adisease

Showing entry for Keratitis

General Disease Information
BXGD Id	BXGD001552
Disease Name	Keratitis
Disease CUI Id	C0022568
MeSH Codes	C11
Disease Class Name	Eye Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0002715 HP:0000478
Human Phenotype Ontology Term	Abnormality of the immune system; Abnormality of the eye
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O14920	BXGT004110	Inhibitor of nuclear factor kappa-B kinase subunit beta	3551	reviewed	Kinase
O43318	BXGT004586	Mitogen-activated protein kinase kinase kinase 7	6885	reviewed	Kinase
O60603	BXGT004887	Toll-like receptor 2	7097	reviewed
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01138	BXGT005738	Beta-nerve growth factor	4803	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P02533	BXGT005887	Keratin, type I cytoskeletal 14	3861	reviewed
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P02788	BXGT005963	Lactotransferrin	4057	reviewed	Enzyme
P04040	BXGT006132	Catalase	847	reviewed	Enzyme
P04054	BXGT006136	Phospholipase A2	5319	reviewed	Enzyme
P04629	BXGT006239	High affinity nerve growth factor receptor	4914	reviewed	Kinase
P05109	BXGT006318	Protein S100-A8	6279	reviewed	Calcium-binding protein
P05161	BXGT006331	Ubiquitin-like protein ISG15	9636	reviewed	Nucleic acid binding
P05164	BXGT006333	Myeloperoxidase	4353	reviewed	Enzyme
P05231	BXGT006345	Interleukin-6	3569	reviewed
P07996	BXGT006710	Thrombospondin-1	7057	reviewed
P09429	BXGT006889	High mobility group protein B1	3146	reviewed	Nucleic acid binding
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10147	BXGT007543	C-C motif chemokine 3	6348	reviewed	Signaling
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P11215	BXGT007672	Integrin alpha-M	3684	reviewed
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P13569	BXGT007923	Cystic fibrosis transmembrane conductance regulator	1080	reviewed	Ion channel
P14174	BXGT007991	Macrophage migration inhibitory factor	4282	reviewed
P14555	BXGT008020	Phospholipase A2, membrane associated	5320	reviewed	Enzyme
P15289	BXGT008102	Arylsulfatase A	410	reviewed	Enzyme
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P17735	BXGT008335	Tyrosine aminotransferase	6898	reviewed
P18074	BXGT008374	General transcription and DNA repair factor IIH helicase subunit XPD	2068	reviewed	Enzyme
P18848	BXGT008432	Cyclic AMP-dependent transcription factor ATF-4	468	reviewed
P19838	BXGT008526	Nuclear factor NF-kappa-B p105 subunit	4790	reviewed	Transcription factor
P20309	BXGT008562	Muscarinic acetylcholine receptor M3	1131	reviewed	G-protein coupled receptor
P20930	BXGT008616	Filaggrin	2312	reviewed	Cellular structure
P21802	BXGT008691	Fibroblast growth factor receptor 2	2263	reviewed	Kinase
P25025	BXGT009006	C-X-C chemokine receptor type 2	3579	reviewed	G-protein coupled receptor
P25311	BXGT009036	Zinc-alpha-2-glycoprotein	563	reviewed
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P28907	BXGT009301	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	952	reviewed	Enzyme
P29033	BXGT009308	Gap junction beta-2 protein	2706	reviewed	Cell-cell junction
P29460	BXGT009348	Interleukin-12 subunit beta	3593	reviewed	Signaling
P29466	BXGT009349	Caspase-1	834	reviewed	Enzyme
P30536	BXGT009435	Translocator protein	706	reviewed
P30876	BXGT009476	DNA-directed RNA polymerase II subunit RPB2	5431	reviewed	Enzyme
P36222	BXGT009914	Chitinase-3-like protein 1	1116	reviewed
P36955	BXGT009946	Pigment epithelium-derived factor	5176	reviewed	Enzyme modulator
P39900	BXGT010148	Macrophage metalloelastase	4321	reviewed	Enzyme
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P42574	BXGT010317	Caspase-3	836	reviewed	Enzyme
P45983	BXGT010494	Mitogen-activated protein kinase 8	5599	reviewed	Kinase
P46108	BXGT010509	Adapter molecule crk	1398	reviewed
P48061	BXGT010616	Stromal cell-derived factor 1	6387	reviewed
P49116	BXGT010678	Nuclear receptor subfamily 2 group C member 2	7182	reviewed	Nuclear receptor
P49767	BXGT010739	Vascular endothelial growth factor C	7424	reviewed	Signaling
P49913	BXGT010761	Cathelicidin antimicrobial peptide	820	reviewed
P50591	BXGT010814	Tumor necrosis factor ligand superfamily member 10	8743	reviewed	Signaling
P51617	BXGT010868	Interleukin-1 receptor-associated kinase 1	3654	reviewed	Kinase
P55211	BXGT011111	Caspase-9	842	reviewed	Enzyme
P60022	BXGT011285	Beta-defensin 1	1672	reviewed
P61073	BXGT011352	C-X-C chemokine receptor type 4	7852	reviewed	G-protein coupled receptor
P63104	BXGT011499	14-3-3 protein zeta/delta	7534	reviewed	Chaperone
P78380	BXGT011841	Oxidized low-density lipoprotein receptor 1	4973	reviewed
Q01831	BXGT012621	DNA repair protein complementing XP-C cells	7508	reviewed	Nucleic acid binding
Q03468	BXGT012716	DNA excision repair protein ERCC-6	2074	reviewed
Q09428	BXGT013036	ATP-binding cassette sub-family C member 8	6833	reviewed	Transporter
Q13155	BXGT013320	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	7965	reviewed
Q14627	BXGT013492	Interleukin-13 receptor subunit alpha-2	3598	reviewed	Signaling
Q15149	BXGT013547	Plectin	5339	reviewed	Cellular structure
Q16539	BXGT013634	Mitogen-activated protein kinase 14	1432	reviewed	Kinase
Q6P589	BXGT016452	Tumor necrosis factor alpha-induced protein 8-like protein 2	79626	reviewed
Q8N6T7	BXGT018525	NAD-dependent protein deacetylase sirtuin-6	51548	reviewed	Epigenetic regulator
Q8NBJ7	BXGT018537	Inactive C-alpha-formylglycine-generating enzyme 2	25870	reviewed
Q8NER1	BXGT018556	Transient receptor potential cation channel subfamily V member 1	7442	reviewed	Ion channel
Q96J66	BXGT019680	ATP-binding cassette sub-family C member 11	85320	reviewed	Transporter
Q96P20	BXGT019704	NACHT, LRR and PYD domains-containing protein 3	114548	reviewed
Q99836	BXGT019970	Myeloid differentiation primary response protein MyD88	4615	reviewed	Enzyme modulator
Q9HC29	BXGT020526	Nucleotide-binding oligomerization domain-containing protein 2	64127	reviewed	Enzyme
Q9NP99	BXGT021148	Triggering receptor expressed on myeloid cells 1	54210	reviewed
Q9NR96	BXGT021181	Toll-like receptor 9	54106	reviewed
Q9NWM0	BXGT021232	Spermine oxidase	54498	reviewed
Q9ULY5	BXGT021770	C-type lectin domain family 4 member E	26253	reviewed	Receptor
Q9Y253	BXGT022216	DNA polymerase eta	5429	reviewed
Q9Y6K9	BXGT022333	NF-kappa-B essential modulator	8517	reviewed	Kinase
P16284	BXGT022972	Platelet endothelial cell adhesion molecule	5175	reviewed	Cell adhesion
Q16552	BXGT023419	Interleukin-17A	3605	reviewed
Q59FF6	BXGT023693	Excision repair cross-complementing rodent repair deficiency, complementation group 6 variant	2074	unreviewed
Q13007	BXGT023883	Interleukin-24	11009	reviewed
Q14807	BXGT024966	Kinesin-like protein KIF22	3835	reviewed	Cellular structure
P28715	BXGT025675	DNA repair protein complementing XP-G cells	2073	reviewed
Q96RD7	BXGT025890	Pannexin-1	24145	reviewed	Ion channel

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}