Showing entry for Pannexin-1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT025890
Protein NamePannexin-1
Uniport IdQ96RD7
GenePANX1
Gene Id24145
DomainInnexin
Pfam PF00876  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04621 NOD-like receptor signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006816 calcium ion transport
Biological Process GO:0006812 cation transport
Biological Process GO:0007267 cell-cell signaling
Biological Process GO:0048477 oogenesis
Biological Process GO:0050715 positive regulation of cytokine secretion
Biological Process GO:0032730 positive regulation of interleukin-1 alpha production
Biological Process GO:0032731 positive regulation of interleukin-1 beta production
Biological Process GO:0033198 response to ATP
Biological Process GO:0002931 response to ischemia
molecular function GO:0051015 actin filament binding
molecular function GO:0005262 calcium channel activity
molecular function GO:0005243 gap junction channel activity
molecular function GO:0044325 ion channel binding
molecular function GO:0022840 leak channel activity
molecular function GO:0002020 protease binding
molecular function GO:0097110 scaffold protein binding
molecular function GO:0005102 signaling receptor binding
molecular function GO:0005198 structural molecule activity
molecular function GO:0022829 wide pore channel activity
cellular component GO:0032059 bleb
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0005921 gap junction
cellular component GO:0016021 integral component of membrane
cellular component GO:0016020 membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0032991 protein-containing complex
Reactome
Pathway Id Pathway Name
R-HSA-112303 Electric Transmission Across Gap Junctions
R-HSA-112307 Transmission across Electrical Synapses
R-HSA-112316 Neuronal System
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
R-HSA-622312 Inflammasomes
R-HSA-844456 The NLRP3 inflammasome
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000833 BXGD000014 Abscess Pathological Conditions, Signs and Symptoms; Infections
C0001364 BXGD000047 Massive Hepatic Necrosis Digestive System Diseases
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003862 BXGD000230 Arthralgia Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004943 BXGD000297 Behcet Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases; Stomatognathic Diseases; Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007682 BXGD000471 CNS disorder Nervous System Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013264 BXGD000808 Muscular Dystrophy, Duchenne Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0013404 BXGD000833 Dyspnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014556 BXGD000932 Epilepsy, Temporal Lobe Nervous System Diseases
C0018794 BXGD001222 Heart Block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0019193 BXGD001299 Hepatitis, Toxic Digestive System Diseases; Chemically-Induced Disorders
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0021361 BXGD001499 Female infertility Female Urogenital Diseases and Pregnancy Complications
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0022568 BXGD001552 Keratitis Eye Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0024530 BXGD001783 Malaria Infections
C0025202 BXGD001832 melanoma Neoplasms
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029104 BXGD002109 Opioid withdrawal Chemically-Induced Disorders; Mental Disorders
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0032584 BXGD002363 polyps Pathological Conditions, Signs and Symptoms
C0035412 BXGD002548 Rhabdomyosarcoma Neoplasms
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0038525 BXGD002768 Subarachnoid Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0040997 BXGD002894 Trigeminal Neuralgia Nervous System Diseases; Stomatognathic Diseases
C0041234 BXGD002901 Chagas Disease Infections
C0085548 BXGD003183 Autosomal Recessive Polycystic Kidney Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0152459 BXGD003600 Linear atrophy Pathological Conditions, Signs and Symptoms
C0153594 BXGD003669 Malignant neoplasm of testis Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C0162557 BXGD003956 Liver Failure, Acute Digestive System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0201836 BXGD004052 Alanine aminotransferase measurement
C0201899 BXGD004056 Aspartate aminotransferase measurement
C0206655 BXGD004218 Alveolar rhabdomyosarcoma Neoplasms
C0220611 BXGD004295 Childhood Rhabdomyosarcoma Neoplasms
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0234958 BXGD004702 Muscle degeneration Musculoskeletal Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0278488 BXGD006515 Carcinoma breast stage IV
C0279550 BXGD006635 Adult Rhabdomyosarcoma Neoplasms
C0338484 BXGD007188 Familial Hemiplegic Migraine Nervous System Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0376618 BXGD008003 Endotoxemia Pathological Conditions, Signs and Symptoms; Infections
C0442874 BXGD008814 Neuropathy Nervous System Diseases
C0520679 BXGD009101 Sleep Apnea, Obstructive Respiratory Tract Diseases; Nervous System Diseases
C0520739 BXGD009106 Hereditary pyropoikilocytosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0729777 BXGD009934 Corneal Infection Infections; Eye Diseases
C0745130 BXGD010117 Resistant hypertensive disorder Cardiovascular Diseases
C0796074 BXGD010793 MOHR-TRANEBJAERG SYNDROME Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Mental Disorders; Otorhinolaryngologic Diseases; Behavior and Behavior Mechanisms
C0855197 BXGD011079 Malignant Testicular Germ Cell Tumor Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C0856169 BXGD011096 Endothelial dysfunction
C0860207 BXGD011220 Drug-Induced Liver Disease Digestive System Diseases; Chemically-Induced Disorders
C0947751 BXGD011494 Vascular inflammations Cardiovascular Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1096063 BXGD011600 Drug Resistant Epilepsy Nervous System Diseases
C1262760 BXGD011886 Hepatitis, Drug-Induced Digestive System Diseases; Chemically-Induced Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1531624 BXGD013300 Cardioembolic stroke
C1562113 BXGD013372 Fleck corneal dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1720983 BXGD013698 Channelopathies Pathological Conditions, Signs and Symptoms
C1861172 BXGD016016 Venous Thromboembolism Cardiovascular Diseases
C1883008 BXGD016593 Serum Alanine Aminotransferase Measurement
C1961099 BXGD016672 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1963943 BXGD016706 Atherothrombosis
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2936719 BXGD018130 Mechanical Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2938983 BXGD018170 Focal cortical dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3658290 BXGD019256 Drug-Induced Acute Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C4277682 BXGD022376 Chemical and Drug Induced Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C4279912 BXGD022378 Chemically-Induced Liver Toxicity Digestive System Diseases; Chemically-Induced Disorders
C4531211 BXGD023205 Internal carotid artery calcification
C4699512 BXGD023639 Large-artery atherosclerosis (embolus/thrombosis)
C4703473 BXGD023650 Atherosclerotic lesion Cardiovascular Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0038316 Cholesterol 386.35
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein