Showing entry for Emodin


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0007029
Compound NameEmodin
Structure
FormulaC15H10O5
InchiKeyRHMXXJGYXNZAPX-UHFFFAOYSA-N
SMILESCC1=CC2=C(C(O)=C1)C(=O)C1=C(C=C(O)C=C1O)C2=O
InchiInChI=1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3
IUPAC1,3,8-trihydroxy-6-methyl-9,10-dihydroanthracene-9,10-dione
Molecular Weight270.24
Pubchem Id3220
Chembl IdCHEMBL289277
Targets of Information Source
DrugBank DB07715
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P68400 BXGT011599 Casein kinase II subunit alpha reviewed Kinase CSNK2A1 investigational -
P16544 BXGT008241 Putative ketoacyl reductase reviewed - actIII investigational -
Q5G940 BXGT015383 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ unreviewed - fabZ investigational -
P35869 BXGT009877 Aryl hydrocarbon receptor reviewed Transcription factor AHR investigational agonist
PDB EMO
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P28523 BXGT009269 Casein kinase II subunit alpha reviewed ACK2 - - - - -
P16544 BXGT008241 Putative ketoacyl reductase reviewed actIII - 15000 - - -
P16544 BXGT008241 Putative ketoacyl reductase reviewed actIII - - - - -
P68400 BXGT011599 Casein kinase II subunit alpha reviewed CSNK2A1 Kinase - ~2000 - -
P68400 BXGT011599 Casein kinase II subunit alpha reviewed CSNK2A1 Kinase - - - -
Q5G940 BXGT015383 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ unreviewed fabZ - - - 450 -
Binding DB 11318
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT009269 Casein kinase II subunit alpha reviewed ACK2 1850 - - -
reviewed BXGT011599 Casein kinase II subunit alpha reviewed Kinase CSNK2A1 1850 890 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 5200 - -
reviewed BXGT006969 Accessory gene regulator protein A reviewed agrA - 17100 - -
reviewed BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK - 5 - -
reviewed BXGT009770 Bifunctional epoxide hydrolase 2 reviewed Enzyme EPHX2 - 36400 - -
reviewed BXGT011599 Casein kinase II subunit alpha reviewed Kinase CSNK2A1 - 2000 - -
reviewed BXGT007685 Serine/threonine-protein kinase pim-1 reviewed Kinase PIM1 - 2500 - -
reviewed BXGT008083 Aldo-keto reductase family 1 member B1 reviewed Enzyme AKR1B1 - 2690 - -
reviewed BXGT008083 Aldo-keto reductase family 1 member B1 reviewed Enzyme AKR1B1 2113 - - -
reviewed BXGT022265 Sialidase-2 reviewed Enzyme NEU2 - 760000 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 770 - - -
reviewed BXGT005115 Protein tyrosine phosphatase type IVA 3 reviewed PTP4A3 - 3500 - -
reviewed BXGT005115 Protein tyrosine phosphatase type IVA 3 reviewed PTP4A3 - 28000 - -
reviewed BXGT005115 Protein tyrosine phosphatase type IVA 3 reviewed PTP4A3 - 35000 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 2700 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 1500 - - -
reviewed BXGT006756 Neutrophil elastase reviewed Enzyme ELANE - 52000 - -
reviewed BXGT020448 P2Y purinoceptor 12 reviewed G-protein coupled receptor P2RY12 >10000 - - -
CHEMBL CHEMBL289277
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 398 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 12589 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency - 15848 nM
P68400 BXGT011599 Casein kinase II subunit alpha reviewed Kinase CSNK2A1 IC50 '=' 890 nM
P24941 BXGT009002 Cyclin-dependent kinase 2 reviewed Kinase CDK2 Activity '=' 75 %
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 25929 nM
P97697 BXGT012214 Inositol monophosphatase 1 reviewed - Impa1 Potency '=' 31622 nM
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform reviewed Kinase PIK3CA Inhibition - - -
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 135 %
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE Inhibition '=' 55 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Potency - 19952 nM
O75365 BXGT005115 Protein tyrosine phosphatase type IVA 3 reviewed - PTP4A3 Inhibition '=' 70 %
O75365 BXGT005115 Protein tyrosine phosphatase type IVA 3 reviewed - PTP4A3 Inhibition - - -
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 10000 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Potency '=' 12589 nM
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 3981 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Potency '=' 3981 nM
P68400 BXGT011599 Casein kinase II subunit alpha reviewed Kinase CSNK2A1 IC50 '=' 2000 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency '=' 12589 nM
P54132 BXGT011032 Bloom syndrome protein reviewed - BLM Potency '=' 3548 nM
O75365 BXGT005115 Protein tyrosine phosphatase type IVA 3 reviewed - PTP4A3 IC50 '=' 28000 nM
P19224 BXGT008468 UDP-glucuronosyltransferase 1-6 reviewed - UGT1A6 Activity '=' 0 pm/min/mg
P49841 BXGT010750 Glycogen synthase kinase-3 beta reviewed Kinase GSK3B Activity '=' 68 %
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 8912 nM
P25779 BXGT009067 Cruzipain reviewed - Potency '=' 3162 nM
P53778 BXGT011013 Mitogen-activated protein kinase 12 reviewed Kinase MAPK12 Activity '=' 92 %
P49137 BXGT010680 MAP kinase-activated protein kinase 2 reviewed Kinase MAPKAPK2 Activity '=' 82 %
P16473 BXGT008234 Thyrotropin receptor reviewed G-protein coupled receptor TSHR Potency '=' 7943 nM
P34913 BXGT009770 Bifunctional epoxide hydrolase 2 reviewed Enzyme EPHX2 Inhibition - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 50118 nM
O75365 BXGT005115 Protein tyrosine phosphatase type IVA 3 reviewed - PTP4A3 IC50 '=' 35000 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 22387 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 5200 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Potency '=' 7943 nM
Q194T2 BXGT013743 Non-structural protein 1 unreviewed - NS1 Potency '=' 12589 nM
P35503 BXGT009840 UDP-glucuronosyltransferase 1-3 reviewed - UGT1A3 Activity '=' 149 pm/min/mg
P19784 BXGT008513 Casein kinase II subunit alpha' reviewed Kinase CSNK2A2 IC50 '=' 2000 nM
P68400 BXGT011599 Casein kinase II subunit alpha reviewed Kinase CSNK2A1 IC50 '=' 2000 nM
P67870 BXGT011566 Casein kinase II subunit beta reviewed Kinase CSNK2B IC50 '=' 2000 nM
P10828 BXGT007624 Thyroid hormone receptor beta reviewed Nuclear receptor THRB Potency '=' 112201 nM
P83916 BXGT012025 Chromobox protein homolog 1 reviewed Epigenetic regulator CBX1 Potency - 22387 nM
P62157 BXGT011410 Calmodulin reviewed - CALM Activity - - -
O14757 BXGT004092 Serine/threonine-protein kinase Chk1 reviewed Kinase CHEK1 Activity '=' 89 %
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 1683 nM
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Activity '=' 160 pm/min/mg
Q9HAW9 BXGT020510 UDP-glucuronosyltransferase 1-8 reviewed - UGT1A8 Activity '=' 809 pm/min/mg
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha reviewed Transcription factor HIF1A Potency '=' 10000 nM
P16234 BXGT008209 Platelet-derived growth factor receptor alpha reviewed Kinase PDGFRA Activity - - -
P09619 BXGT006911 Platelet-derived growth factor receptor beta reviewed Kinase PDGFRB Activity - - -
Q4Q090 BXGT014858 2,3-bisphosphoglycerate-independent phosphoglycerate mutase unreviewed - PGAM Potency - 37933 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 10000 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 35481 nM
P12931 BXGT007859 Proto-oncogene tyrosine-protein kinase Src reviewed Kinase SRC IC50 - - -
P16473 BXGT008234 Thyrotropin receptor reviewed G-protein coupled receptor TSHR Potency '=' 31622 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Potency '=' 25118 nM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 4228 nM
P02791 BXGT005965 Ferritin light chain reviewed - FTL Potency '=' 39810 nM
P51449 BXGT010846 Nuclear receptor ROR-gamma reviewed Nuclear receptor RORC Potency - 42163 nM
P54855 BXGT011088 UDP-glucuronosyltransferase 2B15 reviewed - UGT2B15 Activity '=' 71 pm/min/mg
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE IC50 '=' 52000 nM
Q99549 BXGT019932 M-phase phosphoprotein 8 reviewed Epigenetic regulator MPHOSPH8 Potency - 39810 nM
P35869 BXGT009877 Aryl hydrocarbon receptor reviewed Transcription factor AHR Potency - 44668 nM
O75365 BXGT005115 Protein tyrosine phosphatase type IVA 3 reviewed - PTP4A3 IC50 '=' 3500 nM
O43451 BXGT004594 Maltase-glucoamylase, intestinal reviewed Enzyme MGAM Inhibition - - -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Activity '=' 71 %
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase reviewed Kinase AKT1 Activity '=' 82 %
O75116 BXGT005100 Rho-associated protein kinase 2 reviewed Kinase ROCK2 Activity '=' 90 %
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 31622 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Potency - 44668 nM
P15311 BXGT008106 Ezrin reviewed Cellular structure EZR Inhibition - - -
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Activity '=' 350 pm/min/mg
Q9HAW8 BXGT020509 UDP-glucuronosyltransferase 1-10 reviewed - UGT1A10 Activity '=' 233 pm/min/mg
Q9HAW9 BXGT020510 UDP-glucuronosyltransferase 1-8 reviewed - UGT1A8 Activity '=' 944 pm/min/mg
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 15848 nM
P16473 BXGT008234 Thyrotropin receptor reviewed G-protein coupled receptor TSHR Potency '=' 2511 nM
Q99549 BXGT019932 M-phase phosphoprotein 8 reviewed Epigenetic regulator MPHOSPH8 Potency - 10621 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 89125 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 10000 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Control '<' 126 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Control '<' 126 %
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 19952 nM
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 Potency '=' 10000 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 1835 nM
P15917 BXGT008169 Lethal factor reviewed - lef Potency '=' 2511 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency '=' 35481 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 25118 nM
P09769 BXGT006917 Tyrosine-protein kinase Fgr reviewed Kinase FGR Activity '=' 99 %
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 39810 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 39810 nM
P53350 BXGT010984 Serine/threonine-protein kinase PLK1 reviewed Kinase PLK1 Potency - 26679 nM
Q9H244 BXGT020448 P2Y purinoceptor 12 reviewed G-protein coupled receptor P2RY12 Inhibition '=' 5 %
Q9H244 BXGT020448 P2Y purinoceptor 12 reviewed G-protein coupled receptor P2RY12 Ki '>' 10000 nM
Q9HC16 BXGT020525 DNA dC->dU-editing enzyme APOBEC-3G reviewed Enzyme APOBEC3G Potency - 23715 nM
P08419 BXGT006770 Chymotrypsin-like elastase family member 2A reviewed - CELA2A Inhibition - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki '=' 770 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Control '<' 165 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Control '<' 165 %
P04353 BXGT006194 Calmodulin reviewed - Activity - - -
O15264 BXGT004144 Mitogen-activated protein kinase 13 reviewed Kinase MAPK13 Activity '=' 100 %
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK Activity '=' 79 %
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 119 %
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 9439 nM
P22310 BXGT008754 UDP-glucuronosyltransferase 1-4 reviewed - UGT1A4 Activity '=' 0 pm/min/mg
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 31622 nM
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Potency '=' 11220 nM
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 39810 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 33587 nM
Q9NR56 BXGT021179 Muscleblind-like protein 1 reviewed Nucleic acid binding MBNL1 Potency - 15848 nM
P53396 BXGT010988 ATP-citrate synthase reviewed Enzyme ACLY Inhibition '=' 0 %
P19793 BXGT008515 Retinoic acid receptor RXR-alpha reviewed Nuclear receptor RXRA Potency - 15848 nM
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG Inhibition '=' 42 %
P06746 BXGT006496 DNA polymerase beta reviewed Enzyme POLB Potency '=' 11220 nM
P15121 BXGT008083 Aldo-keto reductase family 1 member B1 reviewed Enzyme AKR1B1 Ki '=' 2113 nM
P19784 BXGT008513 Casein kinase II subunit alpha' reviewed Kinase CSNK2A2 IC50 '=' 1000 nM
P68400 BXGT011599 Casein kinase II subunit alpha reviewed Kinase CSNK2A1 IC50 '=' 1000 nM
P67870 BXGT011566 Casein kinase II subunit beta reviewed Kinase CSNK2B IC50 '=' 1000 nM
Q9Y4K4 BXGT022282 Mitogen-activated protein kinase kinase kinase kinase 5 reviewed Kinase MAP4K5 Activity '=' 89 %
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 Potency - 39810 nM
P13267 BXGT007895 DNA polymerase III PolC-type reviewed - polC Potency - 23778 nM
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 5 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 18833 nM
P23443 BXGT008866 Ribosomal protein S6 kinase beta-1 reviewed Kinase RPS6KB1 Activity '=' 84 %
P54646 BXGT011062 5'-AMP-activated protein kinase catalytic subunit alpha-2 reviewed Kinase PRKAA2 Activity '=' 89 %
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Activity '=' 88 %
P45984 BXGT010495 Mitogen-activated protein kinase 9 reviewed Kinase MAPK9 Activity '=' 101 %
P53779 BXGT011014 Mitogen-activated protein kinase 10 reviewed Kinase MAPK10 Activity '=' 101 %
P45983 BXGT010494 Mitogen-activated protein kinase 8 reviewed Kinase MAPK8 Activity '=' 101 %
P22612 BXGT008785 cAMP-dependent protein kinase catalytic subunit gamma reviewed Kinase PRKACG Activity '=' 94 %
P17612 BXGT008322 cAMP-dependent protein kinase catalytic subunit alpha reviewed Kinase PRKACA Activity '=' 94 %
P22694 BXGT008797 cAMP-dependent protein kinase catalytic subunit beta reviewed Kinase PRKACB Activity '=' 94 %
O00141 BXGT003882 Serine/threonine-protein kinase Sgk1 reviewed Kinase SGK1 Activity '=' 55 %
P53323 BXGT010982 EKC/KEOPS complex subunit BUD32 reviewed - BUD32 Activity '=' 90 %
P43405 BXGT010386 Tyrosine-protein kinase SYK reviewed Kinase SYK Activity '=' 96 %
P41240 BXGT010242 Tyrosine-protein kinase CSK reviewed Kinase CSK Activity '=' 109 %
O75365 BXGT005115 Protein tyrosine phosphatase type IVA 3 reviewed - PTP4A3 Inhibition '>' 80 %
P12931 BXGT007859 Proto-oncogene tyrosine-protein kinase Src reviewed Kinase SRC Inhibition '=' 22 %
P68400 BXGT011599 Casein kinase II subunit alpha reviewed Kinase CSNK2A1 Ki '>' 40000 nM
P68400 BXGT011599 Casein kinase II subunit alpha reviewed Kinase CSNK2A1 Ki '=' 1850 nM
Q15759 BXGT013595 Mitogen-activated protein kinase 11 reviewed Kinase MAPK11 Activity '=' 101 %
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Kinase DYRK1A Activity '=' 29 %
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 50118 nM
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR Potency - 25118 nM
Q03181 BXGT012701 Peroxisome proliferator-activated receptor delta reviewed Nuclear receptor PPARD Potency - 15848 nM
Q4U254 BXGT014890 Protease unreviewed - protease IC50 '>' 150000 nM
P12823 BXGT007851 Genome polyprotein reviewed - IC50 '=' 79800 nM
O15530 BXGT004177 3-phosphoinositide-dependent protein kinase 1 reviewed Kinase PDPK1 Activity '=' 90 %
P34913 BXGT009770 Bifunctional epoxide hydrolase 2 reviewed Enzyme EPHX2 Inhibition '=' 56 %
P00784 BXGT005655 Papain reviewed - IC50 - - -
P68400 BXGT011599 Casein kinase II subunit alpha reviewed Kinase CSNK2A1 IC50 '=' 460 nM
P67870 BXGT011566 Casein kinase II subunit beta reviewed Kinase CSNK2B IC50 '=' 460 nM
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Potency - 10000 nM
Q9Y253 BXGT022216 DNA polymerase eta reviewed - POLH Potency - 15848 nM
Q8IW41 BXGT018352 MAP kinase-activated protein kinase 5 reviewed Kinase MAPKAPK5 Activity '=' 81 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Control '<' 196 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Control '<' 196 %
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 28183 nM
P19784 BXGT008513 Casein kinase II subunit alpha' reviewed Kinase CSNK2A2 Inhibition '=' 99 %
P68400 BXGT011599 Casein kinase II subunit alpha reviewed Kinase CSNK2A1 Inhibition '=' 99 %
P67870 BXGT011566 Casein kinase II subunit beta reviewed Kinase CSNK2B Inhibition '=' 99 %
P11308 BXGT007684 Transcriptional regulator ERG reviewed Transcription factor ERG Potency - 28183 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 21136 nM
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Potency '=' 12589 nM
P40225 BXGT010168 Thrombopoietin reviewed - THPO Potency '=' 12589 nM
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK IC50 '=' 5 ug.mL-1
P12823 BXGT007851 Genome polyprotein reviewed - IC50 '=' 16870 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE Inhibition '=' 1 %
P10145 BXGT007542 Interleukin-8 reviewed Signaling CXCL8 Potency - 66824 nM
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 15003 nM
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma reviewed Nuclear receptor PPARG Potency - 44668 nM
P00766 BXGT005647 Chymotrypsinogen A reviewed - Inhibition '=' 2 %
P68400 BXGT011599 Casein kinase II subunit alpha reviewed Kinase CSNK2A1 Activity '=' 51 %
P07948 BXGT006702 Tyrosine-protein kinase Lyn reviewed Kinase LYN Activity '=' 90 %
O15118 BXGT004127 NPC intracellular cholesterol transporter 1 reviewed Transporter NPC1 Potency '=' 20596 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 17782 nM
P11309 BXGT007685 Serine/threonine-protein kinase pim-1 reviewed Kinase PIM1 IC50 '=' 2500 nM
P15121 BXGT008083 Aldo-keto reductase family 1 member B1 reviewed Enzyme AKR1B1 IC50 '=' 2690 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 14125 nM
Q13951 BXGT013407 Core-binding factor subunit beta reviewed - CBFB Potency - 14125 nM
Q01196 BXGT012575 Runt-related transcription factor 1 reviewed Transcription factor RUNX1 Potency - 14125 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Potency - 50118 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Potency '=' 7943 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 14125 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency - 22387 nM
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 6701 nM
P23739 BXGT008901 Sucrase-isomaltase, intestinal reviewed - Si NT - - -
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' 24 %
Q13951 BXGT013407 Core-binding factor subunit beta reviewed - CBFB Potency - 12589 nM
Q01196 BXGT012575 Runt-related transcription factor 1 reviewed Transcription factor RUNX1 Potency - 12589 nM
Q03181 BXGT012701 Peroxisome proliferator-activated receptor delta reviewed Nuclear receptor PPARD Potency - 44668 nM
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR Potency - 35481 nM
P34913 BXGT009770 Bifunctional epoxide hydrolase 2 reviewed Enzyme EPHX2 IC50 '=' 36400 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 28183 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 28183 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 18356 nM
Q03181 BXGT012701 Peroxisome proliferator-activated receptor delta reviewed Nuclear receptor PPARD Potency - 5623 nM
O60656 BXGT004889 UDP-glucuronosyltransferase 1-9 reviewed - UGT1A9 Activity '=' 1900 pm/min/mg
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 9688 nM
O75164 BXGT005104 Lysine-specific demethylase 4A reviewed - KDM4A Potency - 44668 nM
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR Potency - 22387 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 12589 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 35481 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Potency '=' 31622 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 11885 nM
Q9Y3R4 BXGT022265 Sialidase-2 reviewed Enzyme NEU2 IC50 '=' 760000 nM
P14550 BXGT008019 Aldo-keto reductase family 1 member A1 reviewed Enzyme AKR1A1 Inhibition - - -
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 reviewed - PIN1 Potency - 50118 nM
Q03181 BXGT012701 Peroxisome proliferator-activated receptor delta reviewed Nuclear receptor PPARD Potency - 19952 nM
Q02750 BXGT012662 Dual specificity mitogen-activated protein kinase kinase 1 reviewed Kinase MAP2K1 Activity '=' 111 %
Q15418 BXGT013569 Ribosomal protein S6 kinase alpha-1 reviewed Kinase RPS6KA1 Activity '=' 103 %
O75582 BXGT005137 Ribosomal protein S6 kinase alpha-5 reviewed Kinase RPS6KA5 Activity '=' 90 %
P48729 BXGT010655 Casein kinase I isoform alpha reviewed Kinase CSNK1A1 Activity '=' 79 %
P49674 BXGT010725 Casein kinase I isoform epsilon reviewed - CSNK1E Activity '=' 79 %
P48730 BXGT010656 Casein kinase I isoform delta reviewed Kinase CSNK1D Activity '=' 79 %
P78368 BXGT011840 Casein kinase I isoform gamma-2 reviewed Kinase CSNK1G2 Activity '=' 79 %
Q9HCP0 BXGT020536 Casein kinase I isoform gamma-1 reviewed Kinase CSNK1G1 Activity '=' 79 %
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 Activity '=' 92 %
Q96RI1 BXGT019727 Bile acid receptor reviewed Nuclear receptor NR1H4 Potency - 44668 nM
P15121 BXGT008083 Aldo-keto reductase family 1 member B1 reviewed Enzyme AKR1B1 Inhibition - - -
P68400 BXGT011599 Casein kinase II subunit alpha reviewed Kinase CSNK2A1 Inhibition '=' 99 %
P67870 BXGT011566 Casein kinase II subunit beta reviewed Kinase CSNK2B Inhibition '=' 99 %
P49798 BXGT010745 Regulator of G-protein signaling 4 reviewed Enzyme modulator RGS4 Potency - 10621 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 89125 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 8912 nM
O60218 BXGT004858 Aldo-keto reductase family 1 member B10 reviewed Enzyme AKR1B10 Inhibition - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 2700 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki '=' 1500 nM
P19784 BXGT008513 Casein kinase II subunit alpha' reviewed Kinase CSNK2A2 IC50 '=' 580 nM
P68400 BXGT011599 Casein kinase II subunit alpha reviewed Kinase CSNK2A1 IC50 '=' 580 nM
P67870 BXGT011566 Casein kinase II subunit beta reviewed Kinase CSNK2B IC50 '=' 580 nM
Q03431 BXGT012714 Parathyroid hormone/parathyroid hormone-related peptide receptor reviewed G-protein coupled receptor PTH1R Potency - 19952 nM
O15648 BXGT004185 ATP-dependent 6-phosphofructokinase reviewed - pfk Potency - 23934 nM
P15289 BXGT008102 Arylsulfatase A reviewed Enzyme ARSA Potency - 2133 nM
P04798 BXGT006265 Cytochrome P450 1A1 reviewed Enzyme CYP1A1 IC50 '=' 12250 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 7695 nM
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 IC50 '=' 3730 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 6513 nM
P0A0I7 BXGT006969 Accessory gene regulator protein A reviewed - agrA IC50 '=' 17100 nM
P68400 BXGT011599 Casein kinase II subunit alpha reviewed Kinase CSNK2A1 IC50 '=' 580 nM
P67870 BXGT011566 Casein kinase II subunit beta reviewed Kinase CSNK2B IC50 '=' 580 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00111 Cornmint Mentha arvensis Herbs and Spices
BXGF00154 Garden rhubarb Rheum rhabarbarum Vegetables
BXGF00164 Sorrel Rumex acetosa Herbs and Spices
BXGF00323 Dock Rumex Herbs and Spices
BXGF00459 Wax gourd Benincasa hispida Gourds
BXGF00857 Mitracarpus scaber Mitracarpus scaber Others
BXGF00892 Leptocereus quadricostatus Leptocereus quadricostatus Others
BXGF00894 Heynea trijuga Heynea trijuga Medicinal Plant
BXGF00896 Magnolia figo Magnolia figo Human Edible Plant
BXGF00919 Chaiturus marrubiastrum Chaiturus marrubiastrum Others
BXGF00981 Flacourtia jangomas Flacourtia jangomas Medicinal Plant
BXGF01126 Polygonum cuspidatum Polygonum cuspidatum Medicinal Plant
BXGF01187 Onobrychis arenaria Onobrychis arenaria Others
BXGF01223 Eria mollis Eria mollis Others
BXGF01302 Dysoxylum cumingianum Dysoxylum cumingianum Others
BXGF01311 Aizopsis selskiana Aizopsis selskiana Others
BXGF01344 Psychotria stachyoides Psychotria stachyoides Others
BXGF01357 Ampelopsis japonica Ampelopsis japonica Medicinal Plant
BXGF01391 Dodonaea viscosa Dodonaea viscosa Medicinal Plant
BXGF01495 Pleione yunnanensis Pleione yunnanensis Others
BXGF01529 Rhamnus davurica Rhamnus davurica Medicinal Plant
BXGF01541 Rumex patientia Rumex patientia Medicinal Plant
BXGF01568 Teucrium yemense Teucrium yemense Others
BXGF01570 Pinalia stricta Pinalia stricta Others
BXGF01623 Amphorogyne spicata Amphorogyne spicata Others
BXGF01641 Neobalanocarpus heimii Neobalanocarpus heimii Others
BXGF01683 Aconitum tasiromontanum Aconitum tasiromontanum Others
BXGF01695 Tanacetum coccineum Tanacetum coccineum Medicinal Plant
BXGF01716 Mentha canadensis Mentha canadensis Medicinal Plant
BXGF01764 Dendriopoterium menendezii Dendriopoterium menendezii Others
BXGF01794 Adansonia grandidieri Adansonia grandidieri Human Edible Plant
BXGF01799 Mandragora autumnalis Mandragora autumnalis Medicinal Plant
BXGF01812 Physalis alkekengi Physalis alkekengi Medicinal Plant
BXGF01836 Aphyllocladus denticulatus Aphyllocladus denticulatus Others
BXGF01850 Bassia muricata Bassia muricata Medicinal Plant
BXGF01915 Vismia laurentii Vismia laurentii Medicinal Plant
BXGF01931 Dalbergia lanceolaria subsp. paniculata Dalbergia lanceolaria subsp. paniculata Medicinal Plant
BXGF01947 Senecio subdentatus Senecio subdentatus Others
BXGF02006 Aconitum seravschanicum Aconitum seravschanicum Others
BXGF02037 Carduus tenuiflorus Carduus tenuiflorus Others
BXGF02203 Verbascum thapsiforme Verbascum thapsiforme Medicinal Plant
BXGF02256 Rumex chalepensis Rumex chalepensis Others
BXGF02289 Rhododendron dahuricum Rhododendron dahuricum Others
BXGF02323 Dalbergia hupeana Dalbergia hupeana Medicinal Plant
BXGF02357 Euodia bodinieri Euodia bodinieri Others
BXGF02387 Salvia greggii Salvia greggii Medicinal Plant
BXGF02496 Pleione bulbocodioides Pleione bulbocodioides Others
BXGF02499 Cremastra appendiculata Cremastra appendiculata Medicinal Plant
BXGF02503 Balanophora laxiflora Balanophora laxiflora Others
BXGF02528 Cirsium oligophyllum Cirsium oligophyllum Medicinal Plant
BXGF02566 Fridericia triplinervia Fridericia triplinervia Others
BXGF02576 Anaphalis lactea Anaphalis lactea Others
BXGF02632 Metrodorea nigra Metrodorea nigra Others
BXGF02662 Rheum wittrocki Rheum wittrocki Medicinal Plant
BXGF02737 Artemisia scoparia Artemisia scoparia Medicinal Plant
BXGF02814 Senecio praecox Senecio praecox Others
BXGF02817 Garcinia polyantha Garcinia polyantha Medicinal Plant
BXGF02853 Anchusa azurea Anchusa azurea Medicinal Plant
BXGF02880 Nepeta granatensis Nepeta granatensis Others
BXGF02900 Gleichenia quadripartita Gleichenia quadripartita Others
BXGF02932 Dipsacus azureus Dipsacus azureus Others
BXGF02958 Jacquemontia paniculata Jacquemontia paniculata Others
BXGF02978 Tetradium ruticarpum Tetradium ruticarpum Medicinal Plant
BXGF02993 Caulerpa peltata Caulerpa peltata Human Edible Plant
BXGF03028 Lespedeza tomentosa Lespedeza tomentosa Medicinal Plant
BXGF03042 Rosa pomifera Rosa pomifera Human Edible Plant
BXGF03064 Degenia velebitica Degenia velebitica Others
BXGF03077 Albizia myriophylla Albizia myriophylla Medicinal Plant
BXGF03088 Erythrophleum ivorense Erythrophleum ivorense Medicinal Plant
BXGF03114 Delphinium virgatum Delphinium virgatum Others
BXGF03135 Grangea maderaspatana Grangea maderaspatana Medicinal Plant
BXGF03158 Rheum officinale Rheum officinale Medicinal Plant
BXGF03167 Tagetes filifolia Tagetes filifolia Medicinal Plant
BXGF03217 Delphinium nuttallianum Delphinium nuttallianum Others
BXGF03251 Lupinus corymbosus Lupinus corymbosus Others
BXGF03298 Senecio behnii Senecio behnii Others
BXGF03317 Dillenia indica Dillenia indica Medicinal Plant
BXGF03436 Photinia serratifolia Photinia serratifolia Medicinal Plant
BXGF03485 Justicia secunda Justicia secunda Others
BXGF03512 Helichrysum chionosphaerum Helichrysum chionosphaerum Medicinal Plant
BXGF03556 Actinidia chinensis planch Actinidia chinensis planch Others
BXGF03583 Epimedium koreanum Epimedium koreanum Medicinal Plant
BXGF03683 Cynanchum viminale Cynanchum viminale Medicinal Plant
BXGF03748 Ventilago leiocarpa Ventilago leiocarpa Medicinal Plant
BXGF03855 Rumex dentatus Rumex dentatus Medicinal Plant
BXGF03988 Rheum coreanum Rheum coreanum Others
BXGF04062 Spatholobus suberectus Spatholobus suberectus Medicinal Plant
BXGF04064 Rumex japonicus Rumex japonicus Medicinal Plant
BXGF04205 Aster sedifolius Aster sedifolius Others
BXGF04229 Petunia integrifolia subsp. inflata Petunia integrifolia subsp. inflata Others
BXGF04231 Andrographis neesiana Andrographis neesiana Others
BXGF04244 Coreopsis tinctoria Coreopsis tinctoria Medicinal Plant
BXGF04303 Anemarrhena asphodeloides Anemarrhena asphodeloides Medicinal Plant
BXGF04340 Quercus rubra Quercus rubra Medicinal Plant
BXGF04351 Baccharis potosina Baccharis potosina Others
BXGF04395 Maclura tinctoria Maclura tinctoria Medicinal Plant
BXGF04438 Stevia berlandieri Stevia berlandieri Others
BXGF04499 Ravenia spectabilis Ravenia spectabilis Others
BXGF04539 Rheum palmatum Rheum palmatum Medicinal Plant
BXGF04605 Senna alexandrina Senna alexandrina Medicinal Plant
BXGF04665 Magnolia ovata Magnolia ovata Others
BXGF04713 Aster tataricus Aster tataricus Medicinal Plant
BXGF04837 Nekemias grossedentata Nekemias grossedentata Others
BXGF04881 Fallopia multiflora Fallopia multiflora Medicinal Plant
BXGF04886 Boehmeria nivea Boehmeria nivea Medicinal Plant
BXGF04912 Corydalis rhizoma Corydalis rhizoma Others
BXGF04917 Cassia obtusifolia Cassia obtusifolia Medicinal Plant
BXGF04936 Cassia occidentalis Cassia occidentalis Medicinal Plant
BXGF04956 Rhamnus frangula Rhamnus frangula Medicinal Plant
BXGF04984 Selaginella labordei Selaginella labordei Others
BXGF04990 Cassia tora Cassia tora Medicinal Plant
BXGF05018 Lavandula vera Lavandula vera Medicinal Plant
BXGF05022 rumex plants rumex plants Others
BXGF05051 Rhamnus Rhamnus Medicinal Plant
BXGF05183 Lanaria lanata Lanaria lanata Others
BXGF05192 Frangula purshiana Frangula purshiana Medicinal Plant
BXGF05224 Cranfillia fluviatilis Cranfillia fluviatilis Medicinal Plant
BXGF05269 Hypericum perforatum Hypericum perforatum Medicinal Plant
BXGF05356 Euodia officinalis Euodia officinalis Others
BXGF05489 Hypericum prolificum Hypericum prolificum Others
BXGF05511 Acorus gramineus Acorus gramineus Medicinal Plant
BXGF05524 Rumex nepalensis Rumex nepalensis Medicinal Plant
BXGF05728 Persicaria perfoliata Persicaria perfoliata Medicinal Plant
BXGF05790 Glycyrrhiza uralensis Glycyrrhiza uralensis Medicinal Plant
BXGF05802 Scilla socialis Scilla socialis Others
BXGF05877 Rheum tanguticum Rheum tanguticum Medicinal Plant
BXGF05886 Senna tora Senna tora Medicinal Plant
BXGF06002 Euodia ruticarpa Euodia ruticarpa Others
BXGF06009 Picrasma quassioides Picrasma quassioides Medicinal Plant
BXGF06011 Enceliopsis argophylla Enceliopsis argophylla Others
BXGF06071 Acorus tatarinowii Acorus tatarinowii Medicinal Plant
BXGF06095 Rheum undulatum Rheum undulatum Medicinal Plant
BXGF06114 Senna obtusifolia Senna obtusifolia Medicinal Plant
BXGF06281 Miliusa velutina Miliusa velutina Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease