Showing entry for Complement C5


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005720
Protein NameComplement C5
Uniport IdP01031
GeneC5
Gene Id727
DomainA2M; A2M_BRD; A2M_recep; ANATO; MG1; MG2; MG3; MG4; NTR; TED_complement
Pfam PF00207   PF07703   PF07677   PF01821   PF17790   PF01835   PF17791   PF17789   PF01759   PF07678  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
5. Organismal Systems 5.1 Immune system hsa04610 Complement and coagulation cascades
6. Human Diseases 6.4 Neurodegenerative diseases hsa05020 Prion diseases
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05133 Pertussis
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05150 Staphylococcus aureus infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05168 Herpes simplex virus 1 infection
6. Human Diseases 6.3 Immune diseases hsa05322 Systemic lupus erythematosus
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0000187 activation of MAPK activity
Biological Process GO:0007166 cell surface receptor signaling pathway
Biological Process GO:0006935 chemotaxis
Biological Process GO:0006957 complement activation, alternative pathway
Biological Process GO:0006958 complement activation, classical pathway
Biological Process GO:0019835 cytolysis
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0006954 inflammatory response
Biological Process GO:0001701 in utero embryonic development
Biological Process GO:0010760 negative regulation of macrophage chemotaxis
Biological Process GO:0045766 positive regulation of angiogenesis
Biological Process GO:0090197 positive regulation of chemokine secretion
Biological Process GO:0010575 positive regulation of vascular endothelial growth factor production
Biological Process GO:0030449 regulation of complement activation
molecular function GO:0008009 chemokine activity
molecular function GO:0004866 endopeptidase inhibitor activity
molecular function GO:0005102 signaling receptor binding
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0005579 membrane attack complex
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-166658 Complement cascade
R-HSA-166665 Terminal pathway of complement
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-174577 Activation of C3 and C5
R-HSA-372790 Signaling by GPCR
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-418594 G alpha (i) signalling events
R-HSA-500792 GPCR ligand binding
R-HSA-977606 Regulation of Complement cascade
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003257 BXGD000189 Antibody Deficiency Syndrome Immune System Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003868 BXGD000233 Arthritis, Gouty Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0003907 BXGD000240 Arthus Reaction Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004623 BXGD000282 Bacterial Infections Infections
C0004936 BXGD000295 Mental disorders Mental Disorders
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007682 BXGD000471 CNS disorder Nervous System Diseases
C0007786 BXGD000486 Brain Ischemia Nervous System Diseases; Cardiovascular Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0011603 BXGD000734 Dermatitis Skin and Connective Tissue Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0016059 BXGD001043 Fibrosis Pathological Conditions, Signs and Symptoms
C0016412 BXGD001058 Folic Acid Deficiency Nutritional and Metabolic Diseases
C0017205 BXGD001105 Gaucher Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0017661 BXGD001139 IGA Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0018133 BXGD001176 Graft-vs-Host Disease Immune System Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020951 BXGD001473 Immune Complex Diseases Immune System Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0021359 BXGD001498 Infertility Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0021368 BXGD001502 Inflammation Pathological Conditions, Signs and Symptoms
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0024138 BXGD001738 Lupus Erythematosus, Discoid Skin and Connective Tissue Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024143 BXGD001741 Lupus Nephritis Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Male Urogenital Diseases; Immune System Diseases
C0024790 BXGD001804 Paroxysmal nocturnal hemoglobinuria Hemic and Lymphatic Diseases
C0025048 BXGD001823 Meconium Aspiration Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Respiratory Tract Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0025294 BXGD001854 Meningococcal meningitis Infections; Nervous System Diseases
C0025295 BXGD001855 Meningitis, Pneumococcal Infections; Nervous System Diseases
C0025306 BXGD001859 Meningococcemia Infections
C0026896 BXGD001946 Myasthenia Gravis Neoplasms; Immune System Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027055 BXGD001964 Myocardial Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027794 BXGD002036 Neural Tube Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0027947 BXGD002061 Neutropenia Hemic and Lymphatic Diseases
C0031069 BXGD002279 Familial Mediterranean Fever Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0031099 BXGD002282 Periodontitis Stomatognathic Diseases
C0031154 BXGD002291 Peritonitis Digestive System Diseases; Infections
C0035126 BXGD002509 Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0035222 BXGD002513 Respiratory Distress Syndrome, Adult Respiratory Tract Diseases
C0035235 BXGD002519 Respiratory Syncytial Virus Infections Infections
C0035439 BXGD002551 Rheumatic Heart Disease Infections; Cardiovascular Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0037284 BXGD002679 Skin lesion Skin and Connective Tissue Diseases
C0037769 BXGD002701 West Syndrome Nervous System Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0038525 BXGD002768 Subarachnoid Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0042384 BXGD002979 Vasculitis Cardiovascular Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0085409 BXGD003168 Polyendocrinopathies, Autoimmune Immune System Diseases; Endocrine System Diseases
C0086438 BXGD003283 Hypogammaglobulinemia Immune System Diseases; Hemic and Lymphatic Diseases
C0151650 BXGD003454 Renal fibrosis Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0154830 BXGD003746 Proliferative diabetic retinopathy Pathological Conditions, Signs and Symptoms; Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0155877 BXGD003830 Allergic asthma Respiratory Tract Diseases; Immune System Diseases
C0162309 BXGD003934 Adrenoleukodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Endocrine System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206754 BXGD004289 Neuroendocrine Tumors Neoplasms
C0231818 BXGD004526 Airway constriction
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0239998 BXGD005012 Recurrent infections Pathological Conditions, Signs and Symptoms; Infections; Musculoskeletal Diseases
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0272242 BXGD006330 Complement deficiency disease Immune System Diseases; Hemic and Lymphatic Diseases
C0302809 BXGD006852 Fulminant hepatitis Digestive System Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0343047 BXGD007591 Complement component 5 deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases
C0343713 BXGD007638 Gonococcal arthritis dermatitis syndrome Infections; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0494165 BXGD009022 Secondary malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0701807 BXGD009901 Acute anterior uveitis Eye Diseases
C0743178 BXGD010077 Intractable diarrhea Pathological Conditions, Signs and Symptoms
C0744451 BXGD010096 Disseminated infection caused by Neisseria gonorrhoeae Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0746495 BXGD010143 Recurrent meningitis Infections; Nervous System Diseases
C0851883 BXGD010928 Neisseria infection Infections
C0867389 BXGD011300 Chronic graft-versus-host disease Immune System Diseases
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1260959 BXGD011846 Drusen
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1397307 BXGD012996 Cardiac fibrosis
C1449646 BXGD013088 Primary Peritonitis Digestive System Diseases; Infections
C1449647 BXGD013089 Secondary Peritonitis Digestive System Diseases; Infections
C1527311 BXGD013268 Brain Edema Nervous System Diseases
C1837249 BXGD014210 Malformations of Cortical Development, Group II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1969372 BXGD016775 Tubulointerstitial fibrosis
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2315100 BXGD017021 Pediatric failure to thrive Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Mental Disorders
C2347126 BXGD017036 Microscopic Polyarteritis Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C2717865 BXGD017513 Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Immune System Diseases; Cardiovascular Diseases
C2717961 BXGD017519 Thrombotic Microangiopathies Hemic and Lymphatic Diseases
C2745963 BXGD017571 Kashin-Beck Disease Musculoskeletal Diseases
C2931788 BXGD018064 Atypical Hemolytic Uremic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Hemic and Lymphatic Diseases
C2985280 BXGD018223 Blood Protein Measurement
C3495559 BXGD018994 Juvenile arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3495801 BXGD019004 Granulomatosis with polyangiitis Respiratory Tract Diseases; Immune System Diseases; Cardiovascular Diseases
C3662483 BXGD019270 Allergic sensitization
C3810402 BXGD019654 ECULIZUMAB, POOR RESPONSE TO
C3887638 BXGD019906 Failure to thrive in infant Pathological Conditions, Signs and Symptoms
C3887898 BXGD019926 Infantile Spasm Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4024844 BXGD021437 Generalized seborrheic dermatitis Skin and Connective Tissue Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4554344 BXGD023564 IgE-mediated food allergy Immune System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002616 Copper 63.55
BXGC0002682 Zinc 65.41
BXGC0006271 L-Cysteine 121.16
BXGC0018397 beta-1,4-mannan 180.06
BXGC0042315 1,4-dioxane 88.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein