acompound

Showing entry for Norharman

General Compound Information
BXGC Id	BXGC0004115
Compound Name	Norharman
Structure
Formula	C11H8N2
InchiKey	AIFRHYZBTHREPW-UHFFFAOYSA-N
SMILES	N1C2=CC=CC=C2C2=C1C=NC=C2
Inchi	InChI=1S/C11H8N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-7,13H
IUPAC	9H-pyrido[3,4-b]indole
Molecular Weight	168.19
Pubchem Id	64961
Chembl Id	CHEMBL275224

Targets of Information Source

DrugBank

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type

PDB

NRH

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Q2KDX6	BXGT014114	Probable sugar kinase protein	unreviewed	RHE_CH00135	-	-	-	-	-

Binding DB

50013811

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
reviewed	BXGT005100	Rho-associated protein kinase 2	reviewed	Kinase	ROCK2	-	>19880	-	-
reviewed	BXGT004126	Inhibitor of nuclear factor kappa-B kinase subunit alpha	reviewed	Kinase	CHUK	-	15000	-	-
reviewed	BXGT008322	cAMP-dependent protein kinase catalytic subunit alpha	reviewed	Kinase	PRKACA	-	>25000	-	-
reviewed	BXGT008294	Protein kinase C alpha type	reviewed	Kinase	PRKCA	-	>25000	-	-
reviewed	BXGT008065	Indoleamine 2,3-dioxygenase 1	reviewed		IDO1	120	-	-	-
reviewed	BXGT009172	Amine oxidase [flavin-containing] B	reviewed		MAOB	1200	-	-	-
reviewed	BXGT008065	Indoleamine 2,3-dioxygenase 1	reviewed		IDO1	-	90000	-	-

CHEMBL

CHEMBL275224

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	width="10%">Type	Relation	value	Units
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Type	Relation	value	Units
O89049	BXGT005293	Thioredoxin reductase 1, cytoplasmic	reviewed	-	Txnrd1	Potency	-	79432	nM
B2RXH2	BXGT002006	Lysine-specific demethylase 4E	reviewed	-	KDM4E	Potency	'='	28183	nM
P15428	BXGT008121	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	reviewed	-	HPGD	Potency	'='	31622	nM
Q16637	BXGT013646	Survival motor neuron protein	reviewed	Epigenetic regulator	SMN1	Potency	'='	1412	nM
B2RXH2	BXGT002006	Lysine-specific demethylase 4E	reviewed	-	KDM4E	Potency	'='	31622	nM
P19784	BXGT008513	Casein kinase II subunit alpha'	reviewed	Kinase	CSNK2A2	IC50	'>'	25000	nM
P68400	BXGT011599	Casein kinase II subunit alpha	reviewed	Kinase	CSNK2A1	IC50	'>'	25000	nM
P67870	BXGT011566	Casein kinase II subunit beta	reviewed	Kinase	CSNK2B	IC50	'>'	25000	nM
Q04759	BXGT012781	Protein kinase C theta type	reviewed	Kinase	PRKCQ	IC50	'>'	25000	nM
Q15139	BXGT013546	Serine/threonine-protein kinase D1	reviewed	Kinase	PRKD1	IC50	'>'	25000	nM
P24723	BXGT008989	Protein kinase C eta type	reviewed	Kinase	PRKCH	IC50	'>'	25000	nM
Q02156	BXGT012639	Protein kinase C epsilon type	reviewed	Kinase	PRKCE	IC50	'>'	25000	nM
Q05513	BXGT012820	Protein kinase C zeta type	reviewed	Kinase	PRKCZ	IC50	'>'	25000	nM
P05771	BXGT006384	Protein kinase C beta type	reviewed	Kinase	PRKCB	IC50	'>'	25000	nM
Q05655	BXGT012832	Protein kinase C delta type	reviewed	Kinase	PRKCD	IC50	'>'	25000	nM
P05129	BXGT006322	Protein kinase C gamma type	reviewed	Kinase	PRKCG	IC50	'>'	25000	nM
P17252	BXGT008294	Protein kinase C alpha type	reviewed	Kinase	PRKCA	IC50	'>'	25000	nM
P41743	BXGT010270	Protein kinase C iota type	reviewed	Kinase	PRKCI	IC50	'>'	25000	nM
O94806	BXGT005335	Serine/threonine-protein kinase D3	reviewed	Kinase	PRKD3	IC50	'>'	25000	nM
P83916	BXGT012025	Chromobox protein homolog 1	reviewed	Epigenetic regulator	CBX1	Potency	-	63095	nM
P81908	BXGT011959	Cholinesterase	reviewed	-	BCHE	Inhibition	'='	28	%
Q16445	BXGT013629	Gamma-aminobutyric acid receptor subunit alpha-6	reviewed	Ion channel	GABRA6	IC50	'='	1621	nM
P31644	BXGT009557	Gamma-aminobutyric acid receptor subunit alpha-5	reviewed	Ion channel	GABRA5	IC50	'='	1621	nM
P47869	BXGT010590	Gamma-aminobutyric acid receptor subunit alpha-2	reviewed	Ion channel	GABRA2	IC50	'='	1621	nM
P78334	BXGT011834	Gamma-aminobutyric acid receptor subunit epsilon	reviewed	Ion channel	GABRE	IC50	'='	1621	nM
P18505	BXGT008409	Gamma-aminobutyric acid receptor subunit beta-1	reviewed	Ion channel	GABRB1	IC50	'='	1621	nM
Q8N1C3	BXGT018498	Gamma-aminobutyric acid receptor subunit gamma-1	reviewed	Ion channel	GABRG1	IC50	'='	1621	nM
O14764	BXGT004094	Gamma-aminobutyric acid receptor subunit delta	reviewed	Ion channel	GABRD	IC50	'='	1621	nM
O00591	BXGT003939	Gamma-aminobutyric acid receptor subunit pi	reviewed	Ion channel	GABRP	IC50	'='	1621	nM
P34903	BXGT009769	Gamma-aminobutyric acid receptor subunit alpha-3	reviewed	Ion channel	GABRA3	IC50	'='	1621	nM
Q9UN88	BXGT021783	Gamma-aminobutyric acid receptor subunit theta	reviewed	Ion channel	GABRQ	IC50	'='	1621	nM
Q99928	BXGT019975	Gamma-aminobutyric acid receptor subunit gamma-3	reviewed	Ion channel	GABRG3	IC50	'='	1621	nM
P48169	BXGT010622	Gamma-aminobutyric acid receptor subunit alpha-4	reviewed	Ion channel	GABRA4	IC50	'='	1621	nM
P28472	BXGT009260	Gamma-aminobutyric acid receptor subunit beta-3	reviewed	Ion channel	GABRB3	IC50	'='	1621	nM
P18507	BXGT008411	Gamma-aminobutyric acid receptor subunit gamma-2	reviewed	Ion channel	GABRG2	IC50	'='	1621	nM
P47870	BXGT010591	Gamma-aminobutyric acid receptor subunit beta-2	reviewed	Ion channel	GABRB2	IC50	'='	1621	nM
P14867	BXGT008061	Gamma-aminobutyric acid receptor subunit alpha-1	reviewed	Ion channel	GABRA1	IC50	'='	1621	nM
Q9ES14	BXGT020314	Gamma-aminobutyric acid receptor subunit epsilon	reviewed	-	Gabre	IC50	'='	1620	nM
Q91ZM7	BXGT019327	GABA theta subunit	unreviewed	-	Gabrq	IC50	'='	1620	nM
P63138	BXGT011502	Gamma-aminobutyric acid receptor subunit beta-2	reviewed	-	Gabrb2	IC50	'='	1620	nM
P63079	BXGT011491	Gamma-aminobutyric acid receptor subunit beta-3	reviewed	-	Gabrb3	IC50	'='	1620	nM
P62813	BXGT011460	Gamma-aminobutyric acid receptor subunit alpha-1	reviewed	-	Gabra1	IC50	'='	1620	nM
P30191	BXGT009410	Gamma-aminobutyric acid receptor subunit alpha-6	reviewed	-	Gabra6	IC50	'='	1620	nM
P28473	BXGT009261	Gamma-aminobutyric acid receptor subunit gamma-3	reviewed	-	Gabrg3	IC50	'='	1620	nM
P28471	BXGT009259	Gamma-aminobutyric acid receptor subunit alpha-4	reviewed	-	Gabra4	IC50	'='	1620	nM
P23576	BXGT008885	Gamma-aminobutyric acid receptor subunit alpha-2	reviewed	-	Gabra2	IC50	'='	1620	nM
P23574	BXGT008884	Gamma-aminobutyric acid receptor subunit gamma-1	reviewed	-	Gabrg1	IC50	'='	1620	nM
P20236	BXGT008551	Gamma-aminobutyric acid receptor subunit alpha-3	reviewed	-	Gabra3	IC50	'='	1620	nM
P19969	BXGT008536	Gamma-aminobutyric acid receptor subunit alpha-5	reviewed	-	Gabra5	IC50	'='	1620	nM
P18508	BXGT008412	Gamma-aminobutyric acid receptor subunit gamma-2	reviewed	-	Gabrg2	IC50	'='	1620	nM
P18506	BXGT008410	Gamma-aminobutyric acid receptor subunit delta	reviewed	-	Gabrd	IC50	'='	1620	nM
P15431	BXGT008122	Gamma-aminobutyric acid receptor subunit beta-1	reviewed	-	Gabrb1	IC50	'='	1620	nM
O09028	BXGT004049	Gamma-aminobutyric acid receptor subunit pi	reviewed	-	Gabrp	IC50	'='	1620	nM
P02791	BXGT005965	Ferritin light chain	reviewed	-	FTL	Potency	'='	28183	nM
Q63470	BXGT016073	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	reviewed	-	Dyrk1a	AC50	'='	8746	nM
O14920	BXGT004110	Inhibitor of nuclear factor kappa-B kinase subunit beta	reviewed	Kinase	IKBKB	Ki	'='	7943	nM
P24941	BXGT009002	Cyclin-dependent kinase 2	reviewed	Kinase	CDK2	Inhibition	'='	37	%
P00352	BXGT005510	Retinal dehydrogenase 1	reviewed	Enzyme	ALDH1A1	Potency	'='	35481	nM
O15111	BXGT004126	Inhibitor of nuclear factor kappa-B kinase subunit alpha	reviewed	Kinase	CHUK	IC50	'='	15000	nM
P00352	BXGT005510	Retinal dehydrogenase 1	reviewed	Enzyme	ALDH1A1	Potency	'='	31622	nM
Q9Y6L6	BXGT022334	Solute carrier organic anion transporter family member 1B1	reviewed	Transporter	SLCO1B1	Inhibition	'='	95	%
Q00535	BXGT012534	Cyclin-dependent-like kinase 5	reviewed	Kinase	CDK5	Inhibition	'='	35	%
P14902	BXGT008065	Indoleamine 2,3-dioxygenase 1	reviewed	-	IDO1	IC50	'='	90000	nM
Q9ES14	BXGT020314	Gamma-aminobutyric acid receptor subunit epsilon	reviewed	-	Gabre	IC50	'='	1621	nM
Q91ZM7	BXGT019327	GABA theta subunit	unreviewed	-	Gabrq	IC50	'='	1621	nM
P63138	BXGT011502	Gamma-aminobutyric acid receptor subunit beta-2	reviewed	-	Gabrb2	IC50	'='	1621	nM
P63079	BXGT011491	Gamma-aminobutyric acid receptor subunit beta-3	reviewed	-	Gabrb3	IC50	'='	1621	nM
P62813	BXGT011460	Gamma-aminobutyric acid receptor subunit alpha-1	reviewed	-	Gabra1	IC50	'='	1621	nM
P30191	BXGT009410	Gamma-aminobutyric acid receptor subunit alpha-6	reviewed	-	Gabra6	IC50	'='	1621	nM
P28473	BXGT009261	Gamma-aminobutyric acid receptor subunit gamma-3	reviewed	-	Gabrg3	IC50	'='	1621	nM
P28471	BXGT009259	Gamma-aminobutyric acid receptor subunit alpha-4	reviewed	-	Gabra4	IC50	'='	1621	nM
P23576	BXGT008885	Gamma-aminobutyric acid receptor subunit alpha-2	reviewed	-	Gabra2	IC50	'='	1621	nM
P23574	BXGT008884	Gamma-aminobutyric acid receptor subunit gamma-1	reviewed	-	Gabrg1	IC50	'='	1621	nM
P20236	BXGT008551	Gamma-aminobutyric acid receptor subunit alpha-3	reviewed	-	Gabra3	IC50	'='	1621	nM
P19969	BXGT008536	Gamma-aminobutyric acid receptor subunit alpha-5	reviewed	-	Gabra5	IC50	'='	1621	nM
P18508	BXGT008412	Gamma-aminobutyric acid receptor subunit gamma-2	reviewed	-	Gabrg2	IC50	'='	1621	nM
P18506	BXGT008410	Gamma-aminobutyric acid receptor subunit delta	reviewed	-	Gabrd	IC50	'='	1621	nM
P15431	BXGT008122	Gamma-aminobutyric acid receptor subunit beta-1	reviewed	-	Gabrb1	IC50	'='	1621	nM
O09028	BXGT004049	Gamma-aminobutyric acid receptor subunit pi	reviewed	-	Gabrp	IC50	'='	1621	nM
Q9ES14	BXGT020314	Gamma-aminobutyric acid receptor subunit epsilon	reviewed	-	Gabre	Ki	'='	1620	nM
Q91ZM7	BXGT019327	GABA theta subunit	unreviewed	-	Gabrq	Ki	'='	1620	nM
P63138	BXGT011502	Gamma-aminobutyric acid receptor subunit beta-2	reviewed	-	Gabrb2	Ki	'='	1620	nM
P63079	BXGT011491	Gamma-aminobutyric acid receptor subunit beta-3	reviewed	-	Gabrb3	Ki	'='	1620	nM
P62813	BXGT011460	Gamma-aminobutyric acid receptor subunit alpha-1	reviewed	-	Gabra1	Ki	'='	1620	nM
P30191	BXGT009410	Gamma-aminobutyric acid receptor subunit alpha-6	reviewed	-	Gabra6	Ki	'='	1620	nM
P28473	BXGT009261	Gamma-aminobutyric acid receptor subunit gamma-3	reviewed	-	Gabrg3	Ki	'='	1620	nM
P28471	BXGT009259	Gamma-aminobutyric acid receptor subunit alpha-4	reviewed	-	Gabra4	Ki	'='	1620	nM
P23576	BXGT008885	Gamma-aminobutyric acid receptor subunit alpha-2	reviewed	-	Gabra2	Ki	'='	1620	nM
P23574	BXGT008884	Gamma-aminobutyric acid receptor subunit gamma-1	reviewed	-	Gabrg1	Ki	'='	1620	nM
P20236	BXGT008551	Gamma-aminobutyric acid receptor subunit alpha-3	reviewed	-	Gabra3	Ki	'='	1620	nM
P19969	BXGT008536	Gamma-aminobutyric acid receptor subunit alpha-5	reviewed	-	Gabra5	Ki	'='	1620	nM
P18508	BXGT008412	Gamma-aminobutyric acid receptor subunit gamma-2	reviewed	-	Gabrg2	Ki	'='	1620	nM
P18506	BXGT008410	Gamma-aminobutyric acid receptor subunit delta	reviewed	-	Gabrd	Ki	'='	1620	nM
P15431	BXGT008122	Gamma-aminobutyric acid receptor subunit beta-1	reviewed	-	Gabrb1	Ki	'='	1620	nM
O09028	BXGT004049	Gamma-aminobutyric acid receptor subunit pi	reviewed	-	Gabrp	Ki	'='	1620	nM
P11309	BXGT007685	Serine/threonine-protein kinase pim-1	reviewed	Kinase	PIM1	Ki	'='	6309	nM
O42275	BXGT004559	Acetylcholinesterase	reviewed	-	ache	Inhibition	'='	-1	%
P22612	BXGT008785	cAMP-dependent protein kinase catalytic subunit gamma	reviewed	Kinase	PRKACG	IC50	'>'	25000	nM
P17612	BXGT008322	cAMP-dependent protein kinase catalytic subunit alpha	reviewed	Kinase	PRKACA	IC50	'>'	25000	nM
P22694	BXGT008797	cAMP-dependent protein kinase catalytic subunit beta	reviewed	Kinase	PRKACB	IC50	'>'	25000	nM
Q96QE3	BXGT019718	ATPase family AAA domain-containing protein 5	reviewed	-	ATAD5	Potency	-	4109	nM
Q96KQ7	BXGT019687	Histone-lysine N-methyltransferase EHMT2	reviewed	Epigenetic regulator	EHMT2	Potency	-	446	nM
P27695	BXGT009199	DNA-(apurinic or apyrimidinic site) lyase	reviewed	-	APEX1	Potency	-	25118	nM
P21397	BXGT008644	Amine oxidase [flavin-containing] A	reviewed	-	MAOA	Ki	'='	260	nM
P28593	BXGT009278	Trypanothione reductase	reviewed	-	TPR	Inhibition	'='	10	%
O75496	BXGT005132	Geminin	reviewed	-	GMNN	Potency	-	92	nM
P14902	BXGT008065	Indoleamine 2,3-dioxygenase 1	reviewed	-	IDO1	Ki	'='	120	nM
O14965	BXGT004117	Aurora kinase A	reviewed	Kinase	AURKA	Ki	'='	15848	nM
P27695	BXGT009199	DNA-(apurinic or apyrimidinic site) lyase	reviewed	-	APEX1	Potency	-	15	nM
Q9NPD5	BXGT021151	Solute carrier organic anion transporter family member 1B3	reviewed	Transporter	SLCO1B3	Inhibition	'='	87	%
Q25615	BXGT013900	Chitinase	unreviewed	-		IC50	'='	8460	nM
P27338	BXGT009172	Amine oxidase [flavin-containing] B	reviewed	-	MAOB	Ki	'='	1200	nM

Foods containing the compound

Foods

BXGF Id	Food Name	Scientific Name	Food Group
BXGF Id	Food Name	Scientific Name	Food Group
BXGF00049	Chicory	Cichorium intybus	Vegetables
BXGF04400	Polygala tenuifolia	Polygala tenuifolia	Medicinal Plant
BXGF05330	Arum ternatum thunb	Arum ternatum thunb	Others
BXGF05358	Codonopsis radix	Codonopsis radix	Others
BXGF06009	Picrasma quassioides	Picrasma quassioides	Medicinal Plant

The compound-realted diseases

Diseases

BXGD Id	Disease Name	CUI Disease Id	Disease Class Name	Number of targets^{?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease}