Showing entry for H(+)/Cl(-) exchange transporter 3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010890
Protein NameH(+)/Cl(-) exchange transporter 3
Uniport IdP51790
GeneCLCN3
Gene Id1182
DomainCBS; Voltage_CLC
Pfam PF00571   PF00654  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:1902476 chloride transmembrane transport
Biological Process GO:0048388 endosomal lumen acidification
Biological Process GO:0045794 negative regulation of cell volume
Biological Process GO:0006885 regulation of pH
molecular function GO:0015297 antiporter activity
molecular function GO:0005524 ATP binding
molecular function GO:0005254 chloride channel activity
molecular function GO:0031404 chloride ion binding
molecular function GO:0030165 PDZ domain binding
molecular function GO:0015299 solute:proton antiporter activity
molecular function GO:0005247 voltage-gated chloride channel activity
molecular function GO:0072320 volume-sensitive chloride channel activity
cellular component GO:0009986 cell surface
cellular component GO:0031410 cytoplasmic vesicle
cellular component GO:0005769 early endosome
cellular component GO:0031901 early endosome membrane
cellular component GO:0005768 endosome
cellular component GO:0010008 endosome membrane
cellular component GO:0009897 external side of plasma membrane
cellular component GO:0005794 Golgi apparatus
cellular component GO:0000139 Golgi membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0005770 late endosome
cellular component GO:0031902 late endosome membrane
cellular component GO:0005765 lysosomal membrane
cellular component GO:0016020 membrane
cellular component GO:0045335 phagocytic vesicle
cellular component GO:0005886 plasma membrane
cellular component GO:0055037 recycling endosome
cellular component GO:0032587 ruffle membrane
cellular component GO:0030141 secretory granule
cellular component GO:0042581 specific granule
cellular component GO:0008021 synaptic vesicle
cellular component GO:0012506 vesicle membrane
Reactome
Pathway Id Pathway Name
R-HSA-2672351 Stimuli-sensing channels
R-HSA-382551 Transport of small molecules
R-HSA-983712 Ion channel transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0008074 BXGD000519 Child Development Disorders, Pervasive Mental Disorders
C0008479 BXGD000544 Chondrosarcoma Neoplasms
C0008489 BXGD000546 Chorea Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013390 BXGD000828 Dysmenorrhea Pathological Conditions, Signs and Symptoms
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0022340 BXGD001536 Late-Infantile Neuronal Ceroid Lipfuscinosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0022797 BXGD001586 Adult Neuronal Ceroid Lipofuscinosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024232 BXGD001751 Lymphatic Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027430 BXGD001988 Nasal Polyps Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027877 BXGD002055 Neuronal Ceroid-Lipofuscinoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038356 BXGD002747 Stomach Neoplasms Digestive System Diseases; Neoplasms
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0235874 BXGD004781 Disease Exacerbation Pathological Conditions, Signs and Symptoms
C0259783 BXGD005221 mixed gliomas Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279671 BXGD006677 Cervical Squamous Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0343641 BXGD007636 Human papilloma virus infection Infections
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376618 BXGD008003 Endotoxemia Pathological Conditions, Signs and Symptoms; Infections
C0403823 BXGD008315 Asthenozoospermia Male Urogenital Diseases
C0424605 BXGD008535 Developmental delay (disorder) Mental Disorders
C0456909 BXGD008883 Blindness Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0555198 BXGD009432 Malignant Glioma Neoplasms
C0557874 BXGD009444 Global developmental delay
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0751383 BXGD010422 Juvenile Neuronal Ceroid Lipofuscinosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0947751 BXGD011494 Vascular inflammations Cardiovascular Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1708349 BXGD013597 Hereditary Diffuse Gastric Cancer Digestive System Diseases; Neoplasms
C1868773 BXGD016535 Diabetic encephalopathy
C1960398 BXGD016658 HER2-positive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C2945695 BXGD018187 Limb ischemia
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0020212 Cinobufagin 442.24
BXGC0022167 Bufalin 386.25
BXGC0036734 Desacetylbufotalin 402.24
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein