Showing entry for Histone H4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011457
Protein NameHistone H4
Uniport IdP62805
GeneH4C1
Gene Id121504;554313;8294;8359;8360;8361;8362;8363;8364;8365;8366;8367;8368;8370
DomainCENP-T_C
Pfam PF15511  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.5 Substance dependence hsa05034 Alcoholism
6. Human Diseases 6.1 Cancers: Overview hsa05203 Viral carcinogenesis
6. Human Diseases 6.3 Immune diseases hsa05322 Systemic lupus erythematosus
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0044267 cellular protein metabolic process
Biological Process GO:0034080 CENP-A containing nucleosome assembly
Biological Process GO:0006335 DNA replication-dependent nucleosome assembly
Biological Process GO:0006336 DNA replication-independent nucleosome assembly
Biological Process GO:0006352 DNA-templated transcription, initiation
Biological Process GO:0006303 double-strand break repair via nonhomologous end joining
Biological Process GO:0045814 negative regulation of gene expression, epigenetic
Biological Process GO:0045653 negative regulation of megakaryocyte differentiation
Biological Process GO:0006334 nucleosome assembly
Biological Process GO:0000183 rDNA heterochromatin assembly
Biological Process GO:0060964 regulation of gene silencing by miRNA
Biological Process GO:0045652 regulation of megakaryocyte differentiation
Biological Process GO:0016233 telomere capping
Biological Process GO:0032200 telomere organization
molecular function GO:0003677 DNA binding
molecular function GO:0019904 protein domain specific binding
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0003723 RNA binding
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0042025 host cell nucleus
cellular component GO:0016020 membrane
cellular component GO:0000228 nuclear chromosome
cellular component GO:0000784 nuclear chromosome, telomeric region
cellular component GO:0000788 nuclear nucleosome
cellular component GO:0005654 nucleoplasm
cellular component GO:0000786 nucleosome
cellular component GO:0005634 nucleus
cellular component GO:0032991 protein-containing complex
Reactome
Pathway Id Pathway Name
R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine
R-HSA-110329 Cleavage of the damaged pyrimidine
R-HSA-110330 Recognition and association of DNA glycosylase with site containing an affected purine
R-HSA-110330 Recognition and association of DNA glycosylase with site containing an affected purine
R-HSA-110331 Cleavage of the damaged purine
R-HSA-110331 Cleavage of the damaged purine
R-HSA-1221632 Meiotic synapsis
R-HSA-1266738 Developmental Biology
R-HSA-1474165 Reproduction
R-HSA-1500620 Meiosis
R-HSA-157118 Signaling by NOTCH
R-HSA-157579 Telomere Maintenance
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-1640170 Cell Cycle
R-HSA-1640170 Cell Cycle
R-HSA-1643685 Disease
R-HSA-171306 Packaging Of Telomere Ends
R-HSA-1912408 Pre-NOTCH Transcription and Translation
R-HSA-1912422 Pre-NOTCH Expression and Processing
R-HSA-194315 Signaling by Rho GTPases
R-HSA-195258 RHO GTPase Effectors
R-HSA-195721 Signaling by WNT
R-HSA-195721 Signaling by WNT
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex
R-HSA-211000 Gene Silencing by RNA
R-HSA-212165 Epigenetic regulation of gene expression
R-HSA-212165 Epigenetic regulation of gene expression
R-HSA-212300 PRC2 methylates histones and DNA
R-HSA-212436 Generic Transcription Pathway
R-HSA-212436 Generic Transcription Pathway
R-HSA-2262752 Cellular responses to stress
R-HSA-2299718 Condensation of Prophase Chromosomes
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-2559583 Cellular Senescence
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence
R-HSA-2990846 SUMOylation
R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins
R-HSA-3214815 HDACs deacetylate histones
R-HSA-3214841 PKMTs methylate histone lysines
R-HSA-3214842 HDMs demethylate histones
R-HSA-3214847 HATs acetylate histones
R-HSA-3214847 HATs acetylate histones
R-HSA-3214858 RMTs methylate histone arginines
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-392499 Metabolism of proteins
R-HSA-427359 SIRT1 negatively regulates rRNA expression
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4839726 Chromatin organization
R-HSA-4839726 Chromatin organization
R-HSA-5250913 Positive epigenetic regulation of rRNA expression
R-HSA-5250913 Positive epigenetic regulation of rRNA expression
R-HSA-5250924 B-WICH complex positively regulates rRNA expression
R-HSA-5250941 Negative epigenetic regulation of rRNA expression
R-HSA-5250941 Negative epigenetic regulation of rRNA expression
R-HSA-5334118 DNA methylation
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-5619507 Activation of HOX genes during differentiation
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-HSA-5663205 Infectious disease
R-HSA-5693532 DNA Double-Strand Break Repair
R-HSA-5693538 Homology Directed Repair
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
R-HSA-5693571 Nonhomologous End-Joining (NHEJ)
R-HSA-5693606 DNA Double Strand Break Response
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-597592 Post-translational protein modification
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-68875 Mitotic Prophase
R-HSA-68886 M Phase
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-69473 G2/M DNA damage checkpoint
R-HSA-69481 G2/M Checkpoints
R-HSA-69620 Cell Cycle Checkpoints
R-HSA-73728 RNA Polymerase I Promoter Opening
R-HSA-73772 RNA Polymerase I Promoter Escape
R-HSA-73854 RNA Polymerase I Promoter Clearance
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-73864 RNA Polymerase I Transcription
R-HSA-73884 Base Excision Repair
R-HSA-73884 Base Excision Repair
R-HSA-73886 Chromosome Maintenance
R-HSA-73894 DNA Repair
R-HSA-73894 DNA Repair
R-HSA-73927 Depurination
R-HSA-73927 Depurination
R-HSA-73928 Depyrimidination
R-HSA-73929 Base-Excision Repair, AP Site Formation
R-HSA-73929 Base-Excision Repair, AP Site Formation
R-HSA-74160 Gene expression (Transcription)
R-HSA-74160 Gene expression (Transcription)
R-HSA-774815 Nucleosome assembly
R-HSA-8878171 Transcriptional regulation by RUNX1
R-HSA-8878171 Transcriptional regulation by RUNX1
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-HSA-8939211 ESR-mediated signaling
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-9018519 Estrogen-dependent gene expression
R-HSA-912446 Meiotic recombination
R-HSA-9609646 HCMV Infection
R-HSA-9609690 HCMV Early Events
R-HSA-9610379 HCMV Late Events
R-HSA-9616222 Transcriptional regulation of granulopoiesis
R-HSA-9670095 Inhibition of DNA recombination at telomere
R-HSA-977225 Amyloid fiber formation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004135 BXGD000257 Ataxia Telangiectasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0023418 BXGD001642 leukemia Neoplasms
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023465 BXGD001656 Acute monocytic leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0024131 BXGD001736 Lupus Vulgaris Infections; Skin and Connective Tissue Diseases
C0024138 BXGD001738 Lupus Erythematosus, Discoid Skin and Connective Tissue Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024305 BXGD001763 Lymphoma, Non-Hodgkin Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027794 BXGD002036 Neural Tube Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0029925 BXGD002181 Ovarian Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0035372 BXGD002544 Rett Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0036220 BXGD002587 Kaposi Sarcoma Neoplasms; Infections
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0153633 BXGD003674 Malignant neoplasm of brain Neoplasms; Nervous System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206754 BXGD004289 Neuroendocrine Tumors Neoplasms
C0220605 BXGD004294 Adult Non-Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0220612 BXGD004296 Childhood Non-Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238288 BXGD004905 Muscular Dystrophy, Facioscapulohumeral Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0278484 BXGD006511 Malignant neoplasm of colon stage IV Digestive System Diseases; Neoplasms
C0278504 BXGD006523 Non-small cell lung cancer stage I
C0278704 BXGD006567 Malignant Childhood Neoplasm Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0279680 BXGD006680 Transitional cell carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0409974 BXGD008401 Lupus Erythematosus Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Immune System Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0549493 BXGD009385 Alveolitis Skin and Connective Tissue Diseases; Respiratory Tract Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677936 BXGD009737 Refractory cancer Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0730328 BXGD009959 Central Serous Chorioretinopathy Eye Diseases
C0751606 BXGD010523 Adult Acute Lymphocytic Leukemia
C0849748 BXGD010890 caruncle Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0949541 BXGD011578 Hurthle Cell Tumor Neoplasms
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1270972 BXGD012006 Mild cognitive disorder Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1335468 BXGD012789 precancerous polyps
C1378050 BXGD012931 Oncocytic Neoplasm
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1510502 BXGD013175 Oxyphilic Adenoma Neoplasms
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1704272 BXGD013537 Benign Prostatic Hyperplasia Male Urogenital Diseases
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C1851710 BXGD015226 LATERAL MENINGOCELE SYNDROME Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1863753 BXGD016197 LIMB-MAMMARY SYNDROME Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1961102 BXGD016673 Precursor Cell Lymphoblastic Leukemia Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1961835 BXGD016676 Gaucher Disease, Type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2936719 BXGD018130 Mechanical Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3241937 BXGD018578 Nonalcoholic Steatohepatitis Digestive System Diseases
C3536893 BXGD019076 Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor Neoplasms
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3850141 BXGD019810 Acute-On-Chronic Liver Failure Digestive System Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4529962 BXGD023178 Fatty Liver Disease
C4721532 BXGD023752 Lymphoma, Non-Hodgkin, Familial Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0003705 Chloride 35.45
BXGC0004275 Acetaldehyde 44.05
BXGC0024661 Norleucine 131.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein