Showing entry for Aspartate aminotransferase, cytoplasmic


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008289
Protein NameAspartate aminotransferase, cytoplasmic
Uniport IdP17174
GeneGOT1
Gene Id2805
DomainAminotran_1_2
Pfam PF00155  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.5 Amino acid metabolism hsa00220 Arginine biosynthesis
1. Metabolism 1.5 Amino acid metabolism hsa00250 Alanine, aspartate and glutamate metabolism
1. Metabolism 1.5 Amino acid metabolism hsa00270 Cysteine and methionine metabolism
1. Metabolism 1.5 Amino acid metabolism hsa00330 Arginine and proline metabolism
1. Metabolism 1.5 Amino acid metabolism hsa00350 Tyrosine metabolism
1. Metabolism 1.5 Amino acid metabolism hsa00360 Phenylalanine metabolism
1. Metabolism 1.5 Amino acid metabolism hsa00400 Phenylalanine, tyrosine and tryptophan biosynthesis
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
1. Metabolism 1.0 Global and overview maps hsa01200 Carbon metabolism
1. Metabolism 1.0 Global and overview maps hsa01210 2-Oxocarboxylic acid metabolism
1. Metabolism 1.0 Global and overview maps hsa01230 Biosynthesis of amino acids
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006103 2-oxoglutarate metabolic process
Biological Process GO:0006532 aspartate biosynthetic process
Biological Process GO:0006533 aspartate catabolic process
Biological Process GO:0006531 aspartate metabolic process
Biological Process GO:0008652 cellular amino acid biosynthetic process
Biological Process GO:0032869 cellular response to insulin stimulus
Biological Process GO:0071260 cellular response to mechanical stimulus
Biological Process GO:0055089 fatty acid homeostasis
Biological Process GO:0006094 gluconeogenesis
Biological Process GO:0019551 glutamate catabolic process to 2-oxoglutarate
Biological Process GO:0019550 glutamate catabolic process to aspartate
Biological Process GO:0006536 glutamate metabolic process
Biological Process GO:0006114 glycerol biosynthetic process
Biological Process GO:0032966 negative regulation of collagen biosynthetic process
Biological Process GO:0051481 negative regulation of cytosolic calcium ion concentration
Biological Process GO:0051902 negative regulation of mitochondrial depolarization
Biological Process GO:0007219 Notch signaling pathway
Biological Process GO:0006107 oxaloacetate metabolic process
Biological Process GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
Biological Process GO:0046686 response to cadmium ion
Biological Process GO:0009743 response to carbohydrate
Biological Process GO:0051384 response to glucocorticoid
Biological Process GO:0035902 response to immobilization stress
Biological Process GO:1990267 response to transition metal nanoparticle
Biological Process GO:0060290 transdifferentiation
molecular function GO:0031406 carboxylic acid binding
molecular function GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity
molecular function GO:0047801 L-cysteine:2-oxoglutarate aminotransferase activity
molecular function GO:0004609 phosphatidylserine decarboxylase activity
molecular function GO:0030170 pyridoxal phosphate binding
cellular component GO:0043679 axon terminus
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005764 lysosome
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1237112 Methionine salvage pathway
R-HSA-1430728 Metabolism
R-HSA-1430728 Metabolism
R-HSA-1614635 Sulfur amino acid metabolism
R-HSA-70263 Gluconeogenesis
R-HSA-70326 Glucose metabolism
R-HSA-71291 Metabolism of amino acids and derivatives
R-HSA-71291 Metabolism of amino acids and derivatives
R-HSA-71387 Metabolism of carbohydrates
R-HSA-8963693 Aspartate and asparagine metabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0007787 BXGD000487 Transient Ischemic Attack Nervous System Diseases; Cardiovascular Diseases
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009952 BXGD000639 Febrile Convulsions Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0017636 BXGD001131 Glioblastoma Neoplasms
C0019193 BXGD001299 Hepatitis, Toxic Digestive System Diseases; Chemically-Induced Disorders
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019880 BXGD001351 Homocystinuria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases; Nervous System Diseases
C0022346 BXGD001537 Icterus Pathological Conditions, Signs and Symptoms
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023892 BXGD001715 Biliary cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0031090 BXGD002280 Periodontal Diseases Stomatognathic Diseases
C0033141 BXGD002400 Cardiomyopathies, Primary Cardiovascular Diseases
C0035078 BXGD002505 Kidney Failure Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0036529 BXGD002624 Myocardial Diseases, Secondary Cardiovascular Diseases
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0043346 BXGD003043 Xeroderma Pigmentosum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0153452 BXGD003647 Malignant neoplasm of gallbladder Digestive System Diseases; Neoplasms
C0201899 BXGD004056 Aspartate aminotransferase measurement
C0206754 BXGD004289 Neuroendocrine Tumors Neoplasms
C0235782 BXGD004769 Gallbladder Carcinoma Digestive System Diseases; Neoplasms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0242488 BXGD005170 Acute Lung Injury Respiratory Tract Diseases
C0242706 BXGD005191 Hyperoxia Pathological Conditions, Signs and Symptoms
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0278883 BXGD006614 Metastatic melanoma Neoplasms
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0403555 BXGD008294 Ochoa syndrome Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0410702 BXGD008447 Adolescent idiopathic scoliosis Musculoskeletal Diseases
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0860207 BXGD011220 Drug-Induced Liver Disease Digestive System Diseases; Chemically-Induced Disorders
C0877008 BXGD011325 Enzyme inhibition disorder
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C1175175 BXGD011797 Severe Acute Respiratory Syndrome Infections; Respiratory Tract Diseases
C1262760 BXGD011886 Hepatitis, Drug-Induced Digestive System Diseases; Chemically-Induced Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1335302 BXGD012775 Pancreatic Ductal Adenocarcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1565489 BXGD013401 Renal Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1704436 BXGD013564 Peripheral Arterial Diseases Cardiovascular Diseases
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1837461 BXGD014234 SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
C1842247 BXGD014508 CORONARY ARTERY DISEASE, AUTOSOMAL DOMINANT, 1 Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1861453 BXGD016049 Pseudohyperkalemia Cardiff Nutritional and Metabolic Diseases
C2347761 BXGD017049 Childhood Myelodysplastic Syndrome Hemic and Lymphatic Diseases
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3658290 BXGD019256 Drug-Induced Acute Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C3900098 BXGD020106 Adult Myelodysplastic Syndrome Hemic and Lymphatic Diseases
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4277682 BXGD022376 Chemical and Drug Induced Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C4279912 BXGD022378 Chemically-Induced Liver Toxicity Digestive System Diseases; Chemically-Induced Disorders
C4525297 BXGD023131 Stage 0 Gallbladder Cancer AJCC v8
C4525300 BXGD023132 Stage IIA Gallbladder Cancer AJCC v8
C4525301 BXGD023133 Stage IIB Gallbladder Cancer AJCC v8
C4525302 BXGD023134 Stage III Gallbladder Cancer AJCC v8
C4525305 BXGD023135 Stage IV Gallbladder Cancer AJCC v8
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000076 p-Coumaroyl tartaric acid glucosidic ester 150.09
BXGC0000436 Glycerol 92.09
BXGC0002436 Fumaric acid 116.07
BXGC0002616 Copper 63.55
BXGC0006162 L-Glutamic acid 147.13
BXGC0006186 L-Aspartic acid 133.1
BXGC0006271 L-Cysteine 121.16
BXGC0030612 tetraethylene glycol 194.12
BXGC0043088 Pyridoxal Phosphate 247.02
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein