Showing entry for Retinopathy of Prematurity


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD002541
Disease NameRetinopathy of Prematurity
Disease CUI IdC0035344
MeSH Codes C16   C11  
Disease Class NameCongenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id HP:0000478  
Human Phenotype Ontology TermAbnormality of the eye
Disease Ontology Id DOID:630   DOID:7  
Disease Ontology Class Namegenetic disease; disease of anatomical entity
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O14786 BXGT004099 Neuropilin-1 8829 reviewed
O15123 BXGT004130 Angiopoietin-2 285 reviewed Signaling
O43324 BXGT004588 Eukaryotic translation elongation factor 1 epsilon-1 9521 reviewed
O43854 BXGT004630 EGF-like repeat and discoidin I-like domain-containing protein 3 10085 reviewed Enzyme
O60462 BXGT004876 Neuropilin-2 8828 reviewed
P00441 BXGT005540 Superoxide dismutase [Cu-Zn] 6647 reviewed Enzyme
P00734 BXGT005630 Prothrombin 2147 reviewed Enzyme
P00797 BXGT005658 Renin 5972 reviewed Enzyme
P01019 BXGT005717 Angiotensinogen 183 reviewed Enzyme modulator
P01024 BXGT005719 Complement C3 718 reviewed Enzyme modulator
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01138 BXGT005738 Beta-nerve growth factor 4803 reviewed Signaling
P01236 BXGT005744 Prolactin 5617 reviewed Signaling
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01579 BXGT005770 Interferon gamma 3458 reviewed
P01583 BXGT005771 Interleukin-1 alpha 3552 reviewed
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P02741 BXGT005936 C-reactive protein 1401 reviewed
P03372 BXGT006059 Estrogen receptor 2099 reviewed Nuclear receptor
P03950 BXGT006116 Angiogenin 283 reviewed
P04040 BXGT006132 Catalase 847 reviewed Enzyme
P04083 BXGT006147 Annexin A1 301 reviewed
P04179 BXGT006163 Superoxide dismutase [Mn], mitochondrial 6648 reviewed Enzyme
P05164 BXGT006333 Myeloperoxidase 4353 reviewed Enzyme
P05231 BXGT006345 Interleukin-6 3569 reviewed
P05362 BXGT006350 Intercellular adhesion molecule 1 3383 reviewed
P06702 BXGT006476 Protein S100-A9 6280 reviewed Calcium-binding protein
P07225 BXGT006572 Vitamin K-dependent protein S 5627 reviewed
P07359 BXGT006612 Platelet glycoprotein Ib alpha chain 2811 reviewed Receptor
P08069 BXGT006723 Insulin-like growth factor 1 receptor 3480 reviewed Kinase
P08253 BXGT006757 72 kDa type IV collagenase 4313 reviewed Enzyme
P08581 BXGT006794 Hepatocyte growth factor receptor 4233 reviewed Kinase
P09038 BXGT006851 Fibroblast growth factor 2 2247 reviewed Signaling
P09382 BXGT006882 Galectin-1 3956 reviewed Signaling
P09488 BXGT006899 Glutathione S-transferase Mu 1 2944 reviewed
P09601 BXGT006909 Heme oxygenase 1 3162 reviewed
P10145 BXGT007542 Interleukin-8 3576 reviewed Signaling
P10646 BXGT007598 Tissue factor pathway inhibitor 7035 reviewed Enzyme modulator
P11166 BXGT007661 Solute carrier family 2, facilitated glucose transporter member 1 6513 reviewed Transporter
P11597 BXGT007727 Cholesteryl ester transfer protein 1071 reviewed
P12314 BXGT007798 High affinity immunoglobulin gamma Fc receptor I 2209 reviewed Cell adhesion
P12821 BXGT007849 Angiotensin-converting enzyme 1636 reviewed Enzyme
P13236 BXGT007891 C-C motif chemokine 4 6351 reviewed
P13501 BXGT007917 C-C motif chemokine 5 6352 reviewed Signaling
P13945 BXGT007972 Beta-3 adrenergic receptor 155 reviewed G-protein coupled receptor
P14210 BXGT007994 Hepatocyte growth factor 3082 reviewed Enzyme
P14780 BXGT008053 Matrix metalloproteinase-9 4318 reviewed Enzyme
P14921 BXGT008068 Protein C-ets-1 2113 reviewed Transcription factor
P15144 BXGT008087 Aminopeptidase N 290 reviewed Enzyme
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P17936 BXGT008357 Insulin-like growth factor-binding protein 3 3486 reviewed Enzyme modulator
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 2321 reviewed Kinase
P18848 BXGT008432 Cyclic AMP-dependent transcription factor ATF-4 468 reviewed
P19438 BXGT008480 Tumor necrosis factor receptor superfamily member 1A 7132 reviewed
P21980 BXGT008715 Protein-glutamine gamma-glutamyltransferase 2 7052 reviewed Enzyme
P23528 BXGT008879 Cofilin-1 1072 reviewed
P23560 BXGT008883 Brain-derived neurotrophic factor 627 reviewed Signaling
P28482 BXGT009263 Mitogen-activated protein kinase 1 5594 reviewed Kinase
P28676 BXGT009284 Grancalcin 25801 reviewed
P29323 BXGT009334 Ephrin type-B receptor 2 2048 reviewed Kinase
P29474 BXGT009352 Nitric oxide synthase, endothelial 4846 reviewed
P29475 BXGT009353 Nitric oxide synthase, brain 4842 reviewed
P30556 BXGT009441 Type-1 angiotensin II receptor 185 reviewed G-protein coupled receptor
P30711 BXGT009460 Glutathione S-transferase theta-1 2952 reviewed
P34913 BXGT009770 Bifunctional epoxide hydrolase 2 2053 reviewed Enzyme
P35228 BXGT009800 Nitric oxide synthase, inducible 4843 reviewed
P35968 BXGT009887 Vascular endothelial growth factor receptor 2 3791 reviewed Kinase
P36955 BXGT009946 Pigment epithelium-derived factor 5176 reviewed Enzyme modulator
P39060 BXGT010088 Collagen alpha-1(XVIII) chain 80781 reviewed
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5291 reviewed Kinase
P42898 BXGT010344 Methylenetetrahydrofolate reductase 4524 reviewed
P43681 BXGT010407 Neuronal acetylcholine receptor subunit alpha-4 1137 reviewed Ion channel
P46531 BXGT010526 Neurogenic locus notch homolog protein 1 4851 reviewed
P48506 BXGT010635 Glutamate--cysteine ligase catalytic subunit 2729 reviewed Enzyme
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 reviewed Kinase
P49763 BXGT010737 Placenta growth factor 5228 reviewed Signaling
P51572 BXGT010859 B-cell receptor-associated protein 31 10134 reviewed Transporter
P53985 BXGT011022 Monocarboxylate transporter 1 6566 reviewed Transporter
P58004 BXGT011222 Sestrin-2 83667 reviewed Enzyme
P60709 BXGT011322 Actin, cytoplasmic 1 60 reviewed Cellular structure
P63279 BXGT011514 SUMO-conjugating enzyme UBC9 7329 reviewed
P78417 BXGT011843 Glutathione S-transferase omega-1 9446 reviewed
Q00604 BXGT012538 Norrin 4693 reviewed
Q02763 BXGT012667 Angiopoietin-1 receptor 7010 reviewed Kinase
Q13467 BXGT013358 Frizzled-5 7855 reviewed G-protein coupled receptor
Q14623 BXGT013490 Indian hedgehog protein 3549 reviewed
Q14790 BXGT013505 Caspase-8 841 reviewed Enzyme
Q15078 BXGT013534 Cyclin-dependent kinase 5 activator 1 8851 reviewed Enzyme modulator
Q15389 BXGT013564 Angiopoietin-1 284 reviewed Signaling
Q15485 BXGT013574 Ficolin-2 2220 reviewed Signaling
Q15561 BXGT013578 Transcriptional enhancer factor TEF-3 7004 reviewed Transcription factor
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha 3091 reviewed Transcription factor
Q71U36 BXGT016705 Tubulin alpha-1A chain 7846 reviewed Cellular structure
Q8IVS2 BXGT018349 Malonyl-CoA-acyl carrier protein transacylase, mitochondrial 27349 reviewed
Q8NEM0 BXGT018555 Microcephalin 79648 reviewed Nucleic acid binding
Q99593 BXGT019939 T-box transcription factor TBX5 6910 reviewed Transcription factor
Q99814 BXGT019965 Endothelial PAS domain-containing protein 1 2034 reviewed Transcription factor
Q9BXA5 BXGT020163 Succinate receptor 1 56670 reviewed G-protein coupled receptor
Q9BXJ9 BXGT020170 N-alpha-acetyltransferase 15, NatA auxiliary subunit 80155 reviewed Enzyme
Q9BYW2 BXGT020192 Histone-lysine N-methyltransferase SETD2 29072 reviewed Epigenetic regulator
Q9NP99 BXGT021148 Triggering receptor expressed on myeloid cells 1 54210 reviewed
Q9P289 BXGT021300 Serine/threonine-protein kinase 26 51765 reviewed Kinase
Q9UJU2 BXGT021730 Lymphoid enhancer-binding factor 1 51176 reviewed
Q9ULV1 BXGT021764 Frizzled-4 8322 reviewed G-protein coupled receptor
Q9Y251 BXGT022215 Heparanase 10855 reviewed Enzyme
Q9Y3B4 BXGT022255 Splicing factor 3B subunit 6 51639 reviewed
Q9Y5S8 BXGT022302 NADPH oxidase 1 27035 reviewed
P19235 BXGT022895 Erythropoietin receptor 2057 reviewed Receptor
Q16552 BXGT023419 Interleukin-17A 3605 reviewed
Q12888 BXGT024878 TP53-binding protein 1 7158 reviewed Epigenetic regulator
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease