Showing entry for Eupafolin


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0001742
Compound NameEupafolin
Structure
FormulaC16H12O7
InchiKeyFHHSEFRSDKWJKJ-UHFFFAOYSA-N
SMILESCOC1=C(O)C2=C(OC(=CC2=O)C2=CC(O)=C(O)C=C2)C=C1O
InchiInChI=1S/C16H12O7/c1-22-16-11(20)6-13-14(15(16)21)10(19)5-12(23-13)7-2-3-8(17)9(18)4-7/h2-6,17-18,20-21H,1H3
IUPAC2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-methoxy-4H-chromen-4-one
Molecular Weight316.26
Pubchem Id5317284
Chembl IdCHEMBL172350
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 23412
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT006255 Alpha-amylase 1 reviewed AMY1A - 48000 - -
reviewed BXGT022194 Zinc finger protein mex-5 reviewed mex-5 - - - 36029
reviewed BXGT005431 M1 family aminopeptidase reviewed - - 15570 - -
reviewed BXGT020189 Serine/threonine-protein kinase 33 reviewed Kinase STK33 - - - 11000
reviewed BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 - 22200 - -
reviewed BXGT011014 Mitogen-activated protein kinase 10 reviewed Kinase MAPK10 - 15900 - -
reviewed BXGT005130 PC4 and SFRS1-interacting protein reviewed Signaling PSIP1 - 9885 - -
reviewed BXGT005130 PC4 and SFRS1-interacting protein reviewed Signaling PSIP1 - 1835 - -
reviewed BXGT012095 RNA-editing ligase 1, mitochondrial reviewed REL1 - >96559 - -
reviewed BXGT012692 Cyclin-dependent-like kinase 5 reviewed Cdk5 - - - 40000
CHEMBL CHEMBL172350
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 7079 nM
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed - XDH Inhibition '=' 49 %
O97447 BXGT005436 Putative fructose-1,6-bisphosphate aldolase unreviewed - ald Potency '=' 17740 nM
Q14191 BXGT013452 Werner syndrome ATP-dependent helicase reviewed Enzyme WRN Potency - 25118 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 14125 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 39810 nM
P06746 BXGT006496 DNA polymerase beta reviewed Enzyme POLB Potency '=' 6309 nM
Q8IEK1 BXGT018263 M1-family alanyl aminopeptidase unreviewed - PF3D7_1311800 IC50 '=' 15570 nM
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency - 4466 nM
P54132 BXGT011032 Bloom syndrome protein reviewed - BLM Potency '=' 44668 nM
Q9WV87 BXGT021945 NADPH oxidase 1 reviewed - Nox1 Activity '=' 80 %
P04745 BXGT006255 Alpha-amylase 1 reviewed - AMY1A Inhibition '=' 99 %
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 751 nM
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 50118 nM
O15118 BXGT004127 NPC intracellular cholesterol transporter 1 reviewed Transporter NPC1 Potency '=' 5623 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency '=' 6309 nM
Q9WV87 BXGT021945 NADPH oxidase 1 reviewed - Nox1 Activity '=' 24 %
Q9WV87 BXGT021945 NADPH oxidase 1 reviewed - Nox1 Activity '=' 41 %
Q9WV87 BXGT021945 NADPH oxidase 1 reviewed - Nox1 Activity '=' 50 %
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 7943 nM
P04062 BXGT006140 Lysosomal acid glucosylceramidase reviewed - GBA Potency - 25118 nM
O75164 BXGT005104 Lysine-specific demethylase 4A reviewed - KDM4A Potency - 31622 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 3162 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 23109 nM
P43220 BXGT010367 Glucagon-like peptide 1 receptor reviewed G-protein coupled receptor GLP1R Potency - 7943 nM
Q7ZJM1 BXGT017268 Integrase unreviewed - pol IC50 '=' 94300 nM
P10828 BXGT007624 Thyroid hormone receptor beta reviewed Nuclear receptor THRB Potency '=' 50118 nM
Q9Y253 BXGT022216 DNA polymerase eta reviewed - POLH Potency - 3548 nM
P55789 BXGT011126 FAD-linked sulfhydryl oxidase ALR reviewed Enzyme GFER AC50 '=' 230 nM
P04745 BXGT006255 Alpha-amylase 1 reviewed - AMY1A IC50 '=' 48000 nM
Q03431 BXGT012714 Parathyroid hormone/parathyroid hormone-related peptide receptor reviewed G-protein coupled receptor PTH1R Potency - 44668 nM
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency - 1995 nM
Q63470 BXGT016073 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed - Dyrk1a AC50 '=' 12728 nM
Q962Y6 BXGT019597 Thioredoxin glutathione reductase unreviewed - TGR Potency '=' 39810 nM
Q7ZJM1 BXGT017268 Integrase unreviewed - pol IC50 '=' 39100 nM
O94925 BXGT005342 Glutaminase kidney isoform, mitochondrial reviewed Enzyme GLS Potency - 8912 nM
P84022 BXGT012027 Mothers against decapentaplegic homolog 3 reviewed Transcription factor SMAD3 Potency - 7943 nM
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - Potency - 19011 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 10000 nM
Q9UIF8 BXGT021718 Bromodomain adjacent to zinc finger domain protein 2B reviewed - BAZ2B Potency - 50118 nM
Q9HC16 BXGT020525 DNA dC->dU-editing enzyme APOBEC-3G reviewed Enzyme APOBEC3G Potency - 35481 nM
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 11220 nM
P86926 BXGT012095 RNA-editing ligase 1, mitochondrial reviewed - REL1 IC50 '>' 96559 nM
Q9XUB2 BXGT022194 Zinc finger protein mex-5 reviewed - mex-5 EC50 '=' 36029 nM
G5EF15 BXGT003524 Cytoplasmic zinc-finger protein unreviewed - pos-1 EC50 '=' 93141 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 20587 nM
P07378 BXGT006616 Phosphoglycerate kinase, glycosomal reviewed - Potency - 31622 nM
O95398 BXGT005378 Rap guanine nucleotide exchange factor 3 reviewed Enzyme modulator RAPGEF3 Potency - 50118 nM
P11021 BXGT007644 Endoplasmic reticulum chaperone BiP reviewed - HSPA5 Potency - 19952 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 12589 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 12589 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 18356 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency - 50118 nM
Q03114 BXGT012692 Cyclin-dependent-like kinase 5 reviewed - Cdk5 EC50 '=' 40000 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 5011 nM
P10253 BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA Potency '=' 10000 nM
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 17782 nM
P11021 BXGT007644 Endoplasmic reticulum chaperone BiP reviewed - HSPA5 Potency - 44668 nM
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 reviewed - PIN1 Potency - 39810 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 12589 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 12990 nM
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 8912 nM
Q9WV87 BXGT021945 NADPH oxidase 1 reviewed - Nox1 Activity '=' 64 %
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 50118 nM
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 19952 nM
P55212 BXGT011112 Caspase-6 reviewed Enzyme CASP6 AC50 '=' 29320 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00010 Lemon verbena Aloysia triphylla Herbs and Spices
BXGF00159 Rosemary Rosmarinus officinalis Herbs and Spices
BXGF00165 Common sage Salvia officinalis Herbs and Spices
BXGF00170 Sesame Sesamum orientale Herbs and Spices
BXGF00269 Asian pear Pyrus pyrifolia Fruits
BXGF00422 Mamey sapote Pouteria sapota Fruits
BXGF00870 Othonna sedifolia Othonna sedifolia Others
BXGF00945 Chrysanthemum sinense Chrysanthemum sinense Others
BXGF01065 Artemisia capillaris Artemisia capillaris Medicinal Plant
BXGF01109 Styrax benzoin Styrax benzoin Medicinal Plant
BXGF01145 Pterocarpus officinalis Pterocarpus officinalis Medicinal Plant
BXGF01177 Vernonia lanuginosa Vernonia lanuginosa Others
BXGF01188 Calycanthus floridus Calycanthus floridus Medicinal Plant
BXGF01319 Adenia globosa Adenia globosa Others
BXGF01403 Aglaia grandis Aglaia grandis Medicinal Plant
BXGF01433 Catunaregam tomentosa Catunaregam tomentosa Human Edible Plant
BXGF01461 Liriodendron tulipifera Liriodendron tulipifera Medicinal Plant
BXGF01467 Torreya fargesii var. yunnanensis Torreya fargesii var. yunnanensis Medicinal Plant
BXGF01629 Satureja odora Satureja odora Medicinal Plant
BXGF01681 Barleria acanthoides Barleria acanthoides Medicinal Plant
BXGF01748 Dacryodes normandii Dacryodes normandii Others
BXGF01750 Leucaena leucocephala Leucaena leucocephala Medicinal Plant
BXGF01790 Riccia fluitans Riccia fluitans Others
BXGF01826 Hypericum hirsutum Hypericum hirsutum Medicinal Plant
BXGF01952 Senecio microglossus Senecio microglossus Others
BXGF02118 Polygonatum prattii Polygonatum prattii Medicinal Plant
BXGF02129 Hunteria zeylanica Hunteria zeylanica Medicinal Plant
BXGF02175 Micromeria japonica Micromeria japonica Others
BXGF02245 Peperomia villipetiola Peperomia villipetiola Others
BXGF02272 Muraltia heisteria Muraltia heisteria Medicinal Plant
BXGF02336 Marrubium globosum Marrubium globosum Others
BXGF02406 Selaginella apoda Selaginella apoda Others
BXGF02475 Uncaria sessilifructus Uncaria sessilifructus Medicinal Plant
BXGF02526 Santalum album Santalum album Medicinal Plant
BXGF02551 Inula britannica Inula britannica Medicinal Plant
BXGF02767 Aloe nobilis Aloe nobilis Others
BXGF02783 Hexalobus crispiflorus Hexalobus crispiflorus Medicinal Plant
BXGF02837 Tsuga heterophylla Tsuga heterophylla Medicinal Plant
BXGF02899 Euodia lunu-ankenda Euodia lunu-ankenda Others
BXGF03175 Pseudognaphalium affine Pseudognaphalium affine Others
BXGF03469 Vernonia pachyclada Vernonia pachyclada Others
BXGF04121 Cordia elaeagnoides Cordia elaeagnoides Others
BXGF04300 Tetrapanax papyrifer Tetrapanax papyrifer Medicinal Plant
BXGF04477 Artemisia vestita Artemisia vestita Medicinal Plant
BXGF04820 Panax ginseng Panax ginseng 0
BXGF05399 Zanthoxylum myriacanthum Zanthoxylum myriacanthum Medicinal Plant
BXGF05456 Anaphalis araneosa Anaphalis araneosa Others
BXGF05492 Bhesa nitidissima Bhesa nitidissima Others
BXGF05639 Mulguraea tridens Mulguraea tridens Others
BXGF05700 Crepis pygmaea Crepis pygmaea Others
BXGF05724 Rothmannia wittii Rothmannia wittii Medicinal Plant
BXGF05846 Ranzania japonica Ranzania japonica Others
BXGF05856 Isodon leucophyllus Isodon leucophyllus Medicinal Plant
BXGF05864 Ptelea viscosa Ptelea viscosa Others
BXGF05867 Asphodelus tenuifolius Asphodelus tenuifolius Medicinal Plant
BXGF05904 Impatiens edgeworthii Impatiens edgeworthii Others
BXGF05940 Artemisia kurramensis Artemisia kurramensis Others
BXGF05965 Episcia cupreata Episcia cupreata Others
BXGF06038 Eupatorium lindleyanum Eupatorium lindleyanum Medicinal Plant
BXGF06156 Inula japonica Inula japonica Medicinal Plant
BXGF06186 Jasonia candicans Jasonia candicans Others
BXGF06218 Siphocampylus foliosus Siphocampylus foliosus Others
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease