Showing entry for Galangin


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0000363
Compound NameGalangin
Structure
FormulaC15H10O5
InchiKeyVCCRNZQBSJXYJD-UHFFFAOYSA-N
SMILESOC1=CC(O)=C2C(OC(=C(O)C2=O)C2=CC=CC=C2)=C1
InchiInChI=1S/C15H10O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,16-17,19H
IUPAC3,5,7-trihydroxy-2-phenyl-4H-chromen-4-one
Molecular Weight270.24
Pubchem Id5281616
Chembl IdCHEMBL309490
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 50049391
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT012099 Mitochondrial import inner membrane translocase subunit TIM10 reviewed TIM10 - >100000 - -
reviewed BXGT019667 Aurora kinase B reviewed Kinase AURKB - 9800 - -
reviewed BXGT021247 Dipeptidyl peptidase 3 reviewed Enzyme DPP3 - 23400 - -
reviewed BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A 18100 - - -
reviewed BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A 33000 - - -
reviewed BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 589 - - -
reviewed BXGT009437 Adenosine receptor A2a reviewed Adora2a 966 - - -
reviewed BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 3150 - - -
reviewed BXGT009016 Adenosine receptor A1 reviewed Adora1 863 - - -
reviewed BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK - 8 - -
reviewed BXGT008651 ATP-dependent translocase ABCB1 reviewed Abcb1a - - 5900 -
reviewed BXGT005690 Carbonic anhydrase 2 reviewed CA2 >10000 - - -
reviewed BXGT005689 Carbonic anhydrase 1 reviewed CA1 >10000 - - -
reviewed BXGT008802 Carbonic anhydrase 4 reviewed CA4 568 - - -
reviewed BXGT010364 Carbonic anhydrase 7 reviewed CA7 25 - - -
reviewed BXGT004601 Carbonic anhydrase 12 reviewed CA12 42 - - -
reviewed BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP - >500000 - -
reviewed BXGT004563 Polyphenol oxidase 2 reviewed PPO2 - >100000 - -
reviewed BXGT007329 DNA gyrase subunit A reviewed gyrA - >1850000 - -
reviewed BXGT006265 Cytochrome P450 1A1 reviewed Enzyme CYP1A1 - 77 - -
reviewed BXGT013656 Cytochrome P450 1B1 reviewed Enzyme CYP1B1 - 25 - -
reviewed BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A 16700 - - -
reviewed BXGT010602 Xanthine dehydrogenase/oxidase reviewed Enzyme XDH - 1800 - -
reviewed BXGT007717 Aromatase reviewed Enzyme CYP19A1 100000 - - -
reviewed BXGT006430 Cholinesterase reviewed BCHE 6900 - - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE 85600 - - -
reviewed BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 - - 5888 -
reviewed BXGT009938 Receptor-type tyrosine-protein kinase FLT3 reviewed Kinase FLT3 - >10000 - -
CHEMBL CHEMBL309490
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P87108 BXGT012099 Mitochondrial import inner membrane translocase subunit TIM10 reviewed - TIM10 IC50 '=' 35500 nM
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR EC150 '=' 633 uM
O75874 BXGT005157 Isocitrate dehydrogenase [NADP] cytoplasmic reviewed - IDH1 Activity '=' 89 %
P06276 BXGT006430 Cholinesterase reviewed - BCHE Ki '=' 6900 nM
P54855 BXGT011088 UDP-glucuronosyltransferase 2B15 reviewed - UGT2B15 Activity '=' 65 pm/min/mg
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 15848 nM
Q04206 BXGT012754 Transcription factor p65 reviewed Transcription factor RELA Inhibition - - -
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit reviewed Transcription factor NFKB1 Inhibition - - -
Q00653 BXGT012541 Nuclear factor NF-kappa-B p100 subunit reviewed Transcription factor NFKB2 Inhibition - - -
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 EC150 '=' 633 uM
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 IC50 '=' 40 nM
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 pKi(uM) '=' 0 -
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki '=' 33000 nM
Q965D5 BXGT019600 Enoyl-acyl-carrier protein reductase unreviewed - fabI Activity - - -
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 39810 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 39810 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Potency '=' 3981 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 17782 nM
P84022 BXGT012027 Mothers against decapentaplegic homolog 3 reviewed Transcription factor SMAD3 Potency - 35481 nM
Q965D6 BXGT019601 3-oxoacyl-acyl-carrier protein reductase unreviewed - fabG IC50 '=' 100000 nM
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Inhibition '=' 28 %
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki '=' 18100 nM
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK IC50 '=' 80 ug.mL-1
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 11220 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 11220 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 14581 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 11220 nM
P87108 BXGT012099 Mitochondrial import inner membrane translocase subunit TIM10 reviewed - TIM10 IC50 '>' 100000 nM
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a Ki '=' 966 nM
P29276 BXGT009329 Adenosine receptor A2b reviewed - Adora2b Ki '=' 966 nM
O60656 BXGT004889 UDP-glucuronosyltransferase 1-9 reviewed - UGT1A9 Activity '=' 2500 pm/min/mg
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Inhibition '=' 38 %
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 IC50 '>' 100000 nM
P0AES4 BXGT007329 DNA gyrase subunit A reviewed - gyrA IC50 '>' 500 ug.mL-1
P0AES6 BXGT007331 DNA gyrase subunit B reviewed - gyrB IC50 '>' 500 ug.mL-1
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 Ki '=' 863 nM
P21447 BXGT008651 ATP-dependent translocase ABCB1 reviewed - Abcb1a Kd '=' 5900 nM
Q86831 BXGT017584 Polyprotein II unreviewed - Inhibition '=' 42 %
P11388 BXGT007697 DNA topoisomerase 2-alpha reviewed - TOP2A Activity - - -
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a pKi(uM) - - -
Q965D7 BXGT019602 Beta-hydroxyacyl-ACP dehydratase unreviewed - fabZ Activity - - -
P21447 BXGT008651 ATP-dependent translocase ABCB1 reviewed - Abcb1a Delta Fmax '=' 95 %
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Inhibition '=' 22 %
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Inhibition '=' 34 %
P38398 BXGT010037 Breast cancer type 1 susceptibility protein reviewed Enzyme BRCA1 Potency - 22387 nM
P04798 BXGT006265 Cytochrome P450 1A1 reviewed Enzyme CYP1A1 IC50 '=' 77 nM
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Activity - - -
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Activity - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Ki '=' 85600 nM
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 Ki '=' 3150 nM
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Inhibition '=' 26 %
P47989 BXGT010602 Xanthine dehydrogenase/oxidase reviewed Enzyme XDH IC50 '=' 1800 nM
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 89125 nM
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki '=' 16700 nM
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 pKi(uM) - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Potency '=' 3162 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Potency '=' 19952 nM
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a Ki '=' 966 nM
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Activity '=' 80 pm/min/mg
O94925 BXGT005342 Glutaminase kidney isoform, mitochondrial reviewed Enzyme GLS Potency - 12589 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Activity - - -
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Ki '>' 10000 nM
O75795 BXGT005152 UDP-glucuronosyltransferase 2B17 reviewed - UGT2B17 Activity - - -
P22310 BXGT008754 UDP-glucuronosyltransferase 1-4 reviewed - UGT1A4 Activity '=' 0 pm/min/mg
P11511 BXGT007717 Aromatase reviewed Enzyme CYP19A1 Ki '=' 100000 nM
P28647 BXGT009282 Adenosine receptor A3 reviewed - Adora3 Ratio '=' 0 -
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 Ratio '=' 0 -
P03126 BXGT006024 Protein E6 reviewed - E6 Inhibition - - -
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 32642 nM
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Activity '=' 115 pm/min/mg
P19224 BXGT008468 UDP-glucuronosyltransferase 1-6 reviewed - UGT1A6 Activity '=' 0 pm/min/mg
P35503 BXGT009840 UDP-glucuronosyltransferase 1-3 reviewed - UGT1A3 Activity '=' 610 pm/min/mg
P32897 BXGT009676 Mitochondrial import inner membrane translocase subunit TIM23 reviewed - TIM23 IC50 '=' 8560 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 12990 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 18837 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 29855 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE Inhibition '=' 2 %
P36888 BXGT009938 Receptor-type tyrosine-protein kinase FLT3 reviewed Kinase FLT3 IC50 '>' 10000 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 12 nM
Q16678 BXGT013656 Cytochrome P450 1B1 reviewed Enzyme CYP1B1 IC50 '=' 25 nM
P27338 BXGT009172 Amine oxidase [flavin-containing] B reviewed - MAOB IC50 '=' 3650 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP IC50 '>' 500000 nM
Q02880 BXGT012677 DNA topoisomerase 2-beta reviewed - TOP2B CC50 - - -
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Kd '=' 5888 nM
Q15118 BXGT013540 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial reviewed Kinase PDK1 Inhibition - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 25929 nM
O75874 BXGT005157 Isocitrate dehydrogenase [NADP] cytoplasmic reviewed - IDH1 Activity '=' 95 %
P43166 BXGT010364 Carbonic anhydrase 7 reviewed - CA7 Ki '=' 24 nM
P00915 BXGT005689 Carbonic anhydrase 1 reviewed - CA1 Ki '>' 10000 nM
Q15118 BXGT013540 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial reviewed Kinase PDK1 Inhibition '=' 8 %
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' 6 %
P22748 BXGT008802 Carbonic anhydrase 4 reviewed - CA4 Ki '=' 568 nM
O43570 BXGT004601 Carbonic anhydrase 12 reviewed - CA12 Ki '=' 41 nM
Q4QEW7 BXGT014876 Dihydroorotate dehydrogenase (fumarate) unreviewed - DHODH IC50 '=' 501187 nM
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA IC50 '=' 130 nM
Q16678 BXGT013656 Cytochrome P450 1B1 reviewed Enzyme CYP1B1 IC50 '=' 3 nM
Q4QEW7 BXGT014876 Dihydroorotate dehydrogenase (fumarate) unreviewed - DHODH IC50 '=' 480600 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00102 Mexican oregano Lippia graveolens Herbs and Spices
BXGF00199 Gram bean Vigna mungo Pulses
BXGF00503 Rowal Pangium edule Herbs and Spices
BXGF00818 Herbs and Spices Herbs and Spices
BXGF00857 Mitracarpus scaber Mitracarpus scaber Others
BXGF00900 Melaleuca cuticularis Melaleuca cuticularis Others
BXGF01051 Callicarpa japonica Callicarpa japonica Medicinal Plant
BXGF01061 Avrainvillea longicaulis Avrainvillea longicaulis Others
BXGF01104 Garcinia cambogia Garcinia cambogia Medicinal Plant
BXGF01252 Petasites laevigatus Petasites laevigatus Medicinal Plant
BXGF01404 Sphaeranthus confertifolius Sphaeranthus confertifolius Others
BXGF01556 Ornithoglossum viride Ornithoglossum viride Others
BXGF01599 Helichrysum cephaloideum Helichrysum cephaloideum Medicinal Plant
BXGF01606 Schizanthus tricolor Schizanthus tricolor Others
BXGF01631 Anodendron affine Anodendron affine Medicinal Plant
BXGF01669 Hertia cheirifolia Hertia cheirifolia Others
BXGF01684 Hemionitis japonica Hemionitis japonica Others
BXGF01720 Cedrela salvadorensis Cedrela salvadorensis Others
BXGF01793 Sedum obtuso-lineare Sedum obtuso-lineare Others
BXGF01890 Trollius chinensis Trollius chinensis Medicinal Plant
BXGF02053 Hypericum balearicum Hypericum balearicum Others
BXGF02199 Bryum argenteum Bryum argenteum Medicinal Plant
BXGF02341 Euphorbia amygdaloides Euphorbia amygdaloides Medicinal Plant
BXGF02380 Entada phaseoloides Entada phaseoloides Medicinal Plant
BXGF02421 Hesperis matronalis Hesperis matronalis Medicinal Plant
BXGF02449 Jatropha macrorhiza Jatropha macrorhiza Others
BXGF02540 Jackiella javanica Jackiella javanica Medicinal Plant
BXGF02587 Rhus vulgaris Rhus vulgaris Human Edible Plant
BXGF02610 Cladrastis platycarpa Cladrastis platycarpa Others
BXGF02646 Eremanthus seidelii Eremanthus seidelii Others
BXGF02732 Senecio adenophyllus Senecio adenophyllus Others
BXGF02768 Lilium umbellatum Lilium umbellatum Others
BXGF02784 Artemisia rehan Artemisia rehan Others
BXGF02807 Elephantopus hirtiflorus Elephantopus hirtiflorus Others
BXGF02828 Nematolepis phebalioides Nematolepis phebalioides Others
BXGF02839 Solidago flexicaulis Solidago flexicaulis Human Edible Plant
BXGF02854 Ligularia cymbulifera Ligularia cymbulifera Others
BXGF02877 Coprosma areolata Coprosma areolata Medicinal Plant
BXGF02907 Oreopteris quelpaertensis Oreopteris quelpaertensis Others
BXGF02948 Viguiera linearis Viguiera linearis Others
BXGF03189 Rhododendron dauricum Rhododendron dauricum Medicinal Plant
BXGF03234 Plantago major Plantago major Medicinal Plant
BXGF03313 Magnolia montana Magnolia montana Medicinal Plant
BXGF03504 Sterculia foetida Sterculia foetida Medicinal Plant
BXGF03733 Alpinia officinarum Alpinia officinarum Medicinal Plant
BXGF04255 Gmelina asiatica Gmelina asiatica Medicinal Plant
BXGF04659 Phyllanthus emblica Phyllanthus emblica Medicinal Plant
BXGF04849 Pinus excelsa Pinus excelsa Medicinal Plant
BXGF04964 Chrysanthemum morifolium Chrysanthemum morifolium Medicinal Plant
BXGF05285 Aglaia formosana Aglaia formosana Others
BXGF05383 Alpinia galanga Alpinia galanga Medicinal Plant
BXGF05436 Rubia tetragona Rubia tetragona Others
BXGF05459 Vachellia pennatula Vachellia pennatula Medicinal Plant
BXGF05790 Glycyrrhiza uralensis Glycyrrhiza uralensis Medicinal Plant
BXGF05858 Ormosia hosiei Ormosia hosiei Medicinal Plant
BXGF06250 Licaria chrysophylla Licaria chrysophylla Others
BXGF06301 Oricia gabonensis Oricia gabonensis Others
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease