Showing entry for Beta-defensin 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011285
Protein NameBeta-defensin 1
Uniport IdP60022
GeneDEFB1
Gene Id1672
DomainDefensin_beta
Pfam PF00711  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.1 Membrane transport hsa02010 ABC transporters
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05150 Staphylococcus aureus infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0019731 antibacterial humoral response
Biological Process GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
Biological Process GO:0019730 antimicrobial humoral response
Biological Process GO:0035584 calcium-mediated signaling using intracellular calcium source
Biological Process GO:0019933 cAMP-mediated signaling
Biological Process GO:0006935 chemotaxis
Biological Process GO:0042742 defense response to bacterium
Biological Process GO:0050829 defense response to Gram-negative bacterium
Biological Process GO:0050830 defense response to Gram-positive bacterium
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0006955 immune response
Biological Process GO:0045087 innate immune response
Biological Process GO:0002227 innate immune response in mucosa
Biological Process GO:0060474 positive regulation of flagellated sperm motility involved in capacitation
Biological Process GO:0009617 response to bacterium
molecular function GO:0031731 CCR6 chemokine receptor binding
molecular function GO:0042802 identical protein binding
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0019898 extrinsic component of membrane
cellular component GO:0005796 Golgi lumen
cellular component GO:1990742 microvesicle
cellular component GO:0097225 sperm midpiece
Reactome
Pathway Id Pathway Name
R-HSA-1461957 Beta defensins
R-HSA-1461973 Defensins
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-6803157 Antimicrobial peptides
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001144 BXGD000028 Acne Vulgaris Skin and Connective Tissue Diseases
C0001249 BXGD000035 Actinobacillus Infections Infections
C0001339 BXGD000041 Acute pancreatitis Digestive System Diseases
C0001342 BXGD000042 Acute periodontitis Stomatognathic Diseases
C0003615 BXGD000212 Appendicitis Digestive System Diseases; Infections
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004610 BXGD000281 Bacteremia Pathological Conditions, Signs and Symptoms; Infections
C0004623 BXGD000282 Bacterial Infections Infections
C0004763 BXGD000289 Barrett Esophagus Digestive System Diseases; Neoplasms
C0004943 BXGD000297 Behcet Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases; Stomatognathic Diseases; Cardiovascular Diseases
C0005398 BXGD000311 Cholestasis, Extrahepatic Digestive System Diseases
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0006840 BXGD000409 Candidiasis Infections
C0006849 BXGD000413 Oral candidiasis Infections; Stomatognathic Diseases
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007112 BXGD000429 Adenocarcinoma of prostate Neoplasms; Male Urogenital Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007570 BXGD000467 Celiac Disease Digestive System Diseases; Nutritional and Metabolic Diseases
C0008312 BXGD000527 Primary biliary cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0008370 BXGD000534 Cholestasis Digestive System Diseases
C0008373 BXGD000536 Cholesteatoma Skin and Connective Tissue Diseases
C0008924 BXGD000574 Cleft upper lip Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010043 BXGD000644 Corneal Ulcer Infections; Eye Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011334 BXGD000716 Dental caries Stomatognathic Diseases
C0011389 BXGD000718 Dental Plaque Stomatognathic Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011603 BXGD000734 Dermatitis Skin and Connective Tissue Diseases
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0011616 BXGD000739 Contact Dermatitis Skin and Connective Tissue Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0012242 BXGD000773 Digestive System Disorders Digestive System Diseases
C0013371 BXGD000823 Shigella Infections Digestive System Diseases; Infections
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0014335 BXGD000908 Enteritis Digestive System Diseases
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0017152 BXGD001096 Gastritis Digestive System Diseases
C0017178 BXGD001102 Gastrointestinal Diseases Digestive System Diseases
C0017574 BXGD001122 Gingivitis Infections; Stomatognathic Diseases
C0019340 BXGD001321 Herpes NOS Infections
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0021364 BXGD001500 Male infertility Male Urogenital Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0022568 BXGD001552 Keratitis Eye Diseases
C0022650 BXGD001568 Kidney Calculi Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022665 BXGD001573 Kidney Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023343 BXGD001635 Leprosy Infections
C0023348 BXGD001636 Leprosy, Lepromatous Infections
C0023418 BXGD001642 leukemia Neoplasms
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023531 BXGD001684 Leukoplakia Pathological Conditions, Signs and Symptoms; Neoplasms
C0023532 BXGD001685 Leukoplakia, Oral Pathological Conditions, Signs and Symptoms; Neoplasms; Stomatognathic Diseases
C0024115 BXGD001732 Lung diseases Respiratory Tract Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024959 BXGD001819 Maxillary Sinusitis Infections; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0025286 BXGD001850 Meningioma Neoplasms; Nervous System Diseases
C0025303 BXGD001858 Meningococcal Infections Infections
C0026277 BXGD001899 Mixed Salivary Gland Tumor Neoplasms
C0026948 BXGD001952 Mycosis Fungoides Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0031090 BXGD002280 Periodontal Diseases Stomatognathic Diseases
C0031099 BXGD002282 Periodontitis Stomatognathic Diseases
C0031106 BXGD002283 Aggressive Periodontitis Stomatognathic Diseases
C0032580 BXGD002362 Adenomatous Polyposis Coli Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0033740 BXGD002416 Protozoan Infections Infections
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0034103 BXGD002464 Pulpitis Stomatognathic Diseases
C0035222 BXGD002513 Respiratory Distress Syndrome, Adult Respiratory Tract Diseases
C0035243 BXGD002522 Respiratory Tract Infections Infections; Respiratory Tract Diseases
C0036117 BXGD002577 Salmonella infections Infections
C0037284 BXGD002679 Skin lesion Skin and Connective Tissue Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0040425 BXGD002863 Tonsillitis Infections; Respiratory Tract Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C0040580 BXGD002877 Tracheal Diseases Respiratory Tract Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0041912 BXGD002937 Upper Respiratory Infections Infections; Respiratory Tract Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0042900 BXGD003012 Vitiligo Skin and Connective Tissue Diseases
C0042929 BXGD003015 Polyp of vocal cord Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0085693 BXGD003241 Acute appendicitis NOS (disorder) Digestive System Diseases; Infections
C0149517 BXGD003325 Chronic tonsillitis Infections; Respiratory Tract Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C0149642 BXGD003338 Cervical lymphadenitis Hemic and Lymphatic Diseases
C0156147 BXGD003838 Crohn's disease of large bowel Digestive System Diseases
C0158646 BXGD003897 Cleft palate with cleft lip Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0162351 BXGD003938 Contact hypersensitivity Skin and Connective Tissue Diseases
C0206139 BXGD004159 Lichen Planus, Oral Skin and Connective Tissue Diseases; Stomatognathic Diseases
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0221228 BXGD004412 Comedone Skin and Connective Tissue Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0263361 BXGD005292 Psoriasis vulgaris Skin and Connective Tissue Diseases
C0264408 BXGD005387 Childhood asthma Respiratory Tract Diseases; Immune System Diseases
C0265797 BXGD005576 Congenital emphysema Respiratory Tract Diseases
C0266929 BXGD005722 Chronic Periodontitis Stomatognathic Diseases
C0271441 BXGD006203 Chronic otitis media Otorhinolaryngologic Diseases
C0272386 BXGD006361 Hypertrophy of tonsils Pathological Conditions, Signs and Symptoms
C0275518 BXGD006375 Acute infectious disease Pathological Conditions, Signs and Symptoms; Infections
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0333519 BXGD006958 Caries (morphologic abnormality) Pathological Conditions, Signs and Symptoms
C0343641 BXGD007636 Human papilloma virus infection Infections
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0374997 BXGD007967 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
C0375023 BXGD007970 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376620 BXGD008004 Pouchitis Digestive System Diseases
C0392525 BXGD008052 Nephrolithiasis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0399495 BXGD008249 Inflammatory fibrous hyperplasia of mouth Pathological Conditions, Signs and Symptoms; Stomatognathic Diseases
C0497169 BXGD009054 hiv-infection/aids Infections
C0524910 BXGD009248 Hepatitis C, Chronic Digestive System Diseases; Infections
C0555971 BXGD009438 Oral infection Infections; Respiratory Tract Diseases; Stomatognathic Diseases
C0566602 BXGD009489 Primary sclerosing cholangitis Digestive System Diseases
C0574143 BXGD009503 Liver calculus
C0585362 BXGD009592 Squamous cell carcinoma of mouth Digestive System Diseases; Neoplasms; Stomatognathic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0702166 BXGD009912 Acne Skin and Connective Tissue Diseases
C0740457 BXGD010000 Malignant neoplasm of kidney Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0748355 BXGD010195 Acute respiratory distress Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0751571 BXGD010505 Cancer of Urinary Tract Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0940937 BXGD011490 precancerous lesions
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C0949272 BXGD011573 IIeocolitis Digestive System Diseases
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1282227 BXGD012139 Postoperative endophthalmitis Pathological Conditions, Signs and Symptoms; Infections; Eye Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1378703 BXGD012933 Renal carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1608408 BXGD013434 Malignant transformation
C1707758 BXGD013592 Direct Contact Transmission Infection Pathological Conditions, Signs and Symptoms; Infections
C1719495 BXGD013656 Aggressive periodontitis, generalized Stomatognathic Diseases
C1719672 BXGD013659 Severe Sepsis Pathological Conditions, Signs and Symptoms; Infections
C1847835 BXGD014892 VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) Skin and Connective Tissue Diseases
C1858991 BXGD015841 Childhood Ataxia with Central Nervous System Hypomyelinization Nervous System Diseases
C1960274 BXGD016656 Nongonococcal cervicitis Female Urogenital Diseases and Pregnancy Complications
C1961102 BXGD016673 Precursor Cell Lymphoblastic Leukemia Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2363741 BXGD017100 HIV-1 infection
C2607914 BXGD017148 Allergic rhinitis (disorder) Respiratory Tract Diseases; Immune System Diseases; Otorhinolaryngologic Diseases
C2936258 BXGD018104 Peri-Implantitis Stomatognathic Diseases
C2937365 BXGD018161 Recurrent aphthous ulcer Stomatognathic Diseases
C2985280 BXGD018223 Blood Protein Measurement
C3495801 BXGD019004 Granulomatosis with polyangiitis Respiratory Tract Diseases; Immune System Diseases; Cardiovascular Diseases
C3714514 BXGD019409 Infection Infections
C3811653 BXGD019662 Experimental Organism Basal Cell Carcinoma Neoplasms
C3850141 BXGD019810 Acute-On-Chronic Liver Failure Digestive System Diseases
C3875321 BXGD019874 Inflammatory dermatosis Skin and Connective Tissue Diseases
C4050407 BXGD021962 Pauci-immune Glomerulonephritis associated with Granulomatosis with Polyangiitis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C4321245 BXGD022744 Cleft lip or lips
C4321358 BXGD022749 Immune-Mediated Coagulopathy Hemic and Lymphatic Diseases
C4721806 BXGD023772 Carcinoma, Basal Cell Neoplasms
C4722014 BXGD023787 Kynurenine Measurement
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000226 Glycine 75.07
BXGC0000436 Glycerol 92.09
BXGC0002591 Potassium 39.1
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein