological Process GO:0001843 neural tube closure
Biological Process GO:0010737 protein kinase A signaling
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0070613 regulation of protein processing
Biological Process GO:0003091 renal water homeostasis
Biological Process GO:0097338 response to clozapine
Biological Process GO:0007165 signal transduction
Biological Process GO:0002223 stimulatory C-type lectin receptor signaling pathway
molecular function GO:0004679 AMP-activated protein kinase activity
molecular function GO:0005524 ATP binding
molecular function GO:0004691 cAMP-dependent protein kinase activity
molecular function GO:0000287 magnesium ion binding
molecular function GO:0034237 protein kinase A regulatory subunit binding
molecular function GO:0031625 ubiquitin protein ligase binding
cellular component GO:0005952 cAMP-dependent protein kinase complex
cellular component GO:0005813 centrosome
cellular component GO:0097546 ciliary base
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0045171 intercellular bridge
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-111885 Opioid Signalling
R-HSA-111885 Opioid Signalling
R-HSA-111931 PKA-mediated phosphorylation of CREB
R-HSA-111931 PKA-mediated phosphorylation of CREB
R-HSA-111933 Calmodulin induced events
R-HSA-111933 Calmodulin induced events
R-HSA-111996 Ca-dependent events
R-HSA-111996 Ca-dependent events
R-HSA-111997 CaM pathway
R-HSA-111997 CaM pathway
R-HSA-112040 G-protein mediated events
R-HSA-112040 G-protein mediated events
R-HSA-112043 PLC beta mediated events
R-HSA-112043 PLC beta mediated events
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-112316 Neuronal System
R-HSA-1266738 Developmental Biology
R-HSA-1266738 Developmental Biology
R-HSA-1280218 Adaptive Immune System
R-HSA-1430728 Metabolism
R-HSA-1430728 Metabolism
R-HSA-1489509 DAG and IP3 signaling
R-HSA-1489509 DAG and IP3 signaling
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-163358 PKA-mediated phosphorylation of key metabolic factors
R-HSA-163359 Glucagon signaling in metabolic regulation
R-HSA-163560 Triglyceride catabolism
R-HSA-163615 PKA activation
R-HSA-163685 Integration of energy metabolism
R-HSA-163685 Integration of energy metabolism
R-HSA-1643685 Disease
R-HSA-1643685 Disease
R-HSA-164378 PKA activation in glucagon signalling
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance
R-HSA-180024 DARPP-32 events
R-HSA-194138 Signaling by VEGF
R-HSA-372790 Signaling by GPCR
R-HSA-372790 Signaling by GPCR
R-HSA-376176 Signaling by ROBO receptors
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-382551 Transport of small molecules
R-HSA-388396 GPCR downstream signalling
R-HSA-388396 GPCR downstream signalling
R-HSA-392517 Rap1 signalling
R-HSA-418594 G alpha (i) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-422356 Regulation of insulin secretion
R-HSA-422356 Regulation of insulin secretion
R-HSA-422475 Axon guidance
R-HSA-422475 Axon guidance
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-438064 Post NMDA receptor activation events
R-HSA-438064 Post NMDA receptor activation events
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-442720 CREB1 phosphorylation through the activation of Adenylate Cyclase
R-HSA-442720 CREB1 phosphorylation through the activation of Adenylate Cyclase
R-HSA-442755 Activation of NMDA receptors and postsynaptic events
R-HSA-442755 Activation of NMDA receptors and postsynaptic events
R-HSA-445717 Aquaporin-mediated transport
R-HSA-5358351 Signaling by Hedgehog
R-HSA-5358351 Signaling by Hedgehog
R-HSA-556833 Metabolism of lipids
R-HSA-5610780 Degradation of GLI1 by the proteasome
R-HSA-5610783 Degradation of GLI2 by the proteasome
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome
R-HSA-5610787 Hedgehog 'off' state
R-HSA-5610787 Hedgehog 'off' state
R-HSA-5621481 C-type lectin receptors (CLRs)
R-HSA-5621575 CD209 (DC-SIGN) signaling
R-HSA-5663205 Infectious disease
R-HSA-5663205 Infectious disease
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5687128 MAPK6/MAPK4 signaling
R-HSA-70171 Glycolysis
R-HSA-70326 Glucose metabolism
R-HSA-71387 Metabolism of carbohydrates
R-HSA-8853659 RET signaling
R-HSA-8963896 HDL assembly
R-HSA-8963898 Plasma lipoprotein assembly
R-HSA-8979227 Triglyceride metabolism
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9010642 ROBO receptors bind AKAP5
R-HSA-9634600 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
R-HSA-9658195 Leishmania infection
R-HSA-9658195 Leishmania infection
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection
R-HSA-9664323 FCGR3A-mediated IL10 synthesis
R-HSA-9664323 FCGR3A-mediated IL10 synthesis
R-HSA-9664433 Leishmania parasite growth and survival
R-HSA-9664433 Leishmania parasite growth and survival
R-HSA-9675108 Nervous system development
R-HSA-9675108 Nervous system development
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001206 BXGD000033 Acromegaly Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases
C0001430 BXGD000054 Adenoma Neoplasms
C0001624 BXGD000067 Adrenal Gland Neoplasms Neoplasms; Endocrine System Diseases
C0001627 BXGD000068 Congenital adrenal hyperplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002902 BXGD000154 Anencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0005426 BXGD000314 Biliary Tract Neoplasm Digestive System Diseases; Neoplasms
C0007786 BXGD000486 Brain Ischemia Nervous System Diseases; Cardiovascular Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009777 BXGD000630 Conn Adenoma Neoplasms; Endocrine System Diseases
C0010481 BXGD000673 Cushing Syndrome Endocrine System Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027794 BXGD002036 Neural Tube Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0206667 BXGD004228 Adrenal Cortical Adenoma Neoplasms; Endocrine System Diseases
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0342443 BXGD007481 Adrenal Cushing's syndrome Endocrine System Diseases
C0345905 BXGD007746 Intrahepatic Cholangiocarcinoma Neoplasms
C0346302 BXGD007807 Growth Hormone-Secreting Pituitary Adenoma Neoplasms; Nervous System Diseases; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0406810 BXGD008374 Carney Complex Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Cardiovascular Diseases
C0476073 BXGD008976 Papillary neoplasm Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0750952 BXGD010263 Biliary Tract Cancer Digestive System Diseases; Neoplasms
C0858864 BXGD011194 Spot pigmented
C1621895 BXGD013466 Adrenal hyperplasia Pathological Conditions, Signs and Symptoms; Neoplasms; Endocrine System Diseases
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C3805278 BXGD019474 Extrahepatic Cholangiocarcinoma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002071 Apigenin 270.24
BXGC0004115 Norharman 168.19
BXGC0006193 Ellagic acid 302.19
BXGC0007029 Emodin 270.24
BXGC0007052 Olomoucine 298.34
BXGC0023872 Adenine 135.05
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0042409 2-Bromo-1-Phenylethanone 197.97
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein