protein

Showing entry for Insulin-like growth factor-binding protein 1

General Target Information
BXGT Id	BXGT006827
Protein Name	Insulin-like growth factor-binding protein 1
Uniport Id	P08833
Gene	IGFBP1
Gene Id	3484
Domain	IGFBP; Thyroglobulin_1
Pfam	PF00219 PF00086
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0007568	aging
Biological Process	GO:0044267	cellular protein metabolic process
Biological Process	GO:0008286	insulin receptor signaling pathway
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway
Biological Process	GO:0036499	PERK-mediated unfolded protein response
Biological Process	GO:0030307	positive regulation of cell growth
Biological Process	GO:0043687	post-translational protein modification
Biological Process	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway
Biological Process	GO:0007165	signal transduction
Biological Process	GO:0042246	tissue regeneration
molecular function	GO:0005520	insulin-like growth factor binding
molecular function	GO:0031994	insulin-like growth factor I binding
molecular function	GO:0031995	insulin-like growth factor II binding
molecular function	GO:0005102	signaling receptor binding
cellular component	GO:0005788	endoplasmic reticulum lumen
cellular component	GO:0005576	extracellular region
cellular component	GO:0005615	extracellular space
cellular component	GO:0005794	Golgi apparatus

Reactome

Pathway Id	Pathway Name
R-HSA-212436	Generic Transcription Pathway
R-HSA-380994	ATF4 activates genes in response to endoplasmic reticulum stress
R-HSA-381042	PERK regulates gene expression
R-HSA-381119	Unfolded Protein Response (UPR)
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-392499	Metabolism of proteins
R-HSA-597592	Post-translational protein modification
R-HSA-73857	RNA Polymerase II Transcription
R-HSA-74160	Gene expression (Transcription)
R-HSA-8957275	Post-translational protein phosphorylation
R-HSA-9614085	FOXO-mediated transcription
R-HSA-9615017	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0000786	BXGD000010	Spontaneous abortion	Female Urogenital Diseases and Pregnancy Complications
C0000822	BXGD000012	Abortion, Tubal	Female Urogenital Diseases and Pregnancy Complications
C0001127	BXGD000026	Acidosis, Respiratory	Nutritional and Metabolic Diseases; Respiratory Tract Diseases
C0001418	BXGD000050	Adenocarcinoma	Neoplasms
C0001430	BXGD000054	Adenoma	Neoplasms
C0001624	BXGD000067	Adrenal Gland Neoplasms	Neoplasms; Endocrine System Diseases
C0002395	BXGD000111	Alzheimer's Disease	Nervous System Diseases; Mental Disorders
C0002965	BXGD000162	Angina, Unstable	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003125	BXGD000179	Anorexia Nervosa	Mental Disorders
C0003130	BXGD000183	Anoxia	Pathological Conditions, Signs and Symptoms
C0003850	BXGD000225	Arteriosclerosis	Cardiovascular Diseases
C0003873	BXGD000236	Rheumatoid Arthritis	Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096	BXGD000252	Asthma	Respiratory Tract Diseases; Immune System Diseases
C0004153	BXGD000260	Atherosclerosis	Cardiovascular Diseases
C0005411	BXGD000313	Biliary Atresia	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0005684	BXGD000319	Malignant neoplasm of urinary bladder	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695	BXGD000323	Bladder Neoplasm	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142	BXGD000374	Malignant neoplasm of breast	Neoplasms; Skin and Connective Tissue Diseases
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0007102	BXGD000425	Malignant tumor of colon	Digestive System Diseases; Neoplasms
C0007103	BXGD000426	Malignant neoplasm of endometrium	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007115	BXGD000432	Malignant neoplasm of thyroid	Neoplasms; Endocrine System Diseases
C0007131	BXGD000441	Non-Small Cell Lung Carcinoma	Neoplasms; Respiratory Tract Diseases
C0007137	BXGD000445	Squamous cell carcinoma	Neoplasms
C0007194	BXGD000452	Hypertrophic Cardiomyopathy	Cardiovascular Diseases
C0007222	BXGD000454	Cardiovascular Diseases	Cardiovascular Diseases
C0008312	BXGD000527	Primary biliary cirrhosis	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0009375	BXGD000602	Colonic Neoplasms	Digestive System Diseases; Neoplasms
C0009402	BXGD000605	Colorectal Carcinoma	Digestive System Diseases; Neoplasms
C0009404	BXGD000606	Colorectal Neoplasms	Digestive System Diseases; Neoplasms
C0010054	BXGD000647	Coronary Arteriosclerosis	Cardiovascular Diseases
C0010068	BXGD000648	Coronary heart disease	Cardiovascular Diseases
C0011570	BXGD000729	Mental Depression	Behavior and Behavior Mechanisms
C0011581	BXGD000733	Depressive disorder	Mental Disorders
C0011847	BXGD000749	Diabetes	Endocrine System Diseases
C0011849	BXGD000751	Diabetes Mellitus	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854	BXGD000753	Diabetes Mellitus, Insulin-Dependent	Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860	BXGD000755	Diabetes Mellitus, Non-Insulin-Dependent	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881	BXGD000760	Diabetic Nephropathy	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0013221	BXGD000804	Drug toxicity	Chemically-Induced Disorders
C0013336	BXGD000815	Dwarfism	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013537	BXGD000853	Eclampsia	Female Urogenital Diseases and Pregnancy Complications
C0013720	BXGD000861	Ehlers-Danlos Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0014170	BXGD000902	Endometrial Neoplasms	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0014175	BXGD000904	Endometriosis	Female Urogenital Diseases and Pregnancy Complications
C0014859	BXGD000961	Esophageal Neoplasms	Digestive System Diseases; Neoplasms
C0015695	BXGD001013	Fatty Liver	Digestive System Diseases
C0015934	BXGD001026	Fetal Growth Retardation	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0017150	BXGD001095	Gastrinoma	Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0017638	BXGD001132	Glioma	Neoplasms
C0017661	BXGD001139	IGA Glomerulonephritis	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0017980	BXGD001160	Glycosuria, Renal	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0018801	BXGD001226	Heart failure	Cardiovascular Diseases
C0018802	BXGD001227	Congestive heart failure	Cardiovascular Diseases
C0019163	BXGD001295	Hepatitis B	Digestive System Diseases; Infections
C0019196	BXGD001301	Hepatitis C	Digestive System Diseases; Infections
C0020217	BXGD001365	Hydatidiform Mole	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0020255	BXGD001369	Hydrocephalus	Nervous System Diseases
C0020456	BXGD001392	Hyperglycemia	Nutritional and Metabolic Diseases
C0020459	BXGD001394	Hyperinsulinism	Nutritional and Metabolic Diseases
C0020538	BXGD001422	Hypertensive disease	Cardiovascular Diseases
C0020550	BXGD001429	Hyperthyroidism	Endocrine System Diseases
C0020676	BXGD001462	Hypothyroidism	Endocrine System Diseases
C0021670	BXGD001509	insulinoma	Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0022658	BXGD001570	Kidney Diseases	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022660	BXGD001571	Kidney Failure, Acute	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022661	BXGD001572	Kidney Failure, Chronic	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023267	BXGD001626	Fibroid Tumor	Neoplasms
C0023449	BXGD001650	Acute lymphocytic leukemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023890	BXGD001713	Liver Cirrhosis	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023892	BXGD001715	Biliary cirrhosis	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023893	BXGD001716	Liver Cirrhosis, Experimental	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023895	BXGD001717	Liver diseases	Digestive System Diseases
C0023903	BXGD001720	Liver neoplasms	Digestive System Diseases; Neoplasms
C0024530	BXGD001783	Malaria	Infections
C0024586	BXGD001787	Malignant Carcinoid Syndrome	Neoplasms
C0024623	BXGD001791	Malignant neoplasm of stomach	Digestive System Diseases; Neoplasms
C0026769	BXGD001930	Multiple Sclerosis	Immune System Diseases; Nervous System Diseases
C0026896	BXGD001946	Myasthenia Gravis	Neoplasms; Immune System Diseases; Nervous System Diseases
C0027051	BXGD001963	Myocardial Infarction	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627	BXGD002006	Neoplasm Metastasis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651	BXGD002009	Neoplasms	Neoplasms
C0027773	BXGD002035	Nesidioblastosis	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases
C0028754	BXGD002082	Obesity	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408	BXGD002137	Degenerative polyarthritis	Musculoskeletal Diseases
C0029453	BXGD002154	Osteopenia	Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029463	BXGD002160	Osteosarcoma	Neoplasms
C0030193	BXGD002191	Pain	Pathological Conditions, Signs and Symptoms
C0030552	BXGD002238	Paresis	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0031511	BXGD002304	Pheochromocytoma	Neoplasms
C0032002	BXGD002320	Pituitary Diseases	Nervous System Diseases; Endocrine System Diseases
C0032051	BXGD002326	Placental Insufficiency	Female Urogenital Diseases and Pregnancy Complications
C0032460	BXGD002355	Polycystic Ovary Syndrome	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0032463	BXGD002357	Polycythemia Vera	Neoplasms; Hemic and Lymphatic Diseases
C0032914	BXGD002379	Pre-Eclampsia	Female Urogenital Diseases and Pregnancy Complications
C0032927	BXGD002381	Precancerous Conditions	Neoplasms
C0033578	BXGD002408	Prostatic Neoplasms	Neoplasms; Male Urogenital Diseases
C0035309	BXGD002530	Retinal Diseases	Eye Diseases
C0040100	BXGD002840	Thymoma	Neoplasms; Hemic and Lymphatic Diseases
C0041696	BXGD002932	Unipolar Depression	Mental Disorders
C0041755	BXGD002933	Adverse reaction to drug	Chemically-Induced Disorders
C0042133	BXGD002960	Uterine Fibroids	Neoplasms
C0085207	BXGD003140	Gestational Diabetes	Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0085278	BXGD003150	Antiphospholipid Syndrome	Immune System Diseases
C0149925	BXGD003387	Small cell carcinoma of lung	Neoplasms; Respiratory Tract Diseases
C0151744	BXGD003469	Myocardial Ischemia	Cardiovascular Diseases
C0151786	BXGD003475	Muscle Weakness	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0152018	BXGD003518	Esophageal carcinoma	Digestive System Diseases; Neoplasms
C0155626	BXGD003806	Acute myocardial infarction	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0175693	BXGD004001	Russell-Silver syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0178664	BXGD004032	Glomerulosclerosis (disorder)	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Cardiovascular Diseases
C0206754	BXGD004289	Neuroendocrine Tumors	Neoplasms
C0220630	BXGD004302	Adult Liver Carcinoma	Digestive System Diseases; Neoplasms
C0235974	BXGD004796	Pancreatic carcinoma	Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238065	BXGD004869	Secondary Biliary Cholangitis	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0238104	BXGD004875	Chronic endometritis	Female Urogenital Diseases and Pregnancy Complications; Infections
C0238463	BXGD004938	Papillary thyroid carcinoma	Neoplasms; Endocrine System Diseases
C0239946	BXGD005010	Fibrosis, Liver	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0242379	BXGD005157	Malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C0269102	BXGD006053	Endometrioma	Female Urogenital Diseases and Pregnancy Complications
C0271183	BXGD006169	Severe myopia	Eye Diseases
C0271650	BXGD006227	Impaired glucose tolerance	Nutritional and Metabolic Diseases
C0279000	BXGD006622	Liver and Intrahepatic Biliary Tract Carcinoma	Digestive System Diseases; Neoplasms
C0282313	BXGD006803	Condition, Preneoplastic	Neoplasms
C0341439	BXGD007408	Chronic liver disease	Digestive System Diseases
C0341858	BXGD007425	Endometriosis of uterus	Female Urogenital Diseases and Pregnancy Complications
C0342335	BXGD007461	insulin resistance in diabetes	Nutritional and Metabolic Diseases
C0342541	BXGD007499	Precocious pubarche	Endocrine System Diseases
C0344315	BXGD007666	Depressed mood	Behavior and Behavior Mechanisms
C0345904	BXGD007745	Malignant neoplasm of liver	Digestive System Diseases; Neoplasms
C0346647	BXGD007832	Malignant neoplasm of pancreas	Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0346976	BXGD007838	Secondary malignant neoplasm of pancreas	Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349489	BXGD007911	Fetal Hypoxia	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0374997	BXGD007967	Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
C0376358	BXGD007992	Malignant neoplasm of prostate	Neoplasms; Male Urogenital Diseases
C0376618	BXGD008003	Endotoxemia	Pathological Conditions, Signs and Symptoms; Infections
C0398623	BXGD008202	Thrombophilia	Hemic and Lymphatic Diseases
C0400966	BXGD008266	Non-alcoholic Fatty Liver Disease	Digestive System Diseases
C0410207	BXGD008419	Tubular Aggregate Myopathy	Musculoskeletal Diseases; Nervous System Diseases
C0456065	BXGD008862	Infant, Extremely Low Birth Weight
C0476089	BXGD008977	Endometrial Carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0494165	BXGD009022	Secondary malignant neoplasm of liver	Digestive System Diseases; Neoplasms
C0524620	BXGD009236	Metabolic Syndrome X	Nutritional and Metabolic Diseases
C0546837	BXGD009343	Malignant neoplasm of esophagus	Digestive System Diseases; Neoplasms
C0549473	BXGD009384	Thyroid carcinoma	Neoplasms; Endocrine System Diseases
C0585442	BXGD009593	Osteosarcoma of bone	Neoplasms
C0596263	BXGD009639	Carcinogenesis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139	BXGD009695	Prostate carcinoma	Neoplasms; Male Urogenital Diseases
C0677886	BXGD009734	Epithelial ovarian cancer	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222	BXGD009749	Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C0684249	BXGD009790	Carcinoma of lung	Neoplasms; Respiratory Tract Diseases
C0699791	BXGD009867	Stomach Carcinoma	Digestive System Diseases; Neoplasms
C0699885	BXGD009869	Carcinoma of bladder	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0796160	BXGD010807	MENTAL RETARDATION, X-LINKED, SNYDER-ROBINSON TYPE	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0853892	BXGD010984	Catabolic state
C0919267	BXGD011426	ovarian neoplasm	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1135868	BXGD011700	Gestational Trophoblastic Neoplasms	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C1140680	BXGD011718	Malignant neoplasm of ovary	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1153706	BXGD011769	Endometrial adenocarcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C1269683	BXGD012001	Major Depressive Disorder	Mental Disorders
C1269955	BXGD012005	Tumor Cell Invasion
C1306459	BXGD012361	Primary malignant neoplasm	Neoplasms
C1306460	BXGD012362	Primary malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C1332986	BXGD012574	Childhood Osteosarcoma	Neoplasms
C1458155	BXGD013136	Mammary Neoplasms	Neoplasms; Skin and Connective Tissue Diseases
C1512409	BXGD013188	Hepatocarcinogenesis	Pathological Conditions, Signs and Symptoms; Neoplasms
C1518693	BXGD013225	Clear cell adenocarcinoma of ovary	Neoplasms
C1565489	BXGD013401	Renal Insufficiency	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1565662	BXGD013402	Acute Kidney Insufficiency	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1608408	BXGD013434	Malignant transformation
C1623038	BXGD013475	Cirrhosis	Pathological Conditions, Signs and Symptoms
C1698581	BXGD013519	Rokitansky Kuster Hauser syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C1739135	BXGD013733	Progression of prostate cancer
C1834582	BXGD013982	MYELOPROLIFERATIVE SYNDROME, TRANSIENT	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Hemic and Lymphatic Diseases
C1956346	BXGD016627	Coronary Artery Disease	Cardiovascular Diseases
C2239176	BXGD016965	Liver carcinoma	Digestive System Diseases; Neoplasms
C2316810	BXGD017030	Chronic kidney disease stage 5	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2609414	BXGD017182	Acute kidney injury	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2711227	BXGD017478	Steatohepatitis	Digestive System Diseases
C2931822	BXGD018068	Nasopharyngeal carcinoma	Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C3463897	BXGD018900	HYDATIDIFORM MOLE, RECURRENT, 1
C3830362	BXGD019751	Early Pregnancy Loss	Female Urogenital Diseases and Pregnancy Complications
C4509223	BXGD022971	Heart failure with reduced ejection fraction [HFrEF]
C4509226	BXGD022972	Heart failure with preserved ejection fraction [HFpEF]
C4520983	BXGD023052	Congenital atresia of extrahepatic bile duct	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C4551595	BXGD023367	Biliary Cirrhosis, Primary, 1	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C4551683	BXGD023389	Adrenal Gland Pheochromocytoma	Neoplasms; Endocrine System Diseases
C4552766	BXGD023523	Miscarriage	Female Urogenital Diseases and Pregnancy Complications
C4721610	BXGD023760	Carcinoma, Ovarian Epithelial	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085	BXGD023788	Malignant neoplasm of colon and/or rectum
C4732730	BXGD023895	Blood spots

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0042315	1,4-dioxane		88.05

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}