Showing entry for Troponin T, cardiac muscle


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010459
Protein NameTroponin T, cardiac muscle
Uniport IdP45379
GeneTNNT2
Gene Id7139
DomainTroponin
Pfam PF00992  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.3 Circulatory system hsa04260 Cardiac muscle contraction
5. Organismal Systems 5.3 Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes
6. Human Diseases 6.6 Cardiovascular diseases hsa05410 Hypertrophic cardiomyopathy (HCM)
6. Human Diseases 6.6 Cardiovascular diseases hsa05414 Dilated cardiomyopathy (DCM)
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0051764 actin crosslink formation
Biological Process GO:0060048 cardiac muscle contraction
Biological Process GO:0006936 muscle contraction
Biological Process GO:0030049 muscle filament sliding
Biological Process GO:0032780 negative regulation of ATPase activity
Biological Process GO:0032781 positive regulation of ATPase activity
Biological Process GO:0008016 regulation of heart contraction
Biological Process GO:0032972 regulation of muscle filament sliding speed
Biological Process GO:0051592 response to calcium ion
Biological Process GO:0045214 sarcomere organization
Biological Process GO:0003009 skeletal muscle contraction
Biological Process GO:0055010 ventricular cardiac muscle tissue morphogenesis
molecular function GO:0003779 actin binding
molecular function GO:0005509 calcium ion binding
molecular function GO:0042802 identical protein binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0030674 protein-macromolecule adaptor activity
molecular function GO:0005523 tropomyosin binding
molecular function GO:0030172 troponin C binding
molecular function GO:0031013 troponin I binding
cellular component GO:0097512 cardiac myofibril
cellular component GO:1990584 cardiac Troponin complex
cellular component GO:0005829 cytosol
cellular component GO:0030017 sarcomere
cellular component GO:0005865 striated muscle thin filament
cellular component GO:0005861 troponin complex
Reactome
Pathway Id Pathway Name
R-HSA-390522 Striated Muscle Contraction
R-HSA-397014 Muscle contraction
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003507 BXGD000203 Aortic Valve Stenosis Cardiovascular Diseases
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0007193 BXGD000451 Cardiomyopathy, Dilated Cardiovascular Diseases
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0007196 BXGD000453 Restrictive cardiomyopathy Cardiovascular Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0008031 BXGD000511 Chest Pain Pathological Conditions, Signs and Symptoms
C0011071 BXGD000696 Sudden death Pathological Conditions, Signs and Symptoms
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0016719 BXGD001074 Friedreich Ataxia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0017921 BXGD001152 Glycogen storage disease type II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0018800 BXGD001225 Cardiomegaly Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0023212 BXGD001616 Left-Sided Heart Failure Cardiovascular Diseases
C0023787 BXGD001698 Lipodystrophy Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027540 BXGD001996 Necrosis Pathological Conditions, Signs and Symptoms
C0033141 BXGD002400 Cardiomyopathies, Primary Cardiovascular Diseases
C0035220 BXGD002512 Respiratory Distress Syndrome, Newborn Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C0036529 BXGD002624 Myocardial Diseases, Secondary Cardiovascular Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0039070 BXGD002787 Syncope Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0042514 BXGD002989 Tachycardia, Ventricular Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0043202 BXGD003037 Wolff-Parkinson-White Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0085298 BXGD003155 Sudden Cardiac Death Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085612 BXGD003204 Ventricular arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0149721 BXGD003349 Left Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0202236 BXGD004086 Triglycerides measurement
C0235527 BXGD004753 Heart Failure, Right-Sided Cardiovascular Diseases
C0241005 BXGD005072 Creatine phosphokinase serum increased
C0242698 BXGD005189 Ventricular Dysfunction, Left Cardiovascular Diseases
C0264886 BXGD005432 Conduction disorder of the heart Cardiovascular Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0340279 BXGD007314 Ventricular hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0340427 BXGD007329 Familial dilated cardiomyopathy Cardiovascular Diseases
C0342751 BXGD007542 Generalized glycogen storage disease of infants Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0348616 BXGD007876 Other restrictive cardiomyopathy Cardiovascular Diseases
C0427515 BXGD008619 Neutrophil abnormality
C0476403 BXGD008992 Electromyogram abnormal
C0523953 BXGD009226 Cardiac troponin T measurement
C0597124 BXGD009651 Obstructive asymmetric septal hypertrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0699743 BXGD009862 Congenital muscular dystrophy (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0700053 BXGD009873 Idiopathic hypertrophic subaortic stenosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0742343 BXGD010061 Acute Chest Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C0745103 BXGD010114 Hyperlipoproteinemia Type IIa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0751172 BXGD010335 Adult Glycogen Storage Disease Type II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0751173 BXGD010336 Glycogen Storage Disease Type II, Infantile Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0751174 BXGD010337 Glycogen Storage Disease Type II, Juvenile Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0948089 BXGD011504 Acute Coronary Syndrome Cardiovascular Diseases
C0949658 BXGD011582 Cardiomyopathy, Hypertrophic, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1280433 BXGD012125 Lipoatrophy Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C1383860 BXGD012935 Cardiac Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1527303 BXGD013265 Chronic Airflow Obstruction Respiratory Tract Diseases
C1611743 BXGD013456 Familial (FPAH)
C1720824 BXGD013686 Sudden Cardiac Arrest Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1832243 BXGD013814 CARDIOMYOPATHY, DILATED, 1D (disorder) Cardiovascular Diseases
C1841658 BXGD014480 Progressive Familial Heart Block, Type II Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1861861 BXGD016083 CARDIOMYOPATHY, FAMILIAL RESTRICTIVE, 1 (disorder) Cardiovascular Diseases
C1861864 BXGD016086 Cardiomyopathy, Familial Hypertrophic, 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1959583 BXGD016637 Myocardial Failure Cardiovascular Diseases
C1960469 BXGD016664 Left ventricular noncompaction Cardiovascular Diseases
C1961112 BXGD016674 Heart Decompensation Cardiovascular Diseases
C2676271 BXGD017330 CARDIOMYOPATHY, FAMILIAL RESTRICTIVE, 3 (disorder) Cardiovascular Diseases
C3495498 BXGD018989 Cardiomyopathy, Familial Hypertrophic, 1 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C4021133 BXGD020563 Left ventricular noncompaction cardiomyopathy Pathological Conditions, Signs and Symptoms
C4521042 BXGD023055 Complete Trisomy 21 Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4551472 BXGD023303 Hypertrophic obstructive cardiomyopathy Cardiovascular Diseases
C4551675 BXGD023384 Keratoderma, Palmoplantar Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C4551854 BXGD023422 HYPOPLASTIC LEFT HEART SYNDROME 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0022009 (9R)-9-[(9R)-2-Carboxy-4-Hydroxy-10-Oxo-5-[(3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Oxy-9H-Anthracen-9-Yl]-4-Hydroxy-10-Oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Oxy-9H-Anthracene-2-Carboxylic Acid 862.2
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein