Showing entry for HLA class II histocompatibility antigen, DR beta 5 chain


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT014296
Protein NameHLA class II histocompatibility antigen, DR beta 5 chain
Uniport IdQ30154
GeneHLA-DRB5
Gene Id3127
DomainC1-set; MHC_II_beta
Pfam PF07654   PF00969  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04145 Phagosome
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04514 Cell adhesion molecules (CAMs)
5. Organismal Systems 5.1 Immune system hsa04612 Antigen processing and presentation
5. Organismal Systems 5.1 Immune system hsa04640 Hematopoietic cell lineage
5. Organismal Systems 5.1 Immune system hsa04658 Th1 and Th2 cell differentiation
5. Organismal Systems 5.1 Immune system hsa04659 Th17 cell differentiation
5. Organismal Systems 5.1 Immune system hsa04672 Intestinal immune network for IgA production
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04940 Type I diabetes mellitus
6. Human Diseases 6.10 Infectious diseases: Parasitic hsa05140 Leishmaniasis
6. Human Diseases 6.10 Infectious diseases: Parasitic hsa05145 Toxoplasmosis
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05150 Staphylococcus aureus infection
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05152 Tuberculosis
6. Human Diseases 6.9 Infectious diseases: Viral hsa05164 Influenza A
6. Human Diseases 6.9 Infectious diseases: Viral hsa05166 Human T-cell leukemia virus 1 infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05168 Herpes simplex virus 1 infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05169 Epstein-Barr virus infection
6. Human Diseases 6.3 Immune diseases hsa05310 Asthma
6. Human Diseases 6.3 Immune diseases hsa05320 Autoimmune thyroid disease
6. Human Diseases 6.3 Immune diseases hsa05321 Inflammatory bowel disease (IBD)
6. Human Diseases 6.3 Immune diseases hsa05322 Systemic lupus erythematosus
6. Human Diseases 6.3 Immune diseases hsa05323 Rheumatoid arthritis
6. Human Diseases 6.3 Immune diseases hsa05330 Allograft rejection
6. Human Diseases 6.3 Immune diseases hsa05332 Graft-versus-host disease
6. Human Diseases 6.6 Cardiovascular diseases hsa05416 Viral myocarditis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002250 adaptive immune response
Biological Process GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
Biological Process GO:0060333 interferon-gamma-mediated signaling pathway
Biological Process GO:0050852 T cell receptor signaling pathway
molecular function GO:0042605 peptide antigen binding
cellular component GO:0030669 clathrin-coated endocytic vesicle membrane
cellular component GO:0030666 endocytic vesicle membrane
cellular component GO:0012507 ER to Golgi transport vesicle membrane
cellular component GO:0070062 extracellular exosome
cellular component GO:0000139 Golgi membrane
cellular component GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane
cellular component GO:0031902 late endosome membrane
cellular component GO:0005765 lysosomal membrane
cellular component GO:0042613 MHC class II protein complex
cellular component GO:0005886 plasma membrane
cellular component GO:0032588 trans-Golgi network membrane
cellular component GO:0030658 transport vesicle membrane
Reactome
Pathway Id Pathway Name
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1280218 Adaptive Immune System
R-HSA-168256 Immune System
R-HSA-202403 TCR signaling
R-HSA-202424 Downstream TCR signaling
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains
R-HSA-202430 Translocation of ZAP-70 to Immunological synapse
R-HSA-202433 Generation of second messenger molecules
R-HSA-2132295 MHC class II antigen presentation
R-HSA-388841 Costimulation by the CD28 family
R-HSA-389948 PD-1 signaling
R-HSA-877300 Interferon gamma signaling
R-HSA-913531 Interferon Signaling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007384 BXGD000463 Cataplexy Nervous System Diseases; Mental Disorders
C0008074 BXGD000519 Child Development Disorders, Pervasive Mental Disorders
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0011644 BXGD000744 Scleroderma Skin and Connective Tissue Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0014059 BXGD000881 Encephalomyelitis, Acute Disseminated Immune System Diseases; Nervous System Diseases
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0020517 BXGD001415 Hypersensitivity Immune System Diseases
C0020524 BXGD001418 Disorders of Excessive Somnolence Nervous System Diseases; Mental Disorders
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0026269 BXGD001897 Mitral Valve Stenosis Cardiovascular Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027404 BXGD001984 Narcolepsy Nervous System Diseases; Mental Disorders
C0027651 BXGD002009 Neoplasms Neoplasms
C0029134 BXGD002118 Optic Neuritis Eye Diseases; Nervous System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0035920 BXGD002570 Rubella Infections
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0040100 BXGD002840 Thymoma Neoplasms; Hemic and Lymphatic Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0086445 BXGD003285 Idiopathic Membranous Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0151450 BXGD003420 Secondary Sjögren's syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C0151517 BXGD003431 Complete atrioventricular block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0206062 BXGD004148 Lung Diseases, Interstitial Respiratory Tract Diseases
C0238669 BXGD004952 Aortic root dilatation Cardiovascular Diseases
C0276496 BXGD006426 Familial Alzheimer Disease (FAD) Nervous System Diseases; Mental Disorders
C0333307 BXGD006946 Superficial ulcer Pathological Conditions, Signs and Symptoms
C0494463 BXGD009029 Alzheimer Disease, Late Onset Nervous System Diseases; Mental Disorders
C0521585 BXGD009145 Gastrointestinal mucositis Digestive System Diseases; Stomatognathic Diseases
C0546126 BXGD009328 Acute Confusional Senile Dementia Nervous System Diseases; Mental Disorders
C0566602 BXGD009489 Primary sclerosing cholangitis Digestive System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0750900 BXGD010241 Alzheimer's Disease, Focal Onset Nervous System Diseases; Mental Disorders
C0750901 BXGD010242 Alzheimer Disease, Early Onset Nervous System Diseases; Mental Disorders
C0851578 BXGD010925 Sleep Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1318973 BXGD012407 Staphylococcus aureus infection Infections
C1527304 BXGD013266 Allergic Reaction Immune System Diseases
C1720983 BXGD013698 Channelopathies Pathological Conditions, Signs and Symptoms
C1857276 BXGD015688 Trichohepatoenteric Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C2985280 BXGD018223 Blood Protein Measurement
C3150275 BXGD018300 COMPLEMENT COMPONENT 2 DEFICIENCY
C3495559 BXGD018994 Juvenile arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3714757 BXGD019430 Juvenile rheumatoid arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3899844 BXGD020102 C4 Deficiency
C4049006 BXGD021912 Selective immunoglobulin A deficiency
C4543926 BXGD023281 Narcolepsy type 1 Nervous System Diseases; Mental Disorders
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein