Showing entry for Insulin-degrading enzyme


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008042
Protein NameInsulin-degrading enzyme
Uniport IdP14735
GeneIDE
Gene Id3416
DomainPeptidase_M16; Peptidase_M16_C; Peptidase_M16_M
Pfam PF00675   PF05193   PF16187  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.4 Neurodegenerative diseases hsa05010 Alzheimer disease
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0097242 amyloid-beta clearance
Biological Process GO:0150094 amyloid-beta clearance by cellular catabolic process
Biological Process GO:0050435 amyloid-beta metabolic process
Biological Process GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
Biological Process GO:0010815 bradykinin catabolic process
Biological Process GO:0044257 cellular protein catabolic process
Biological Process GO:0008340 determination of adult lifespan
Biological Process GO:0042447 hormone catabolic process
Biological Process GO:1901143 insulin catabolic process
Biological Process GO:1901142 insulin metabolic process
Biological Process GO:0008286 insulin receptor signaling pathway
Biological Process GO:0045861 negative regulation of proteolysis
Biological Process GO:0043171 peptide catabolic process
Biological Process GO:0032092 positive regulation of protein binding
Biological Process GO:0045732 positive regulation of protein catabolic process
Biological Process GO:0030163 protein catabolic process
Biological Process GO:0006625 protein targeting to peroxisome
Biological Process GO:0006508 proteolysis
Biological Process GO:0051603 proteolysis involved in cellular protein catabolic process
Biological Process GO:1903715 regulation of aerobic respiration
Biological Process GO:0010992 ubiquitin recycling
molecular function GO:0001540 amyloid-beta binding
molecular function GO:0016887 ATPase activity
molecular function GO:0005524 ATP binding
molecular function GO:0031626 beta-endorphin binding
molecular function GO:0004175 endopeptidase activity
molecular function GO:0042802 identical protein binding
molecular function GO:0043559 insulin binding
molecular function GO:0004222 metalloendopeptidase activity
molecular function GO:0042277 peptide binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0140036 ubiquitin-dependent protein binding
molecular function GO:0001618 virus receptor activity
molecular function GO:0008270 zinc ion binding
cellular component GO:0016323 basolateral plasma membrane
cellular component GO:0009986 cell surface
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0031597 cytosolic proteasome complex
cellular component GO:0009897 external side of plasma membrane
cellular component GO:0070062 extracellular exosome
cellular component GO:0005615 extracellular space
cellular component GO:0005739 mitochondrion
cellular component GO:0005634 nucleus
cellular component GO:0005782 peroxisomal matrix
cellular component GO:0005777 peroxisome
Reactome
Pathway Id Pathway Name
R-HSA-392499 Metabolism of proteins
R-HSA-5688426 Deubiquitination
R-HSA-5689880 Ub-specific processing proteases
R-HSA-597592 Post-translational protein modification
R-HSA-9033241 Peroxisomal protein import
R-HSA-9033241 Peroxisomal protein import
R-HSA-9609507 Protein localization
R-HSA-9609507 Protein localization
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0022638 BXGD001567 Ketosis Nutritional and Metabolic Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024530 BXGD001783 Malaria Infections
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0037278 BXGD002678 Skin Diseases, Infectious Infections; Skin and Connective Tissue Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0039070 BXGD002787 Syncope Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0085220 BXGD003142 Cerebral Amyloid Angiopathy Nutritional and Metabolic Diseases; Nervous System Diseases; Cardiovascular Diseases
C0085648 BXGD003221 Synovial Cyst Neoplasms
C0221765 BXGD004477 Chronic schizophrenia Mental Disorders
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0242723 BXGD005193 Parasitemia Pathological Conditions, Signs and Symptoms; Infections
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0276496 BXGD006426 Familial Alzheimer Disease (FAD) Nervous System Diseases; Mental Disorders
C0333463 BXGD006954 Senile Plaques Pathological Conditions, Signs and Symptoms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0362046 BXGD007959 Prediabetes syndrome Nutritional and Metabolic Diseases; Endocrine System Diseases
C0494463 BXGD009029 Alzheimer Disease, Late Onset Nervous System Diseases; Mental Disorders
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0542476 BXGD009276 Forgetful Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0546126 BXGD009328 Acute Confusional Senile Dementia Nervous System Diseases; Mental Disorders
C0586989 BXGD009612 Varicella Zoster Virus Infection Infections
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0740380 BXGD009983 Varicella zoster
C0750900 BXGD010241 Alzheimer's Disease, Focal Onset Nervous System Diseases; Mental Disorders
C0750901 BXGD010242 Alzheimer Disease, Early Onset Nervous System Diseases; Mental Disorders
C0751071 BXGD010311 Familial Dementia Nervous System Diseases; Mental Disorders
C0854193 BXGD011005 Cognitive deterioration
C0877008 BXGD011325 Enzyme inhibition disorder
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0948379 BXGD011533 Impaired insulin secretion
C1258666 BXGD011825 Myxoid cyst Neoplasms; Skin and Connective Tissue Diseases
C1842675 BXGD014528 AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)
C1842937 BXGD014546 AURAL ATRESIA, CONGENITAL Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1843013 BXGD014549 Alzheimer disease, familial, type 3 Nervous System Diseases; Mental Disorders
C1862939 BXGD016144 AMYOTROPHIC LATERAL SCLEROSIS 1 Nutritional and Metabolic Diseases; Nervous System Diseases
C1862941 BXGD016145 Amyotrophic Lateral Sclerosis, Sporadic Nutritional and Metabolic Diseases; Nervous System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2750440 BXGD017660 FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 1
C2750441 BXGD017661 LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
C2931689 BXGD018049 Dystrophia myotonica 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C3150651 BXGD018316 FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 2
C3542025 BXGD019103 AMYOTROPHIC LATERAL SCLEROSIS 1, AUTOSOMAL RECESSIVE
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4521042 BXGD023055 Complete Trisomy 21 Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000952 6-Oxocamphor 457.91
BXGC0004277 Acetic acid 60.05
BXGC0009993 (R)-Mahanine 347.45
BXGC0021255 4-[(3S)-8,8-Dimethyl-3,4-Dihydro-2H-Pyrano[2,3-F]Chromen-3-Yl]Benzene-1,3-Diol 324.14
BXGC0026123 Biotin 244.09
BXGC0036681 7,11B-Dihydro-6H-Indeno[2,1-C]Chromene-3,6A,9,10-Tetrol 286.08
BXGC0042315 1,4-dioxane 88.05
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein