protein

Showing entry for Nuclear receptor subfamily 2 group C member 2

General Target Information
BXGT Id	BXGT010678
Protein Name	Nuclear receptor subfamily 2 group C member 2
Uniport Id	P49116
Gene	NR2C2
Gene Id	7182
Domain	Hormone_recep; zf-C4
Pfam	PF00104 PF00105
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0048856	anatomical structure development
Biological Process	GO:0030154	cell differentiation
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Biological Process	GO:0007399	nervous system development
Biological Process	GO:0040019	positive regulation of embryonic development
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0006355	regulation of transcription, DNA-templated
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II
Biological Process	GO:0007283	spermatogenesis
Biological Process	GO:0006367	transcription initiation from RNA polymerase II promoter
molecular function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific
molecular function	GO:0003700	DNA-binding transcription factor activity
molecular function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific
molecular function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding
molecular function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding
molecular function	GO:0043565	sequence-specific DNA binding
molecular function	GO:1990837	sequence-specific double-stranded DNA binding
molecular function	GO:0008270	zinc ion binding
cellular component	GO:0000790	nuclear chromatin
cellular component	GO:0005654	nucleoplasm
cellular component	GO:0005634	nucleus

Reactome

Pathway Id	Pathway Name
R-HSA-212436	Generic Transcription Pathway
R-HSA-383280	Nuclear Receptor transcription pathway
R-HSA-73857	RNA Polymerase II Transcription
R-HSA-74160	Gene expression (Transcription)

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0002395	BXGD000111	Alzheimer's Disease	Nervous System Diseases; Mental Disorders
C0002736	BXGD000127	Amyotrophic Lateral Sclerosis	Nutritional and Metabolic Diseases; Nervous System Diseases
C0003864	BXGD000231	Arthritis	Musculoskeletal Diseases
C0003873	BXGD000236	Rheumatoid Arthritis	Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0006142	BXGD000374	Malignant neoplasm of breast	Neoplasms; Skin and Connective Tissue Diseases
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0007102	BXGD000425	Malignant tumor of colon	Digestive System Diseases; Neoplasms
C0007131	BXGD000441	Non-Small Cell Lung Carcinoma	Neoplasms; Respiratory Tract Diseases
C0007137	BXGD000445	Squamous cell carcinoma	Neoplasms
C0007847	BXGD000492	Malignant tumor of cervix	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0008925	BXGD000575	Cleft Palate	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0009319	BXGD000596	Colitis	Digestive System Diseases
C0009402	BXGD000605	Colorectal Carcinoma	Digestive System Diseases; Neoplasms
C0010346	BXGD000664	Crohn Disease	Digestive System Diseases
C0011847	BXGD000749	Diabetes	Endocrine System Diseases
C0011849	BXGD000751	Diabetes Mellitus	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860	BXGD000755	Diabetes Mellitus, Non-Insulin-Dependent	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881	BXGD000760	Diabetic Nephropathy	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0011991	BXGD000766	Diarrhea	Pathological Conditions, Signs and Symptoms
C0013274	BXGD000809	Patent ductus arteriosus	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0014175	BXGD000904	Endometriosis	Female Urogenital Diseases and Pregnancy Complications
C0015695	BXGD001013	Fatty Liver	Digestive System Diseases
C0017638	BXGD001132	Glioma	Neoplasms
C0018099	BXGD001172	Gout	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0018133	BXGD001176	Graft-vs-Host Disease	Immune System Diseases
C0019158	BXGD001293	Hepatitis	Digestive System Diseases
C0022568	BXGD001552	Keratitis	Eye Diseases
C0022660	BXGD001571	Kidney Failure, Acute	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023449	BXGD001650	Acute lymphocytic leukemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023465	BXGD001656	Acute monocytic leukemia	Neoplasms
C0023467	BXGD001658	Leukemia, Myelocytic, Acute	Neoplasms
C0024117	BXGD001734	Chronic Obstructive Airway Disease	Respiratory Tract Diseases
C0024299	BXGD001758	Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0025202	BXGD001832	melanoma	Neoplasms
C0025517	BXGD001875	Metabolic Diseases	Nutritional and Metabolic Diseases
C0026948	BXGD001952	Mycosis Fungoides	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0027627	BXGD002006	Neoplasm Metastasis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651	BXGD002009	Neoplasms	Neoplasms
C0027708	BXGD002025	Nephroblastoma	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0028754	BXGD002082	Obesity	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408	BXGD002137	Degenerative polyarthritis	Musculoskeletal Diseases
C0029463	BXGD002160	Osteosarcoma	Neoplasms
C0032273	BXGD002343	Pneumoconiosis	Respiratory Tract Diseases; Occupational Diseases
C0032285	BXGD002344	Pneumonia	Infections; Respiratory Tract Diseases
C0034902	BXGD002494	Pure Red-Cell Aplasia	Hemic and Lymphatic Diseases
C0036631	BXGD002626	Seminoma	Neoplasms
C0038454	BXGD002760	Cerebrovascular accident	Nervous System Diseases; Cardiovascular Diseases
C0038525	BXGD002768	Subarachnoid Hemorrhage	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0041296	BXGD002903	Tuberculosis	Infections
C0041330	BXGD002917	Tuberculosis, Spinal	Infections; Musculoskeletal Diseases
C0042769	BXGD002999	Virus Diseases	Infections
C0079731	BXGD003087	B-Cell Lymphomas	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079744	BXGD003090	Diffuse Large B-Cell Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079773	BXGD003100	Lymphoma, T-Cell, Cutaneous	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0149782	BXGD003365	Squamous cell carcinoma of lung	Neoplasms; Respiratory Tract Diseases
C0153676	BXGD003679	Secondary malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C0153690	BXGD003684	Secondary malignant neoplasm of bone	Pathological Conditions, Signs and Symptoms; Neoplasms; Musculoskeletal Diseases
C0155094	BXGD003769	Corneal pannus	Pathological Conditions, Signs and Symptoms; Eye Diseases
C0156147	BXGD003838	Crohn's disease of large bowel	Digestive System Diseases
C0162670	BXGD003970	Mitochondrial Myopathies	Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0178874	BXGD004037	Tumor Progression	Pathological Conditions, Signs and Symptoms
C0206664	BXGD004226	Teratocarcinoma	Neoplasms
C0221406	BXGD004459	Pituitary-dependent Cushing's disease	Nervous System Diseases; Endocrine System Diseases
C0235974	BXGD004796	Pancreatic carcinoma	Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0235989	BXGD004801	Renal interstitial fibrosis	Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Male Urogenital Diseases
C0238790	BXGD004956	bone destruction
C0239946	BXGD005010	Fibrosis, Liver	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0241910	BXGD005123	Autoimmune Chronic Hepatitis	Digestive System Diseases; Immune System Diseases
C0242379	BXGD005157	Malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C0269102	BXGD006053	Endometrioma	Female Urogenital Diseases and Pregnancy Complications
C0278488	BXGD006515	Carcinoma breast stage IV
C0279626	BXGD006657	Squamous cell carcinoma of esophagus	Digestive System Diseases; Neoplasms
C0279628	BXGD006659	Adenocarcinoma Of Esophagus	Digestive System Diseases; Neoplasms
C0279702	BXGD006685	Conventional (Clear Cell) Renal Cell Carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0282612	BXGD006820	Prostatic Intraepithelial Neoplasias	Neoplasms
C0302592	BXGD006851	Cervix carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0334634	BXGD007144	Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0338078	BXGD007166	Non-Functioning Pituitary Gland Neoplasm	Neoplasms; Nervous System Diseases; Endocrine System Diseases
C0338451	BXGD007176	Frontotemporal dementia	Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0346647	BXGD007832	Malignant neoplasm of pancreas	Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358	BXGD007992	Malignant neoplasm of prostate	Neoplasms; Male Urogenital Diseases
C0521607	BXGD009146	Peritoneal Fibrosis	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0585442	BXGD009593	Osteosarcoma of bone	Neoplasms
C0596263	BXGD009639	Carcinogenesis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0598935	BXGD009674	Tumor Initiation	Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139	BXGD009695	Prostate carcinoma	Neoplasms; Male Urogenital Diseases
C0677898	BXGD009735	invasive cancer	Neoplasms
C0678222	BXGD009749	Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C0684249	BXGD009790	Carcinoma of lung	Neoplasms; Respiratory Tract Diseases
C0686619	BXGD009835	Secondary malignant neoplasm of lymph node	Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790	BXGD009866	Colon Carcinoma	Digestive System Diseases; Neoplasms
C0751213	BXGD010352	Tactile Allodynia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751214	BXGD010353	Hyperalgesia, Thermal	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0850666	BXGD010901	Infection caused by Helicobacter pylori	Infections
C1269955	BXGD012005	Tumor Cell Invasion
C1290884	BXGD012198	Inflammatory disorder	Pathological Conditions, Signs and Symptoms
C1306459	BXGD012361	Primary malignant neoplasm	Neoplasms
C1306460	BXGD012362	Primary malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C1328504	BXGD012469	Hormone refractory prostate cancer	Neoplasms; Male Urogenital Diseases
C1332201	BXGD012502	Adult Diffuse Large B-Cell Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332206	BXGD012504	Adult Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332979	BXGD012571	Childhood Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332986	BXGD012574	Childhood Osteosarcoma	Neoplasms
C1458155	BXGD013136	Mammary Neoplasms	Neoplasms; Skin and Connective Tissue Diseases
C1519666	BXGD013240	Tumor-Associated Vasculature
C1519670	BXGD013241	Tumor Angiogenesis	Pathological Conditions, Signs and Symptoms
C1621958	BXGD013468	Glioblastoma Multiforme	Neoplasms
C1837218	BXGD014207	Cleft palate, isolated	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C1841972	BXGD014484	Glucocorticoid Receptor Deficiency	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C1961102	BXGD016673	Precursor Cell Lymphoblastic Leukemia Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1969372	BXGD016775	Tubulointerstitial fibrosis
C2239176	BXGD016965	Liver carcinoma	Digestive System Diseases; Neoplasms
C2711227	BXGD017478	Steatohepatitis	Digestive System Diseases
C2936904	BXGD018150	Opitz GBBB Syndrome, X-Linked	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases; Male Urogenital Diseases; Stomatognathic Diseases
C2939419	BXGD018178	Secondary Neoplasm	Pathological Conditions, Signs and Symptoms; Neoplasms
C2981150	BXGD018211	Uranostaphyloschisis	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Respiratory Tract Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C3203102	BXGD018555	Idiopathic pulmonary arterial hypertension	Respiratory Tract Diseases
C3539878	BXGD019087	Triple Negative Breast Neoplasms	Neoplasms; Skin and Connective Tissue Diseases
C3539920	BXGD019089	ECTODERMAL DYSPLASIA 11B, HYPOHIDROTIC/HAIR/TOOTH TYPE, AUTOSOMAL RECESSIVE
C3541517	BXGD019097	ECTODERMAL DYSPLASIA 11A, HYPOHIDROTIC/HAIR/TOOTH TYPE, AUTOSOMAL DOMINANT
C3714636	BXGD019421	Pneumonitis	Infections; Respiratory Tract Diseases
C3887494	BXGD019881	ECTODERMAL DYSPLASIA 10B, HYPOHIDROTIC/HAIR/TOOTH TYPE, AUTOSOMAL RECESSIVE	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C3888065	BXGD019946	ECTODERMAL DYSPLASIA 10A, HYPOHIDROTIC/HAIR/NAIL TYPE, AUTOSOMAL DOMINANT
C4048328	BXGD021903	cervical cancer	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4282128	BXGD022420	PATENT DUCTUS ARTERIOSUS 1	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C4529962	BXGD023178	Fatty Liver Disease
C4721414	BXGD023738	Mantle cell lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4721555	BXGD023755	Autoimmune hepatitis	Digestive System Diseases
C4721579	BXGD023759	Secondary malignant neoplasm of colon and/or rectum	Digestive System Diseases; Neoplasms
C4722085	BXGD023788	Malignant neoplasm of colon and/or rectum
C4722518	BXGD023806	Triple-Negative Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0050099	(2E,5S,6S,8Z,11S)-5,6,15-Trihydroxy-17-Methoxy-11-Methyl-12-Oxabicyclo[12.4.0]Octadeca-1(14),2,8,15,17-Pentaene-7,13-Dione		362.14

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}