Showing entry for Plectin


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013547
Protein NamePlectin
Uniport IdQ15149
GenePLEC
Gene Id5339
DomainCH; Plectin; S10_plectin; SH3_10; Spectrin_like
Pfam PF00307   PF00681   PF03501   PF17902   PF18373  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0031581 hemidesmosome assembly
Biological Process GO:0045104 intermediate filament cytoskeleton organization
Biological Process GO:0042060 wound healing
molecular function GO:0003779 actin binding
molecular function GO:0030506 ankyrin binding
molecular function GO:0045296 cadherin binding
molecular function GO:0003723 RNA binding
molecular function GO:0005200 structural constituent of cytoskeleton
molecular function GO:0008307 structural constituent of muscle
molecular function GO:0005198 structural molecule activity
cellular component GO:0005903 brush border
cellular component GO:0043034 costamere
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005925 focal adhesion
cellular component GO:0030056 hemidesmosome
cellular component GO:0045111 intermediate filament cytoskeleton
cellular component GO:0016020 membrane
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0005886 plasma membrane
cellular component GO:0042383 sarcolemma
cellular component GO:0016528 sarcoplasm
Reactome
Pathway Id Pathway Name
R-HSA-109581 Apoptosis
R-HSA-111465 Apoptotic cleavage of cellular proteins
R-HSA-1474244 Extracellular matrix organization
R-HSA-1474290 Collagen formation
R-HSA-1500931 Cell-Cell communication
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins
R-HSA-446107 Type I hemidesmosome assembly
R-HSA-446728 Cell junction organization
R-HSA-5357801 Programmed Cell Death
R-HSA-75153 Apoptotic execution phase
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001430 BXGD000054 Adenoma Neoplasms
C0002170 BXGD000105 Alopecia Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0003537 BXGD000208 Aphasia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003886 BXGD000238 Arthrogryposis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0004144 BXGD000259 Atelectasis Respiratory Tract Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0005890 BXGD000345 Body Height
C0006271 BXGD000384 Bronchiolitis Infections; Respiratory Tract Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0008370 BXGD000534 Cholestasis Digestive System Diseases
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0011175 BXGD000701 Dehydration Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0011334 BXGD000716 Dental caries Stomatognathic Diseases
C0011351 BXGD000717 Dental Enamel Hypoplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013528 BXGD000851 Echolalia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013592 BXGD000857 Ectropion Eye Diseases
C0014527 BXGD000923 Epidermolysis Bullosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0014772 BXGD000948 Red Blood Cell Count measurement
C0014850 BXGD000957 Esophageal Atresia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0016169 BXGD001048 pathologic fistula Pathological Conditions, Signs and Symptoms
C0016529 BXGD001068 Forced expiratory volume function
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017658 BXGD001138 Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0020224 BXGD001366 Polyhydramnios Female Urogenital Diseases and Pregnancy Complications
C0020295 BXGD001372 Hydronephrosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0022568 BXGD001552 Keratitis Eye Diseases
C0022596 BXGD001563 Palmoplantar Keratosis Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0022972 BXGD001596 Lambert-Eaton Myasthenic Syndrome Neoplasms; Immune System Diseases; Nervous System Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0026825 BXGD001934 Flaccid Muscle Tone Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0026850 BXGD001942 Muscular Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026884 BXGD001945 Mutism Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027868 BXGD002053 Neuromuscular Diseases Nervous System Diseases
C0028866 BXGD002094 Oculomotor Nerve Paralysis Eye Diseases; Nervous System Diseases
C0029089 BXGD002107 Ophthalmoplegia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029410 BXGD002138 Osteoarthritis of hip Musculoskeletal Diseases
C0030297 BXGD002204 Pancreatic Neoplasm Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0030805 BXGD002256 Bullous pemphigoid Skin and Connective Tissue Diseases; Immune System Diseases
C0032181 BXGD002332 Platelet Count measurement
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0035220 BXGD002512 Respiratory Distress Syndrome, Newborn Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0037274 BXGD002676 Dermatologic disorders Skin and Connective Tissue Diseases
C0037285 BXGD002680 Skin Manifestations Pathological Conditions, Signs and Symptoms
C0038450 BXGD002759 Stridor Pathological Conditions, Signs and Symptoms
C0041960 BXGD002943 Ureterocele Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0041974 BXGD002945 Urethral Stenosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0042063 BXGD002953 Urogenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0079298 BXGD003073 Epidermolysis Bullosa Simplex Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0079299 BXGD003074 Epidermolysis Bullosa Simplex Kobner Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0085615 BXGD003206 Right bundle branch block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151514 BXGD003429 Atrophic condition of skin Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0151526 BXGD003432 Premature Birth Female Urogenital Diseases and Pregnancy Complications
C0151785 BXGD003474 Disease of mucous membrane Pathological Conditions, Signs and Symptoms
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0152423 BXGD003587 Congenital small ears Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Otorhinolaryngologic Diseases
C0153594 BXGD003669 Malignant neoplasm of testis Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C0162154 BXGD003922 Atrophic scar Pathological Conditions, Signs and Symptoms
C0162830 BXGD003987 Dermatitis, Phototoxic Skin and Connective Tissue Diseases
C0178664 BXGD004032 Glomerulosclerosis (disorder) Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Cardiovascular Diseases
C0178879 BXGD004038 Urinary tract obstruction Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0200638 BXGD004043 Eosinophil count procedure
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0220810 BXGD004346 Congenital defects
C0221260 BXGD004424 Dystrophia unguium Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0231807 BXGD004524 Dyspnea on exertion Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0234146 BXGD004626 Absent reflex Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234182 BXGD004631 Gowers sign
C0235831 BXGD004773 Renal Cell Dysplasia Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0239067 BXGD004961 Difficulty walking up stairs Pathological Conditions, Signs and Symptoms
C0241005 BXGD005072 Creatine phosphokinase serum increased
C0241181 BXGD005084 Fragile skin
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0259799 BXGD005224 Punctate keratitis Eye Diseases
C0263537 BXGD005323 Onychogryposis Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0265998 BXGD005600 ANONYCHIA Pathological Conditions, Signs and Symptoms
C0266159 BXGD005624 Pyloric Atresia Digestive System Diseases
C0268731 BXGD006029 Renal glomerular disease Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0270726 BXGD006093 Alexander Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0278510 BXGD006526 Childhood Medulloblastoma Neoplasms
C0278876 BXGD006607 Adult Medulloblastoma Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0282160 BXGD006797 Aplasia Cutis Congenita Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0332563 BXGD006894 Papule Pathological Conditions, Signs and Symptoms
C0333068 BXGD006920 Flexion contracture Musculoskeletal Diseases
C0337428 BXGD007155 Fibrinogen assay
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0345996 BXGD007761 Milium Cyst Pathological Conditions, Signs and Symptoms; Neoplasms; Skin and Connective Tissue Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349588 BXGD007933 Short stature
C0349788 BXGD007956 Arrhythmogenic Right Ventricular Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0393934 BXGD008158 Slow channel syndrome Nervous System Diseases
C0406458 BXGD008342 Diffuse alopecia Skin and Connective Tissue Diseases
C0410264 BXGD008423 Contracture of tendo achilles
C0423224 BXGD008475 Sunken eyes Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0423798 BXGD008510 Increased tendency to bruise Wounds and Injuries
C0424678 BXGD008537 Lean body mass
C0427064 BXGD008603 Pelvic girdle weakness Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0428474 BXGD008631 Serum LDL cholesterol measurement
C0432317 BXGD008774 Epidermolysis bullosa simplex, Ogna type Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0442874 BXGD008814 Neuropathy Nervous System Diseases
C0520947 BXGD009126 Clumsiness - motor delay Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0541794 BXGD009262 Skeletal muscle atrophy
C0549225 BXGD009364 Myasthenic Syndrome
C0557874 BXGD009444 Global developmental delay
C0566620 BXGD009490 Nasal voice
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686353 BXGD009833 Muscular Dystrophies, Limb-Girdle Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0740927 BXGD010017 Elevated maternal serum alpha-fetoprotein
C0743178 BXGD010077 Intractable diarrhea Pathological Conditions, Signs and Symptoms
C0746674 BXGD010147 Generalized muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0751882 BXGD010626 Myasthenic Syndromes, Congenital Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0850703 BXGD010905 Frequent falls Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0853945 BXGD010986 Oral mucosal blisters
C0855197 BXGD011079 Malignant Testicular Germ Cell Tumor Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C0871470 BXGD011316 Systolic Pressure
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0947912 BXGD011497 Myasthenias Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0973461 BXGD011595 Dysphasia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1184923 BXGD011800 Lumbar hyperlordosis Musculoskeletal Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1274224 BXGD012026 Inherited epidermolysis bullosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1325327 BXGD012455 fibrinogen activity
C1335302 BXGD012775 Pancreatic Ductal Adenocarcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1445957 BXGD013081 Serum total cholesterol measurement
C1519353 BXGD013236 Skin Papule Skin and Connective Tissue Diseases
C1561955 BXGD013367 Fibrinogen, CTCAE
C1562761 BXGD013378 Punctate epithelial keratitis Eye Diseases
C1608408 BXGD013434 Malignant transformation
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1832926 BXGD013884 EPIDERMOLYSIS BULLOSA SIMPLEX, AUTOSOMAL RECESSIVE (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C1834055 BXGD013953 Underdeveloped nasal alae
C1834405 BXGD013970 Nail dysplasia Pathological Conditions, Signs and Symptoms
C1836156 BXGD014085 Progressive proximal muscle weakness
C1836450 BXGD014117 Distal lower limb muscle weakness
C1837658 BXGD014257 Gross motor development delay Mental Disorders
C1838681 BXGD014337 Rapidly progressive
C1839653 BXGD014392 Decreased cervical spine flexion due to contractures of posterior cervical muscles
C1843057 BXGD014552 Calf muscle hypertrophy
C1844738 BXGD014671 Axillary pterygium Eye Diseases
C1844825 BXGD014683 Hyperconvex fingernails
C1849097 BXGD015006 Loss of ability to walk
C1851562 BXGD015220 Skin fragility with non-scarring blistering
C1854301 BXGD015391 Motor delay Mental Disorders
C1856786 BXGD015645 Hypoplastic fingernail
C1856934 BXGD015659 Epidermolysis bullosa with pyloric atresia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C1856954 BXGD015661 Plantar hyperkeratosis
C1857108 BXGD015677 Limitation of joint mobility
C1858430 BXGD015792 Death in infancy
C1865916 BXGD016355 Bilateral ptosis Eye Diseases
C1866021 BXGD016363 Increased connective tissue
C1869123 BXGD016553 Limb-girdle muscular dystrophy type 2A Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C2132198 BXGD016930 Abnormal blistering of the skin
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2363741 BXGD017100 HIV-1 infection
C2677349 BXGD017372 Epidermolysis Bullosa Simplex With Pyloric Atresia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C2919142 BXGD017867 Short Stature, CTCAE
C2931072 BXGD017951 Epidermolysa bullosa simplex and limb girdle muscular dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Nervous System Diseases
C3150989 BXGD018371 MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 2Q
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3279947 BXGD018789 NAIL DISORDER, NONSYNDROMIC CONGENITAL, 9
C3536714 BXGD019069 Renal dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3714514 BXGD019409 Infection Infections
C3806301 BXGD019504 Scarring alopecia of scalp
C3814530 BXGD019668 Skin Vesicle Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C3825201 BXGD019684 Mitochondrial pathology
C3887524 BXGD019892 Skin Erosion Skin and Connective Tissue Diseases
C4020732 BXGD020474 Mitochondrial abnormalities
C4021133 BXGD020563 Left ventricular noncompaction cardiomyopathy Pathological Conditions, Signs and Symptoms
C4021726 BXGD020735 EMG: myopathic abnormalities Musculoskeletal Diseases; Nervous System Diseases
C4021730 BXGD020739 Junctional split
C4021800 BXGD020790 Abnormality of dental enamel
C4023812 BXGD021269 Aplasia of the bladder
C4024679 BXGD021367 Onychogryposis of toenails
C4024942 BXGD021489 Late-onset muscular dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C4025327 BXGD021646 Congenital pyloric atresia
C4025699 BXGD021739 Abnormality of the stomach
C4073207 BXGD022065 Bilateral facial muscle weakness Pathological Conditions, Signs and Symptoms; Infections; Nervous System Diseases; Stomatognathic Diseases
C4086152 BXGD022123 Childhood Astrocytoma Neoplasms
C4225309 BXGD022218 EPIDERMOLYSIS BULLOSA SIMPLEX WITH NAIL DYSTROPHY
C4280686 BXGD022384 Proximal upper limb muscle hypertrophy
C4281993 BXGD022418 Neonatal respiratory distress Respiratory Tract Diseases
C4477031 BXGD022907 Axial muscle atrophy
C4477095 BXGD022922 Increased lactate dehydrogenase activity
C4552811 BXGD023526 Generalized Muscle Weakness, CTCAE
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0004965 Rhein 284.22
BXGC0023687 (S)-(+)-1,2-Propanediol 76.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein