adisease

Showing entry for Thalassemia

General Disease Information
BXGD Id	BXGD002826
Disease Name	Thalassemia
Disease CUI Id	C0039730
MeSH Codes	C16 C15
Disease Class Name	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id	DOID:630
Disease Ontology Class Name	genetic disease
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O60674	BXGT004892	Tyrosine-protein kinase JAK2	3717	reviewed	Kinase
O60760	BXGT004899	Hematopoietic prostaglandin D synthase	27306	reviewed
O60885	BXGT004906	Bromodomain-containing protein 4	23476	reviewed	Epigenetic regulator
P00390	BXGT005526	Glutathione reductase, mitochondrial	2936	reviewed	Enzyme
P00441	BXGT005540	Superoxide dismutase [Cu-Zn]	6647	reviewed	Enzyme
P00734	BXGT005630	Prothrombin	2147	reviewed	Enzyme
P01008	BXGT005713	Antithrombin-III	462	reviewed	Enzyme modulator
P01009	BXGT005714	Alpha-1-antitrypsin	5265	reviewed	Enzyme modulator
P01034	BXGT005721	Cystatin-C	1471	reviewed
P01270	BXGT005746	Parathyroid hormone	5741	reviewed
P01275	BXGT005747	Glucagon	2641	reviewed
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01889	BXGT005809	HLA class I histocompatibility antigen, B-7 alpha chain	3106	reviewed
P01911	BXGT005816	HLA class II histocompatibility antigen, DRB1-15 beta chain	3123	reviewed	Immune response
P02008	BXGT005832	Hemoglobin subunit zeta	3050	reviewed
P02042	BXGT005834	Hemoglobin subunit delta	3045	reviewed
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P02730	BXGT005935	Band 3 anion transport protein	6521	reviewed	Transporter
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02751	BXGT005943	Fibronectin	2335	reviewed	Signaling
P02786	BXGT005961	Transferrin receptor protein 1	7037	reviewed	Enzyme
P05181	BXGT006337	Cytochrome P450 2E1	1571	reviewed
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05556	BXGT006368	Integrin beta-1	3688	reviewed	Receptor
P07225	BXGT006572	Vitamin K-dependent protein S	5627	reviewed
P08514	BXGT006781	Integrin alpha-IIb	3674	reviewed
P08684	BXGT006812	Cytochrome P450 3A4	1576	reviewed	Enzyme
P08700	BXGT006816	Interleukin-3	3562	reviewed
P09429	BXGT006889	High mobility group protein B1	3146	reviewed	Nucleic acid binding
P10747	BXGT007609	T-cell-specific surface glycoprotein CD28	940	reviewed
P11413	BXGT007701	Glucose-6-phosphate 1-dehydrogenase	2539	reviewed	Enzyme
P11473	BXGT007709	Vitamin D3 receptor	7421	reviewed	Nuclear receptor
P11498	BXGT007714	Pyruvate carboxylase, mitochondrial	5091	reviewed	Enzyme
P15529	BXGT008134	Membrane cofactor protein	4179	reviewed
P16410	BXGT008224	Cytotoxic T-lymphocyte protein 4	1493	reviewed
P16442	BXGT008227	Histo-blood group ABO system transferase	28	reviewed	Enzyme
P19224	BXGT008468	UDP-glucuronosyltransferase 1-6	54578	reviewed
P19320	BXGT008470	Vascular cell adhesion protein 1	7412	reviewed
P22309	BXGT008753	UDP-glucuronosyltransferase 1-1	54658	reviewed
P22310	BXGT008754	UDP-glucuronosyltransferase 1-4	54657	reviewed
P24298	BXGT008960	Alanine aminotransferase 1	2875	reviewed	Enzyme
P27695	BXGT009199	DNA-(apurinic or apyrimidinic site) lyase	328	reviewed
P28072	BXGT009231	Proteasome subunit beta type-6	5694	reviewed
P28908	BXGT009302	Tumor necrosis factor receptor superfamily member 8	943	reviewed
P29016	BXGT009304	T-cell surface glycoprotein CD1b	910	reviewed
P29017	BXGT009305	T-cell surface glycoprotein CD1c	911	reviewed
P35579	BXGT009852	Myosin-9	4627	reviewed
P46100	BXGT010508	Transcriptional regulator ATRX	546	reviewed
P49281	BXGT010689	Natural resistance-associated macrophage protein 2	4891	reviewed	Transporter
P52209	BXGT010923	6-phosphogluconate dehydrogenase, decarboxylating	5226	reviewed	Enzyme
P61769	BXGT011383	Beta-2-microglobulin	567	reviewed	Immune response
P68871	BXGT011615	Hemoglobin subunit beta	3043	reviewed
P69891	BXGT011646	Hemoglobin subunit gamma-1	3047	reviewed
P69892	BXGT011647	Hemoglobin subunit gamma-2	3048	reviewed
P69905	BXGT011649	Hemoglobin subunit alpha	3040	reviewed
P81172	BXGT011935	Hepcidin	57817	reviewed
Q01196	BXGT012575	Runt-related transcription factor 1	861	reviewed	Transcription factor
Q02083	BXGT012633	N-acylethanolamine-hydrolyzing acid amidase	27163	reviewed	Enzyme
Q13705	BXGT013393	Activin receptor type-2B	93	reviewed	Kinase
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q16595	BXGT013643	Frataxin, mitochondrial	2395	reviewed	Enzyme
Q30201	BXGT014297	Hereditary hemochromatosis protein	3077	reviewed
Q92900	BXGT019392	Regulator of nonsense transcripts 1	5976	reviewed	Enzyme
Q96IY4	BXGT019678	Carboxypeptidase B2	1361	reviewed	Enzyme
Q96KS0	BXGT019688	Egl nine homolog 2	112398	reviewed
Q9BX66	BXGT020158	Sorbin and SH3 domain-containing protein 1	10580	reviewed
Q9H6Z9	BXGT020488	Egl nine homolog 3	112399	reviewed
Q9HAW7	BXGT020508	UDP-glucuronosyltransferase 1-7	54577	reviewed
Q9HAW8	BXGT020509	UDP-glucuronosyltransferase 1-10	54575	reviewed
Q9HAW9	BXGT020510	UDP-glucuronosyltransferase 1-8	54576	reviewed
Q9NZD4	BXGT021271	Alpha-hemoglobin-stabilizing protein	51327	reviewed	Chaperone
Q9UHD8	BXGT021698	Septin-9	10801	reviewed	Enzyme modulator
Q9UIQ6	BXGT021721	Leucyl-cystinyl aminopeptidase	4012	reviewed	Enzyme
Q9UNN8	BXGT021791	Endothelial protein C receptor	10544	reviewed	Enzyme modulator
P04439	BXGT022649	HLA class I histocompatibility antigen, A-3 alpha chain	3105	reviewed
P00738	BXGT022874	Haptoglobin	3240	reviewed	Enzyme
P11836	BXGT025994	B-lymphocyte antigen CD20	931	reviewed	Receptor

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}