Showing entry for Lactotransferrin


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005963
Protein NameLactotransferrin
Uniport IdP02788
GeneLTF
Gene Id4057
DomainTransferrin
Pfam PF00405  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0019731 antibacterial humoral response
Biological Process GO:0019732 antifungal humoral response
Biological Process GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
Biological Process GO:0019730 antimicrobial humoral response
Biological Process GO:0060349 bone morphogenesis
Biological Process GO:0044267 cellular protein metabolic process
Biological Process GO:0050829 defense response to Gram-negative bacterium
Biological Process GO:0050830 defense response to Gram-positive bacterium
Biological Process GO:0006959 humoral immune response
Biological Process GO:0045087 innate immune response
Biological Process GO:0002227 innate immune response in mucosa
Biological Process GO:0031640 killing of cells of other organism
Biological Process GO:0051673 membrane disruption in other organism
Biological Process GO:0044793 negative regulation by host of viral process
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0032780 negative regulation of ATPase activity
Biological Process GO:2000117 negative regulation of cysteine-type endopeptidase activity
Biological Process GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway
Biological Process GO:0045837 negative regulation of membrane potential
Biological Process GO:2001205 negative regulation of osteoclast development
Biological Process GO:1900229 negative regulation of single-species biofilm formation in or on host organism
Biological Process GO:2000308 negative regulation of tumor necrosis factor (ligand) superfamily member 11 production
Biological Process GO:0045071 negative regulation of viral genome replication
Biological Process GO:0048525 negative regulation of viral process
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0001503 ossification
Biological Process GO:1900159 positive regulation of bone mineralization involved in bone maturation
Biological Process GO:1902732 positive regulation of chondrocyte proliferation
Biological Process GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process GO:0051092 positive regulation of NF-kappaB transcription factor activity
Biological Process GO:0045669 positive regulation of osteoblast differentiation
Biological Process GO:0033690 positive regulation of osteoblast proliferation
Biological Process GO:0071902 positive regulation of protein serine/threonine kinase activity
Biological Process GO:0034145 positive regulation of toll-like receptor 4 signaling pathway
Biological Process GO:0001817 regulation of cytokine production
Biological Process GO:0032680 regulation of tumor necrosis factor production
Biological Process GO:0001895 retina homeostasis
Biological Process GO:0033214 siderophore-dependent iron import into cell
molecular function GO:0004869 cysteine-type endopeptidase inhibitor activity
molecular function GO:0003677 DNA binding
molecular function GO:0008201 heparin binding
molecular function GO:0005506 iron ion binding
molecular function GO:0001530 lipopolysaccharide binding
molecular function GO:0043539 protein serine/threonine kinase activator activity
molecular function GO:0004252 serine-type endopeptidase activity
cellular component GO:0009986 cell surface
cellular component GO:0005737 cytoplasm
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0005634 nucleus
cellular component GO:0097013 phagocytic vesicle lumen
cellular component GO:0032991 protein-containing complex
cellular component GO:0030141 secretory granule
cellular component GO:0042581 specific granule
cellular component GO:0035580 specific granule lumen
cellular component GO:1904724 tertiary granule lumen
Reactome
Pathway Id Pathway Name
R-HSA-1222449 Mtb iron assimilation by chelation
R-HSA-1222499 Latent infection - Other responses of Mtb to phagocytosis
R-HSA-1643685 Disease
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-392499 Metabolism of proteins
R-HSA-5663205 Infectious disease
R-HSA-6798695 Neutrophil degranulation
R-HSA-6799990 Metal sequestration by antimicrobial proteins
R-HSA-6803157 Antimicrobial peptides
R-HSA-9635486 Infection with Mycobacterium tuberculosis
R-HSA-977225 Amyloid fiber formation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001342 BXGD000042 Acute periodontitis Stomatognathic Diseases
C0001787 BXGD000076 Osteoporosis, Age-Related Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006145 BXGD000376 Breast Diseases Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0006849 BXGD000413 Oral candidiasis Infections; Stomatognathic Diseases
C0006852 BXGD000414 Candidiasis of vagina Female Urogenital Diseases and Pregnancy Complications; Infections
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0010278 BXGD000660 Craniosynostosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011226 BXGD000704 Hepatitis D Infection Digestive System Diseases; Infections
C0011334 BXGD000716 Dental caries Stomatognathic Diseases
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013371 BXGD000823 Shigella Infections Digestive System Diseases; Infections
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0014061 BXGD000883 Tick-Borne Encephalitis Infections; Nervous System Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0014335 BXGD000908 Enteritis Digestive System Diseases
C0014836 BXGD000954 Escherichia coli Infections Infections
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0017181 BXGD001103 Gastrointestinal Hemorrhage Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0018932 BXGD001251 Hematochezia Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0019069 BXGD001277 Hemophilia A Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0019193 BXGD001299 Hepatitis, Toxic Digestive System Diseases; Chemically-Induced Disorders
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019348 BXGD001325 Herpes Simplex Infections Infections; Skin and Connective Tissue Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020557 BXGD001432 Hypertriglyceridemia Nutritional and Metabolic Diseases
C0020649 BXGD001459 Hypotension Cardiovascular Diseases
C0021368 BXGD001502 Inflammation Pathological Conditions, Signs and Symptoms
C0021831 BXGD001516 Intestinal Diseases Digestive System Diseases
C0022408 BXGD001544 Arthropathy Musculoskeletal Diseases
C0022568 BXGD001552 Keratitis Eye Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024894 BXGD001810 Mastitis Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029459 BXGD002159 Osteoporosis, Senile Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029925 BXGD002181 Ovarian Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0029927 BXGD002182 Ovarian Cysts Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0031090 BXGD002280 Periodontal Diseases Stomatognathic Diseases
C0031099 BXGD002282 Periodontitis Stomatognathic Diseases
C0031106 BXGD002283 Aggressive Periodontitis Stomatognathic Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0040425 BXGD002863 Tonsillitis Infections; Respiratory Tract Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C0085110 BXGD003126 Severe Combined Immunodeficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0085669 BXGD003233 Acute leukemia Pathological Conditions, Signs and Symptoms; Neoplasms
C0086692 BXGD003306 Benign Neoplasm Neoplasms
C0149745 BXGD003356 Oral Ulcer Stomatognathic Diseases
C0151526 BXGD003432 Premature Birth Female Urogenital Diseases and Pregnancy Complications
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0158266 BXGD003878 Intervertebral Disc Degeneration Musculoskeletal Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0201850 BXGD004053 Alkaline phosphatase measurement
C0205770 BXGD004121 Choroid Plexus Papilloma Neoplasms; Nervous System Diseases
C0221014 BXGD004364 Reactive systemic amyloidosis Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0242231 BXGD005144 Coronary Stenosis Cardiovascular Diseases
C0242339 BXGD005150 Dyslipidemias Nutritional and Metabolic Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0266929 BXGD005722 Chronic Periodontitis Stomatognathic Diseases
C0269102 BXGD006053 Endometrioma Female Urogenital Diseases and Pregnancy Complications
C0275524 BXGD006376 Coinfection Infections
C0277528 BXGD006472 Traveler's diarrhea Digestive System Diseases; Infections
C0333519 BXGD006958 Caries (morphologic abnormality) Pathological Conditions, Signs and Symptoms
C0339273 BXGD007233 Corneal dystrophy, Lattice type 3 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases
C0340970 BXGD007379 Congenital neutropenia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0343863 BXGD007652 Candida infection of genital region Female Urogenital Diseases and Pregnancy Complications; Infections
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0392622 BXGD008058 Toxic effect of carbon tetrachloride Chemically-Induced Disorders
C0398593 BXGD008196 Specific granule deficiency Hemic and Lymphatic Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0520459 BXGD009084 Necrotizing Enterocolitis Digestive System Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0684275 BXGD009792 Hemophilia, NOS Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0700345 BXGD009886 Candidiasis, Vulvovaginal Female Urogenital Diseases and Pregnancy Complications; Infections
C0751406 BXGD010428 Post-Traumatic Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0860029 BXGD011212 Vaginal Yeast Infections Female Urogenital Diseases and Pregnancy Complications; Infections
C0860207 BXGD011220 Drug-Induced Liver Disease Digestive System Diseases; Chemically-Induced Disorders
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1262477 BXGD011882 Weight decreased Pathological Conditions, Signs and Symptoms
C1262760 BXGD011886 Hepatitis, Drug-Induced Digestive System Diseases; Chemically-Induced Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1527336 BXGD013271 Sjogren's Syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C1701940 BXGD013526 Pneumonia, Ventilator-Associated Pathological Conditions, Signs and Symptoms; Infections; Respiratory Tract Diseases
C1851841 BXGD015242 ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Stomatognathic Diseases
C1853118 BXGD015302 Severe congenital neutropenia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C2118460 BXGD016927 Acute colitis Digestive System Diseases
C2363741 BXGD017100 HIV-1 infection
C2676739 BXGD017342 Chromosome 2q32-Q33 Deletion Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C2939149 BXGD018173 Amyloid of cornea
C2985280 BXGD018223 Blood Protein Measurement
C3203653 BXGD018569 IgG4-Related Sclerosing Disease Immune System Diseases
C3536715 BXGD019070 AA amyloidosis Nutritional and Metabolic Diseases
C3658290 BXGD019256 Drug-Induced Acute Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C3714514 BXGD019409 Infection Infections
C3714731 BXGD019425 Early childhood caries Stomatognathic Diseases
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4087124 BXGD022132 Immunoglobulin G4-Related Disease Immune System Diseases
C4277682 BXGD022376 Chemical and Drug Induced Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C4279912 BXGD022378 Chemically-Induced Liver Toxicity Digestive System Diseases; Chemically-Induced Disorders
C4704876 BXGD023683 Genital Vulvovaginal Candidiasis Female Urogenital Diseases and Pregnancy Complications; Infections
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002248 Dodecanoic acid 200.32
BXGC0003533 Carbonate 60.01
BXGC0003705 Chloride 35.45
BXGC0018397 beta-1,4-mannan 180.06
BXGC0032834 2-[4-[(2R)-2-Hydroxy-3-(Propan-2-Ylamino)Propoxy]Phenyl]Acetamide 266.16
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein