Showing entry for Protein polybromo-1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT017611
Protein NameProtein polybromo-1
Uniport IdQ86U86
GenePBRM1
Gene Id55193
DomainBAH; Bromodomain; HMG_box
Pfam PF01426   PF00439   PF00505  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.2 Cancers: Specific types hsa05225 Hepatocellular carcinoma
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0043044 ATP-dependent chromatin remodeling
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0000278 mitotic cell cycle
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0006337 nucleosome disassembly
Biological Process GO:0006368 transcription elongation from RNA polymerase II promoter
molecular function GO:0003682 chromatin binding
molecular function GO:0003677 DNA binding
cellular component GO:0000228 nuclear chromosome
cellular component GO:0005654 nucleoplasm
cellular component GO:0016586 RSC-type complex
Reactome
Pathway Id Pathway Name
R-HSA-212436 Generic Transcription Pathway
R-HSA-3214858 RMTs methylate histone arginines
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-4839726 Chromatin organization
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-8878171 Transcriptional regulation by RUNX1
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007398 BXGD000465 Catatonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0014772 BXGD000948 Red Blood Cell Count measurement
C0018798 BXGD001223 Congenital Heart Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0019562 BXGD001336 Von Hippel-Lindau Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Cardiovascular Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0021704 BXGD001510 Intelligence Behavior and Behavior Mechanisms
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0035204 BXGD002511 Respiration Disorders Respiratory Tract Diseases
C0035242 BXGD002521 Respiratory Tract Diseases Respiratory Tract Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0037369 BXGD002691 Smoking Behavior and Behavior Mechanisms
C0040100 BXGD002840 Thymoma Neoplasms; Hemic and Lymphatic Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0149721 BXGD003349 Left Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0153452 BXGD003647 Malignant neoplasm of gallbladder Digestive System Diseases; Neoplasms
C0153690 BXGD003684 Secondary malignant neoplasm of bone Pathological Conditions, Signs and Symptoms; Neoplasms; Musculoskeletal Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205682 BXGD004105 Waist-Hip Ratio
C0205969 BXGD004143 Thymic Carcinoma Neoplasms; Hemic and Lymphatic Diseases
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0220668 BXGD004317 Congenital contractural arachnodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0235782 BXGD004769 Gallbladder Carcinoma Digestive System Diseases; Neoplasms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0277524 BXGD006468 Infectious colitis Digestive System Diseases
C0278678 BXGD006556 Metastatic Renal Cell Cancer
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0345905 BXGD007746 Intrahepatic Cholangiocarcinoma Neoplasms
C0345967 BXGD007756 Malignant mesothelioma Neoplasms; Respiratory Tract Diseases
C0346255 BXGD007805 Oncocytoma, renal Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349204 BXGD007892 Nonorganic psychosis Mental Disorders
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0424621 BXGD008536 Body Fat Distribution
C0496956 BXGD009052 Neoplasm of uncertain or unknown behavior of breast Neoplasms; Skin and Connective Tissue Diseases
C0521158 BXGD009130 Recurrent tumor
C0525045 BXGD009255 Mood Disorders Mental Disorders
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598935 BXGD009674 Tumor Initiation Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0740457 BXGD010000 Malignant neoplasm of kidney Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0853879 BXGD010982 Invasive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C0858004 BXGD011168 Influenza A virus infection Infections; Respiratory Tract Diseases
C0858252 BXGD011172 Breast adenocarcinoma Neoplasms; Skin and Connective Tissue Diseases
C1266042 BXGD011938 Chromophobe Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1266043 BXGD011939 Sarcomatoid Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1266044 BXGD011940 Collecting Duct Carcinoma of the Kidney Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1301363 BXGD012292 Blastic plasmacytoid dendritic cell neoplasm Neoplasms; Skin and Connective Tissue Diseases
C1305855 BXGD012348 Body mass index
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1306837 BXGD012377 Papillary Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1334978 BXGD012753 Non-Hereditary Clear Cell Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1378703 BXGD012933 Renal carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1516490 BXGD013214 Cholangiolocellular Carcinoma Neoplasms
C1519383 BXGD013237 Smoking Behaviors Behavior and Behavior Mechanisms
C1839839 BXGD014416 MAJOR AFFECTIVE DISORDER 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Mental Disorders
C1852197 BXGD015264 MAJOR AFFECTIVE DISORDER 1 Mental Disorders
C1970943 BXGD016852 MAJOR AFFECTIVE DISORDER 4 Mental Disorders
C1970945 BXGD016853 MAJOR AFFECTIVE DISORDER 6 Mental Disorders
C2062441 BXGD016897 Influenza A
C2076602 BXGD016913 Influenza A (H3N2)
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2700366 BXGD017465 Adiponectin Measurement
C2700438 BXGD017469 MAJOR AFFECTIVE DISORDER 7 Mental Disorders
C2700439 BXGD017470 MAJOR AFFECTIVE DISORDER 8 Mental Disorders
C2700440 BXGD017471 MAJOR AFFECTIVE DISORDER 9 Mental Disorders
C2826323 BXGD017790 Refractory Cytopenia of Childhood
C2931852 BXGD018079 Clear-cell metastatic renal cell carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C2985280 BXGD018223 Blood Protein Measurement
C3805278 BXGD019474 Extrahepatic Cholangiocarcinoma Neoplasms
C3888391 BXGD019969 Nonnuclear polymorphic congenital cataract
C4045991 BXGD021888 Perihilar Cholangiocarcinoma Neoplasms
C4049938 BXGD021956 Physical Activity Measurement
C4284013 BXGD022428 Primary cholangiocarcinoma of intrahepatic biliary tract Neoplasms
C4509017 BXGD022965 Blastic plasmacytoid dendritic cell neoplasm (BPDCN)
C4518333 BXGD023017 Clear cell papillary renal cell carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C4525297 BXGD023131 Stage 0 Gallbladder Cancer AJCC v8
C4525300 BXGD023132 Stage IIA Gallbladder Cancer AJCC v8
C4525301 BXGD023133 Stage IIB Gallbladder Cancer AJCC v8
C4525302 BXGD023134 Stage III Gallbladder Cancer AJCC v8
C4525305 BXGD023135 Stage IV Gallbladder Cancer AJCC v8
C4551683 BXGD023389 Adrenal Gland Pheochromocytoma Neoplasms; Endocrine System Diseases
C4721698 BXGD023763 Metastatic Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0000528 Salicylic acid 138.12
BXGC0002591 Potassium 39.1
BXGC0002722 Nitrate 62
BXGC0003705 Chloride 35.45
BXGC0006198 Citric acid 192.12
BXGC0006635 Luteolin 286.24
BXGC0031118 N-methylpyrrolidone 99.07
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein