Showing entry for Regulatory-associated protein of mTOR


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT026091
Protein NameRegulatory-associated protein of mTOR
Uniport IdQ8N122
GeneRPTOR
Gene Id57521
DomainHEAT; Raptor_N; WD40
Pfam PF02985   PF14538   PF00400  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04136 Autophagy - other
4. Cellular Processes 4.1 Transport and catabolism hsa04140 Autophagy - animal
3. Environmental Information Processing 3.2 Signal transduction hsa04150 mTOR signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04151 PI3K-Akt signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04152 AMPK signaling pathway
5. Organismal Systems 5.9 Aging hsa04211 Longevity regulating pathway
5. Organismal Systems 5.9 Aging hsa04213 Longevity regulating pathway - multiple species
5. Organismal Systems 5.10 Environmental adaptation hsa04714 Thermogenesis
5. Organismal Systems 5.2 Endocrine system hsa04910 Insulin signaling pathway
6. Human Diseases 6.1 Cancers: Overview hsa05206 MicroRNAs in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007050 cell cycle arrest
Biological Process GO:0071230 cellular response to amino acid stimulus
Biological Process GO:0071233 cellular response to leucine
Biological Process GO:0031669 cellular response to nutrient levels
Biological Process GO:0009267 cellular response to starvation
Biological Process GO:0030307 positive regulation of cell growth
Biological Process GO:0001938 positive regulation of endothelial cell proliferation
Biological Process GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
Biological Process GO:0033138 positive regulation of peptidyl-serine phosphorylation
Biological Process GO:0010800 positive regulation of peptidyl-threonine phosphorylation
Biological Process GO:0071902 positive regulation of protein serine/threonine kinase activity
Biological Process GO:0032008 positive regulation of TOR signaling
Biological Process GO:0045945 positive regulation of transcription by RNA polymerase III
Biological Process GO:0010506 regulation of autophagy
Biological Process GO:0001558 regulation of cell growth
Biological Process GO:0008361 regulation of cell size
Biological Process GO:1900034 regulation of cellular response to heat
Biological Process GO:0016241 regulation of macroautophagy
Biological Process GO:0038202 TORC1 signaling
Biological Process GO:0031929 TOR signaling
Biological Process GO:0016032 viral process
molecular function GO:0071889 14-3-3 protein binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0030295 protein kinase activator activity
molecular function GO:0019901 protein kinase binding
molecular function GO:0030674 protein-macromolecule adaptor activity
molecular function GO:0030291 protein serine/threonine kinase inhibitor activity
molecular function GO:0001002 RNA polymerase III type 1 promoter sequence-specific DNA binding
molecular function GO:0001003 RNA polymerase III type 2 promoter sequence-specific DNA binding
molecular function GO:0001006 RNA polymerase III type 3 promoter sequence-specific DNA binding
molecular function GO:0001156 TFIIIC-class transcription factor complex binding
cellular component GO:0005737 cytoplasm
cellular component GO:0010494 cytoplasmic stress granule
cellular component GO:0005829 cytosol
cellular component GO:0030425 dendrite
cellular component GO:0005765 lysosomal membrane
cellular component GO:0005764 lysosome
cellular component GO:0043025 neuronal cell body
cellular component GO:0005654 nucleoplasm
cellular component GO:0031931 TORC1 complex
Reactome
Pathway Id Pathway Name
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-162582 Signal Transduction
R-HSA-1632852 Macroautophagy
R-HSA-165159 MTOR signalling
R-HSA-166208 mTORC1-mediated signalling
R-HSA-212436 Generic Transcription Pathway
R-HSA-2262752 Cellular responses to stress
R-HSA-3371556 Cellular response to heat stress
R-HSA-3371571 HSF1-dependent transactivation
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-6807070 PTEN Regulation
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-8943724 Regulation of PTEN gene transcription
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-9612973 Autophagy
R-HSA-9639288 Amino acids regulate mTORC1
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0005940 BXGD000352 Bone Diseases Musculoskeletal Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0008928 BXGD000576 Cleidocranial Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011311 BXGD000714 Dengue Fever Infections
C0017638 BXGD001132 Glioma Neoplasms
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019829 BXGD001350 Hodgkin Disease Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0020428 BXGD001377 Hyperaldosteronism Endocrine System Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021364 BXGD001500 Male infertility Male Urogenital Diseases
C0022806 BXGD001588 Kwashiorkor Nutritional and Metabolic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0026654 BXGD001914 Moyamoya Disease Nervous System Diseases; Cardiovascular Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027831 BXGD002047 Neurofibromatosis 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0028043 BXGD002066 Nicotine Dependence Chemically-Induced Disorders; Mental Disorders
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0035328 BXGD002537 Retinal Vein Occlusion Eye Diseases; Cardiovascular Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0037369 BXGD002691 Smoking Behavior and Behavior Mechanisms
C0039984 BXGD002832 Thoracic Outlet Syndrome Nervous System Diseases; Cardiovascular Diseases
C0040332 BXGD002858 Tobacco Dependence Chemically-Induced Disorders; Mental Disorders
C0041341 BXGD002918 Tuberous Sclerosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0151517 BXGD003431 Complete atrioventricular block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0162674 BXGD003973 Chronic progressive external ophthalmoplegia Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Eye Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0264511 BXGD005396 Lymphoid interstitial pneumonia Respiratory Tract Diseases
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376384 BXGD007995 Nicotine Use Disorder Chemically-Induced Disorders; Mental Disorders
C0426799 BXGD008578 Congenital hypoplasia of clavicle Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0428886 BXGD008640 Mean blood pressure
C0521585 BXGD009145 Gastrointestinal mucositis Digestive System Diseases; Stomatognathic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0751651 BXGD010539 Mitochondrial Diseases Nutritional and Metabolic Diseases
C0871470 BXGD011316 Systolic Pressure
C1269955 BXGD012005 Tumor Cell Invasion
C1305855 BXGD012348 Body mass index
C1314691 BXGD012388 Age at menarche Behavior and Behavior Mechanisms
C2931384 BXGD018014 Moyamoya disease 1 Nervous System Diseases; Cardiovascular Diseases
C2985280 BXGD018223 Blood Protein Measurement
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3714514 BXGD019409 Infection Infections
C4551683 BXGD023389 Adrenal Gland Pheochromocytoma Neoplasms; Endocrine System Diseases
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002953 2-Phenethyl isothiocyanate 163.24
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein