Showing entry for Phloretin


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0008184
Compound NamePhloretin
Structure
FormulaC15H14O5
InchiKeyVGEREEWJJVICBM-UHFFFAOYSA-N
SMILESOC1=CC=C(CCC(=O)C2=C(O)C=C(O)C=C2O)C=C1
InchiInChI=1S/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H2
IUPAC3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
Molecular Weight274.27
Pubchem Id4788
Chembl IdCHEMBL45068
Targets of Information Source
DrugBank DB07810
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Q9AIU0 BXGT020066 HTH-type transcriptional regulator TtgR reviewed - ttgR experimental -
PDB G50
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Q9AIU0 BXGT020066 HTH-type transcriptional regulator TtgR reviewed ttgR - - - 50 -
Binding DB 23446
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT020189 Serine/threonine-protein kinase 33 reviewed Kinase STK33 - - - 21410
reviewed BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR - 25000000 - -
reviewed BXGT020507 Solute carrier family 28 member 3 reviewed Transporter SLC28A3 32280 - - -
reviewed BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 86000 - - -
reviewed BXGT011023 Monocarboxylate transporter 1 reviewed Slc16a1 - 28000 - -
reviewed BXGT007661 Solute carrier family 2, facilitated glucose transporter member 1 reviewed Transporter SLC2A1 - 21400 - -
CHEMBL CHEMBL45068
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 12589 nM
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Inhibition '=' 28 %
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Inhibition '=' 4 %
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 10000 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 22387 nM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 10000 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Potency '=' 25118 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 31622 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 17782 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 28183 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 AC50 '=' 19952 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 7943 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 7943 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 1995 nM
P31639 BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 IC50 '=' 18300 nM
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 AC50 '=' 6309 nM
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 25118 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 35481 nM
Q9HCT0 BXGT020538 Fibroblast growth factor 22 reviewed Signaling FGF22 AbsAC0.54_uM '=' 2 uM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 125892 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 31622 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 15848 nM
O15296 BXGT004148 Arachidonate 15-lipoxygenase B reviewed Enzyme ALOX15B Potency - 12589 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Potency '=' 3981 nM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 21192 nM
P13866 BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 Ki '=' 86000 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 25118 nM
Q04206 BXGT012754 Transcription factor p65 reviewed Transcription factor RELA IC50 '=' 41000 nM
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit reviewed Transcription factor NFKB1 IC50 '=' 41000 nM
Q00653 BXGT012541 Nuclear factor NF-kappa-B p100 subunit reviewed Transcription factor NFKB2 IC50 '=' 41000 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 12589 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Potency '=' 2511 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 670 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 28183 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 39810 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 39810 nM
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 15848 nM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 28183 nM
Q9YQ12 BXGT022394 Protease unreviewed - protease Inhibition '=' 27 %
P15289 BXGT008102 Arylsulfatase A reviewed Enzyme ARSA Potency - 2685 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 39810 nM
P11166 BXGT007661 Solute carrier family 2, facilitated glucose transporter member 1 reviewed Transporter SLC2A1 IC50 '=' 21400 nM
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Potency '=' 31622 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 39810 nM
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR IC50 '=' 25000000 nM
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 5 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 AC50 '=' 39810 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Potency '=' 12589 nM
Q194T2 BXGT013743 Non-structural protein 1 unreviewed - NS1 Potency '=' 12589 nM
P49798 BXGT010745 Regulator of G-protein signaling 4 reviewed Enzyme modulator RGS4 Potency - 18887 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 31622 nM
Q13315 BXGT013339 Serine-protein kinase ATM reviewed Kinase ATM Potency '=' 28183 nM
P06746 BXGT006496 DNA polymerase beta reviewed Enzyme POLB Potency '=' 89125 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Potency '=' 39810 nM
Q99549 BXGT019932 M-phase phosphoprotein 8 reviewed Epigenetic regulator MPHOSPH8 Potency - 707 nM
P11064 BXGT007646 Low molecular weight phosphotyrosine protein phosphatase reviewed - ACP1 Inhibition '=' 14 %
P81908 BXGT011959 Cholinesterase reviewed - BCHE Inhibition '=' 17 %
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Inhibition '=' 46 %
Q9HAS3 BXGT020507 Solute carrier family 28 member 3 reviewed Transporter SLC28A3 Ki '=' 32280 nM
P10828 BXGT007624 Thyroid hormone receptor beta reviewed Nuclear receptor THRB Potency '=' 44668 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 28183 nM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 14125 nM
P31639 BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 Inhibition - - -
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Inhibition '=' 62 %
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' -6 %
P16473 BXGT008234 Thyrotropin receptor reviewed G-protein coupled receptor TSHR Potency '=' 15848 nM
P11388 BXGT007697 DNA topoisomerase 2-alpha reviewed - TOP2A IC50 '=' 46 ug.mL-1
P04062 BXGT006140 Lysosomal acid glucosylceramidase reviewed - GBA Potency - 15848 nM
Q01453 BXGT012588 Peripheral myelin protein 22 reviewed Cellular structure PMP22 Potency '=' 84921 nM
P06746 BXGT006496 DNA polymerase beta reviewed Enzyme POLB Potency '=' 7079 nM
P53987 BXGT011023 Monocarboxylate transporter 1 reviewed - Slc16a1 IC50 '=' 28000 nM
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 Potency - 12589 nM
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Potency '=' 28183 nM
P15917 BXGT008169 Lethal factor reviewed - lef Potency '=' 7943 nM
Q12791 BXGT013264 Calcium-activated potassium channel subunit alpha-1 reviewed Ion channel KCNMA1 Control '=' 119 %
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 31622 nM
Q66HS9 BXGT016172 Monocarboxylate transporter 2 unreviewed - Slc16a7 IC50 '=' 14000 nM
Q66HS9 BXGT016172 Monocarboxylate transporter 2 unreviewed - Slc16a7 Activity '=' 3 %
Q92830 BXGT019379 Histone acetyltransferase KAT2A reviewed - KAT2A Potency - 31622 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 AC50 '=' 10000 nM
P10253 BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA Potency '=' 31381 nM
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - Potency - 37933 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 35481 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 25118 nM
P13866 BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 IC50 '=' 12400 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 39810 nM
P33527 BXGT009728 Multidrug resistance-associated protein 1 reviewed Transporter ABCC1 Activity '=' 295 %
P04062 BXGT006140 Lysosomal acid glucosylceramidase reviewed - GBA Potency - 17782 nM
P84022 BXGT012027 Mothers against decapentaplegic homolog 3 reviewed Transcription factor SMAD3 Potency - 5623 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 23109 nM
Q9UNQ0 BXGT021792 ATP-binding cassette sub-family G member 2 reviewed Transporter ABCG2 Activity - - -
P16473 BXGT008234 Thyrotropin receptor reviewed G-protein coupled receptor TSHR Potency '=' 12589 nM
P53987 BXGT011023 Monocarboxylate transporter 1 reviewed - Slc16a1 Activity '=' 14 %
P33527 BXGT009728 Multidrug resistance-associated protein 1 reviewed Transporter ABCC1 Activity '=' 251 %
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 50118 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 20596 nM
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Inhibition '=' 17 %
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 2908 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 AC50 '=' 12589 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 31622 nM
O94925 BXGT005342 Glutaminase kidney isoform, mitochondrial reviewed Enzyme GLS Potency - 10000 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 10000 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 10000 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 25929 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Activity - - -
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Inhibition '=' 48 %
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 290 nM
P13866 BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 Inhibition - - -
Q9HCT0 BXGT020538 Fibroblast growth factor 22 reviewed Signaling FGF22 AbsAC1 '=' 1 uM
O15427 BXGT004167 Monocarboxylate transporter 4 reviewed Transporter SLC16A3 IC50 '=' 41000 nM
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 12589 nM
C3TDZ2 BXGT002450 3-oxoacyl-[acyl-carrier-protein] synthase 3 unreviewed - fabH K '=' 2 10'7/M
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 15848 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 300 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 83 %
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Activity - - -
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 23778 nM
P00591 BXGT005592 Pancreatic triacylglycerol lipase reviewed - PNLIP IC50 '=' 50400 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Potency '=' 19952 nM
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 98 %
O43826 BXGT004629 Glucose-6-phosphate exchanger SLC37A4 reviewed Transporter SLC37A4 IC50 '=' 340000 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00054 Lemon Citrus limon Fruits
BXGF00105 Apple Malus pumila Fruits
BXGF00151 Pomegranate Punica granatum Fruits
BXGF00303 Chia Salvia hispanica Herbs and Spices
BXGF00808 Pomes Fruits
BXGF00998 Syncarpia hillii Syncarpia hillii Others
BXGF01250 Colchicum filifolium Colchicum filifolium Others
BXGF01255 Lemaireocereus griseus Lemaireocereus griseus Human Edible Plant
BXGF01256 Cynoglossum macrostylum Cynoglossum macrostylum Others
BXGF01455 Diospyros eriantha Diospyros eriantha Others
BXGF01491 Alkanna cappadocica Alkanna cappadocica Medicinal Plant
BXGF01524 Artemisia dentata Artemisia dentata Others
BXGF01633 Scorzonera pseudodivaricata Scorzonera pseudodivaricata Others
BXGF01649 Rapanea lancifolia Rapanea lancifolia Others
BXGF01670 Ononis vaginalis Ononis vaginalis Others
BXGF01686 Pulsatilla chinensis Pulsatilla chinensis Medicinal Plant
BXGF01721 Humulus lupulus Humulus lupulus Medicinal Plant
BXGF02206 Mucuna holtonii Mucuna holtonii Others
BXGF02233 Quercus marilandica Quercus marilandica Medicinal Plant
BXGF02446 Centaurea scoparia Centaurea scoparia Others
BXGF02663 Atalantia racemosa Atalantia racemosa Medicinal Plant
BXGF02846 Kalmia latifolia Kalmia latifolia Medicinal Plant
BXGF03054 Mimosa pigra Mimosa pigra Medicinal Plant
BXGF03342 Buddleja cordata Buddleja cordata Others
BXGF03601 Maclura cochinchinensis Maclura cochinchinensis Medicinal Plant
BXGF03747 Millettia erythrocalyx Millettia erythrocalyx Medicinal Plant
BXGF03814 Juniperus rigida var. conferta Juniperus rigida var. conferta Medicinal Plant
BXGF03978 Hoffmannia strigillosa Hoffmannia strigillosa Others
BXGF04035 Campanula choziatowskyi Campanula choziatowskyi Others
BXGF04208 Salvia patens Salvia patens Others
BXGF04214 Dialium excelsum Dialium excelsum Others
BXGF04380 Euphorbia hylonoma Euphorbia hylonoma Others
BXGF04409 Senecio platyphylloides Senecio platyphylloides Others
BXGF04418 Drymaria cordata Drymaria cordata Medicinal Plant
BXGF04442 Boesenbergia pandurata Boesenbergia pandurata Medicinal Plant
BXGF04447 Helleborus macranthus Helleborus macranthus Others
BXGF04448 Salix rosmarinifolia Salix rosmarinifolia Others
BXGF04455 Heliotropium scabrum Heliotropium scabrum Others
BXGF04457 Podocarpus dacrydioides Podocarpus dacrydioides Medicinal Plant
BXGF04469 Centaurea sonchifolia Centaurea sonchifolia Others
BXGF04472 Matricaria sabulosa Matricaria sabulosa Others
BXGF04489 Pterocaulon serrulatum Pterocaulon serrulatum Medicinal Plant
BXGF04504 Boswellia ovalifoliolata Boswellia ovalifoliolata Medicinal Plant
BXGF04515 Hardenbergia violacea Hardenbergia violacea Medicinal Plant
BXGF04529 Lonchocarpus chiricanus Lonchocarpus chiricanus Others
BXGF04533 Astragalus circassicus Astragalus circassicus Others
BXGF04543 Erythrina hypaphorus Erythrina hypaphorus Others
BXGF04548 Beilschmiedia madang Beilschmiedia madang Medicinal Plant
BXGF04555 Salvia lavanduloides Salvia lavanduloides Others
BXGF04573 Rubia akane Rubia akane Medicinal Plant
BXGF04586 Aniba santalodora Aniba santalodora Others
BXGF04618 Mentzelia decapetala Mentzelia decapetala Human Edible Plant
BXGF04648 Amorphophallus konjac Amorphophallus konjac Human Edible Plant
BXGF05231 Salvia virgata Salvia virgata Human Edible Plant
BXGF05560 Crambe tatarica Crambe tatarica Medicinal Plant
BXGF05566 Petunia axillaris subsp. parodii Petunia axillaris subsp. parodii Medicinal Plant
BXGF06116 Pteris semipinnata Pteris semipinnata Others
BXGF06122 Bethencourtia palmensis Bethencourtia palmensis Others
BXGF06193 Fritillaria ningguoensis Fritillaria ningguoensis Medicinal Plant
BXGF06203 Lepechinia urbanii Lepechinia urbanii Others
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease