Showing entry for Keratin, type I cytoskeletal 14


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005887
Protein NameKeratin, type I cytoskeletal 14
Uniport IdP02533
GeneKRT14
Gene Id3861
DomainFilament
Pfam PF00038  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.2 Endocrine system hsa04915 Estrogen signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007568 aging
Biological Process GO:0070268 cornification
Biological Process GO:0008544 epidermis development
Biological Process GO:0042633 hair cycle
Biological Process GO:0031581 hemidesmosome assembly
Biological Process GO:0045110 intermediate filament bundle assembly
Biological Process GO:0031424 keratinization
molecular function GO:1990254 keratin filament binding
molecular function GO:0005200 structural constituent of cytoskeleton
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005882 intermediate filament
cellular component GO:0045095 keratin filament
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-1500931 Cell-Cell communication
R-HSA-446107 Type I hemidesmosome assembly
R-HSA-446728 Cell junction organization
R-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002448 BXGD000115 Ameloblastoma Neoplasms
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004763 BXGD000289 Barrett Esophagus Digestive System Diseases; Neoplasms
C0004779 BXGD000291 Basal Cell Nevus Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Musculoskeletal Diseases; Stomatognathic Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007124 BXGD000437 Noninfiltrating Intraductal Carcinoma Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007138 BXGD000446 Carcinoma, Transitional Cell Neoplasms
C0007621 BXGD000468 Neoplastic Cell Transformation Pathological Conditions, Signs and Symptoms; Neoplasms
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0010606 BXGD000677 Adenoid Cystic Carcinoma Neoplasms
C0011334 BXGD000716 Dental caries Stomatognathic Diseases
C0011351 BXGD000717 Dental Enamel Hypoplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0013575 BXGD000854 Ectodermal Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0014527 BXGD000923 Epidermolysis Bullosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0014599 BXGD000939 Epithelial hyperplasia Pathological Conditions, Signs and Symptoms
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020458 BXGD001393 Hyperhidrosis disorder Skin and Connective Tissue Diseases
C0020620 BXGD001448 Hypohidrosis Skin and Connective Tissue Diseases
C0020757 BXGD001466 Ichthyoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0020758 BXGD001467 Congenital ichthyosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0022283 BXGD001533 Incontinentia Pigmenti Achromians Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0022568 BXGD001552 Keratitis Eye Diseases
C0022584 BXGD001559 Keratoderma, Palmoplantar, Diffuse Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0022595 BXGD001562 Keratosis Follicularis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0022596 BXGD001563 Palmoplantar Keratosis Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0023532 BXGD001685 Leukoplakia, Oral Pathological Conditions, Signs and Symptoms; Neoplasms; Stomatognathic Diseases
C0024899 BXGD001812 Mastocytosis Neoplasms; Skin and Connective Tissue Diseases; Immune System Diseases
C0026850 BXGD001942 Muscular Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0030354 BXGD002214 Papilloma Neoplasms
C0030436 BXGD002221 Parakeratosis Skin and Connective Tissue Diseases
C0032927 BXGD002381 Precancerous Conditions Neoplasms
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0035229 BXGD002516 Respiratory Insufficiency Respiratory Tract Diseases
C0035851 BXGD002567 Root Resorption Stomatognathic Diseases
C0036305 BXGD002593 Schamberg Disease Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0037274 BXGD002676 Dermatologic disorders Skin and Connective Tissue Diseases
C0037277 BXGD002677 Skin Diseases, Genetic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0040411 BXGD002859 Tongue Neoplasms Neoplasms; Stomatognathic Diseases
C0040580 BXGD002877 Tracheal Diseases Respiratory Tract Diseases
C0040997 BXGD002894 Trigeminal Neuralgia Nervous System Diseases; Stomatognathic Diseases
C0079295 BXGD003071 Epidermolysis Bullosa Herpetiformis Dowling-Meara Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0079298 BXGD003073 Epidermolysis Bullosa Simplex Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0079299 BXGD003074 Epidermolysis Bullosa Simplex Kobner Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0080333 BXGD003114 Weber-Cockayne Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0151514 BXGD003429 Atrophic condition of skin Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0153349 BXGD003621 Malignant neoplasm of tongue Neoplasms; Stomatognathic Diseases
C0162154 BXGD003922 Atrophic scar Pathological Conditions, Signs and Symptoms
C0162810 BXGD003982 Cicatrix, Hypertrophic Pathological Conditions, Signs and Symptoms
C0162834 BXGD003988 Hyperpigmentation Skin and Connective Tissue Diseases
C0162835 BXGD003989 Hypopigmentation disorder Skin and Connective Tissue Diseases
C0205874 BXGD004136 Papilloma, Squamous Cell Neoplasms
C0206062 BXGD004148 Lung Diseases, Interstitial Respiratory Tract Diseases
C0206186 BXGD004172 Leukoplakia, Hairy Pathological Conditions, Signs and Symptoms; Neoplasms; Infections; Stomatognathic Diseases
C0206650 BXGD004214 Fibroadenoma Neoplasms
C0206708 BXGD004256 Cervical Intraepithelial Neoplasia Neoplasms
C0221260 BXGD004424 Dystrophia unguium Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0231274 BXGD004490 Intolerant of heat
C0232466 BXGD004543 Feeding difficulties
C0232513 BXGD004553 Premature tooth loss Stomatognathic Diseases
C0241424 BXGD005097 Tongue biting Stomatognathic Diseases
C0241982 BXGD005129 Bulla of lung Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0263537 BXGD005323 Onychogryposis Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0268251 BXGD005869 Gaucher Disease, Type 3 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0268375 BXGD005919 Autosomal dominant epidermolysis bullosa simplex Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0279671 BXGD006677 Cervical Squamous Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0282612 BXGD006820 Prostatic Intraepithelial Neoplasias Neoplasms
C0302142 BXGD006831 Deformity Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0332840 BXGD006900 Amputated structure (morphologic abnormality) Wounds and Injuries
C0334245 BXGD007005 Intraepithelial Squamous Cell Carcinoma Pathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0334254 BXGD007010 Lymphoepithelial carcinoma Neoplasms
C0334267 BXGD007013 Transitional cell carcinoma in situ Neoplasms
C0334318 BXGD007031 Lipid-rich carcinoma Neoplasms
C0334347 BXGD007039 Eccrine spiradenoma Neoplasms
C0343111 BXGD007603 Naegeli syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0345996 BXGD007761 Milium Cyst Pathological Conditions, Signs and Symptoms; Neoplasms; Skin and Connective Tissue Diseases
C0406778 BXGD008372 Dermatopathia pigmentosa reticularis Pathological Conditions, Signs and Symptoms; Neoplasms; Skin and Connective Tissue Diseases
C0423798 BXGD008510 Increased tendency to bruise Wounds and Injuries
C0423820 BXGD008514 Ridged nails
C0432315 BXGD008772 Epidermolysis bullosa simplex herpetiformis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0432316 BXGD008773 Epidermolysis bullosa simplex with mottled pigmentation Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0456070 BXGD008863 Growth delay
C0549567 BXGD009387 Pigmentation Disorders Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0553723 BXGD009416 Squamous cell carcinoma of skin Neoplasms; Skin and Connective Tissue Diseases
C0574769 BXGD009505 Loss of scalp hair Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0586407 BXGD009608 Skin symptom
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0596321 BXGD009642 Chemical Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0751401 BXGD010427 Ophthalmoparesis Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0853087 BXGD010964 Nail abnormality Pathological Conditions, Signs and Symptoms
C0853879 BXGD010982 Invasive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C0853945 BXGD010986 Oral mucosal blisters
C0854107 BXGD010999 Subcutaneous hemorrhage Skin and Connective Tissue Diseases
C0870082 BXGD011309 Hyperkeratosis Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0947912 BXGD011497 Myasthenias Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1112474 BXGD011672 Small cell carcinoma of esophagus
C1257931 BXGD011815 Mammary Neoplasms, Human Neoplasms; Skin and Connective Tissue Diseases
C1262020 BXGD011864 Diffuse alveolar damage
C1269955 BXGD012005 Tumor Cell Invasion
C1270972 BXGD012006 Mild cognitive disorder Mental Disorders
C1275684 BXGD012091 Meibomian gland dysfunction Eye Diseases; Skin and Connective Tissue Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1318562 BXGD012404 Infantile digital fibromatosis Neoplasms
C1332922 BXGD012556 Cervical Squamous Intraepithelial Neoplasia Pathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C1334274 BXGD012695 Invasive Carcinoma Neoplasms
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1721005 BXGD013699 Leukokeratosis, Hereditary Mucosal Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C1832926 BXGD013884 EPIDERMOLYSIS BULLOSA SIMPLEX, AUTOSOMAL RECESSIVE (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C1833225 BXGD013904 Dystrophic toenail
C1834405 BXGD013970 Nail dysplasia Pathological Conditions, Signs and Symptoms
C1836735 BXGD014155 hypopigmented skin patch Skin and Connective Tissue Diseases
C1837388 BXGD014225 Abnormal pattern of respiration
C1851562 BXGD015220 Skin fragility with non-scarring blistering
C1851972 BXGD015253 Reticular hyperpigmentation
C1852148 BXGD015262 Reticulate pigmentation of oral mucosa
C1852150 BXGD015263 Fingerprints, Absence of Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C1853193 BXGD015312 Recurrent skin infections Infections; Skin and Connective Tissue Diseases
C1855106 BXGD015459 Neonatal onset
C1856963 BXGD015662 Fragile nails Pathological Conditions, Signs and Symptoms
C1857656 BXGD015731 Prematurely aged appearance
C1861403 BXGD016045 Variable expressivity
C1969913 BXGD016800 Generalized hyperkeratosis
C2132198 BXGD016930 Abnormal blistering of the skin
C2145472 BXGD016931 Urothelial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3267070 BXGD018612 Oesophageal fibrosis
C3279575 BXGD018764 Reticulated skin pigmentation
C3279947 BXGD018789 NAIL DISORDER, NONSYNDROMIC CONGENITAL, 9
C3472608 BXGD018921 Micropapillary carcinoma
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3551426 BXGD019146 Dystrophic fingernails
C3642347 BXGD019246 Basal-Like Breast Carcinoma
C3694279 BXGD019338 Middle East Respiratory Syndrome Infections
C3715082 BXGD019444 EPIDERMOLYSIS BULLOSA SIMPLEX, AUTOSOMAL RECESSIVE 1
C3814530 BXGD019668 Skin Vesicle Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C4021800 BXGD020790 Abnormality of dental enamel
C4021831 BXGD020812 Hypohidrosis or hyperhidrosis
C4024876 BXGD021451 Palmoplantar blistering
C4025847 BXGD021827 Abnormal conjunctiva morphology
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4302031 BXGD022520 Basal epidermolysis bullosa simplex Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C4518333 BXGD023017 Clear cell papillary renal cell carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C4551675 BXGD023384 Keratoderma, Palmoplantar Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C4704874 BXGD023682 Mammary Carcinoma, Human Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002682 Zinc 65.41
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein