Showing entry for Calcium/calmodulin-dependent protein kinase type 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013437
Protein NameCalcium/calmodulin-dependent protein kinase type 1
Uniport IdQ14012
GeneCAMK1
Gene Id8536
DomainPkinase
Pfam PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04020 Calcium signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04921 Oxytocin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04925 Aldosterone synthesis and secretion
6. Human Diseases 6.2 Cancers: Specific types hsa05214 Glioma
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007049 cell cycle
Biological Process GO:0032091 negative regulation of protein binding
Biological Process GO:0006913 nucleocytoplasmic transport
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0060999 positive regulation of dendritic spine development
Biological Process GO:0051149 positive regulation of muscle cell differentiation
Biological Process GO:0010976 positive regulation of neuron projection development
Biological Process GO:0033138 positive regulation of peptidyl-serine phosphorylation
Biological Process GO:1901985 positive regulation of protein acetylation
Biological Process GO:0046827 positive regulation of protein export from nucleus
Biological Process GO:0071902 positive regulation of protein serine/threonine kinase activity
Biological Process GO:0051835 positive regulation of synapse structural plasticity
Biological Process GO:0060143 positive regulation of syncytium formation by plasma membrane fusion
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0051147 regulation of muscle cell differentiation
Biological Process GO:0043393 regulation of protein binding
Biological Process GO:0032880 regulation of protein localization
Biological Process GO:0007165 signal transduction
molecular function GO:0005524 ATP binding
molecular function GO:0005516 calmodulin binding
molecular function GO:0004683 calmodulin-dependent protein kinase activity
molecular function GO:0004674 protein serine/threonine kinase activity
cellular component GO:0005829 cytosol
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0005634 nucleus
cellular component GO:0014069 postsynaptic density
Reactome
Pathway Id Pathway Name
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-112316 Neuronal System
R-HSA-438064 Post NMDA receptor activation events
R-HSA-438064 Post NMDA receptor activation events
R-HSA-442755 Activation of NMDA receptors and postsynaptic events
R-HSA-442755 Activation of NMDA receptors and postsynaptic events
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission
R-HSA-9619229 Activation of RAC1 downstream of NMDARs
R-HSA-9619229 Activation of RAC1 downstream of NMDARs
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006413 BXGD000397 Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0278510 BXGD006526 Childhood Medulloblastoma Neoplasms
C0278764 BXGD006581 Adult Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0278876 BXGD006607 Adult Medulloblastoma Neoplasms
C0278879 BXGD006610 Childhood Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0278883 BXGD006614 Metastatic melanoma Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000655 Harmalol 200.24
BXGC0001544 Harmaline 214.26
BXGC0001545 Harmine 212.25
BXGC0007014 Harman 182.22
BXGC0012352 Chelerythrine 348.12
BXGC0024554 D-luciferin 280
BXGC0034256 Rottlerin 516.18
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
BXGC0050099 (2E,5S,6S,8Z,11S)-5,6,15-Trihydroxy-17-Methoxy-11-Methyl-12-Oxabicyclo[12.4.0]Octadeca-1(14),2,8,15,17-Pentaene-7,13-Dione 362.14
BXGC0051873 Sl-0101 516.13
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein